cimetidine has been researched along with Atopic Hypersensitivity in 23 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anti-IgE induced histamine release from isolated basophils after Cimetidine and Ranitidine administration was evaluated in 22 patients with atopic bronchial asthma." | 7.67 | The influence of cimetidine and ranitidine on basophil histamine release and bronchial reactivity in asthmatic patients. ( Chyrek-Borowska, S; Hofman, J; Kuczewska, B; Michalska, I, 1987) |
| "Anti-IgE induced histamine release from isolated basophils after Cimetidine and Ranitidine administration was evaluated in 22 patients with atopic bronchial asthma." | 3.67 | The influence of cimetidine and ranitidine on basophil histamine release and bronchial reactivity in asthmatic patients. ( Chyrek-Borowska, S; Hofman, J; Kuczewska, B; Michalska, I, 1987) |
| " Bronchial response was monitored with serial measurements of specific airways conductance (sGaw) and a dose-response curve was constructed for each challenge." | 2.65 | The role of histamine receptors in asthma. ( Eiser, NM; Guz, A; Mills, J; Snashall, PD, 1981) |
| " The hydroxyzine and cetirizine half-life and AUC0-->infinity values were significantly increased and the systemic clearance rates were significantly decreased in the presence of cimetidine." | 1.29 | Effect of the H2-receptor antagonist cimetidine, on the pharmacokinetics and pharmacodynamics of the H1-receptor antagonists hydroxyzine and cetirizine in rabbits. ( Chen, X; Simons, FE; Simons, KJ, 1994) |
| "Histamine and LTD4 were additive in terms of cutaneous microvascular permeability." | 1.28 | Interactive effects of peptidoleukotrienes and histamine on microvascular permeability and their involvement in experimental cutaneous and conjunctival immediate hypersensitivity. ( Gary, RK; Gleason, JG; Nieves, AL; Wasserman, MA; Williams, LS; Woodward, DF, 1989) |
| "Diphenhydramine treatment alone partially inhibited the histologic intensity of LPR in a dose-dependent manner." | 1.27 | The biologic activity of mast cell granules. V. The effects of antihistamine treatment on rat cutaneous early- and late-phase allergic reactions. ( Barr, L; Guthman, DA; Kaliner, M; Lemanske, RF, 1983) |
| "In conjunctival immediate hypersensitivity, neither cimetidine nor pyrilamine alone produced an inhibitory effect, but a cimetidine-pyrilamine combination caused a significant reduction in the number of infiltrating eosinophils and prevented epithelial damage and goblet cell depletion." | 1.27 | Conjunctival eosinophil infiltration evoked by histamine and immediate hypersensitivity. Modification by H1- and H2-receptor blockade. ( Hawley, SB; Nieves, AL; Spada, CS; Woodward, DF, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (65.22) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cho, HJ | 1 |
| Yoo, HS | 1 |
| Park, SY | 1 |
| Yang, EM | 1 |
| Yoon, MG | 1 |
| Park, HS | 1 |
| Ye, YM | 1 |
| Roelofse, J | 1 |
| Norn, S | 1 |
| Permin, H | 1 |
| Skov, PS | 1 |
| Ting, S | 1 |
| Zweiman, B | 1 |
| Lavker, RM | 1 |
| Dunsky, EH | 1 |
| Pincus, SH | 1 |
| DiNapoli, AM | 1 |
| Schooley, WR | 1 |
| Koltai, M | 1 |
| Yanni, JM | 1 |
| Smith, WL | 1 |
| Callaham, EM | 1 |
| Foxwell, MH | 1 |
| Alphin, RS | 1 |
| Lemanske, RF | 1 |
| Barr, L | 1 |
| Guthman, DA | 1 |
| Kaliner, M | 1 |
| Radermecker, M | 1 |
| Maldague, MP | 1 |
| Eiser, NM | 1 |
| Mills, J | 1 |
| Snashall, PD | 1 |
| Guz, A | 1 |
| Simon, MR | 1 |
| Meltzer, BA | 1 |
| Chen, X | 1 |
| Simons, FE | 1 |
| Simons, KJ | 1 |
| Rolland, Y | 1 |
| Mazières, B | 1 |
| Behar, M | 1 |
| Kahn, MF | 1 |
| Cantagrel, A | 1 |
| Laroche, M | 1 |
| Günther, KP | 1 |
| Nelitz, M | 1 |
| Parsch, K | 1 |
| Puhl, W | 1 |
| Smith, JA | 1 |
| Mansfield, LE | 1 |
| Nelson, HS | 1 |
| Hotermans, G | 1 |
| Bury, T | 1 |
| Radermecker, MF | 1 |
| Weiss, RB | 1 |
| Donehower, RC | 1 |
| Wiernik, PH | 1 |
| Ohnuma, T | 1 |
| Gralla, RJ | 1 |
| Trump, DL | 1 |
| Baker, JR | 1 |
| Van Echo, DA | 1 |
| Von Hoff, DD | 1 |
| Leyland-Jones, B | 1 |
| Hofman, J | 1 |
| Michalska, I | 1 |
| Kuczewska, B | 1 |
| Chyrek-Borowska, S | 1 |
| Woodward, DF | 3 |
| Nieves, AL | 3 |
| Williams, LS | 1 |
| Gary, RK | 1 |
| Wasserman, MA | 1 |
| Gleason, JG | 1 |
| Spada, CS | 1 |
| Hawley, SB | 1 |
| Ledgard, SE | 1 |
| Tryba, M | 1 |
| Zevounou, F | 1 |
| Zenz, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Feasibility of a Randomized Controlled Clinical Trial Comparing the Use of Cetirizine to Replace Diphenhydramine in the Prevention of Reactions Related to Paclitaxel[NCT04237090] | Phase 3 | 27 participants (Actual) | Interventional | 2020-02-14 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for cimetidine and Atopic Hypersensitivity
| Article | Year |
|---|---|
Allergic reactions to latex in myelodysplasia: a review of the literature.
