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cimetidine and Blood Pressure, Low

cimetidine has been researched along with Blood Pressure, Low in 28 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Research Excerpts

ExcerptRelevanceReference
" During the first 60 min of bypass, hypotension (40-45 mm Hg) was observed in spite of phenylephrine 14 mg."7.67Bronchospasm and hypotension during cardiopulmonary bypass after preoperative cimetidine and labetalol therapy. ( Durant, PA; Joucken, K, 1984)
"Incidence and mechanisms of cimetidine-induced hypotension were investigated during the first intravenous injection of cimetidine (200 mg over three minutes) in 68 consecutive patients in the intensive care unit."7.67Bolus injection of cimetidine and hypotension in patients in the intensive care unit. Incidence and mechanisms. ( Frei, A; Kiowski, W, 1987)
" H1- and H2-histamine antagonists or placebo were given before dosing with d-tubocurarine in a randomized double-blind fashion to four groups: group 1--placebo; group 2--cimetidine, 4 mg/kg, plus placebo; group 3--chlorpheniramine, 0."6.66Histamine antagonists and d-tubocurarine-induced hypotension in cardiac surgical patients. ( Akins, CW; D'Ambra, MN; Inada, E; Machaj, V; Moss, J; Philbin, DM; Rosow, CE, 1986)
" After immunization with ovalbumin (OVA), a common dietary constituent, we evaluated the efficacy of pretreatment with histamine-receptor or serotonin-receptor blockers administered alone or in combination with a nitric oxide synthase inhibitor (L-NAME) on OVA-induced anaphylactic shock in Brown Norway rats."5.32Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock. ( Bellou, A; Gerard, P; Gillois, P; Guéant, JL; Lambert, H; Longrois, D; Mallié, JP; Montémont, C; Sainte-Laudy, J; Vauthier, E, 2003)
" During the first 60 min of bypass, hypotension (40-45 mm Hg) was observed in spite of phenylephrine 14 mg."3.67Bronchospasm and hypotension during cardiopulmonary bypass after preoperative cimetidine and labetalol therapy. ( Durant, PA; Joucken, K, 1984)
"5 mg/kg) (six times the ED95) can result in significant histamine release, resulting in systemic hypotension."3.67Combined H1 and H2 receptor blockade attenuates the cardiovascular effects of high-dose atracurium for rapid sequence endotracheal intubation. ( Gronert, GA; Hosking, MP; Lennon, RL, 1988)
"Incidence and mechanisms of cimetidine-induced hypotension were investigated during the first intravenous injection of cimetidine (200 mg over three minutes) in 68 consecutive patients in the intensive care unit."3.67Bolus injection of cimetidine and hypotension in patients in the intensive care unit. Incidence and mechanisms. ( Frei, A; Kiowski, W, 1987)
"Mesenteric traction syndrome is described as sudden tachycardia, hypotension and flush."2.70Histamine release in mesenteric traction syndrome during abdominal aortic aneurysm surgery: prophylaxis with H1 and H2 antihistamines. ( Celik, I; Duda, D; Lorenz, W, 2002)
"Hypotension and arrhythmias are the most frequently observed symptoms."2.67[Histamine release and cardiovascular reactions to implantation of bone cement during total hip replacement]. ( Linde, I; Tryba, M; Voshage, G; Zenz, M, 1991)
