cimetidine has been researched along with Anesthesia in 34 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cimetidine and ranitidine are specific and potent H2-receptor antagonists widely used in the effective therapy of peptic ulcer disease." | 8.77 | Actions of cimetidine and ranitidine at some cholinergic sites: implications in toxicology and anesthesia. ( Cheah, LS; Gwee, MC, 1986) |
| "The effects of chloramphenicol, cimetidine and phenobarbital on the xylazine-ketamine anesthesia and the development of tolerance to xylazine-ketamine and xylazine were studied in dogs." | 7.68 | Effects of chloramphenicol, cimetidine and phenobarbital on and tolerance to xylazine-ketamine anesthesia in dogs. ( Amouzadeh, HR; Nossaman, BC; Sangiah, S, 1990) |
| "Effects of tizanidine, a centrally acting muscle relaxant, on gastric acid secretion and gastric ulcers were studied in the rat." | 7.66 | [Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats]. ( Kanaoka, R; Maeda-Hagiwara, M; Watanabe, H; Watanabe, K, 1983) |
| "Cimetidine and ranitidine are specific and potent H2-receptor antagonists widely used in the effective therapy of peptic ulcer disease." | 4.77 | Actions of cimetidine and ranitidine at some cholinergic sites: implications in toxicology and anesthesia. ( Cheah, LS; Gwee, MC, 1986) |
| "The effects of chloramphenicol, cimetidine and phenobarbital on the xylazine-ketamine anesthesia and the development of tolerance to xylazine-ketamine and xylazine were studied in dogs." | 3.68 | Effects of chloramphenicol, cimetidine and phenobarbital on and tolerance to xylazine-ketamine anesthesia in dogs. ( Amouzadeh, HR; Nossaman, BC; Sangiah, S, 1990) |
| "Effects of tizanidine, a centrally acting muscle relaxant, on gastric acid secretion and gastric ulcers were studied in the rat." | 3.66 | [Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats]. ( Kanaoka, R; Maeda-Hagiwara, M; Watanabe, H; Watanabe, K, 1983) |
| "Cimetidine is a commonly used H2-receptor antagonist that has been recommended for the prevention of acid aspiration syndrome and has been shown to potentiate vecuronium-induced neuromuscular block." | 2.68 | [The effects of cimetidine on the pharmacodynamics of rocuronium]. ( de Almeida, MC; Kleemann, PP; Latorre, F; Stanek, A; Weiler, N, 1996) |
| "Cimetidine appears to be an excellent agent to use as a preventative measure against aspiration during the induction of anaesthesia." | 2.65 | A comparative evaluation of cimetidine and sodium citrate to decrease gastric acidity: effectiveness at the time of induction of anaesthesia. ( Foulkes, E; Jenkins, LC, 1981) |
| "Cimetidine has been effective in the treatment of peptic ulcer disease because of its ability to elevate gastric pH." | 2.65 | Cimetidine for the prophylaxis of potential gastric acid aspiration pneumonitis in trauma patients. ( Markovchick, VJ; Moore, EE; Strain, JD; Van Duzer-Moore, S, 1981) |
| "Famotidine has been already demonstrated to be a competitive H2-receptor antagonist in the stomachs of dogs and cats." | 1.28 | Selective and competitive histamine H2-receptor blocking effect of famotidine on the blood pressure response in dogs and the acid secretory response in rats. ( Fujihara, A; Kamato, T; Miyata, K; Takeda, M, 1990) |
