Page last updated: 2024-10-25

cimetidine and Alzheimer Disease

cimetidine has been researched along with Alzheimer Disease in 7 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (71.43)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Tang, H3
Zhao, LZ1
Zhao, HT2
Huang, SL1
Zhong, SM2
Qin, JK1
Chen, ZF2
Huang, ZS1
Liang, H2
Wang, ZY1
Di Pietro, O1
Pérez-Areales, FJ2
Juárez-Jiménez, J1
Espargaró, A2
Clos, MV1
Pérez, B3
Lavilla, R1
Sabaté, R2
Luque, FJ1
Muñoz-Torrero, D2
Wei, S1
Chen, W1
Qin, J1
Huangli, Y1
Wang, L1
Shen, Y1
Turcu, AL2
Barniol-Xicota, M1
Pont, C1
Pivetta, D1
Bartolini, M1
De Simone, A1
Andrisano, V1
Sureda, FX2
Vázquez, S2
Companys-Alemany, J1
Phillips, MB1
Patel, DS1
Griñán-Ferré, C1
Loza, MI1
Brea, JM1
Soto, D1
Kurnikova, MG1
Johnson, JW1
Pallàs, M1
Larson, EB1
Reifler, BV1
Sumi, SM1
Canfield, CG1
Chinn, NM1

Other Studies

7 other studies available for cimetidine and Alzheimer Disease

ArticleYear
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:10

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Aporphines; Blood-

2011
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
    Bioorganic & medicinal chemistry letters, 2012, Mar-15, Volume: 22, Issue:6

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Binding Sites; Blood-Bra

2012
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.
    European journal of medicinal chemistry, 2014, Sep-12, Volume: 84

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Cholinesterases; Dose-Response

2014
Multitarget-directed oxoisoaporphine derivatives: Anti-acetylcholinesterase, anti-β-amyloid aggregation and enhanced autophagy activity against Alzheimer's disease.
    Bioorganic & medicinal chemistry, 2016, 11-15, Volume: 24, Issue:22

    Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aporphines; Autophagy; Cholinesteras

2016
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
    European journal of medicinal chemistry, 2019, Oct-15, Volume: 180

    Topics: Acetylcholinesterase; Adamantane; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitor

2019
Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease.
    European journal of medicinal chemistry, 2022, Jun-05, Volume: 236

    Topics: Alzheimer Disease; Animals; Caenorhabditis elegans; Disease Models, Animal; Memantine; Mice; Recepto

2022
Diagnostic evaluation of 200 elderly outpatients with suspected dementia.
    Journal of gerontology, 1985, Volume: 40, Issue:5

    Topics: Aged; Alzheimer Disease; Cimetidine; Cognition Disorders; Dementia; Depression; Follow-Up Studies; H

1985