" H1- and H2-histamine antagonists or placebo were given before dosing with d-tubocurarine in a randomized double-blind fashion to four groups: group 1--placebo; group 2--cimetidine, 4 mg/kg, plus placebo; group 3--chlorpheniramine, 0."2.66Histamine antagonists and d-tubocurarine-induced hypotension in cardiac surgical patients. ( Akins, CW; D'Ambra, MN; Inada, E; Machaj, V; Moss, J; Philbin, DM; Rosow, CE, 1986)
" The warfarin enantiomers were given separately as single doses (15 mg) alone and during chronic administration of cimetidine (1 g day-1)."2.66Stereoselective interaction between the R enantiomer of warfarin and cimetidine. ( Breckenridge, AM; Cholerton, S; Choonara, IA; Haynes, BP; Park, BK, 1986)
" After immunization with ovalbumin (OVA), a common dietary constituent, we evaluated the efficacy of pretreatment with histamine-receptor or serotonin-receptor blockers administered alone or in combination with a nitric oxide synthase inhibitor (L-NAME) on OVA-induced anaphylactic shock in Brown Norway rats."1.32Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock. ( Bellou, A; Gerard, P; Gillois, P; Guéant, JL; Lambert, H; Longrois, D; Mallié, JP; Montémont, C; Sainte-Laudy, J; Vauthier, E, 2003)
"Pretreatment with cyproheptadine (2."1.28Hypotension induced by growth-hormone-releasing peptide is mediated by mast cell serotonin release in the rat. ( Gabel, RA; Macia, RA; Matthews, WD; Reginato, MJ, 1990)
"Pretreatment with cimetidine (300 mg iv) depressed the drinking response to histamine to 30 +/- 10 ml and to pentagastrin to 58 +/- 24 ml."1.27Water drinking induced by gastric secretagogues in pigs. ( Houpt, TR; Troy, DW; Weixler, LC, 1986)
"The hypotension was found to be refractory to intravenous fluids, dopamine, and antihistamines, but was immediately reversed by intravenous epinephrine."1.26Shock syndrome associated with mastocytosis: pharmacologic reversal of the acute episode and therapeutic prevention of recurrent attacks. ( Oates, JA; Roberts, LJ; Turk, JW, 1982)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199019 (67.86)18.7374
1990's6 (21.43)18.2507
2000's3 (10.71)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Duda, D1
Lorenz, W1
Celik, I1
Bellou, A1
Lambert, H1
Gillois, P1
Montémont, C1
Gerard, P1
Vauthier, E1
Sainte-Laudy, J1
Longrois, D1
Guéant, JL1
Mallié, JP1
Breuer, HW1
Meschig, R1
Breuer, J1
Goehlich, G1
Arnold, G1
Scott, HW1
Parris, WC1
Sandidge, PC1
Oates, JA2
Roberts, LJ2
Kaplan, AP1
Yang, MC1
Tenner, TE1
Pang, PK1
Durant, PA1
Joucken, K1
Hammond, JE1
Ware, R1
Turk, JW1
Selby, D1
Renz, C1
Lynch, J1
Thurn, J1
Moss, J2
Guo, Y1
Hedqvist, P1
Gustafsson, LE1
Mahon, WA1
Kolton, M1
Matzen, S1
Secher, NH1
Knigge, U1
Bach, FW1
Warberg, J1
Macia, RA1
Gabel, RA1
Reginato, MJ1
Matthews, WD1
Tryba, M1
Linde, I1
Voshage, G1
Zenz, M1
Iberti, TJ1
Casthely, PA1
Yoganathan, D1
Karyanis, B1
Salem, M1
Yoganathan, T1
Komer, C1
Uribe, M1
Sclafani, S1
Hudak, A1
Wiggins, RC1
Glatfelter, A1
Campbell, AM1
Kunkel, RG1
Ulevitch, RJ1
Inada, E1
Philbin, DM1
Machaj, V1
D'Ambra, MN1
Rosow, CE1
Akins, CW1
Hosking, MP1
Lennon, RL1
Gronert, GA1
Parsons, RS1
Mohandas, K1
Yarbrough, JA1
Moffitt, JE1
Brown, DA1
Stafford, CT1
Houpt, TR1
Weixler, LC1
Troy, DW1
Choonara, IA1
Cholerton, S1
Haynes, BP1
Breckenridge, AM1
Park, BK1
Newman, B1
Lam, AM1
Guay, DR1
Matzke, GR1
Kiowski, W1
Frei, A1