| "Cimetidine (CIM) was used as an interacting agent on the disposition in dogs of dipotassium clorazepate ( CZP ) and its main metabolite nordiazepam (ND) in order to study some of the factors contributing to pharmacokinetic interspecies variation of benzodiazepines in dogs and man." | 1.27 | Cimetidine interaction with dipotassium clorazepate disposition in the anesthetized dog. ( Colin, P; Lelorier, J; Sirois, G, 1984) |
| "Recent data describe the acid aspiration syndrome (AAS) as the cause of 25% of maternal deaths associated with anaesthesia and 19% of all deaths totally attributable to anaesthesia (DHSS, 1982; Lunn and Mushin, 1982)." | 1.27 | Aspiration of gastric contents. ( Nimmo, WS, 1985) |
| " Mepyramine alone displaced the histamine dose-response curve to the right." | 1.26 | Antagonism of vasodepressor and gastric secretory responses to histamine by the H2-receptor antagonists, ranitidine and cimetidine, in the anaesthetized dog. ( Daly, MJ; Humphray, JM; Stables, R, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (67.65) | 18.7374 |
| 1990's | 9 (26.47) | 18.2507 |
| 2000's | 2 (5.88) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Czuprynski, CJ | 1 |
| Faith, NG | 1 |
| Steinberg, H | 1 |
| Neudeck, B | 1 |
| Melo, JR | 1 |
| de Araújo, GK | 1 |
| da Luz, MM | 1 |
| da Conceição, SA | 1 |
| Lisboa, FA | 1 |
| Moraes-Santos, T | 1 |
| Cunha-Melo, JR | 1 |
| Daly, MJ | 2 |
| Humphray, JM | 2 |
| Stables, R | 2 |
| Durrant, JM | 1 |
| Strunin, L | 1 |
| Colin, P | 1 |
| Sirois, G | 1 |
| Lelorier, J | 1 |
| Manchikanti, L | 2 |
| Marrero, TC | 1 |
| Roush, JR | 1 |
| Armstrong, JM | 1 |
| Duval, N | 1 |
| Langer, SZ | 1 |
| Watanabe, K | 1 |
| Watanabe, H | 1 |
| Maeda-Hagiwara, M | 1 |
| Kanaoka, R | 1 |
| Tryba, M | 1 |
| Zenz, M | 1 |
| Spina, G | 1 |
| Fox, U | 1 |
| Glässer, AU | 1 |
| Foulkes, E | 1 |
| Jenkins, LC | 1 |
| Lauven, PM | 1 |
| Stoeckel, H | 1 |
| Schüttler, J | 1 |
| Schwilden, H | 1 |
| Barnes, PJ | 1 |
| Havill, JH | 1 |
| Strain, JD | 1 |
| Moore, EE | 1 |
| Markovchick, VJ | 1 |
| Van Duzer-Moore, S | 1 |
| Revest, PA | 1 |
| Jones, HC | 1 |
| Abbott, NJ | 1 |
| Lin, WC | 1 |
| Latorre, F | 1 |
| de Almeida, MC | 1 |
| Stanek, A | 1 |
| Weiler, N | 1 |
| Kleemann, PP | 1 |
| Celik, I | 1 |
| Lorenz, W | 2 |
| Stinner, B | 2 |
| Duda, D | 2 |
| Sitter, H | 2 |
| Sauer, S | 1 |
| Junge, A | 1 |
| Hoppe, M | 1 |
| Zhou, SY | 1 |
| Piyapolrungroj, N | 1 |
| Pao, L | 1 |
| Li, C | 1 |
| Liu, G | 1 |
| Zimmermann, E | 1 |
| Fleisher, D | 1 |
| Parsons, ME | 1 |
| Bunce, KT | 1 |
| Currington, A | 1 |
| Matheson, F | 1 |
| Pipkin, G | 1 |
| Kapp, B | 1 |
| Gstrein, B | 1 |
| Dietz, W | 1 |
| Doenicke, A | 1 |
| Dick, W | 1 |
| Miyata, K | 2 |
| Kamato, T | 2 |
| Fujihara, A | 2 |
| Takeda, M | 2 |
| Nossaman, BC | 1 |
| Amouzadeh, HR | 1 |
| Sangiah, S | 1 |
| Söhngen, W | 1 |
| Winbury, MM | 1 |
| Kitzen, JM | 1 |
| Ventura, A | 1 |
| Lucchesi, BR | 1 |
| Nimmo, WS | 1 |
| McCammon, RL | 1 |
| Gwee, MC | 1 |
| Cheah, LS | 1 |
| Kambam, JR | 1 |
| Dymond, R | 1 |
| Krestow, M | 1 |
| Handte, RE | 1 |
| Martin, C | 1 |
| Fabre, J | 1 |
| Iba, MM | 1 |
| Grow, JB | 1 |
| Colliver, JA | 1 |
| Hadley, CH | 1 |
| Hohlbein, LJ | 1 |
3 reviews available for cimetidine and Anesthesia
| Article | Year |
|---|---|
[Prevention of aspiration pneumonias].
