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cimetidine and Anesthesia

cimetidine has been researched along with Anesthesia in 34 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

ExcerptRelevanceReference
"Cimetidine and ranitidine are specific and potent H2-receptor antagonists widely used in the effective therapy of peptic ulcer disease."8.77Actions of cimetidine and ranitidine at some cholinergic sites: implications in toxicology and anesthesia. ( Cheah, LS; Gwee, MC, 1986)
"The effects of chloramphenicol, cimetidine and phenobarbital on the xylazine-ketamine anesthesia and the development of tolerance to xylazine-ketamine and xylazine were studied in dogs."7.68Effects of chloramphenicol, cimetidine and phenobarbital on and tolerance to xylazine-ketamine anesthesia in dogs. ( Amouzadeh, HR; Nossaman, BC; Sangiah, S, 1990)
"Effects of tizanidine, a centrally acting muscle relaxant, on gastric acid secretion and gastric ulcers were studied in the rat."7.66[Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats]. ( Kanaoka, R; Maeda-Hagiwara, M; Watanabe, H; Watanabe, K, 1983)
"Cimetidine and ranitidine are specific and potent H2-receptor antagonists widely used in the effective therapy of peptic ulcer disease."4.77Actions of cimetidine and ranitidine at some cholinergic sites: implications in toxicology and anesthesia. ( Cheah, LS; Gwee, MC, 1986)
"The effects of chloramphenicol, cimetidine and phenobarbital on the xylazine-ketamine anesthesia and the development of tolerance to xylazine-ketamine and xylazine were studied in dogs."3.68Effects of chloramphenicol, cimetidine and phenobarbital on and tolerance to xylazine-ketamine anesthesia in dogs. ( Amouzadeh, HR; Nossaman, BC; Sangiah, S, 1990)
"Effects of tizanidine, a centrally acting muscle relaxant, on gastric acid secretion and gastric ulcers were studied in the rat."3.66[Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats]. ( Kanaoka, R; Maeda-Hagiwara, M; Watanabe, H; Watanabe, K, 1983)
"Cimetidine is a commonly used H2-receptor antagonist that has been recommended for the prevention of acid aspiration syndrome and has been shown to potentiate vecuronium-induced neuromuscular block."2.68[The effects of cimetidine on the pharmacodynamics of rocuronium]. ( de Almeida, MC; Kleemann, PP; Latorre, F; Stanek, A; Weiler, N, 1996)
"Cimetidine appears to be an excellent agent to use as a preventative measure against aspiration during the induction of anaesthesia."2.65A comparative evaluation of cimetidine and sodium citrate to decrease gastric acidity: effectiveness at the time of induction of anaesthesia. ( Foulkes, E; Jenkins, LC, 1981)
"Cimetidine has been effective in the treatment of peptic ulcer disease because of its ability to elevate gastric pH."2.65Cimetidine for the prophylaxis of potential gastric acid aspiration pneumonitis in trauma patients. ( Markovchick, VJ; Moore, EE; Strain, JD; Van Duzer-Moore, S, 1981)
"Famotidine has been already demonstrated to be a competitive H2-receptor antagonist in the stomachs of dogs and cats."1.28Selective and competitive histamine H2-receptor blocking effect of famotidine on the blood pressure response in dogs and the acid secretory response in rats. ( Fujihara, A; Kamato, T; Miyata, K; Takeda, M, 1990)
"Cimetidine (CIM) was used as an interacting agent on the disposition in dogs of dipotassium clorazepate ( CZP ) and its main metabolite nordiazepam (ND) in order to study some of the factors contributing to pharmacokinetic interspecies variation of benzodiazepines in dogs and man."1.27Cimetidine interaction with dipotassium clorazepate disposition in the anesthetized dog. ( Colin, P; Lelorier, J; Sirois, G, 1984)
"Recent data describe the acid aspiration syndrome (AAS) as the cause of 25% of maternal deaths associated with anaesthesia and 19% of all deaths totally attributable to anaesthesia (DHSS, 1982; Lunn and Mushin, 1982)."1.27Aspiration of gastric contents. ( Nimmo, WS, 1985)
" Mepyramine alone displaced the histamine dose-response curve to the right."1.26Antagonism of vasodepressor and gastric secretory responses to histamine by the H2-receptor antagonists, ranitidine and cimetidine, in the anaesthetized dog. ( Daly, MJ; Humphray, JM; Stables, R, 1981)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199023 (67.65)18.7374
1990's9 (26.47)18.2507
2000's2 (5.88)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Czuprynski, CJ1
Faith, NG1
Steinberg, H1
Neudeck, B1
Melo, JR1
de Araújo, GK1
da Luz, MM1
da Conceição, SA1
Lisboa, FA1
Moraes-Santos, T1
Cunha-Melo, JR1
Daly, MJ2
Humphray, JM2
Stables, R2
Durrant, JM1
Strunin, L1
Colin, P1
Sirois, G1
Lelorier, J1
Manchikanti, L2
Marrero, TC1
Roush, JR1
Armstrong, JM1
Duval, N1
Langer, SZ1
Watanabe, K1
Watanabe, H1
Maeda-Hagiwara, M1
Kanaoka, R1
Tryba, M1
Zenz, M1
Spina, G1
Fox, U1
Glässer, AU1
Foulkes, E1
Jenkins, LC1
Lauven, PM1
Stoeckel, H1
Schüttler, J1
Schwilden, H1
Barnes, PJ1
Havill, JH1
Strain, JD1
Moore, EE1
Markovchick, VJ1
Van Duzer-Moore, S1
Revest, PA1
Jones, HC1
Abbott, NJ1
Lin, WC1
Latorre, F1
de Almeida, MC1
Stanek, A1
Weiler, N1
Kleemann, PP1
Celik, I1
Lorenz, W2
Stinner, B2
Duda, D2
Sitter, H2
Sauer, S1
Junge, A1
Hoppe, M1
Zhou, SY1
Piyapolrungroj, N1
Pao, L1
Li, C1
Liu, G1
Zimmermann, E1
Fleisher, D1
Parsons, ME1
Bunce, KT1
Currington, A1
Matheson, F1
Pipkin, G1
Kapp, B1
Gstrein, B1
Dietz, W1
Doenicke, A1
Dick, W1
Miyata, K2
Kamato, T2
Fujihara, A2
Takeda, M2
Nossaman, BC1
Amouzadeh, HR1
Sangiah, S1
Söhngen, W1
Winbury, MM1
Kitzen, JM1
Ventura, A1
Lucchesi, BR1
Nimmo, WS1
McCammon, RL1
Gwee, MC1
Cheah, LS1
Kambam, JR1
Dymond, R1
Krestow, M1
Handte, RE1
Martin, C1
Fabre, J1
Iba, MM1
Grow, JB1
Colliver, JA1
Hadley, CH1
Hohlbein, LJ1