Trials

7 trials available for cimetidine and Blood Pressure, Low

ArticleYear
Histamine release in mesenteric traction syndrome during abdominal aortic aneurysm surgery: prophylaxis with H1 and H2 antihistamines.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:10

    Topics: Aortic Aneurysm, Abdominal; Blood Pressure; Cardiac Output; Cimetidine; Dimethindene; Double-Blind M

2002
Histamine release during rapid vancomycin administration.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47 Suppl 1

    Topics: Anti-Bacterial Agents; Cimetidine; Diphenhydramine; Double-Blind Method; Drug Hypersensitivity; Exan

1998
[Histamine release and cardiovascular reactions to implantation of bone cement during total hip replacement].
    Der Anaesthesist, 1991, Volume: 40, Issue:1

    Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Bone Cements; Cimetidine; Clemastine; Female; Hip Pro

1991
Histamine blockade and cardiovascular changes following heparin administration during cardiac surgery.
    Journal of cardiothoracic anesthesia, 1990, Volume: 4, Issue:6

    Topics: Blood Pressure; Calcium; Cardiac Output; Cimetidine; Coronary Artery Bypass; Diphenhydramine; Hepari

1990
Histamine antagonists and d-tubocurarine-induced hypotension in cardiac surgical patients.
    Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:5

    Topics: Blood Pressure; Chlorpheniramine; Cimetidine; Clinical Trials as Topic; Coronary Artery Bypass; Doub

1986
The effect of histamine-receptor blockade on the hemodynamic responses to protamine.
    Journal of cardiothoracic anesthesia, 1989, Volume: 3, Issue:1

    Topics: Blood Pressure; Cardiopulmonary Bypass; Central Venous Pressure; Chlorpheniramine; Cimetidine; Coron

1989
Stereoselective interaction between the R enantiomer of warfarin and cimetidine.
    British journal of clinical pharmacology, 1986, Volume: 21, Issue:3

    Topics: Administration, Oral; Bradycardia; Cimetidine; Drug Eruptions; Drug Interactions; Half-Life; Humans;

1986

Other Studies

21 other studies available for cimetidine and Blood Pressure, Low

ArticleYear
Constitutive nitric oxide synthase inhibition combined with histamine and serotonin receptor blockade improves the initial ovalbumin-induced arterial hypotension but decreases the survival time in brown norway rats anaphylactic shock.
    Shock (Augusta, Ga.), 2003, Volume: 19, Issue:1

    Topics: Anaphylaxis; Animals; Arteries; Cimetidine; Dihydroergotamine; Dinoprostone; Eicosanoids; Enzyme Inh

2003
Hemodynamic studies on cimetidine and ranitidine in anesthetized dogs.
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 1984, Volume: 184, Issue:4

    Topics: Animals; Blood Pressure; Cimetidine; Dogs; Drug Evaluation, Preclinical; Female; Hemodynamics; Hypot

1984
Hazards in operative management of patients with systemic mastocytosis.
    Annals of surgery, 1983, Volume: 197, Issue:5

    Topics: Adult; Chlorpheniramine; Cimetidine; Face; Female; Histamine Release; Humans; Hypotension; Intraoper

1983
Exercise-induced hives.
    The Journal of allergy and clinical immunology, 1984, Volume: 73, Issue:5 Pt 2

    Topics: Cimetidine; Cold Temperature; Cyproheptadine; Histamine; Humans; Hydroxyzine; Hypotension; Methachol

1984
Lack of histamine involvement in parathyroid hormone hypotensive action.
    Pharmacology, 1981, Volume: 22, Issue:5

    Topics: Animals; Blood Pressure; Cimetidine; Dimaprit; Female; Histamine; Hypotension; Male; p-Methoxy-N-met

1981
Bronchospasm and hypotension during cardiopulmonary bypass after preoperative cimetidine and labetalol therapy.
    British journal of anaesthesia, 1984, Volume: 56, Issue:8

    Topics: Bronchial Spasm; Cardiopulmonary Bypass; Cimetidine; Drug Interactions; Humans; Hypotension; Intraop

