cimetidine has been researched along with Arthritis, Rheumatoid in 17 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eighty-six rheumatoid arthritis (RA) patients affected by endoscopically proven DU (n = 44) or GU (n = 42), and on chronic NSAID therapy which was not suspended during anti-ulcer therapy, were randomized to cimetidine (400 mg t." | 9.08 | Peptic ulcer therapy with cimetidine versus tripotassium dicitrato bismuthate in rheumatoid arthritis patients undergoing chronic NSAID treatment. ( Ardizzone, S; Bianchi Porro, G; Caruso, I; Lazzaroni, M; Manzionna, G; Montrone, F; Petrillo, M, 1998) |
| "110 patients with benign gastric ulcer and concomitant joint diseases (rheumatoid arthritis, osteoarthrosis) were treated in a comparative short-term clinical trial to assess the relative efficacy of calcitonin (daily 100 MRC of salmon calcitonin intramuscularly), cimetidine (daily 1000 mg orally) and colloidal bismuth subcitrate (De-Nol-four times a day in doses of 5 ml diluted with 15 ml of water)." | 9.06 | Calcitonin versus cimetidine or De-Nol in gastric ulcer treatment. An endoscopically controlled trial. ( Badurski, J; Janke, A; Namiot, Z; Sajewicz, I; Stasiewicz, J, 1988) |
| "The interaction between sulphasalazine and cimetidine has been studied, a drug combination which is quite likely in view of the higher incidence of peptic ulceration in patients with RA." | 7.68 | Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis. ( Breckenridge, AM; Bucknall, RC; Coleman, MD; Galvani, D; Park, BK; Pirmohamed, M, 1993) |
| "Eighty-six rheumatoid arthritis (RA) patients affected by endoscopically proven DU (n = 44) or GU (n = 42), and on chronic NSAID therapy which was not suspended during anti-ulcer therapy, were randomized to cimetidine (400 mg t." | 5.08 | Peptic ulcer therapy with cimetidine versus tripotassium dicitrato bismuthate in rheumatoid arthritis patients undergoing chronic NSAID treatment. ( Ardizzone, S; Bianchi Porro, G; Caruso, I; Lazzaroni, M; Manzionna, G; Montrone, F; Petrillo, M, 1998) |
| "110 patients with benign gastric ulcer and concomitant joint diseases (rheumatoid arthritis, osteoarthrosis) were treated in a comparative short-term clinical trial to assess the relative efficacy of calcitonin (daily 100 MRC of salmon calcitonin intramuscularly), cimetidine (daily 1000 mg orally) and colloidal bismuth subcitrate (De-Nol-four times a day in doses of 5 ml diluted with 15 ml of water)." | 5.06 | Calcitonin versus cimetidine or De-Nol in gastric ulcer treatment. An endoscopically controlled trial. ( Badurski, J; Janke, A; Namiot, Z; Sajewicz, I; Stasiewicz, J, 1988) |
| "Agranulocytosis and septicaemia developing in a patient with rheumatoid arthritis after 3 years' intermittent treatment with diclofenac, cimetidine and flucloxacillin for staphylococcal osteomyelitis is described." | 3.69 | Agranulocytosis in rheumatoid arthritis associated with long-term flucloxacillin for staphylococcal osteomyelitis. ( Burton, IE; Moussa, KM; Sanders, PA, 1995) |
| "The interaction between sulphasalazine and cimetidine has been studied, a drug combination which is quite likely in view of the higher incidence of peptic ulceration in patients with RA." | 3.68 | Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis. ( Breckenridge, AM; Bucknall, RC; Coleman, MD; Galvani, D; Park, BK; Pirmohamed, M, 1993) |
| "A 41-year-old man with rheumatoid arthritis developed severe acute hepatitis 3 days after starting cimetidine for duodenal ulcer." | 3.68 | [Cimetidine hepatitis]. ( Cohen, N; Golik, A; Zaidenstein, R, 1992) |
| "In a pilot study, 26 rheumatoid arthritic patients taking continuous, stable dosage regimens of nonsteroidal anti-inflammatory drugs and with developed gastric and duodenal lesions were administered sucralfate 1 g four times per day (14 patients) or cimetidine 400 mg twice daily (12 patients) in a single-blind regimen for six weeks." | 2.66 | Effect of sucralfate and cimetidine on rheumatoid patients with active gastroduodenal lesions who are taking nonsteroidal anti-inflammatory drugs. A pilot study. ( Cox, N; Fine, D; Hillier, K; Jewell, R; Shepherd, HA, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (64.71) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kimberly, RP | 1 |
| Weinberg, H | 1 |
| Rudd, E | 1 |
| Permin, H | 2 |
| Norn, S | 2 |
| Skov, PS | 2 |
| Geisler, A | 1 |
| Klysner, R | 1 |
| Andersen, V | 1 |
| Wiik, A | 1 |
| Manthorpe, R | 1 |
| Nielsen, H | 1 |
| Petersen, J | 1 |
