cimetidine has been researched along with Bewilderment in 43 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cimetidine and ranitidine are specific and potent H2-receptor antagonists widely used in the effective therapy of peptic ulcer disease." | 8.77 | Actions of cimetidine and ranitidine at some cholinergic sites: implications in toxicology and anesthesia. ( Cheah, LS; Gwee, MC, 1986) |
| "Cimetidine and ranitidine are specific and potent H2-receptor antagonists widely used in the effective therapy of peptic ulcer disease." | 4.77 | Actions of cimetidine and ranitidine at some cholinergic sites: implications in toxicology and anesthesia. ( Cheah, LS; Gwee, MC, 1986) |
| "A 70-year-old woman free of renal or hepatic dysfunction developed reversible mental confusion, sinus bradycardia, and extreme QT interval prolongation following initiation of intravenous cimetidine 1200 mg daily." | 3.67 | Cimetidine-related cardiac conduction disturbances and confusion. ( Cohen, N; Eshkoly, M; Golik, A; Modai, D; Scapa, E; Theitler, J, 1989) |
| "A patient with severe liver disease and mildly obnormal but stable renal function was given cimetidine on two occasions for gastrointestinal hemorrhage." | 3.66 | Dose and serum concentration relationships in cimetidine-associated mental confusion. ( Berg, MJ; Calleri, G; Cerra, FB; Kimelblatt, BJ; McMillen, MA; Schentag, JJ, 1980) |
| "Cimetidine-related neurotoxicity may be characterized by signs of affective dysfunction, toxic delusional state and/or delirium, confusion and/or amnestic signs, coma, epileptic phenomena and focal neurological signs." | 1.27 | Cimetidine neurotoxicity. EEG and behaviour aspects. ( Kamphuisen, HA; Van Sweden, B, 1984) |
| "Cimetidine may cause mental confusion and should be used with caution and in reduced dosage in the presence of hepatic or renal disease, or both, and in elderly patients." | 1.26 | Cimetidine: clinical uses and possible side effects. ( Babb, RR, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (97.67) | 18.7374 |
| 1990's | 1 (2.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bories, P | 1 |
| Michel, H | 1 |
| Duclos, B | 1 |
| Beraud, JJ | 1 |
| Mirouze, J | 1 |
| Sharpe, PC | 1 |
| Burland, WL | 1 |
| Domschke, S | 1 |
| Domschke, W | 1 |
| Totte, J | 1 |
| Scharpe, S | 1 |
| Verkerk, R | 1 |
| Neels, H | 1 |
| Vanhaeverbeek, M | 1 |
| Smitz, S | 1 |
| Rousseau, JJ | 1 |
| Thomas, JM | 1 |
| Misiewicz, G | 1 |
| Pedrazzoli, S | 1 |
| Petrin, P | 1 |
| Pasquali, C | 1 |
| Militello, C | 1 |
| Sperti, C | 1 |
| Fregonese, V | 1 |
| Simini, G | 1 |
| Humphries, TJ | 1 |
| Myerson, RM | 2 |
| Gifford, LM | 2 |
| Aeugle, ME | 2 |
| Josie, ME | 1 |
| Wood, SL | 1 |
| Tannenbaum, PJ | 2 |
| Van Sweden, B | 2 |
| Kamphuisen, HA | 1 |
| Colavolpe, C | 1 |
| Gineyt, G | 1 |
| Bussac, JJ | 1 |
| François, G | 1 |
| Kimelblatt, BJ | 1 |
| Cerra, FB | 2 |
| Calleri, G | 2 |
| Berg, MJ | 1 |
| McMillen, MA | 1 |
| Schentag, JJ | 3 |
| Babb, RR | 1 |
| Davis, TG | 1 |
| Pickett, DL | 1 |