1984
Hypotension following intravenous cimetidine.
    Anaesthesia, 1983, Volume: 38, Issue:7

    Topics: Cimetidine; Guanidines; Humans; Hypotension

1983
Shock syndrome associated with mastocytosis: pharmacologic reversal of the acute episode and therapeutic prevention of recurrent attacks.
    Advances in shock research, 1982, Volume: 8

    Topics: Aspirin; Chlorpheniramine; Cimetidine; Epinephrine; Humans; Hypotension; Infusions, Parenteral; Pros

1982
Cardiovascular effects of cimetidine.
    The Medical journal of Australia, 1981, Feb-21, Volume: 1, Issue:4

    Topics: Aged; Cimetidine; Female; Guanidines; Humans; Hypotension

1981
Absence of mast cell involvement in active systemic anaphylaxis in rats.
    European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3

    Topics: Anaphylaxis; Animals; Blood Pressure; Cell Degranulation; Chlorpheniramine; Cimetidine; Dextrans; Ge

2001
Hypotension after intravenous cimetidine.
    Lancet (London, England), 1978, Apr-15, Volume: 1, Issue:8068

    Topics: Adult; Cimetidine; Guanidines; Humans; Hypotension; Male; Methods; Middle Aged

1978
Pituitary-adrenal responses to head-up tilt in humans: effect of H1- and H2-receptor blockade.
    The American journal of physiology, 1992, Volume: 263, Issue:1 Pt 2

    Topics: Adult; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Cimetidine; He

1992
Hypotension induced by growth-hormone-releasing peptide is mediated by mast cell serotonin release in the rat.
    Toxicology and applied pharmacology, 1990, Volume: 104, Issue:3

    Topics: Analysis of Variance; Animals; Cimetidine; Cyproheptadine; Dose-Response Relationship, Drug; Drug Sy

1990
Hemodynamic effects of H2-receptor antagonists.
    DICP : the annals of pharmacotherapy, 1990, Volume: 24, Issue:11 Suppl

    Topics: Bradycardia; Cimetidine; Critical Care; Gastric Acid; Histamine H2 Antagonists; Humans; Hypotension;

1990
Acute hypotension due to platelet serotonin-induced chemoreflexes after intravenous injection of dextran sulfate in the rabbit.
    Circulation research, 1985, Volume: 57, Issue:2

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Autonomic Nervous System; Blood Platelets; Bradyc

1985
Combined H1 and H2 receptor blockade attenuates the cardiovascular effects of high-dose atracurium for rapid sequence endotracheal intubation.
    Anesthesia and analgesia, 1988, Volume: 67, Issue:11

    Topics: Atracurium; Blood Pressure; Cimetidine; Diphenhydramine; Heart Rate; Histamine; Histamine H1 Antagon

1988
Cimetidine in the treatment of refractory anaphylaxis.
    Annals of allergy, 1989, Volume: 63, Issue:3

    Topics: Anaphylaxis; Cefuroxime; Cimetidine; Drug Hypersensitivity; Female; Flushing; Humans; Hypotension; I

1989
Water drinking induced by gastric secretagogues in pigs.
    The American journal of physiology, 1986, Volume: 251, Issue:1 Pt 2

    Topics: Analysis of Variance; Animals; Atropine; Bethanechol; Bethanechol Compounds; Cimetidine; Computers;

1986
Induced hypotension for clipping of a cerebral aneurysm during pregnancy: a case report and brief review.
    Anesthesia and analgesia, 1986, Volume: 65, Issue:6

    Topics: Adult; Anesthesia, Inhalation; Blood Pressure; Cimetidine; Female; Fetal Monitoring; Humans; Hypoten

1986
Hypotension after intravenous cimetidine in intensive care unit patients.
    Anesthesiology, 1986, Volume: 65, Issue:1

    Topics: Cimetidine; Critical Care; Humans; Hypotension; Infusions, Parenteral

1986
Bolus injection of cimetidine and hypotension in patients in the intensive care unit. Incidence and mechanisms.
    Archives of internal medicine, 1987, Volume: 147, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Cimetidine; Female; Heart Rate; Humans;

1987