Topics: Adolescent; Child; Cimetidine; Histamine H2 Antagonists; Humans; Hypersensitivity, Immediate; Immuno | 2000 |
2 trials available for cimetidine and Atopic Hypersensitivity
| Article | Year |
|---|---|
The role of histamine receptors in asthma.
Topics: Airway Resistance; Asthma; Bronchial Provocation Tests; Chlorpheniramine; Cimetidine; Dose-Response | 1981 |
Prevention of histamine-induced cardiovascular reactions during the induction of anaesthesia following premedication with H1- + H2-antagonists i.m.
Topics: Adult; Anesthesia, General; Blood Pressure; Cimetidine; Clinical Trials as Topic; Double-Blind Metho | 1986 |
20 other studies available for cimetidine and Atopic Hypersensitivity
| Article | Year |
|---|---|
A case of cimetidine-induced immediate hypersensitivity.
Topics: Adult; Cimetidine; Drug Hypersensitivity; Female; Histamine H2 Antagonists; Humans; Hypersensitivity | 2012 |
Sedation corner 13.
Topics: Anesthesia, Dental; Anti-Bacterial Agents; Cimetidine; Conscious Sedation; Drug Interactions; Female | 2006 |
H2 antihistamines (cimetidine) and allergic-inflammatory reactions.
Topics: Agranulocytosis; Basophils; Cimetidine; Drug Therapy, Combination; Guanidines; Histamine H1 Antagoni | 1980 |
Effect of cimetidine on exogenous histamine inhibition of histamine release in vivo.
Topics: Biopsy; Cimetidine; Guanidines; Histamine Antagonists; Histamine Release; Humans; Hypersensitivity; | 1983 |
Superoxide production by eosinophils: activation by histamine.
Topics: Animals; Chlorpheniramine; Cimetidine; Eosinophils; Guinea Pigs; Histamine; Humans; Hypersensitivity | 1982 |
A new method of testing anti-allergic drugs.
Topics: Animals; Cimetidine; Dexamethasone; Epinephrine; Female; Hypersensitivity, Immediate; Immunologic Te | 1983 |
A method for measuring changes in tracheal mucus gel layer thickness as an indication of an immediate hypersensitivity response.
Topics: Acetylcysteine; Aluminum Hydroxide; Animals; Atropine; Chromones; Cimetidine; Cromolyn Sodium; Dose- | 1984 |
The biologic activity of mast cell granules. V. The effects of antihistamine treatment on rat cutaneous early- and late-phase allergic reactions.
Topics: Animals; Antibodies, Anti-Idiotypic; Ascitic Fluid; Capillary Permeability; Cimetidine; Cytoplasmic | 1983 |
Depression of neutrophil chemotaxis in atopic individuals. An H2 histamine receptor response.
Topics: Chemotaxis, Leukocyte; Cimetidine; Dose-Response Relationship, Immunologic; Dust; Female; Humans; Hy | 1981 |
Cimetidine and immunologic response.
Topics: Candidiasis, Cutaneous; Cimetidine; Guanidines; Humans; Hypersensitivity, Delayed; Hypersensitivity, | 1980 |
Insect stings.
Topics: Cimetidine; Histamine H2 Antagonists; Humans; Hypersensitivity, Immediate; Insect Bites and Stings; | 1994 |
Effect of the H2-receptor antagonist cimetidine, on the pharmacokinetics and pharmacodynamics of the H1-receptor antagonists hydroxyzine and cetirizine in rabbits.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Aspartate Aminotransferases; Cetirizine; Chroma | 1994 |
Does the atopic ("allergic") rheumatism of NERDS really exist? Report of a case.
Topics: Adult; Cetirizine; Cimetidine; Dermatitis; Diagnosis, Differential; Edema; Eosinophilia; Follow-Up S | 1997 |
The effect of cimetidine on the immediate cutaneous response to allergens.
Topics: Allergens; Cimetidine; Guanidines; Humans; Hypersensitivity, Immediate; Skin Tests | 1979 |
Effect of histamine on tumor necrosis factor production by human monocytes.
Topics: Adult; Cimetidine; Dose-Response Relationship, Drug; Histamine; Humans; Hypersensitivity, Immediate; | 1991 |
Hypersensitivity reactions from taxol.
Topics: Adult; Aged; Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Colonic Neoplasms; Dexamethas | 1990 |
The influence of cimetidine and ranitidine on basophil histamine release and bronchial reactivity in asthmatic patients.
Topics: Antibodies, Anti-Idiotypic; Asthma; Basophils; Bronchi; Cimetidine; Histamine Release; Humans; Hyper | 1987 |
Interactive effects of peptidoleukotrienes and histamine on microvascular permeability and their involvement in experimental cutaneous and conjunctival immediate hypersensitivity.
Topics: Animals; Capillary Permeability; Chromium Radioisotopes; Cimetidine; Conjunctiva; Dicarboxylic Acids | 1989 |
Conjunctival eosinophil infiltration evoked by histamine and immediate hypersensitivity. Modification by H1- and H2-receptor blockade.
Topics: Animals; Cell Movement; Cimetidine; Conjunctival Diseases; Eosinophils; Female; Guinea Pigs; Histami | 1986 |
Conjunctival immediate hypersensitivity: re-evaluation of histamine involvement in the vasopermeability response.
Topics: Albumins; Animals; Capillary Permeability; Cimetidine; Conjunctiva; Dimaprit; Dose-Response Relation | 1986 |