Reviews

3 reviews available for cimetidine and Anesthesia

ArticleYear
[Prevention of aspiration pneumonias].
    Deutsche medizinische Wochenschrift (1946), 1982, Aug-06, Volume: 107, Issue:31-32

    Topics: Anesthesia; Antacids; Cimetidine; Fasting; Gastric Juice; Humans; Pneumonia, Aspiration; Posture; Ti

1982
Prophylaxis for aspiration pneumonitis.
    Canadian Anaesthetists' Society journal, 1986, Volume: 33, Issue:3 Pt 2

    Topics: Anesthesia; Animals; Antacids; Cimetidine; Esophagus; Gastric Emptying; Gastric Juice; Gastrointesti

1986
Actions of cimetidine and ranitidine at some cholinergic sites: implications in toxicology and anesthesia.
    Life sciences, 1986, Aug-04, Volume: 39, Issue:5

    Topics: Anesthesia; Animals; Antihypertensive Agents; Bradycardia; Cholinesterase Inhibitors; Cimetidine; Co

1986

Trials

6 trials available for cimetidine and Anesthesia

ArticleYear
Comparative trial of the effect of ranitidine and cimetidine on gastric secretion in fasting patients at induction of anaesthesia.
    Canadian Anaesthetists' Society journal, 1982, Volume: 29, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anesthesia; Cimetidine; Fasting; Female; Furans; Gast

1982
Preanesthetic cimetidine and metoclopramide for acid aspiration prophylaxis in elective surgery.
    Anesthesiology, 1984, Volume: 61, Issue:1

    Topics: Adult; Anesthesia; Cimetidine; Clinical Trials as Topic; Gastric Acid; Gastric Juice; Humans; Inhala

1984
A comparative evaluation of cimetidine and sodium citrate to decrease gastric acidity: effectiveness at the time of induction of anaesthesia.
    Canadian Anaesthetists' Society journal, 1981, Volume: 28, Issue:1

    Topics: Adult; Aged; Anesthesia; Cimetidine; Citrates; Citric Acid; Gastric Acid; Gastric Acidity Determinat

