cimetidine has been researched along with Allergy, Drug in 44 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A rare case of thrombocytopenia associated with ranitidine is described." | 7.67 | Thrombocytopenia associated with hypersensitivity to ranitidine: possible cross-reactivity with cimetidine. ( Gafter, U; Komlos, L; Levi, J; Livni, E; Zevin, D, 1989) |
| "A biopsy-proved case of acute interstitial nephritis related to the use of cimetidine in duodenal ulcer disease is presented." | 7.66 | Acute interstitial nephritis related to cimetidine therapy. ( McGowan, WR; Vermillion, SE, 1980) |
| "A rare case of thrombocytopenia associated with ranitidine is described." | 3.67 | Thrombocytopenia associated with hypersensitivity to ranitidine: possible cross-reactivity with cimetidine. ( Gafter, U; Komlos, L; Levi, J; Livni, E; Zevin, D, 1989) |
| "A rash developed in a man consistent with urticarial vasculitis as demonstrated by biopsy on each of two occasions that he was exposed to cimetidine." | 3.66 | Cimetidine-induced cutaneous vasculitis. ( Magnusson, AR; Mitchell, GG; Weiler, JM, 1983) |
| "A biopsy-proved case of acute interstitial nephritis related to the use of cimetidine in duodenal ulcer disease is presented." | 3.66 | Acute interstitial nephritis related to cimetidine therapy. ( McGowan, WR; Vermillion, SE, 1980) |
| " Weekly paclitaxel at a dose of 67 mg/m2/week was found to have a better safety profile and seemed to be as effective as the equivalently dosed schedule every 3 weeks." | 2.70 | Randomized trial of single agent paclitaxel given weekly versus every three weeks and with peroral versus intravenous steroid premedication to patients with ovarian cancer previously treated with platinum. ( Andersson, H; Boman, K; Parö, G; Puistola, U; Ridderheim, M; Rosenberg, P; Sorbe, B, 2002) |
| "Docetaxel is active for metastatic breast cancer." | 2.68 | Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer. ( Balmaceda, C; Baselga, J; Bruno, R; Crown, JP; Currie, V; Freilich, R; Gilewski, TA; Gollub, M; Hakes, TB; Hudis, CA; Lebwohl, DE; Norton, L; Raptis, G; Robles, M; Seidman, AD, 1996) |
| "Of 180 eligible cancer patients, 100 patients received paclitaxel weekly and 80 patients, every 3 weeks." | 1.35 | Oral premedication for the prevention of hypersensitivity reactions to paclitaxel. ( Abzah, A; Farraj, Z; Friedman, E; Hussein, O; Tamam, S; Zidan, J, 2008) |
| " When HSR was observed administration of paclitaxel was temporally stopped and before the re-challenge additional intravenous dosage of hydrocortisone (200-500 mg) and diphenhydramine (25 mg) was given." | 1.31 | [Paclitaxel hypersensitivity reactions in patients with advanced ovarian carcinoma]. ( Emerich, J; Kobierski, J; Majdak, E; Mielcarek, P, 2002) |
| "Cimetidine has recently proved useful in the prophylaxis of certain allergic and other histamine-mediated reactions." | 1.26 | Cimetidine (Tagamet) combined with steroids and H1 antihistamines for the prevention of serious radiographic contrast material reactions. ( Bloom, FL; Myers, GE, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (56.82) | 18.7374 |
| 1990's | 9 (20.45) | 18.2507 |
| 2000's | 9 (20.45) | 29.6817 |
| 2010's | 1 (2.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hubbard, CR | 1 |
| Blankenship, JC | 1 |
| Scott, TD | 1 |
| Skelding, KA | 1 |
| Berger, PB | 1 |
| Cho, HJ | 1 |
| Yoo, HS | 1 |
| Park, SY | 1 |
| Yang, EM | 1 |
| Yoon, MG | 1 |
| Park, HS | 1 |
| Ye, YM | 1 |
| Quock, J | 1 |
| Dea, G | 1 |
| Tanaka, M | 1 |
| Gandara, D | 1 |
| Lara, P | 1 |