| Schlosser, JH | 1 |
| Soulé, JC | 1 |
| Delchier, JC | 1 |
| Morin, T | 1 |
| Bader, JP | 1 |
| Boström, R | 1 |
| Holmgren, E | 1 |
| Lundberg, D | 1 |
| Grahnén, A | 1 |
| Tyllström, J | 1 |
| Tyllström, B | 1 |
| Jameson, S | 1 |
| Lööf, L | 1 |
| Handler, CE | 1 |
| Besse, CP | 1 |
| Wilson, AO | 1 |
| Ng, JY | 1 |
| Jones, TE | 1 |
| Disney, AP | 1 |
| Mathew, TH | 1 |
| Remakus, RL | 1 |
| Onifer, TM | 1 |
| Brier, KL | 1 |
| Dasta, JF | 1 |
| Kidwell, GA | 1 |
| Schonfeld, SA | 1 |
| Couri, D | 1 |
| Robinson, TJ | 1 |
| Mulligan, TO | 1 |
| DeGlopper, E | 1 |
| Rose, JQ | 1 |
| Bernhard, H | 1 |
| Flind, AC | 1 |
| Rowley-Jones, D | 2 |
| Kinnell, HG | 1 |
| Webb, A | 1 |
| Barnhart, CC | 1 |
| Bowden, CL | 1 |
| Petite, JP | 1 |
| Bloch, F | 1 |
| Graham, JR | 1 |
| Edmonds, ME | 1 |
| Ashford, RF | 1 |
| Brenner, MK | 1 |
| Saunders, A | 1 |
| Babier, JP | 1 |
| Hirsh, JF | 1 |
| Spears, JB | 1 |
| Deheneffe, Y | 1 |
| Reynaert, M | 1 |
| Tremouroux, J | 1 |
| Mogelnicki, SR | 1 |
| Waller, JL | 1 |
| Finlayson, DC | 1 |
| Bouden, A | 1 |
| el Hechmi, Z | 1 |
| Douki, S | 1 |
| Cohen, N | 1 |
| Modai, D | 1 |
| Golik, A | 1 |
| Eshkoly, M | 1 |
| Theitler, J | 1 |
| Scapa, E | 1 |
| Gwee, MC | 1 |
| Cheah, LS | 1 |
| Boyko, DA | 1 |
| Miyanaga, O | 1 |
| Ishibashi, H | 1 |
| Sumita, I | 1 |
| Pujadas, R | 1 |
| Fernández-Monrás, F | 1 |
| Argimón, J | 1 |
| Gago, MJ | 1 |
| Costa, I | 1 |
| García Galera, J | 1 |
| Jané, J | 1 |
4 reviews available for cimetidine and Bewilderment
| Article | Year |
|---|---|
New histamine H2-receptor antagonists.
Topics: Animals; Anticoagulants; Chemical Phenomena; Chemistry; Cimetidine; Confusion; Dogs; Drug Interactio | 1980 |
Histamine H2-receptor antagonists in the short- and long-term treatment of duodenal ulcer.
Topics: Alcohol Drinking; Androgen Antagonists; Anti-Ulcer Agents; Bone Marrow; Cimetidine; Clinical Trials | 1984 |
[Maintenance cimetidine treatment in duodenal ulcer disease. Second part: Side-effects and indications (author's transl)].
Topics: Animals; Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Cimetidine; Confusion; Dogs; | 1980 |
Actions of cimetidine and ranitidine at some cholinergic sites: implications in toxicology and anesthesia.
Topics: Anesthesia; Animals; Antihypertensive Agents; Bradycardia; Cholinesterase Inhibitors; Cimetidine; Co | 1986 |
2 trials available for cimetidine and Bewilderment
| Article | Year |
|---|---|
Histamine H2-receptor antagonists in the short- and long-term treatment of duodenal ulcer.
Topics: Alcohol Drinking; Androgen Antagonists; Anti-Ulcer Agents; Bone Marrow; Cimetidine; Clinical Trials | 1984 |
Evaluation of a worldwide spontaneous reporting system with cimetidine.
Topics: Anticoagulants; Cimetidine; Clinical Trials as Topic; Confusion; Drug Synergism; Guanidines; Humans; | 1980 |
38 other studies available for cimetidine and Bewilderment
| Article | Year |
|---|---|
Use of ranitidine, without mental confusion, in patients with renal failure.