1981
Cimetidine for the prophylaxis of potential gastric acid aspiration pneumonitis in trauma patients.
    The Journal of trauma, 1981, Volume: 21, Issue:1

    Topics: Adolescent; Adult; Anesthesia; Cimetidine; Female; Gastric Acid; Gastric Juice; Guanidines; Humans;

1981
[The effects of cimetidine on the pharmacodynamics of rocuronium].
    Der Anaesthesist, 1996, Volume: 45, Issue:10

    Topics: Adolescent; Adult; Aged; Androstanols; Anesthesia; Cimetidine; Double-Blind Method; Drug Interaction

1996
Controlled clinical trials and cross-sectional studies with plasma histamine measurements and histamine receptor antagonists: solving the problem of preoperative H1- + H2-prophylaxis by asking new questions?
    Agents and actions. Supplements, 1991, Volume: 33

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Atracurium; Cimetidine; Cross-Sectional Stud

1991

Other Studies

25 other studies available for cimetidine and Anesthesia

ArticleYear
Sodium pentobarbital anesthesia transiently enhances the severity of infection following intragastric, but not intravenous, inoculation of Listeria monocytogenes in mice.
    Microbial pathogenesis, 2003, Volume: 35, Issue:2

    Topics: Anesthesia; Animals; Anti-Ulcer Agents; Antidiarrheals; Cell Culture Techniques; Cell Line; Cimetidi

2003
Effect of acid secretion blockade on acute gastric mucosal lesions induced by Tityus serrulatus scorpion toxin in anaesthetized rats.
    Toxicon : official journal of the International Society on Toxinology, 2006, Volume: 48, Issue:5

    Topics: Acute Disease; Anesthesia; Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Drug Ant

2006
Cimetidine and the acid-aspiration syndrome.
    Lancet (London, England), 1980, Mar-01, Volume: 1, Issue:8166

    Topics: Anesthesia; Cimetidine; Female; Gastric Juice; Guanidines; Humans; Hydrogen-Ion Concentration; Male;

1980
Antagonism of vasodepressor and gastric secretory responses to histamine by the H2-receptor antagonists, ranitidine and cimetidine, in the anaesthetized dog.
    British journal of pharmacology, 1981, Volume: 72, Issue:1

    Topics: Anesthesia; Animals; Blood Pressure; Cimetidine; Dogs; Dose-Response Relationship, Drug; Female; Fur

1981
Cimetidine interaction with dipotassium clorazepate disposition in the anesthetized dog.
    Archives internationales de pharmacodynamie et de therapie, 1984, Volume: 268, Issue:1

    Topics: Anesthesia; Animals; Anti-Anxiety Agents; Cimetidine; Clorazepate Dipotassium; Dogs; Drug Interactio

1984
LY 141865 stimulates histamine-2 (H2) receptors and dopamine-2 (DA2) receptors in the anaesthetised dog.
    European journal of pharmacology, 1983, Jan-28, Volume: 87, Issue:1

    Topics: Anesthesia; Animals; Cimetidine; Coronary Circulation; Dogs; Dopamine; Ergolines; Female; Histamine;

1983
[Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1983, Volume: 82, Issue:4

    Topics: Anesthesia; Animals; Anti-Ulcer Agents; Bethanechol Compounds; Cimetidine; Clonidine; Dose-Response

1983
Suppression of gastric acid secretory and ulcerogenic effects of cysteamine in chronic antrectomized rat.
    Pharmacological research communications, 1982, Volume: 14, Issue:7

    Topics: Anesthesia; Animals; Atropine; Cimetidine; Cysteamine; Gastric Acid; Hydrogen-Ion Concentration; Mal

1982
[Prevention of fentanyl rebound by administration of cimetidine (author's transl)].
    Der Anaesthesist, 1981, Volume: 30, Issue:9

    Topics: Adult; Anesthesia; Biotransformation; Cimetidine; Fentanyl; Guanidines; Humans; Hydrogen-Ion Concent

1981
Preoperative cimetidine--effects on gastric fluid.
    Anaesthesia and intensive care, 1980, Volume: 8, Issue:4

    Topics: Adolescent; Adult; Anesthesia; Cimetidine; Double-Blind Method; Female; Gastric Juice; Guanidines; H

1980
Transendothelial electrical potential across pial vessels in anaesthetised rats: a study of ion permeability and transport at the blood-brain barrier.
    Brain research, 1994, Jul-25, Volume: 652, Issue:1

