cimetidine has been researched along with Arrhythmia in 48 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To clarify mechanisms underlying an enhanced susceptibility to cardiac rhythm disturbances in hypertension and myocardial hypertrophy, we evaluated the vulnerability to histamine-induced arrhythmias of isolated left ventricles from spontaneously hypertensive rats (SHR) and age-matched controls (Wistar-Kyoto rats, WKY)." | 7.68 | Enhanced susceptibility to histamine-induced cardiac arrhythmias in spontaneously hypertensive rats. ( Bassett, AL; Cameron, JS; Katz, D; Shin, GS; Swigart, CR, 1990) |
| "Ligation of left anterior descending coronary artery caused various arrhythmias and reduced histamine content in ischemic myocardium in anesthetized cats." | 7.68 | [Histamine and early ischemic arrhythmia in anesthetized cats]. ( Fu, SX; Li, YS; Xu, YF, 1990) |
| "Cardiac anaphylaxis was elicited in isolated working guinea pig hearts in the presence of the histamine receptor antagonists pyrilamine and cimetidine, adenosine or hydrocortisone." | 7.67 | Protective effects of histamine H1 and H2 antagonists, adenosine and hydrocortisone on cardiac anaphylaxis. ( Guo, ZG; Qiu, R, 1989) |
| "The effects of the H1-receptor antagonists promethazine, mepyramine, and chlorpheniramine on ischemic and reperfusion arrhythmias were studied in the isolated perfused rat heart." | 7.67 | Effects of promethazine on ischemic and reperfusion arrhythmias in rat heart. ( Bralet, J; Opie, LH; Rochette, L; Yao-Kouame, J, 1988) |
| "The effects of two histamine H2-receptor antagonists, ranitidine and cimetidine, on ventricular arrhythmias induced by acute coronary artery ligation and by aconitine infusion were studied in pentobarbitone-anaesthetized rats." | 7.67 | Effects of ranitidine and cimetidine on experimentally induced ventricular arrhythmias in anaesthetized rats. ( Dai, S, 1986) |
| "Mexiletine is a new class I antiarrhythmic agent similar to lidocaine which when used orally may have significant gastric side effects." | 6.66 | Usefulness and safety of cimetidine in patients receiving mexiletine for ventricular arrhythmia. ( Klein, AL; Sami, MH, 1985) |
| "Histamine is known to lead to arrhythmias in the human heart." | 4.02 | Human histamine H ( Gergs, U; Griethe, K; Kirchhefer, U; Mißlinger, N; Neumann, J; Weisgut, J, 2021) |
| " The elimination half-life of moricizine is 2 to 6 hours, but its duration of antiarrhythmic action is much longer suggesting active metabolites." | 3.76 | Clinical pharmacokinetics of moricizine. ( Barbey, JT; Schwartz, SL; Siddoway, LA; Woosley, RL, 1990) |
| " Surprisingly, the incidences of ischaemia- and reperfusion-induced arrhythmias were not reduced by ranitidine over an equivalent concentration range (0." | 3.69 | Protection by cimetidine, but not ranitidine, implies that H2 receptors do not mediate arrhythmogenesis in a rat model of regional ischaemia and reperfusion in vitro. ( Banning, MM; Curtis, MJ, 1995) |
| "To clarify mechanisms underlying an enhanced susceptibility to cardiac rhythm disturbances in hypertension and myocardial hypertrophy, we evaluated the vulnerability to histamine-induced arrhythmias of isolated left ventricles from spontaneously hypertensive rats (SHR) and age-matched controls (Wistar-Kyoto rats, WKY)." | 3.68 | Enhanced susceptibility to histamine-induced cardiac arrhythmias in spontaneously hypertensive rats. ( Bassett, AL; Cameron, JS; Katz, D; Shin, GS; Swigart, CR, 1990) |