| Lau, D | 1 |
| Rosenberg, P | 1 |
| Andersson, H | 1 |
| Boman, K | 1 |
| Ridderheim, M | 1 |
| Sorbe, B | 1 |
| Puistola, U | 1 |
| Parö, G | 1 |
| Thomas, RR | 1 |
| Quinn, MG | 1 |
| Schuler, B | 1 |
| Grem, JL | 1 |
| Kobierski, J | 1 |
| Majdak, E | 1 |
| Mielcarek, P | 1 |
| Emerich, J | 1 |
| Herzinger, T | 1 |
| Behr, J | 1 |
| Przybilla, B | 1 |
| Zidan, J | 1 |
| Hussein, O | 1 |
| Abzah, A | 1 |
| Tamam, S | 1 |
| Farraj, Z | 1 |
| Friedman, E | 1 |
| Kaye, M | 1 |
| Gagnon, RF | 1 |
| Mathews, KP | 1 |
| Watson, AJ | 1 |
| Dalbow, MH | 1 |
| Stachura, I | 1 |
| Fragola, JA | 1 |
| Rubin, MF | 1 |
| Watson, RM | 1 |
| Bourke, E | 1 |
| Hansbrough, J | 1 |
| Peterson, V | 1 |
| Zapata-Sirvent, R | 1 |
| Claman, HN | 1 |
| Brandrup, F | 1 |
| Assey, ME | 1 |
| Olson, PL | 1 |
| Mitchell, GG | 1 |
| Magnusson, AR | 1 |
| Weiler, JM | 1 |
| Sandhu, BS | 2 |
| Requena, R | 2 |
| Cohen, SH | 1 |
| Kagen, SL | 1 |
| Leftwich, RB | 1 |
| Simon, RA | 1 |
| García-Ortega, P | 1 |
| Cadahía, A | 1 |
| Myers, GE | 1 |
| Bloom, FL | 1 |
| Lorenzini, I | 1 |
| Jezequel, AM | 1 |
| Orlandi, F | 1 |
| McGowan, WR | 1 |
| Vermillion, SE | 1 |
| Bolser, DC | 1 |
| DeGennaro, FC | 1 |
| O'Reilly, S | 1 |
| Hey, JA | 1 |
| Chapman, RW | 1 |
| Hainsworth, JD | 1 |
| Greco, FA | 1 |
| Saha, N | 1 |
| Sachdev, A | 1 |
| Bhasin, DK | 1 |
| Sankaranahyanan, A | 1 |
| Khosla, PP | 1 |
| Singh, K | 1 |
| Sharma, PL | 1 |
| Hudis, CA | 1 |
| Seidman, AD | 1 |
| Crown, JP | 1 |
| Balmaceda, C | 1 |
| Freilich, R | 1 |
| Gilewski, TA | 1 |
| Hakes, TB | 1 |
| Currie, V | 1 |
| Lebwohl, DE | 1 |
| Baselga, J | 1 |
| Raptis, G | 1 |
| Gollub, M | 1 |
| Robles, M | 1 |
| Bruno, R | 1 |
| Norton, L | 1 |
| Boehm, DK | 1 |
| Maksymiuk, AW | 1 |
| Bookman, MA | 1 |
| Kloth, DD | 1 |
| Kover, PE | 1 |
| Smolinski, S | 1 |
| Ozols, RF | 1 |
| Renz, C | 1 |
| Lynch, J | 1 |
| Thurn, J | 1 |
| Moss, J | 1 |
| Moon, C | 1 |
| Verschraegen, CF | 1 |
| Bevers, M | 1 |
| Freedman, R | 1 |
| Kudelka, AP | 1 |
| Kavanagh, JJ | 1 |
| Avella, J | 1 |
| Madsen, JE | 1 |
| Binder, HJ | 1 |
| Askenase, PW | 1 |
| Delaunois, L | 1 |
| Villeneuve, JP | 1 |
| Warner, HA | 1 |
| Nouel, O | 1 |
| Pariente, EA | 1 |
| Slaoui, H | 1 |
| Renoux, M | 1 |
| Mizuno, H | 1 |
| Kawamura, Y | 1 |
| Iwase, N | 1 |
| Ohno, H | 1 |
| Weiss, RB | 1 |
| Donehower, RC | 1 |
| Wiernik, PH | 2 |
| Ohnuma, T | 1 |
| Gralla, RJ | 1 |
| Trump, DL | 1 |
| Baker, JR | 1 |
| Van Echo, DA | 1 |
| Von Hoff, DD | 1 |
| Leyland-Jones, B | 1 |
| Gafter, U | 1 |
| Zevin, D | 1 |
| Komlos, L | 1 |
| Livni, E | 1 |
| Levi, J | 1 |
| Yarbrough, JA | 1 |
| Moffitt, JE | 1 |
| Brown, DA | 1 |
| Stafford, CT | 1 |
| Schwartz, EL | 1 |
| Einzig, A | 1 |
| Strauman, JJ | 1 |
| Lipton, RB | 1 |
| Dutcher, JP | 1 |
| Cáceres, J | 1 |
| Romański, B | 1 |
| Bokowski, W | 1 |
| Tryba, M | 1 |
| Zevounou, F | 1 |
| Zenz, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Feasibility of a Randomized Controlled Clinical Trial Comparing the Use of Cetirizine to Replace Diphenhydramine in the Prevention of Reactions Related to Paclitaxel[NCT04237090] | Phase 3 | 27 participants (Actual) | Interventional | 2020-02-14 | Completed | ||
| Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534] | 29 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for cimetidine and Allergy, Drug
| Article | Year |
|---|---|
Hypersensitivity and idiosyncratic reactions to oxaliplatin.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents; Antiemetics; Antineoplastic Agents; Cim | 2003 |
Urticaria and angioedema.
