cimetidine has been researched along with Blood Pressure, Low in 28 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| " During the first 60 min of bypass, hypotension (40-45 mm Hg) was observed in spite of phenylephrine 14 mg." | 7.67 | Bronchospasm and hypotension during cardiopulmonary bypass after preoperative cimetidine and labetalol therapy. ( Durant, PA; Joucken, K, 1984) |
| "Incidence and mechanisms of cimetidine-induced hypotension were investigated during the first intravenous injection of cimetidine (200 mg over three minutes) in 68 consecutive patients in the intensive care unit." | 7.67 | Bolus injection of cimetidine and hypotension in patients in the intensive care unit. Incidence and mechanisms. ( Frei, A; Kiowski, W, 1987) |
| " H1- and H2-histamine antagonists or placebo were given before dosing with d-tubocurarine in a randomized double-blind fashion to four groups: group 1--placebo; group 2--cimetidine, 4 mg/kg, plus placebo; group 3--chlorpheniramine, 0." | 6.66 | Histamine antagonists and d-tubocurarine-induced hypotension in cardiac surgical patients. ( Akins, CW; D'Ambra, MN; Inada, E; Machaj, V; Moss, J; Philbin, DM; Rosow, CE, 1986) |
| " After immunization with ovalbumin (OVA), a common dietary constituent, we evaluated the efficacy of pretreatment with histamine-receptor or serotonin-receptor blockers administered alone or in combination with a nitric oxide synthase inhibitor (L-NAME) on OVA-induced anaphylactic shock in Brown Norway rats." | 5.32 | Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock. ( Bellou, A; Gerard, P; Gillois, P; Guéant, JL; Lambert, H; Longrois, D; Mallié, JP; Montémont, C; Sainte-Laudy, J; Vauthier, E, 2003) |
| " During the first 60 min of bypass, hypotension (40-45 mm Hg) was observed in spite of phenylephrine 14 mg." | 3.67 | Bronchospasm and hypotension during cardiopulmonary bypass after preoperative cimetidine and labetalol therapy. ( Durant, PA; Joucken, K, 1984) |
| "5 mg/kg) (six times the ED95) can result in significant histamine release, resulting in systemic hypotension." | 3.67 | Combined H1 and H2 receptor blockade attenuates the cardiovascular effects of high-dose atracurium for rapid sequence endotracheal intubation. ( Gronert, GA; Hosking, MP; Lennon, RL, 1988) |
| "Incidence and mechanisms of cimetidine-induced hypotension were investigated during the first intravenous injection of cimetidine (200 mg over three minutes) in 68 consecutive patients in the intensive care unit." | 3.67 | Bolus injection of cimetidine and hypotension in patients in the intensive care unit. Incidence and mechanisms. ( Frei, A; Kiowski, W, 1987) |
| "Mesenteric traction syndrome is described as sudden tachycardia, hypotension and flush." | 2.70 | Histamine release in mesenteric traction syndrome during abdominal aortic aneurysm surgery: prophylaxis with H1 and H2 antihistamines. ( Celik, I; Duda, D; Lorenz, W, 2002) |
| "Hypotension and arrhythmias are the most frequently observed symptoms." | 2.67 | [Histamine release and cardiovascular reactions to implantation of bone cement during total hip replacement]. ( Linde, I; Tryba, M; Voshage, G; Zenz, M, 1991) |