| "Ligation of left anterior descending coronary artery caused various arrhythmias and reduced histamine content in ischemic myocardium in anesthetized cats." | 3.68 | [Histamine and early ischemic arrhythmia in anesthetized cats]. ( Fu, SX; Li, YS; Xu, YF, 1990) |
| " It is suggested that the circulatory depression and the occurrence of ventricular arrhythmias following the administration of compound 48/80 result from activation of H1- and H2-receptors by elevated blood histamine levels due to release of the amine from tissues." | 3.68 | Circulatory depression and ventricular arrhythmias induced by compound 48/80 in anaesthetized rats. ( Dai, S, 1991) |
| "Thirty-six hospitalized male patients receiving oral sustained-release procainamide every six hours for the treatment of ventricular arrhythmias were studied at steady-state before and after oral cimetidine 300 mg every six hours for three days." | 3.68 | Procainamide-cimetidine drug interaction in elderly male patients. ( Bauer, LA; Black, D; Gensler, A, 1990) |
| "Cardiac anaphylaxis was elicited in isolated working guinea pig hearts in the presence of the histamine receptor antagonists pyrilamine and cimetidine, adenosine or hydrocortisone." | 3.67 | Protective effects of histamine H1 and H2 antagonists, adenosine and hydrocortisone on cardiac anaphylaxis. ( Guo, ZG; Qiu, R, 1989) |
| "The effects of the H1-receptor antagonists promethazine, mepyramine, and chlorpheniramine on ischemic and reperfusion arrhythmias were studied in the isolated perfused rat heart." | 3.67 | Effects of promethazine on ischemic and reperfusion arrhythmias in rat heart. ( Bralet, J; Opie, LH; Rochette, L; Yao-Kouame, J, 1988) |
| "The effects of two histamine H2-receptor antagonists, ranitidine and cimetidine, on ventricular arrhythmias induced by acute coronary artery ligation and by aconitine infusion were studied in pentobarbitone-anaesthetized rats." | 3.67 | Effects of ranitidine and cimetidine on experimentally induced ventricular arrhythmias in anaesthetized rats. ( Dai, S, 1986) |
| "To evaluate the ability of histamine to induce ventricular arrhythmias, we studied the effects of histamine on ventricular rhythmicity in the isolated guinea pig heart with complete atrioventricular conduction block." | 3.66 | Acceleration of idioventricular rhythms by histamine in guinea pig heart: mediation by H2 receptors. ( Levi, R; Zavecz, JH, 1979) |
| "Hypotension and arrhythmias are the most frequently observed symptoms." | 2.67 | [Histamine release and cardiovascular reactions to implantation of bone cement during total hip replacement]. ( Linde, I; Tryba, M; Voshage, G; Zenz, M, 1991) |
| "Mexiletine is a new class I antiarrhythmic agent similar to lidocaine which when used orally may have significant gastric side effects." | 2.66 | Usefulness and safety of cimetidine in patients receiving mexiletine for ventricular arrhythmia. ( Klein, AL; Sami, MH, 1985) |
| "Lastly, the nonspecific arrhythmias associated with endocrine disturbances are outlined." | 2.37 | Arrhythmias in patients with drug toxicity, electrolyte, and endocrine disturbances. ( Commerford, PJ; Lloyd, EA, 1984) |
