cimetidine has been researched along with Agranulocytosis in 43 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe a case of quinidine-induced agranulocytosis in which in vitro marrow culture studies suggested immune inhibition of committed human granulocyte-macrophage progenitors (CFU-GM)." | 7.67 | Quinidine-induced neutropenia: report of a case with drug-dependent inhibition of granulocyte colony generation. ( Ascensao, JL; Flynn, PJ; Jacob, HS; Slungaard, A; Wachsman, W; Zanjani, ED, 1984) |
| "There exist some 12 reported cases of agranulocytosis or pancytopenia occurring after the use of cimetidine to reduce gastric acidity." | 7.66 | Fatal agranulocytosis attributable to cimetidine. ( Crapper, RM, 1981) |
| "We studied the effect of the H2-receptor antagonists, cimetidine and metiamide, on in vitro myeloid colony formation by bone marrow cells from seven normal volunteers and two patients with a cimetidine-associated neutropenia." | 7.66 | Cimetidine and granulopoiesis: bone marrow culture studies in normal man and patients with cimetidine-associated neutropenia. ( Fitchen, JH; Koeffler, HP, 1980) |
| "Neutropenia associated with high-dose cimetidine therapy developed in a patient in whom earlier therapy, as well as rechallenge with low-dose cimetidine, did not result in neutropenia." | 7.66 | Cimetidine-induced neutropenia: a possible dose-related phenomenon. ( Graber, SE; Krantz, SB; Posnett, DN; Stein, RS, 1979) |
| "The value of cimetidine in treatment of duodenal ulcer and the Zollinger-Ellison syndrome appears to be well established." | 4.76 | A consideration of the adverse effects of cimetidine. ( McGuigan, JE, 1981) |
| "Agranulocytosis and septicaemia developing in a patient with rheumatoid arthritis after 3 years' intermittent treatment with diclofenac, cimetidine and flucloxacillin for staphylococcal osteomyelitis is described." | 3.69 | Agranulocytosis in rheumatoid arthritis associated with long-term flucloxacillin for staphylococcal osteomyelitis. ( Burton, IE; Moussa, KM; Sanders, PA, 1995) |
| "We describe a case of quinidine-induced agranulocytosis in which in vitro marrow culture studies suggested immune inhibition of committed human granulocyte-macrophage progenitors (CFU-GM)." | 3.67 | Quinidine-induced neutropenia: report of a case with drug-dependent inhibition of granulocyte colony generation. ( Ascensao, JL; Flynn, PJ; Jacob, HS; Slungaard, A; Wachsman, W; Zanjani, ED, 1984) |
| "There exist some 12 reported cases of agranulocytosis or pancytopenia occurring after the use of cimetidine to reduce gastric acidity." | 3.66 | Fatal agranulocytosis attributable to cimetidine. ( Crapper, RM, 1981) |
| "We studied the effect of the H2-receptor antagonists, cimetidine and metiamide, on in vitro myeloid colony formation by bone marrow cells from seven normal volunteers and two patients with a cimetidine-associated neutropenia." | 3.66 | Cimetidine and granulopoiesis: bone marrow culture studies in normal man and patients with cimetidine-associated neutropenia. ( Fitchen, JH; Koeffler, HP, 1980) |
| "A 67-year-old man with a bleeding ulcer developed fever, thrombocytopenia, and neutropenia with eosinophilia coincidental to receiving 3600 mg of cimetidine." | 3.66 | Cimetidine and hematologic suppression: things are not always as they appear. ( Castell, DO; Gerhardt, DC; Pasquale, DN; Richter, JE, 1980) |