Topics: Acute Kidney Injury; Aged; Cimetidine; Cognition Disorders; Confusion; Duodenal Ulcer; Furans; Hista | 1980 |
Mental confusion and H2-receptor blockers.
Topics: Cimetidine; Cognition Disorders; Confusion; Furans; Guanidines; Histamine H2 Antagonists; Humans; Ki | 1980 |
Neurological dysfunction associated with abnormal levels of cimetidine metabolite.
Topics: Cimetidine; Cognition Disorders; Confusion; Guanidines; Humans; Renal Dialysis; Sulfoxides | 1981 |
H2-receptor blockers and mental confusion.
Topics: Cimetidine; Cognition Disorders; Confusion; Humans; Male; Middle Aged; Ranitidine | 1984 |
Ranitidine reverses cimetidine-induced mental confusion in a patient with Zollinger-Ellison syndrome.
Topics: Cimetidine; Cognition Disorders; Confusion; Female; Furans; Guanidines; Humans; Middle Aged; Ranitid | 1983 |
Mental confusion associated with ranitidine.
Topics: Aged; Cimetidine; Cognition Disorders; Confusion; Female; Humans; Ranitidine | 1983 |
A unique postmarket outpatient surveillance program of cimetidine: report on phase II and final summary.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Cimetidine; Confusion; Drug Interactions; Female; Gastr | 1984 |
Cimetidine neurotoxicity. EEG and behaviour aspects.
Topics: Brain; Brain Diseases; Cimetidine; Confusion; Delusions; Electroencephalography; Epilepsy; Female; H | 1984 |
[Severe confusion following a theophylline-cimetidine combination].
Topics: Aged; Cimetidine; Cognition Disorders; Confusion; Drug Interactions; Humans; Male; Theophylline | 1983 |
Dose and serum concentration relationships in cimetidine-associated mental confusion.
Topics: Blood-Brain Barrier; Cimetidine; Cognition Disorders; Confusion; Dose-Response Relationship, Drug; E | 1980 |
Cimetidine: clinical uses and possible side effects.
Topics: Cimetidine; Confusion; Esophagitis, Peptic; Gastrointestinal Hemorrhage; Guanidines; Humans; Male; N | 1980 |
Respiratory depression after cimetidine reversed by physostigmine.
Topics: Aged; Cimetidine; Confusion; Guanidines; Humans; Male; Physostigmine; Respiratory Insufficiency | 1982 |
Cimetidine accumulation and mental confusion in cirrhosis.
Topics: Adult; Aged; Cimetidine; Cognition Disorders; Confusion; Guanidines; Humans; Liver Cirrhosis; Middle | 1982 |
Extrapyramidal and cerebellar syndrome with encephalopathy associated with cimetidine.
Topics: Aged; Basal Ganglia Diseases; Cerebellar Diseases; Cimetidine; Cognition Disorders; Confusion; Guani | 1982 |
Prolonged confusion after cimetidine.
Topics: Aged; Cimetidine; Cognition Disorders; Confusion; Female; Guanidines; Humans; Male; Nervous System D | 1981 |
Cimetidine postmarket outpatient surveillance program. Interim report on phase I.
Topics: Adolescent; Adult; Aged; Cimetidine; Confusion; Digestive System; Endocrine Glands; Female; Follow-U | 1980 |
Mental confusion falsely attributed to cimetidine.
Topics: Age Factors; Aged; Cimetidine; Cognition Disorders; Confusion; Guanidines; Humans; Male | 1980 |
Cimetidine-induced mental confusion in patients with cirrhosis.
Topics: Cimetidine; Cognition Disorders; Confusion; Guanidines; Humans; Liver Cirrhosis, Biliary | 1980 |
Cimetidine and mental confusion.
Topics: Adult; Cimetidine; Cognition Disorders; Confusion; Guanidines; Humans; Male; Ulcer | 1980 |
Cimetidine and mental-confusion.