| "Previous studies have shown that an anaphylactic reaction in the isolated perfused heart is characterized by drastic coronary constriction, arrhythmias, and severe impairment of contractility." | 1.28 | Characterization of cardiovascular events mediated by platelet activating factor during systemic anaphylaxis. ( Ahmad, Z; Baumann, G; Berdel, WE; Felix, SB; Hashemi, T; Niemczyk, M, 1990) |
| " Also, no difference in efficacy of either drug was observed and changes in dosing of digoxin were not required." | 1.27 | Drug interaction studies and encainide use in renal and hepatic impairment. ( Gallo, DG; Quart, BD; Sami, MH; Wood, AJ, 1986) |
| "Pretreatment with promethazine and cimetidine, as H1 and H2 histamine receptor antagonists, markedly prevented the development of phase II, namely the rise in cardiac frequency, LVPs, MAP and TPR, but did not significantly modify phase I and III." | 1.27 | The pattern of cardiovascular alterations induced by infusion of platelet-activating factor in rabbit is modified by pretreatment with H1-H2 receptor antagonists but not by cyclooxygenase inhibition. ( Alloatti, G; Camussi, G; Emanuelli, G; Mariano, F; Meda, E; Montrucchio, G; Tetta, C, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (68.75) | 18.7374 |
| 1990's | 12 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (4.17) | 24.3611 |
| 2020's | 1 (2.08) | 2.80 |
| Authors | Studies |
|---|---|
| Gergs, U | 1 |
| Weisgut, J | 1 |
| Griethe, K | 1 |
| Mißlinger, N | 1 |
| Kirchhefer, U | 1 |
| Neumann, J | 1 |
| Hughes, A | 1 |
| Hendrickson, RG | 1 |
| Chen, BC | 1 |
| Valento, M | 1 |
| Lasoff, DR | 1 |
| Schneir, A | 1 |
| Somberg, JC | 1 |
| Bounous, H | 1 |
| Cagin, N | 1 |
| Levitt, B | 1 |
| Trzeciakowski, JP | 1 |
| Levi, R | 3 |
| Fu, SX | 4 |
| Li, YS | 4 |
| Commerford, PJ | 1 |
| Lloyd, EA | 1 |
| Tripathi, KD | 2 |
| Tayal, G | 2 |
| Nikolic, G | 1 |
| Singh, JB | 1 |
| Soulé, JC | 1 |
| Delchier, JC | 1 |
| Morin, T | 1 |
| Bader, JP | 1 |
| Mehta, AB | 1 |
| Goldman, JM | 1 |
| Singh, KP | 1 |
| Watson, AJ | 1 |
| Watson, R | 1 |
| Keogh, JA | 1 |
| King, AR | 1 |
| Malm, JR | 1 |
| Bowman, FO | 1 |
| Rosen, MR | 1 |
| MacMahon, B | 1 |
| Bakshi, M | 1 |
| Walsh, MJ | 1 |
| Satoh, H | 1 |
| Jánoskuti, L | 1 |
| Fenyvesi, T | 1 |
| László, Z | 1 |
| Banning, MM | 1 |
| Curtis, MJ | 1 |
| Lada, W | 1 |
| Engel, TR | 1 |
| Luck, JC | 1 |
| Bournerias, F | 1 |
| Ganeval, D | 1 |
| Danan, G | 1 |
| Zavecz, JH | 1 |
| Cohen, J | 1 |
| Weetman, AP | 1 |
| Dargie, HJ | 1 |
| Krikler, DM | 1 |
| Fry, EN | 1 |
| Ligumsky, M | 1 |
| Shochina, M | 1 |
| Rachmilewitz, D | 1 |
| Bonjour, R | 1 |
| Luciano, JJ | 1 |
| Theodorou-Touchais, AM | 1 |
| Souteyrand, P | 1 |
| Chojnacki, J | 1 |
| Tkaczewski, W | 1 |
| Cameron, JS | 2 |
| Swigart, CR | 2 |
| Shin, GS | 1 |
| Katz, D | 2 |
| Bassett, AL | 2 |
| Felix, SB | 1 |
| Baumann, G | 1 |
| Hashemi, T | 1 |
| Niemczyk, M | 1 |
| Ahmad, Z | 1 |
| Berdel, WE | 1 |
| Tryba, M | 1 |
| Linde, I | 1 |
| Voshage, G | 1 |
| Zenz, M | 1 |
| Xu, YF | 1 |
| Dai, S | 2 |
| Bauer, LA | 1 |
| Black, D | 1 |
| Gensler, A | 1 |
| Siddoway, LA | 1 |
| Schwartz, SL | 1 |
| Barbey, JT | 1 |
| Woosley, RL | 1 |
| Kharlamova, IV | 1 |
| Sivkov, II | 1 |
| Starodubtsev, AK | 1 |
| Bogovskiĭ, BP | 1 |