| "Neutropenia associated with high-dose cimetidine therapy developed in a patient in whom earlier therapy, as well as rechallenge with low-dose cimetidine, did not result in neutropenia." | 3.66 | Cimetidine-induced neutropenia: a possible dose-related phenomenon. ( Graber, SE; Krantz, SB; Posnett, DN; Stein, RS, 1979) |
| "Drug-induced agranulocytosis is relatively rare." | 2.36 | Drug-induced agranulocytosis. ( Vincent, PC; Young, GA, 1980) |
| "When cimetidine and lithium were given to volunteers, the granulocytosis normally associated with lithium was not diminished." | 1.26 | Clinical assessment of cimetidine myelotoxicity. ( Howard, CA; Stein, RS, 1981) |
| "On the fifth day of cimetidine therapy, agranulocytosis (800/ml) and a very low platelet count (40,000/ml) were observed; bone-marrow failure was documented both by biopsy and aspiration." | 1.26 | Association of cimetidine and bone-marrow suppression in man. ( Druart, F; Frocrain, C; Martin, J; Matuchansky, C; Metois, P, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (93.02) | 18.7374 |
| 1990's | 2 (4.65) | 18.2507 |
| 2000's | 1 (2.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Terauchi, F | 1 |
| Nagashima, T | 1 |
| Kobayashi, Y | 1 |
| Yamamoto, Y | 1 |
| Moritake, T | 1 |
| Seiki, T | 1 |
| Ogura, H | 1 |
| Norn, S | 1 |
| Permin, H | 1 |
| Skov, PS | 1 |
| Legendre, C | 1 |
| Canaud, B | 1 |
| Beraud, JJ | 1 |
| Brunin, JL | 1 |
| Balmes, JL | 1 |
| Mirouze, J | 1 |
| Ascensao, JL | 1 |
| Flynn, PJ | 1 |
| Slungaard, A | 1 |
| Wachsman, W | 1 |
| Zanjani, ED | 1 |
| Jacob, HS | 1 |
| Spinka, R | 1 |
| Honetz, N | 1 |
| Carloss, HW | 1 |
| Tavassoli, M | 1 |
| McMillan, R | 1 |
| Dammann, HG | 1 |
| Dörner, M | 1 |
| Greten, H | 1 |
| Young, GA | 2 |
| Vincent, PC | 2 |
| McGuigan, JE | 1 |
| Seville, P | 1 |
| Lewis, DS | 1 |
| Beck, ER | 1 |
| Eridani, S | 1 |
| Johnston, ID | 1 |
| Villa, S | 1 |
| Dubost, JL | 1 |
| Chevallier, H | 1 |
| Sultan, R | 1 |
| Fallouh, H | 1 |
| Stein, RS | 2 |
| Howard, CA | 1 |
| Crapper, RM | 1 |
| Smout, AJ | 1 |
| Bakker, B | 1 |
| Selker, HP | 1 |
| Rosenbloom, BE | 1 |
| Weinstein, IM | 1 |
| Pariente, EA | 2 |
| Nouel, O | 2 |
| Dölle, W | 1 |
| Sewing, KF | 1 |
| Sazie, E | 1 |
| Jaffe, JP | 1 |
| Wehr, M | 1 |
| Schäfer, K | 1 |
| Bode, JC | 1 |
| Schmidt, W | 1 |
| Fitchen, JH | 1 |
| Koeffler, HP | 1 |
| Richter, JE | 1 |
| Gerhardt, DC | 1 |
| Pasquale, DN | 1 |
| Castell, DO | 1 |
| Elizaga, FV | 1 |
| Jim, RT | 1 |
| Lam, CB | 1 |
| Berman, SJ | 1 |
| Burton, IE | 1 |
| Moussa, KM | 1 |
| Sanders, PA | 1 |
| Bellows, JG | 1 |
| Posnett, DN | 1 |
| Graber, SE | 1 |
| Krantz, SB | 1 |
| Ahmad, S | 1 |
| Freston, JW | 1 |
| Al-Kawas, FH | 1 |
| Lenes, BA | 1 |
| Sacher, RA | 1 |
| Littlejohn, GO | 1 |
| Urowitz, MB | 1 |
| Chang, HK | 1 |
| Morrison, SL | 1 |
| Druart, F | 1 |
| Frocrain, C | 1 |
| Metois, P | 1 |
| Martin, J | 1 |
| Matuchansky, C | 1 |
| Rate, R | 1 |
| Bonnell, M | 1 |
| Chervenak, C | 1 |
| Pavinich, G | 1 |
| Slaoui, H | 1 |
| Renoux, M | 1 |
| Souza Lima, MS | 1 |
| Klotz, SA | 1 |
| Kay, BF | 1 |
| Teichmann, RK | 1 |
| Zumtobel, V | 1 |
| Heberer, G | 1 |
| Holcombe, RF | 1 |
| List, AF | 1 |
| Beaird, DH | 1 |
| Kummet, T | 1 |
3 reviews available for cimetidine and Agranulocytosis
| Article | Year |
|---|---|
Drug-induced agranulocytosis.
Topics: Agranulocytosis; Autoantibodies; Blood Transfusion; Cimetidine; Female; Granulocytes; Hematopoiesis; | 1980 |
A consideration of the adverse effects of cimetidine.