| " H1- and H2-histamine antagonists or placebo were given before dosing with d-tubocurarine in a randomized double-blind fashion to four groups: group 1--placebo; group 2--cimetidine, 4 mg/kg, plus placebo; group 3--chlorpheniramine, 0." | 2.66 | Histamine antagonists and d-tubocurarine-induced hypotension in cardiac surgical patients. ( Akins, CW; D'Ambra, MN; Inada, E; Machaj, V; Moss, J; Philbin, DM; Rosow, CE, 1986) |
| " The warfarin enantiomers were given separately as single doses (15 mg) alone and during chronic administration of cimetidine (1 g day-1)." | 2.66 | Stereoselective interaction between the R enantiomer of warfarin and cimetidine. ( Breckenridge, AM; Cholerton, S; Choonara, IA; Haynes, BP; Park, BK, 1986) |
| " After immunization with ovalbumin (OVA), a common dietary constituent, we evaluated the efficacy of pretreatment with histamine-receptor or serotonin-receptor blockers administered alone or in combination with a nitric oxide synthase inhibitor (L-NAME) on OVA-induced anaphylactic shock in Brown Norway rats." | 1.32 | Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock. ( Bellou, A; Gerard, P; Gillois, P; Guéant, JL; Lambert, H; Longrois, D; Mallié, JP; Montémont, C; Sainte-Laudy, J; Vauthier, E, 2003) |
| "Pretreatment with cyproheptadine (2." | 1.28 | Hypotension induced by growth-hormone-releasing peptide is mediated by mast cell serotonin release in the rat. ( Gabel, RA; Macia, RA; Matthews, WD; Reginato, MJ, 1990) |
| "Pretreatment with cimetidine (300 mg iv) depressed the drinking response to histamine to 30 +/- 10 ml and to pentagastrin to 58 +/- 24 ml." | 1.27 | Water drinking induced by gastric secretagogues in pigs. ( Houpt, TR; Troy, DW; Weixler, LC, 1986) |
| "The hypotension was found to be refractory to intravenous fluids, dopamine, and antihistamines, but was immediately reversed by intravenous epinephrine." | 1.26 | Shock syndrome associated with mastocytosis: pharmacologic reversal of the acute episode and therapeutic prevention of recurrent attacks. ( Oates, JA; Roberts, LJ; Turk, JW, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (67.86) | 18.7374 |
| 1990's | 6 (21.43) | 18.2507 |
| 2000's | 3 (10.71) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duda, D | 1 |
| Lorenz, W | 1 |
| Celik, I | 1 |
| Bellou, A | 1 |
| Lambert, H | 1 |
| Gillois, P | 1 |
| Montémont, C | 1 |
| Gerard, P | 1 |
| Vauthier, E | 1 |
| Sainte-Laudy, J | 1 |
| Longrois, D | 1 |
| Guéant, JL | 1 |
| Mallié, JP | 1 |
| Breuer, HW | 1 |
| Meschig, R | 1 |
| Breuer, J | 1 |
| Goehlich, G | 1 |
| Arnold, G | 1 |
| Scott, HW | 1 |
| Parris, WC | 1 |
| Sandidge, PC | 1 |
| Oates, JA | 2 |
| Roberts, LJ | 2 |
| Kaplan, AP | 1 |
| Yang, MC | 1 |
| Tenner, TE | 1 |
| Pang, PK | 1 |
| Durant, PA | 1 |
| Joucken, K | 1 |
| Hammond, JE | 1 |
| Ware, R | 1 |
| Turk, JW | 1 |
| Selby, D | 1 |
| Renz, C | 1 |
| Lynch, J | 1 |
| Thurn, J | 1 |
| Moss, J | 2 |
| Guo, Y | 1 |
| Hedqvist, P | 1 |
| Gustafsson, LE | 1 |
| Mahon, WA | 1 |
| Kolton, M | 1 |
| Matzen, S | 1 |
| Secher, NH | 1 |
| Knigge, U | 1 |
| Bach, FW | 1 |
| Warberg, J | 1 |
| Macia, RA | 1 |
| Gabel, RA | 1 |
| Reginato, MJ | 1 |