| Blinkov, IL | 1 |
| Rubin, MP | 1 |
| Qiu, R | 1 |
| Guo, ZG | 1 |
| Quart, BD | 1 |
| Gallo, DG | 1 |
| Sami, MH | 2 |
| Wood, AJ | 1 |
| Li, CG | 1 |
| Rochette, L | 1 |
| Yao-Kouame, J | 1 |
| Bralet, J | 1 |
| Opie, LH | 1 |
| Montrucchio, G | 1 |
| Alloatti, G | 1 |
| Mariano, F | 1 |
| Meda, E | 1 |
| Tetta, C | 1 |
| Emanuelli, G | 1 |
| Camussi, G | 1 |
| Klein, AL | 1 |
| Tanz, RD | 1 |
| Kettelkamp, N | 1 |
| Hirshman, CA | 1 |
5 reviews available for cimetidine and Arrhythmia
| Article | Year |
|---|---|
Arrhythmias in patients with drug toxicity, electrolyte, and endocrine disturbances.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiovascular Agents; Cimetidine; Digitalis Glycoside | 1984 |
[Maintenance cimetidine treatment in duodenal ulcer disease. Second part: Side-effects and indications (author's transl)].
Topics: Animals; Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Cimetidine; Confusion; Dogs; | 1980 |
[Imidazoline receptors and use of drug blocking receptors I1].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Antihypertensive Agents; Arrhythmias, Cardi | 1996 |
[Effects of histamine H2 receptor blockaders on the cardiovascular system].
Topics: Arrhythmias, Cardiac; Cimetidine; Coronary Vasospasm; Coronary Vessels; Heart Conduction System; Hum | 1992 |
Clinical pharmacokinetics of moricizine.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Clinical Trials as Topic; Digoxin; Drug In | 1990 |
3 trials available for cimetidine and Arrhythmia
| Article | Year |
|---|---|
[Histamine release and cardiovascular reactions to implantation of bone cement during total hip replacement].
Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Bone Cements; Cimetidine; Clemastine; Female; Hip Pro | 1991 |
Clinical pharmacokinetics of moricizine.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Clinical Trials as Topic; Digoxin; Drug In | 1990 |
Usefulness and safety of cimetidine in patients receiving mexiletine for ventricular arrhythmia.
Topics: Aged; Arrhythmias, Cardiac; Cardiovascular System; Cimetidine; Clinical Trials as Topic; Double-Blin | 1985 |
41 other studies available for cimetidine and Arrhythmia
| Article | Year |
|---|---|
Human histamine H
Topics: Animals; Arrhythmias, Cardiac; Cimetidine; Dimaprit; Disease Models, Animal; Heart Atria; Heart Vent | 2021 |
Severe loperamide toxicity associated with the use of cimetidine to potentiate the "high".
Topics: Adult; Arrhythmias, Cardiac; Cardiotoxicity; Cimetidine; Drug Misuse; Female; Humans; Loperamide; Pa | 2018 |
Ventricular Dysrhythmias from Loperamide Misuse.
Topics: Arrhythmias, Cardiac; Cimetidine; Heart Conduction System; Humans; Loperamide; Male; Narcotic Antago | 2016 |
Histamine antagonists as antiarrhythmic agents in ouabain cardiotoxicity in the cat.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Female; Histamine; Histamine Anta | 1980 |
The cardiac pharmacology of tiotidine (LCL 125, 211): a new histamine H2-receptor antagonist.
Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Node; Cimetidine; Guanidines; Guinea Pigs; Heart; He | 1980 |
[Anti-arrhythmic action of cimetidine].
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Female; Guanidines; Gu | 1983 |
Histamine antagonists modify systemic digoxin cardiotoxicity by their central action.