Topics: Agranulocytosis; Animals; Bone Marrow; Central Nervous System; Chemical and Drug Induced Liver Injur | 1981 |
Side effects of cimetidine.
Topics: Acute Disease; Aged; Agranulocytosis; Burns; Central Nervous System; Cimetidine; Female; Glucose; Gu | 1979 |
40 other studies available for cimetidine and Agranulocytosis
| Article | Year |
|---|---|
A pilot study of weekly paclitaxel administration for patients with relapsed cervical cancer after heavy medication.
Topics: Agranulocytosis; Alopecia; Antiemetics; Antineoplastic Agents, Phytogenic; Cimetidine; Combined Moda | 2005 |
H2 antihistamines (cimetidine) and allergic-inflammatory reactions.
Topics: Agranulocytosis; Basophils; Cimetidine; Drug Therapy, Combination; Guanidines; Histamine H1 Antagoni | 1980 |
[Severe, recurrent and reversible neutropenia induced by cimetidine].
Topics: Agranulocytosis; Cimetidine; Female; Humans; Middle Aged; Neutropenia; Recurrence | 1984 |
Quinidine-induced neutropenia: report of a case with drug-dependent inhibition of granulocyte colony generation.
Topics: Agranulocytosis; Bone Marrow Examination; Cimetidine; Colony-Forming Units Assay; Granulocytes; Hema | 1984 |
[Acute granulocytopenia caused by cimetidine].
Topics: Acute Disease; Adult; Aged; Agranulocytosis; Cimetidine; Female; Hematemesis; Humans; Male; Middle A | 1984 |
Cimetidine-induced granulocytopenia.
Topics: Aged; Agranulocytosis; Cimetidine; Gastrointestinal Hemorrhage; Guanidines; Humans; Leukocyte Count; | 1980 |
[Cimetidine and Granulocytopenia].
Topics: Adolescent; Adult; Aged; Agranulocytosis; Cimetidine; Female; Gastrointestinal Hemorrhage; Guanidine | 1981 |
Cimetidine and agranulocytosis.
Topics: Agranulocytosis; Cimetidine; Guanidines; Humans; Kidney Diseases | 1982 |
Reversible agranulocytosis in association with cimetidine and hepatic failure.
Topics: Agranulocytosis; Cimetidine; Female; Guanidines; Humans; Liver Diseases; Middle Aged | 1982 |
Cimetidine and granulopoiesis.
Topics: Aged; Agranulocytosis; Cimetidine; Guanidines; Hematopoietic Stem Cells; Humans; Male | 1982 |
Alternative mechanisms for severe neutropenia.
Topics: Agranulocytosis; Carmustine; Cimetidine; Drug Interactions; Humans; Neutropenia | 1982 |
[Neutropenia in a patient treated with cimetidine].
Topics: Agranulocytosis; Cimetidine; Guanidines; Humans; In Vitro Techniques; Male; Middle Aged; Neutropenia | 1980 |
Clinical assessment of cimetidine myelotoxicity.
Topics: Agranulocytosis; Bone Marrow; Cimetidine; Drug Evaluation; Guanidines; Humans; Leukocyte Count; Lith | 1981 |
Fatal agranulocytosis attributable to cimetidine.
Topics: Aged; Agranulocytosis; Cimetidine; Guanidines; Humans; Kidney Failure, Chronic; Leukocyte Count; Mal | 1981 |
Cimetidine agranulocytosis.
Topics: Agranulocytosis; Cimetidine; Guanidines; Humans; Leukocyte Count | 1981 |
[Agranulocytosis caused by cimetidine].
Topics: Aged; Agranulocytosis; Cimetidine; Female; Guanidines; Humans; Stomach Ulcer | 1981 |
Cimetidine and cytopenia.
Topics: Aged; Agranulocytosis; Bone Marrow Cells; Cimetidine; Female; Guanidines; Humans; In Vitro Technique | 1981 |
Cimetidine-induced bone marrow suppression.
Topics: Agranulocytosis; Bone Marrow; Cimetidine; Guanidines; Humans | 1980 |
Agranulocytosis after cimetidine after agranulocytosis induced by carbimazole in a woman with cirrhosis of the liver, hypersplenism and hyperthyroidism.
Topics: Agranulocytosis; Blood Transfusion; Carbimazole; Cimetidine; Female; Granulocytes; Guanidines; Human | 1980 |
Severe granulocytopenia with cimetidine and phenytoin.