Topics: Anesthesia; Antacids; Cimetidine; Fasting; Gastric Juice; Humans; Pneumonia, Aspiration; Posture; Ti | 1982 |
Prophylaxis for aspiration pneumonitis.
Topics: Anesthesia; Animals; Antacids; Cimetidine; Esophagus; Gastric Emptying; Gastric Juice; Gastrointesti | 1986 |
Actions of cimetidine and ranitidine at some cholinergic sites: implications in toxicology and anesthesia.
Topics: Anesthesia; Animals; Antihypertensive Agents; Bradycardia; Cholinesterase Inhibitors; Cimetidine; Co | 1986 |
6 trials available for cimetidine and Anesthesia
| Article | Year |
|---|---|
Comparative trial of the effect of ranitidine and cimetidine on gastric secretion in fasting patients at induction of anaesthesia.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anesthesia; Cimetidine; Fasting; Female; Furans; Gast | 1982 |
Preanesthetic cimetidine and metoclopramide for acid aspiration prophylaxis in elective surgery.
Topics: Adult; Anesthesia; Cimetidine; Clinical Trials as Topic; Gastric Acid; Gastric Juice; Humans; Inhala | 1984 |
A comparative evaluation of cimetidine and sodium citrate to decrease gastric acidity: effectiveness at the time of induction of anaesthesia.
Topics: Adult; Aged; Anesthesia; Cimetidine; Citrates; Citric Acid; Gastric Acid; Gastric Acidity Determinat | 1981 |
Cimetidine for the prophylaxis of potential gastric acid aspiration pneumonitis in trauma patients.
Topics: Adolescent; Adult; Anesthesia; Cimetidine; Female; Gastric Acid; Gastric Juice; Guanidines; Humans; | 1981 |
[The effects of cimetidine on the pharmacodynamics of rocuronium].
Topics: Adolescent; Adult; Aged; Androstanols; Anesthesia; Cimetidine; Double-Blind Method; Drug Interaction | 1996 |
Controlled clinical trials and cross-sectional studies with plasma histamine measurements and histamine receptor antagonists: solving the problem of preoperative H1- + H2-prophylaxis by asking new questions?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Atracurium; Cimetidine; Cross-Sectional Stud | 1991 |
25 other studies available for cimetidine and Anesthesia
| Article | Year |
|---|---|
Sodium pentobarbital anesthesia transiently enhances the severity of infection following intragastric, but not intravenous, inoculation of Listeria monocytogenes in mice.
Topics: Anesthesia; Animals; Anti-Ulcer Agents; Antidiarrheals; Cell Culture Techniques; Cell Line; Cimetidi | 2003 |
Effect of acid secretion blockade on acute gastric mucosal lesions induced by Tityus serrulatus scorpion toxin in anaesthetized rats.
Topics: Acute Disease; Anesthesia; Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Drug Ant | 2006 |
Cimetidine and the acid-aspiration syndrome.
Topics: Anesthesia; Cimetidine; Female; Gastric Juice; Guanidines; Humans; Hydrogen-Ion Concentration; Male; | 1980 |
Antagonism of vasodepressor and gastric secretory responses to histamine by the H2-receptor antagonists, ranitidine and cimetidine, in the anaesthetized dog.
Topics: Anesthesia; Animals; Blood Pressure; Cimetidine; Dogs; Dose-Response Relationship, Drug; Female; Fur | 1981 |
Cimetidine interaction with dipotassium clorazepate disposition in the anesthetized dog.
Topics: Anesthesia; Animals; Anti-Anxiety Agents; Cimetidine; Clorazepate Dipotassium; Dogs; Drug Interactio | 1984 |
LY 141865 stimulates histamine-2 (H2) receptors and dopamine-2 (DA2) receptors in the anaesthetised dog.
Topics: Anesthesia; Animals; Cimetidine; Coronary Circulation; Dogs; Dopamine; Ergolines; Female; Histamine; | 1983 |
[Influence of a muscle relaxant, tizanidine, on gastric acid secretion and gastric ulcer in rats].
Topics: Anesthesia; Animals; Anti-Ulcer Agents; Bethanechol Compounds; Cimetidine; Clonidine; Dose-Response | 1983 |
Suppression of gastric acid secretory and ulcerogenic effects of cysteamine in chronic antrectomized rat.