    Topics: Anesthesia; Animals; Blood-Brain Barrier; Cell Membrane Permeability; Cimetidine; Electrophysiology;

1994
Stimulatory effect of muscimol on gastric acid secretion stimulated by secretagogues in vagotomized rats under anesthesia.
    European journal of pharmacology, 1995, Jun-06, Volume: 279, Issue:1

    Topics: Anesthesia; Animals; Atropine; Bicuculline; Cimetidine; Drug Interactions; Electric Stimulation; GAB

1995
Clinic modelling randomised trials (CMRT's) in animals as a new intermediate between biological experiments and randomised clinical trials: application to antihistamine prophylaxis in anaesthesia and surgery.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47 Suppl 1

    Topics: Anesthesia; Animals; Cimetidine; Dimethindene; Disease Models, Animal; Double-Blind Method; Female;

1998
Regulation of paracellular absorption of cimetidine and 5-aminosalicylate in rat intestine.
    Pharmaceutical research, 1999, Volume: 16, Issue:11

    Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Biological Transpor

1999
Antagonism of vasodepressor and gastric secretory responses to histamine by ranitidine and cimetidine in the anaesthetised dog [proceedings].
    British journal of pharmacology, 1979, Volume: 67, Issue:3

    Topics: Anesthesia; Animals; Cimetidine; Dogs; Furans; Gastric Juice; Guanidines; Hemodynamics; Histamine H2

1979
The effect cystamine on gastric secretion in the rat.
    Agents and actions, 1979, Volume: 9, Issue:3

    Topics: Anesthesia; Animals; Atropine; Cimetidine; Cystamine; Female; Fistula; Gastric Juice; Histamine; Met

1979
Selective and competitive histamine H2-receptor blocking effect of famotidine on the blood pressure response in dogs and the acid secretory response in rats.
    Japanese journal of pharmacology, 1990, Volume: 54, Issue:2

    Topics: Anesthesia; Animals; Blood Pressure; Cimetidine; Dimaprit; Dogs; Famotidine; Female; Gastric Acid; H

1990
Cardiovascular and bronchial actions of famotidine in anesthetized dogs.
    Arzneimittel-Forschung, 1990, Volume: 40, Issue:11

    Topics: Airway Resistance; Anesthesia; Animals; Bronchi; Cimetidine; Dogs; Electrocardiography; Famotidine;

1990
Effects of chloramphenicol, cimetidine and phenobarbital on and tolerance to xylazine-ketamine anesthesia in dogs.
    Veterinary and human toxicology, 1990, Volume: 32, Issue:3

    Topics: Anesthesia; Animals; Behavior, Animal; Chloramphenicol; Cimetidine; Consciousness; Dogs; Dose-Respon

1990
The mechanism for the clonidine-induced coronary artery dilatation in the canine heart.
    Journal of cardiovascular pharmacology, 1988, Volume: 12, Issue:6

    Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Antihypertensive Agents; Blood Platelets; Blood Pres

1988
Aspiration of gastric contents.
    British journal of hospital medicine, 1985, Volume: 34, Issue:3

    Topics: Administration, Oral; Analgesics, Opioid; Anesthesia; Anesthesia, Obstetrical; Cimetidine; Citrates;

1985
Efficacy of histamine H1 and H2 receptor blockers in the anesthetic management during operation for hydatid cysts of liver and lungs.
    Southern medical journal, 1988, Volume: 81, Issue:8

    Topics: Adult; Anaphylaxis; Anesthesia; Blood Pressure; Bronchial Spasm; Central Venous Pressure; Cimetidine

1988
[Bronchopneumopathies caused by inhalation of the gastric contents].
    Cahiers d'anesthesiologie, 1985, Volume: 33, Issue:8

    Topics: Albumins; Anesthesia; Antacids; Anti-Bacterial Agents; Anti-Inflammatory Agents; Cimetidine; Humans;

1985
Decreased duration of pentobarbital anesthesia and increased pentobarbital metabolism in immature rats perinatally exposed to cimetidine.
    Biochemical pharmacology, 1986, Jan-15, Volume: 35, Issue:2

    Topics: Anesthesia; Animals; Animals, Newborn; Cimetidine; Cytochrome P-450 Enzyme System; Female; Fetus; Ma

1986
Bicitra (sodium citrate) and metoclopramide in outpatient anesthesia for prophylaxis against aspiration pneumonitis.
    Anesthesiology, 1985, Volume: 63, Issue:4

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia; Antacids; Cimetidine; Citrates; Citric Acid; Fema

1985