| Mitchell, WS | 1 |
| Sturrock, RD | 1 |
| Gow, PJ | 1 |
| Stewart, JT | 1 |
| O'Laughlin, JC | 1 |
| Silvoso, GR | 1 |
| Ivey, KJ | 1 |
| Pirmohamed, M | 1 |
| Coleman, MD | 1 |
| Galvani, D | 1 |
| Bucknall, RC | 1 |
| Breckenridge, AM | 1 |
| Park, BK | 1 |
| Burton, IE | 1 |
| Moussa, KM | 1 |
| Sanders, PA | 1 |
| Bianchi Porro, G | 1 |
| Lazzaroni, M | 1 |
| Petrillo, M | 1 |
| Ardizzone, S | 1 |
| Manzionna, G | 1 |
| Caruso, I | 1 |
| Montrone, F | 1 |
| Stanislavchuk, MA | 1 |
| Sugiyama, T | 1 |
| Tanaka, H | 1 |
| Kawai, S | 1 |
| Zaidenstein, R | 1 |
| Cohen, N | 1 |
| Golik, A | 1 |
| Shepherd, HA | 1 |
| Fine, D | 1 |
| Hillier, K | 1 |
| Jewell, R | 1 |
| Cox, N | 1 |
| Janke, A | 1 |
| Badurski, J | 1 |
| Stasiewicz, J | 1 |
| Sajewicz, I | 1 |
| Namiot, Z | 1 |
| Roth, SH | 1 |
| Bennett, RE | 1 |
| Mitchell, CS | 1 |
| Hartman, RJ | 1 |
| Dijkmans, BA | 1 |
| van der Voet, GB | 1 |
| Cats, A | 1 |
| de Wolff, FA | 1 |
| Meretey, K | 1 |
| Bohm, U | 1 |
| Falus, A | 1 |
6 trials available for cimetidine and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Peptic ulcer therapy with cimetidine versus tripotassium dicitrato bismuthate in rheumatoid arthritis patients undergoing chronic NSAID treatment.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, | 1998 |
[The effect of combined therapy on the ortofen concentration of the blood plasma and synovial fluid in patients with rheumatoid arthritis].
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cimetidine | 1999 |
Improvement of periarticular osteoporosis in postmenopausal women with rheumatoid arthritis by beta-alanyl-L-histidinato zinc: a pilot study.
Topics: Alkaline Phosphatase; Anti-Ulcer Agents; Arthritis, Rheumatoid; Bone and Bones; Bone Density; Carnos | 2000 |
Effect of sucralfate and cimetidine on rheumatoid patients with active gastroduodenal lesions who are taking nonsteroidal anti-inflammatory drugs. A pilot study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cimetidine; Duodenum; Female; | 1989 |
Calcitonin versus cimetidine or De-Nol in gastric ulcer treatment. An endoscopically controlled trial.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Arthritis, Rheumatoid; Calc | 1988 |
Cimetidine therapy in nonsteroidal anti-inflammatory drug gastropathy. Double-blind long-term evaluation.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cimetidine; Clinical Tri | 1987 |
11 other studies available for cimetidine and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Great reduction in renal function associated with cimetidine.
Topics: Arthritis, Rheumatoid; Cimetidine; Creatinine; Female; Guanidines; Histamine H2 Antagonists; Humans; | 1980 |
[H2-antihistamines (cimetidine) in allergic-inflammatory reactions].
Topics: Arthritis, Rheumatoid; Cimetidine; Guanidines; Histamine H1 Antagonists; Humans; Receptors, Histamin | 1980 |
Possible role of histamine in rheumatoid arthritis. Treatment with cimetidine and mepyramine.
Topics: Adolescent; Adult; Aminopyridines; Arthritis, Rheumatoid; Cimetidine; Drug Therapy, Combination; Fem | 1981 |
Ulcers and anti-inflammatory agents.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cimetidine; Duodenal Ulcer; Female; Gu | 1982 |
The arthritic ulcer: a retrospective study of peptic ulceration in patients with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cimetidine; Drug Therapy, Combination; Duodenal Ulc | 1982 |
Healing of aspirin-associated peptic ulcer disease despite continued salicylate ingestion.
Topics: Adolescent; Adult; Aged; Antacids; Arthritis, Rheumatoid; Aspirin; Cimetidine; Duodenal Ulcer; Femal | 1981 |
Lack of interaction between sulphasalazine and cimetidine in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; | 1993 |
Agranulocytosis in rheumatoid arthritis associated with long-term flucloxacillin for staphylococcal osteomyelitis.
Topics: Aged; Agranulocytosis; Arthritis, Rheumatoid; Cimetidine; Female; Floxacillin; Fluorescent Antibody | 1995 |
[Cimetidine hepatitis].
Topics: Acute Disease; Adult; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cimetidine; Duo | 1992 |
Serum aluminium concentrations in patients with rheumatoid arthritis.
Topics: Aluminum; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cimetidine; Fema | 1987 |
Action of histamine on PHA chemiluminescence response of blood mononuclear cells in autoimmune patients.
Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Cimetidine; Histamine; Humans; Luminescent Measurements; | 1986 |