Topics: Adrenal Cortex Hormones; Angioedema; Child; Cimetidine; Cold Temperature; Complement System Proteins | 1983 |
10 trials available for cimetidine and Allergy, Drug
| Article | Year |
|---|---|
Randomized trial of single agent paclitaxel given weekly versus every three weeks and with peroral versus intravenous steroid premedication to patients with ovarian cancer previously treated with platinum.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemot | 2002 |
Paclitaxel administered by 1-hour infusion. Preliminary results of a phase I/II trial comparing two schedules.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cimetidine; Dexamethasone; Diphenhydr | 1994 |
Clinical evaluation of the effect of omeprazole, cimetidine, famotidine and ranitidine on histamine induced cutaneous wheal and flare response.
Topics: Adult; Cimetidine; Drug Hypersensitivity; Dyspepsia; Famotidine; Female; Histamine; Histamine H2 Ant | 1993 |
Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cimetidine; Dexamethasone; Diphenh | 1996 |
Paclitaxel premedication regimens.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cimetidine; Dexamethasone; Drug Hypersensitivit | 1996 |
Short-course intravenous prophylaxis for paclitaxel-related hypersensitivity reactions.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Cimetidine; Dexamethasone; Diphen | 1997 |
Histamine release during rapid vancomycin administration.
Topics: Anti-Bacterial Agents; Cimetidine; Diphenhydramine; Double-Blind Method; Drug Hypersensitivity; Exan | 1998 |
Effect of histamine H2-receptor antagonists on delayed hypersensitivity.
Topics: Cimetidine; Drug Hypersensitivity; Duodenal Ulcer; Erythema; Female; Guanidines; Humans; Hypersensit | 1978 |
[Evaluation of the therapeutic effect of sodium cromoglycate in patients with gastric and duodenal ulcers, sensitive to exogenous allergens].
Topics: Adolescent; Adult; Cimetidine; Clinical Trials as Topic; Cromolyn Sodium; Drug Hypersensitivity; Fem | 1986 |
Prevention of histamine-induced cardiovascular reactions during the induction of anaesthesia following premedication with H1- + H2-antagonists i.m.
Topics: Adult; Anesthesia, General; Blood Pressure; Cimetidine; Clinical Trials as Topic; Double-Blind Metho | 1986 |
32 other studies available for cimetidine and Allergy, Drug
| Article | Year |
|---|---|
Emergency pretreatment for contrast allergy before direct percutaneous coronary intervention for ST-elevation myocardial infarction.
Topics: Acetates; Angioplasty, Balloon, Coronary; Anti-Inflammatory Agents; Antiemetics; Cimetidine; Contras | 2008 |
A case of cimetidine-induced immediate hypersensitivity.
Topics: Adult; Cimetidine; Drug Hypersensitivity; Female; Histamine H2 Antagonists; Humans; Hypersensitivity | 2012 |
Premedication strategy for weekly paclitaxel.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Cime | 2002 |
[Paclitaxel hypersensitivity reactions in patients with advanced ovarian carcinoma].
Topics: Adult; Aged; Anti-Inflammatory Agents; Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phyto | 2002 |
[Tolerance induction in anaphylaxis to carboplatin].
Topics: Abdominal Neoplasms; Aged; Anaphylaxis; Antineoplastic Agents; Carboplatin; Chemotherapy, Adjuvant; | 2003 |
Oral premedication for the prevention of hypersensitivity reactions to paclitaxel.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Allergic Agents; Antineoplastic Agents, P | 2008 |
Acute allergic interstitial nephritis and eosinophiluria.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Drug Hypersensitivity; Eosinophilia; Histamine | 2008 |
Immunologic studies in cimetidine-induced nephropathy and polymyositis.
Topics: Adult; B-Lymphocytes; Biopsy; Cell Migration Inhibition; Cimetidine; Drug Hypersensitivity; Guanidin | 1983 |
Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs.