Topics: Aminopyridines; Animals; Arrhythmias, Cardiac; Brain; Cats; Cimetidine; Digoxin; Female; Pyrilamine; | 1984 |
Cimetidine, vasopressin and chronotropic incompetence.
Topics: Arrhythmias, Cardiac; Bradycardia; Cimetidine; Coronary Disease; Drug Therapy, Combination; Electroc | 1982 |
Lidocaine-cimetidine interaction can be toxic.
Topics: Arrhythmias, Cardiac; Cimetidine; Drug Interactions; Guanidines; Humans; Lidocaine; Peptic Ulcer | 1982 |
Cimetidine and cardiac dysrhythmias.
Topics: Adolescent; Adult; Arrhythmias, Cardiac; Cimetidine; Guanidines; Humans; Male | 1982 |
Intracerebroventricular aconitine induced cardiac arrhythmia: involvement of central histaminergic receptors.
Topics: Aconitine; Aconitum; Animals; Arrhythmias, Cardiac; Blood Pressure; Cimetidine; Dogs; Heart; Heart R | 1982 |
Cimetidine induced arrhythmias.
Topics: Adult; Arrhythmias, Cardiac; Cimetidine; Guanidines; Humans; Male | 1982 |
Cardiac arrest and cimetidine.
Topics: Arrhythmias, Cardiac; Cimetidine; Guanidines; Humans; Male; Middle Aged | 1981 |
The arrhythmogenic actions of histamine on human atrial fibers.
Topics: Action Potentials; Adolescent; Adult; Aged; Arrhythmias, Cardiac; Child; Child, Preschool; Cimetidin | 1981 |
Cardiac arrhythmias after intravenous cimetidine.
Topics: Arrhythmias, Cardiac; Cimetidine; Guanidines; Humans; Injections, Intravenous; Male; Middle Aged | 1981 |
Modulation of the automaticity by histamine and cimetidine in rabbit sino-atrial node cells.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cell Membrane; Cimetidine; Electrophysiology; Hear | 1993 |
Curing swallowing-induced arrhythmias with cimetidine.
Topics: Arrhythmias, Cardiac; Cimetidine; Deglutition; Esophagitis, Peptic; Humans; Male; Middle Aged | 1994 |
Protection by cimetidine, but not ranitidine, implies that H2 receptors do not mediate arrhythmogenesis in a rat model of regional ischaemia and reperfusion in vitro.
Topics: Animals; Arrhythmias, Cardiac; Cimetidine; Dose-Response Relationship, Drug; Electrocardiography; Hi | 1995 |
Histamine 2 receptor antagonism by cimetidine and sinus-node function.
Topics: Arrhythmias, Cardiac; Cimetidine; Electrocardiography; Guanidines; Heart Rate; Histamine H2 Antagoni | 1979 |
[Fatal cardiac arrhythmia during treatment with cimetidine].
Topics: Adult; Arrhythmias, Cardiac; Bradycardia; Cardiac Complexes, Premature; Cimetidine; Female; Guanidin | 1978 |
Acceleration of idioventricular rhythms by histamine in guinea pig heart: mediation by H2 receptors.
Topics: Anaphylaxis; Animals; Arrhythmias, Cardiac; Chlorpheniramine; Cimetidine; Dose-Response Relationship | 1979 |
Life-threatening arrhythmias and intravenous cimetidine.
Topics: Arrhythmias, Cardiac; Cimetidine; Guanidines; Humans; Injections, Intravenous; Male; Middle Aged | 1979 |
Life-threatening arrhythmias and intravenous cimetidine.
Topics: Arrhythmias, Cardiac; Butylscopolammonium Bromide; Cimetidine; Guanidines; Humans; Scopolamine Deriv | 1979 |
Cimetidine and arrhythmia suppression.