Topics: Aged; Cimetidine; Cognition Disorders; Confusion; Duodenal Ulcer; Guanidines; Histamine H2 Antagonis | 1977 |
Cimetidine and mental confusion.
Topics: Adult; Aged; Cimetidine; Cognition Disorders; Confusion; Duodenal Ulcer; Esophageal and Gastric Vari | 1977 |
Pharmacokinetic and clinical studies in patients with cimetidine-associated mental confusion.
Topics: Aged; Cimetidine; Cognition Disorders; Confusion; Female; Gastrointestinal Hemorrhage; Guanidines; H | 1979 |
Mental confusion and cimetidine.
Topics: Aged; Cimetidine; Cognition Disorders; Confusion; Guanidines; Humans; Middle Aged | 1979 |
Confusion associated with cimetidine.
Topics: Aged; Cimetidine; Cognition Disorders; Confusion; Female; Gastrointestinal Hemorrhage; Guanidines; H | 1979 |
Toxic psychosis with cimetidine.
Topics: Cimetidine; Confusion; Female; Guanidines; Humans; Male; Middle Aged; Orientation; Psychoses, Substa | 1979 |
[Depressive syndrome during cimetidine treatment].
Topics: Cimetidine; Confusion; Depression; Guanidines; Humans; Male; Middle Aged; Psychoses, Substance-Induc | 1979 |
Psychotic reaction to cimetidine, presumably an idiosyncrasy.
Topics: Cimetidine; Cognition Disorders; Confusion; Female; Guanidines; Humans; Middle Aged | 1979 |
Cimetidine: does neurotoxicity occur? Report of three cases.
Topics: Aged; Blood-Brain Barrier; Brain; Cimetidine; Confusion; Female; Guanidines; Humans; Kidney Failure, | 1979 |
[Mental confusion in a patient treated with cimetidine (author's transl)].
Topics: Aged; Cimetidine; Cognition Disorders; Confusion; Esophagitis, Peptic; Guanidines; Humans; Male | 1978 |
Cimetidine and mental confusion.
Topics: Aged; Cimetidine; Cognition Disorders; Confusion; Guanidines; Humans; Male | 1978 |
[Mental confusion during pancreatitis treated with cimetidine].
Topics: Acute Disease; Cimetidine; Cognition Disorders; Confusion; Female; Guanidines; Humans; Male; Middle | 1978 |
Physostigmine reversal of cimetidine--induced mental confusion.
Topics: Cimetidine; Cognition Disorders; Confusion; Humans; Male; Middle Aged; Peptic Ulcer; Physostigmine | 1979 |
[Confusion induced by the combination cimetidine-benzodiazepine; apropos of a case report].
Topics: Anti-Anxiety Agents; Bipolar Disorder; Cimetidine; Clorazepate Dipotassium; Cognition Disorders; Con | 1990 |
Cimetidine-related cardiac conduction disturbances and confusion.
Topics: Aged; Bradycardia; Cimetidine; Cognition Disorders; Confusion; Female; Humans; Pre-Excitation Syndro | 1989 |
Toxic "ictal" confusion in middle age: treatment with benzodiazepines.
Topics: Adult; Benzodiazepinones; Chlorpromazine; Cimetidine; Clonazepam; Cognition Disorders; Confusion; Di | 1985 |
Inaccurate and inadequate reply.
Topics: Cimetidine; Cognition Disorders; Confusion; Humans; Ranitidine | 1986 |
[Three cases of hemorrhagic gastric ulcer and cimetidine-associated mental confusion].
Topics: Aged; Cimetidine; Cognition Disorders; Confusion; Female; Humans; Male; Middle Aged; Peptic Ulcer He | 1986 |
[Neurologic disorders caused by cimetidine and ranitidine. Apropos of a case].
Topics: Aged; Cimetidine; Cognition Disorders; Confusion; Duodenal Ulcer; Humans; Male; Ranitidine | 1986 |