| Matthews, WD | 1 |
| Tryba, M | 1 |
| Linde, I | 1 |
| Voshage, G | 1 |
| Zenz, M | 1 |
| Iberti, TJ | 1 |
| Casthely, PA | 1 |
| Yoganathan, D | 1 |
| Karyanis, B | 1 |
| Salem, M | 1 |
| Yoganathan, T | 1 |
| Komer, C | 1 |
| Uribe, M | 1 |
| Sclafani, S | 1 |
| Hudak, A | 1 |
| Wiggins, RC | 1 |
| Glatfelter, A | 1 |
| Campbell, AM | 1 |
| Kunkel, RG | 1 |
| Ulevitch, RJ | 1 |
| Inada, E | 1 |
| Philbin, DM | 1 |
| Machaj, V | 1 |
| D'Ambra, MN | 1 |
| Rosow, CE | 1 |
| Akins, CW | 1 |
| Hosking, MP | 1 |
| Lennon, RL | 1 |
| Gronert, GA | 1 |
| Parsons, RS | 1 |
| Mohandas, K | 1 |
| Yarbrough, JA | 1 |
| Moffitt, JE | 1 |
| Brown, DA | 1 |
| Stafford, CT | 1 |
| Houpt, TR | 1 |
| Weixler, LC | 1 |
| Troy, DW | 1 |
| Choonara, IA | 1 |
| Cholerton, S | 1 |
| Haynes, BP | 1 |
| Breckenridge, AM | 1 |
| Park, BK | 1 |
| Newman, B | 1 |
| Lam, AM | 1 |
| Guay, DR | 1 |
| Matzke, GR | 1 |
| Kiowski, W | 1 |
| Frei, A | 1 |
7 trials available for cimetidine and Blood Pressure, Low
| Article | Year |
|---|---|
Histamine release in mesenteric traction syndrome during abdominal aortic aneurysm surgery: prophylaxis with H1 and H2 antihistamines.
Topics: Aortic Aneurysm, Abdominal; Blood Pressure; Cardiac Output; Cimetidine; Dimethindene; Double-Blind M | 2002 |
Histamine release during rapid vancomycin administration.
Topics: Anti-Bacterial Agents; Cimetidine; Diphenhydramine; Double-Blind Method; Drug Hypersensitivity; Exan | 1998 |
[Histamine release and cardiovascular reactions to implantation of bone cement during total hip replacement].
Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Bone Cements; Cimetidine; Clemastine; Female; Hip Pro | 1991 |
Histamine blockade and cardiovascular changes following heparin administration during cardiac surgery.
Topics: Blood Pressure; Calcium; Cardiac Output; Cimetidine; Coronary Artery Bypass; Diphenhydramine; Hepari | 1990 |
Histamine antagonists and d-tubocurarine-induced hypotension in cardiac surgical patients.
Topics: Blood Pressure; Chlorpheniramine; Cimetidine; Clinical Trials as Topic; Coronary Artery Bypass; Doub | 1986 |
The effect of histamine-receptor blockade on the hemodynamic responses to protamine.
Topics: Blood Pressure; Cardiopulmonary Bypass; Central Venous Pressure; Chlorpheniramine; Cimetidine; Coron | 1989 |
Stereoselective interaction between the R enantiomer of warfarin and cimetidine.
Topics: Administration, Oral; Bradycardia; Cimetidine; Drug Eruptions; Drug Interactions; Half-Life; Humans; | 1986 |
21 other studies available for cimetidine and Blood Pressure, Low
| Article | Year |
|---|---|
Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock.
Topics: Anaphylaxis; Animals; Arteries; Cimetidine; Dihydroergotamine; Dinoprostone; Eicosanoids; Enzyme Inh | 2003 |
Hemodynamic studies on cimetidine and ranitidine in anesthetized dogs.
Topics: Animals; Blood Pressure; Cimetidine; Dogs; Drug Evaluation, Preclinical; Female; Hemodynamics; Hypot | 1984 |
Hazards in operative management of patients with systemic mastocytosis.
Topics: Adult; Chlorpheniramine; Cimetidine; Face; Female; Histamine Release; Humans; Hypotension; Intraoper | 1983 |
Exercise-induced hives.