Topics: Aged; Arrhythmias, Cardiac; Cimetidine; Guanidines; Heart Rate; Humans; Male | 1978 |
[Cimetidine... and its cardiac effects].
Topics: Arrhythmias, Cardiac; Cimetidine; Guanidines; Humans | 1978 |
[Cimetidine: heart rhythm disorders during therapy].
Topics: Arrhythmias, Cardiac; Cimetidine; Female; Guanidines; Humans; Middle Aged; Stomach Ulcer | 1978 |
Enhanced susceptibility to histamine-induced cardiac arrhythmias in spontaneously hypertensive rats.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cimetidine; Disease Susceptibility; Drug Interacti | 1990 |
Characterization of cardiovascular events mediated by platelet activating factor during systemic anaphylaxis.
Topics: Anaphylaxis; Animals; Arrhythmias, Cardiac; Azepines; Blood Pressure; Cardiac Output; Cimetidine; El | 1990 |
[Histamine and early ischemic arrhythmia in anesthetized cats].
Topics: Animals; Arrhythmias, Cardiac; Cats; Chlorpheniramine; Cimetidine; Female; Histamine; Histamine Rele | 1990 |
Circulatory depression and ventricular arrhythmias induced by compound 48/80 in anaesthetized rats.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascula | 1991 |
Procainamide-cimetidine drug interaction in elderly male patients.
Topics: Aged; Aged, 80 and over; Arrhythmias, Cardiac; Cimetidine; Drug Interactions; Humans; Male; Monitori | 1990 |
Histamine attenuates the arrhythmogenic effects of norepinephrine in hearts of spontaneously hypertensive rats.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cardiomegaly; Cimetidine; Electrocardiography; Hea | 1989 |
[Treatment of arrhythmia in patients with chronic ischemic heart disease using kinilentin combined with an inhibitor or inductor of microsomal oxidation].
Topics: Arrhythmias, Cardiac; Benzhydryl Compounds; Cimetidine; Coronary Disease; Drug Therapy, Combination; | 1989 |
Protective effects of histamine H1 and H2 antagonists, adenosine and hydrocortisone on cardiac anaphylaxis.
Topics: Adenosine; Aminopyridines; Anaphylaxis; Animals; Arrhythmias, Cardiac; Cardiac Output; Cimetidine; G | 1989 |
Drug interaction studies and encainide use in renal and hepatic impairment.
Topics: Adrenergic beta-Antagonists; Adult; Amiodarone; Anilides; Anti-Arrhythmia Agents; Anticoagulants; An | 1986 |
[Analysis of the anti-arrhythmic activity of cimetidine in anesthetized guinea pigs].
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cimetidine; Diphenhydramine; Femal | 1986 |
[Arrhythmogenic effects of histamine on ischemic hearts of guinea pigs].
Topics: Animals; Arrhythmias, Cardiac; Chlorpheniramine; Cimetidine; Cricetinae; Female; Heart Rate; Histami | 1987 |
Effects of promethazine on ischemic and reperfusion arrhythmias in rat heart.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chlorpheniramine; Cimetidine; Coronary Diseas | 1988 |
The pattern of cardiovascular alterations induced by infusion of platelet-activating factor in rabbit is modified by pretreatment with H1-H2 receptor antagonists but not by cyclooxygenase inhibition.
Topics: Animals; Arrhythmias, Cardiac; Cimetidine; Cyclooxygenase Inhibitors; Drug Interactions; Electrocard | 1987 |
Effects of ranitidine and cimetidine on experimentally induced ventricular arrhythmias in anaesthetized rats.
Topics: Aconitine; Animals; Arrhythmias, Cardiac; Blood Pressure; Cimetidine; Coronary Vessels; Heart Rate; | 1986 |
The effect of calcium on cardiac anaphylaxis in guinea-pig Langendorff heart preparations.
Topics: Anaphylaxis; Animals; Arrhythmias, Cardiac; Calcium; Cardiovascular Diseases; Cimetidine; Coronary C | 1985 |