Topics: Animals; Burns; Chlorides; Cimetidine; Cyclophosphamide; Dinitrofluorobenzene; Drug Hypersensitivity | 1984 |
[Urticaria caused by cimetidine therapy].
Topics: Cimetidine; Drug Eruptions; Drug Hypersensitivity; Guanidines; Humans; Urticaria | 1981 |
Radiographic contrast material reaction.
Topics: Cimetidine; Contrast Media; Drug Hypersensitivity; Humans | 1984 |
Cimetidine-induced cutaneous vasculitis.
Topics: Cimetidine; Diagnosis, Differential; Drug Hypersensitivity; Humans; Male; Middle Aged; Urticaria; Va | 1983 |
Drug therapy questions & answers.
Topics: Aluminum; Anesthetics, Local; Cimetidine; Drug Hypersensitivity; Drug Synergism; Duodenal Ulcer; Fem | 1983 |
Cimetidine and hypersensitivity.
Topics: Anaphylaxis; Cimetidine; Drug Hypersensitivity; Guanidines; Humans | 1983 |
Cimetidine and allergy skin testing.
Topics: Cimetidine; Drug Hypersensitivity; Guanidines; Humans; Injections, Intravenous; Skin Tests | 1982 |
Hypersensitivity to cimetidine.
Topics: Adult; Angioedema; Cimetidine; Drug Hypersensitivity; Female; Guanidines; Humans; Pruritus | 1982 |
Cimetidine hypersensitivity.
Topics: Cimetidine; Drug Hypersensitivity; Female; Guanidines; Humans; Meperidine | 1982 |
Hypersensitivity to cimetidine.
Topics: Cimetidine; Drug Hypersensitivity; Guanidines; Humans | 1982 |
Cimetidine (Tagamet) combined with steroids and H1 antihistamines for the prevention of serious radiographic contrast material reactions.
Topics: Adult; Cardiac Catheterization; Cimetidine; Contrast Media; Diphenhydramine; Drug Hypersensitivity; | 1981 |
Cimetidine-induced hepatitis. Electron microscopic observations and clinical pattern of liver injury.
Topics: Adult; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Hypersensitivity; Guanidines; Humans | 1981 |
Acute interstitial nephritis related to cimetidine therapy.
Topics: Adult; Biopsy; Cimetidine; Drug Hypersensitivity; Duodenal Ulcer; Guanidines; Humans; Kidney; Male; | 1980 |
Pharmacological studies of allergic cough in the guinea pig.
Topics: Administration, Oral; Aerosols; Albuterol; Analysis of Variance; Animals; Antitussive Agents; Capsai | 1995 |
Use of docetaxel (Taxotere) in patients with paclitaxel (Taxol) hypersensitivity.
Topics: Adult; Antineoplastic Agents, Phytogenic; Carcinoma; Cimetidine; Cystadenocarcinoma; Dexamethasone; | 2000 |
Hypersensitivity to cimetidine.
Topics: Adult; Angioedema; Cimetidine; Drug Hypersensitivity; Face; Female; Guanidines; Humans; Laryngismus | 1979 |
Cimetidine hepatitis.
Topics: Aged; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Hypersensitivity; Esophagitis, Peptic | 1979 |
[Agranulocytosis due to cimetidine: an immuno-allergic accident?].
Topics: Adult; Agranulocytosis; Cimetidine; Drug Hypersensitivity; Female; Guanidines; Humans | 1979 |
Effects of flutropium on experimental models of drug- and allergy-induced rhinitis in guinea pigs.
Topics: Animals; Atropine; Atropine Derivatives; Cimetidine; Diphenhydramine; Drug Hypersensitivity; Guinea | 1991 |
Hypersensitivity reactions from taxol.
Topics: Adult; Aged; Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Colonic Neoplasms; Dexamethas | 1990 |
Thrombocytopenia associated with hypersensitivity to ranitidine: possible cross-reactivity with cimetidine.
Topics: Cell Migration Inhibition; Cimetidine; Cross Reactions; Drug Hypersensitivity; Humans; Immunoglobuli | 1989 |
Cimetidine in the treatment of refractory anaphylaxis.
Topics: Anaphylaxis; Cefuroxime; Cimetidine; Drug Hypersensitivity; Female; Flushing; Humans; Hypotension; I | 1989 |
Phase I trial of taxol given as a 24-hour infusion every 21 days: responses observed in metastatic melanoma.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Dexamethasone; Diphenhydramine; Drug Admin | 1987 |
[Hazards of iodinated contrast media and their prevention].
Topics: Adrenal Cortex Hormones; Aged; Cimetidine; Contrast Media; Drug Hypersensitivity; Histamine H1 Antag | 1988 |