Topics: Cimetidine; Cold Temperature; Cyproheptadine; Histamine; Humans; Hydroxyzine; Hypotension; Methachol | 1984 |
Lack of histamine involvement in parathyroid hormone hypotensive action.
Topics: Animals; Blood Pressure; Cimetidine; Dimaprit; Female; Histamine; Hypotension; Male; p-Methoxy-N-met | 1981 |
Bronchospasm and hypotension during cardiopulmonary bypass after preoperative cimetidine and labetalol therapy.
Topics: Bronchial Spasm; Cardiopulmonary Bypass; Cimetidine; Drug Interactions; Humans; Hypotension; Intraop | 1984 |
Hypotension following intravenous cimetidine.
Topics: Cimetidine; Guanidines; Humans; Hypotension | 1983 |
Shock syndrome associated with mastocytosis: pharmacologic reversal of the acute episode and therapeutic prevention of recurrent attacks.
Topics: Aspirin; Chlorpheniramine; Cimetidine; Epinephrine; Humans; Hypotension; Infusions, Parenteral; Pros | 1982 |
Cardiovascular effects of cimetidine.
Topics: Aged; Cimetidine; Female; Guanidines; Humans; Hypotension | 1981 |
Absence of mast cell involvement in active systemic anaphylaxis in rats.
Topics: Anaphylaxis; Animals; Blood Pressure; Cell Degranulation; Chlorpheniramine; Cimetidine; Dextrans; Ge | 2001 |
Hypotension after intravenous cimetidine.
Topics: Adult; Cimetidine; Guanidines; Humans; Hypotension; Male; Methods; Middle Aged | 1978 |
Pituitary-adrenal responses to head-up tilt in humans: effect of H1- and H2-receptor blockade.
Topics: Adult; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Cimetidine; He | 1992 |
Hypotension induced by growth-hormone-releasing peptide is mediated by mast cell serotonin release in the rat.
Topics: Analysis of Variance; Animals; Cimetidine; Cyproheptadine; Dose-Response Relationship, Drug; Drug Sy | 1990 |
Hemodynamic effects of H2-receptor antagonists.
Topics: Bradycardia; Cimetidine; Critical Care; Gastric Acid; Histamine H2 Antagonists; Humans; Hypotension; | 1990 |
Acute hypotension due to platelet serotonin-induced chemoreflexes after intravenous injection of dextran sulfate in the rabbit.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Autonomic Nervous System; Blood Platelets; Bradyc | 1985 |
Combined H1 and H2 receptor blockade attenuates the cardiovascular effects of high-dose atracurium for rapid sequence endotracheal intubation.
Topics: Atracurium; Blood Pressure; Cimetidine; Diphenhydramine; Heart Rate; Histamine; Histamine H1 Antagon | 1988 |
Cimetidine in the treatment of refractory anaphylaxis.
Topics: Anaphylaxis; Cefuroxime; Cimetidine; Drug Hypersensitivity; Female; Flushing; Humans; Hypotension; I | 1989 |
Water drinking induced by gastric secretagogues in pigs.
Topics: Analysis of Variance; Animals; Atropine; Bethanechol; Bethanechol Compounds; Cimetidine; Computers; | 1986 |
Induced hypotension for clipping of a cerebral aneurysm during pregnancy: a case report and brief review.
Topics: Adult; Anesthesia, Inhalation; Blood Pressure; Cimetidine; Female; Fetal Monitoring; Humans; Hypoten | 1986 |
Hypotension after intravenous cimetidine in intensive care unit patients.
Topics: Cimetidine; Critical Care; Humans; Hypotension; Infusions, Parenteral | 1986 |
Bolus injection of cimetidine and hypotension in patients in the intensive care unit. Incidence and mechanisms.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Cimetidine; Female; Heart Rate; Humans; | 1987 |