Topics: Adolescent; Agranulocytosis; Cimetidine; Drug Interactions; Guanidines; Humans; Male; Phenytoin | 1980 |
[Granulocytopenia with cimetidine therapy (author's transl)].
Topics: Adult; Agranulocytosis; Bone Marrow; Cimetidine; Guanidines; Humans; Liver Cirrhosis, Alcoholic; Mal | 1980 |
[Granulocytopenia during cimetidine therapy].
Topics: Agranulocytosis; Cimetidine; Duodenal Ulcer; Guanidines; Humans | 1980 |
Cimetidine and granulopoiesis: bone marrow culture studies in normal man and patients with cimetidine-associated neutropenia.
Topics: Adult; Aged; Agranulocytosis; Bone Marrow; Cells, Cultured; Cimetidine; Colony-Forming Units Assay; | 1980 |
Cimetidine and hematologic suppression: things are not always as they appear.
Topics: Aged; Agranulocytosis; Blood Transfusion; Cimetidine; Duodenal Ulcer; Eosinophilia; Fever; Guanidine | 1980 |
Hematologic effects of cimetidine.
Topics: Adult; Agranulocytosis; Cimetidine; Female; Guanidines; Humans | 1981 |
Agranulocytosis in rheumatoid arthritis associated with long-term flucloxacillin for staphylococcal osteomyelitis.
Topics: Aged; Agranulocytosis; Arthritis, Rheumatoid; Cimetidine; Female; Floxacillin; Fluorescent Antibody | 1995 |
Cimetidine therapy for peptic ulcer.
Topics: Agranulocytosis; Bone Marrow; Cimetidine; Guanidines; Histamine H2 Antagonists; Humans; Peptic Ulcer | 1978 |
Cimetidine-induced neutropenia: a possible dose-related phenomenon.
Topics: Adult; Agranulocytosis; Cimetidine; Dose-Response Relationship, Drug; Gastrointestinal Hemorrhage; G | 1979 |
Cimetidine and granulocytopenia.
Topics: Agranulocytosis; Cimetidine; Guanidines; Humans; Risk | 1979 |
Cimetidine and agranulocytosis.
Topics: Aged; Agranulocytosis; Cimetidine; Drug Synergism; Female; Guanidines; Humans; Phenytoin | 1979 |
Cimetidine, lupus erythematosus, and granulocytopenia.
Topics: Adolescent; Agranulocytosis; Cimetidine; Female; Guanidines; Humans; Lupus Erythematosus, Systemic | 1979 |
Bone-marrow suppression associated with cimetidine.
Topics: Aged; Agranulocytosis; Anemia; Bone Marrow; Cimetidine; Guanidines; Humans; Leukopenia; Male | 1979 |
Association of cimetidine and bone-marrow suppression in man.
Topics: Adult; Agranulocytosis; Behcet Syndrome; Biopsy; Blood Cell Count; Bone Marrow; Cimetidine; Female; | 1979 |
Cimetidine and hematologic effects.
Topics: Agranulocytosis; Anemia, Hemolytic; Cimetidine; Female; Guanidines; Humans; Middle Aged; Thrombocyto | 1979 |
[Agranulocytosis due to cimetidine: an immuno-allergic accident?].
Topics: Adult; Agranulocytosis; Cimetidine; Drug Hypersensitivity; Female; Guanidines; Humans | 1979 |
Transient neutropenia and cimetidine.
Topics: Agranulocytosis; Cimetidine; Duodenal Ulcer; Guanidines; Humans; Neutropenia | 1978 |
Cimetidine and Agranulocytosis.
Topics: Aged; Agranulocytosis; Cimetidine; Female; Guanidines; Humans; Middle Aged | 1978 |
[Agranulocytosis through cimetidine].
Topics: Aged; Agranulocytosis; Cimetidine; Female; Gallbladder Diseases; Guanidines; Humans; Peptic Ulcer; P | 1978 |
Drug-induced granulocytopenia with natural killer lymphocytosis after renal transplantation.
Topics: Adult; Agranulocytosis; Azathioprine; Cimetidine; Cytomegalovirus Infections; Drug Therapy, Combinat | 1990 |
Ranitidine-induced granulocytopenia: recurrence with cimetidine administration.
Topics: Agranulocytosis; Bone Marrow; Cimetidine; Humans; Male; Middle Aged; Ranitidine; Recurrence | 1988 |