Topics: Anesthesia; Animals; Atropine; Cimetidine; Cysteamine; Gastric Acid; Hydrogen-Ion Concentration; Mal | 1982 |
[Prevention of fentanyl rebound by administration of cimetidine (author's transl)].
Topics: Adult; Anesthesia; Biotransformation; Cimetidine; Fentanyl; Guanidines; Humans; Hydrogen-Ion Concent | 1981 |
Preoperative cimetidine--effects on gastric fluid.
Topics: Adolescent; Adult; Anesthesia; Cimetidine; Double-Blind Method; Female; Gastric Juice; Guanidines; H | 1980 |
Transendothelial electrical potential across pial vessels in anaesthetised rats: a study of ion permeability and transport at the blood-brain barrier.
Topics: Anesthesia; Animals; Blood-Brain Barrier; Cell Membrane Permeability; Cimetidine; Electrophysiology; | 1994 |
Stimulatory effect of muscimol on gastric acid secretion stimulated by secretagogues in vagotomized rats under anesthesia.
Topics: Anesthesia; Animals; Atropine; Bicuculline; Cimetidine; Drug Interactions; Electric Stimulation; GAB | 1995 |
Clinic modelling randomised trials (CMRT's) in animals as a new intermediate between biological experiments and randomised clinical trials: application to antihistamine prophylaxis in anaesthesia and surgery.
Topics: Anesthesia; Animals; Cimetidine; Dimethindene; Disease Models, Animal; Double-Blind Method; Female; | 1998 |
Regulation of paracellular absorption of cimetidine and 5-aminosalicylate in rat intestine.
Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Biological Transpor | 1999 |
Antagonism of vasodepressor and gastric secretory responses to histamine by ranitidine and cimetidine in the anaesthetised dog [proceedings].
Topics: Anesthesia; Animals; Cimetidine; Dogs; Furans; Gastric Juice; Guanidines; Hemodynamics; Histamine H2 | 1979 |
The effect cystamine on gastric secretion in the rat.
Topics: Anesthesia; Animals; Atropine; Cimetidine; Cystamine; Female; Fistula; Gastric Juice; Histamine; Met | 1979 |
Selective and competitive histamine H2-receptor blocking effect of famotidine on the blood pressure response in dogs and the acid secretory response in rats.
Topics: Anesthesia; Animals; Blood Pressure; Cimetidine; Dimaprit; Dogs; Famotidine; Female; Gastric Acid; H | 1990 |
Cardiovascular and bronchial actions of famotidine in anesthetized dogs.
Topics: Airway Resistance; Anesthesia; Animals; Bronchi; Cimetidine; Dogs; Electrocardiography; Famotidine; | 1990 |
Effects of chloramphenicol, cimetidine and phenobarbital on and tolerance to xylazine-ketamine anesthesia in dogs.
Topics: Anesthesia; Animals; Behavior, Animal; Chloramphenicol; Cimetidine; Consciousness; Dogs; Dose-Respon | 1990 |
The mechanism for the clonidine-induced coronary artery dilatation in the canine heart.
Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Antihypertensive Agents; Blood Platelets; Blood Pres | 1988 |
Aspiration of gastric contents.
Topics: Administration, Oral; Analgesics, Opioid; Anesthesia; Anesthesia, Obstetrical; Cimetidine; Citrates; | 1985 |
Efficacy of histamine H1 and H2 receptor blockers in the anesthetic management during operation for hydatid cysts of liver and lungs.
Topics: Adult; Anaphylaxis; Anesthesia; Blood Pressure; Bronchial Spasm; Central Venous Pressure; Cimetidine | 1988 |
[Bronchopneumopathies caused by inhalation of the gastric contents].
Topics: Albumins; Anesthesia; Antacids; Anti-Bacterial Agents; Anti-Inflammatory Agents; Cimetidine; Humans; | 1985 |
Decreased duration of pentobarbital anesthesia and increased pentobarbital metabolism in immature rats perinatally exposed to cimetidine.
Topics: Anesthesia; Animals; Animals, Newborn; Cimetidine; Cytochrome P-450 Enzyme System; Female; Fetus; Ma | 1986 |
Bicitra (sodium citrate) and metoclopramide in outpatient anesthesia for prophylaxis against aspiration pneumonitis.
Topics: Adult; Ambulatory Surgical Procedures; Anesthesia; Antacids; Cimetidine; Citrates; Citric Acid; Fema | 1985 |