cimetidine has been researched along with Aging in 44 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a double-blind parallel-group study, 98 patients with symptomatic duodenal ulcer received omeprazole 20 mg o." | 9.06 | Symptom relief and duodenal ulcer healing with omeprazole or cimetidine. Opus (Omeprazole Peptic Ulcer Study) Research Group. ( Bate, CM; Crowe, JP; Peers, EM; Richardson, PD; Wilkinson, SP; Willoughby, CP, 1989) |
| "In this study, we compared the effects of cimetidine and omeprazole on the healing of acetic acid-induced gastric ulcers in 8-, 48-, and 96-week-old rats." | 7.71 | Influence of aging on gastric ulcer healing activities of cimetidine and omeprazole. ( Ishihara, M; Ito, M, 2002) |
| "These results suggest that, although the overall histamine-induced venodilation is conserved in aging, there is a loss of the signal transduction pathway activated by way of H2-receptors but no loss in function of H1-receptors." | 7.69 | H1- and H2-histamine receptor-mediated vasodilation varies with aging in humans. ( Bedarida, G; Blaschke, TF; Bushell, E; Hoffman, BB, 1995) |
| "Steady state piroxicam plasma samples from 85 patients suffering from osteoarthritis of the hip and/or the knee, and treated with piroxicam 20 mg daily for at least four weeks, were obtained." | 7.68 | Free plasma concentrations of piroxicam in patients with osteoarthritis: relation to age, sex and efficacy. ( Hundal, O; Rugstad, HE, 1993) |
| "The pharmacokinetics and metabolism of cimetidine were studied in five cystic fibrosis patients (mean age 12." | 7.67 | The bioavailability and pharmacokinetics of cimetidine and its metabolites in juvenile cystic fibrosis patients: age related differences as compared to adults. ( Assael, BM; Padoan, R; Schentag, JJ; Ziemniak, JA, 1984) |
| "Aging and cimetidine may each impair hepatic microsomal drug metabolism." | 7.67 | Effect of aging on hepatic elimination of cimetidine and subsequent interaction of aging and cimetidine on aminopyrine metabolism. ( Henderson, GI; Perez, A; Roberts, RK; Schenker, S; Speeg, KV, 1988) |
| "Cimetidine was a nonselective inhibitor of theophylline metabolic pathways in young men, but it exerted a greater inhibitory effect on N-demethylation pathways in the other groups." | 5.30 | Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers. ( Cusack, BJ; Loi, CM; Parker, BM; Vestal, RE, 1997) |
| ") of stable isotope-labeled theophylline was administered with the oral dose of theophylline." | 5.27 | Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men. ( Cusack, BJ; Dawson, GW; Mercer, GD; Park, BK; Vestal, RE, 1987) |
| "In a double-blind parallel-group study, 98 patients with symptomatic duodenal ulcer received omeprazole 20 mg o." | 5.06 | Symptom relief and duodenal ulcer healing with omeprazole or cimetidine. Opus (Omeprazole Peptic Ulcer Study) Research Group. ( Bate, CM; Crowe, JP; Peers, EM; Richardson, PD; Wilkinson, SP; Willoughby, CP, 1989) |
| "In this study, we compared the effects of cimetidine and omeprazole on the healing of acetic acid-induced gastric ulcers in 8-, 48-, and 96-week-old rats." | 3.71 | Influence of aging on gastric ulcer healing activities of cimetidine and omeprazole. ( Ishihara, M; Ito, M, 2002) |
| "These results suggest that, although the overall histamine-induced venodilation is conserved in aging, there is a loss of the signal transduction pathway activated by way of H2-receptors but no loss in function of H1-receptors." | 3.69 | H1- and H2-histamine receptor-mediated vasodilation varies with aging in humans. ( Bedarida, G; Blaschke, TF; Bushell, E; Hoffman, BB, 1995) |
| "Steady state piroxicam plasma samples from 85 patients suffering from osteoarthritis of the hip and/or the knee, and treated with piroxicam 20 mg daily for at least four weeks, were obtained." | 3.68 | Free plasma concentrations of piroxicam in patients with osteoarthritis: relation to age, sex and efficacy. ( Hundal, O; Rugstad, HE, 1993) |
| "The pharmacokinetics and metabolism of cimetidine were studied in five cystic fibrosis patients (mean age 12." | 3.67 | The bioavailability and pharmacokinetics of cimetidine and its metabolites in juvenile cystic fibrosis patients: age related differences as compared to adults. ( Assael, BM; Padoan, R; Schentag, JJ; Ziemniak, JA, 1984) |
| "Roles of histamine and prostaglandins in the induction of ovarian cysts after unilateral ovarian manipulation (MAN) and in the process of ovulation were evaluated in prepubertal gilts treated with pregnant mare's serum gonadotropin (PMSG) and human chorionic gonadotropin (hCG)." | 3.67 | Formation of ovarian follicular cysts and corpora lutea after treatment with antihistamine or indomethacin in prepubertal gilts. ( Dailey, RA; Hall, JA; Lewis, PE; Meisterling, EM, 1989) |
| "Effects of acute intravenous administration of cimetidine on serum levels or PRL, TSH, LH and FSH were investigated in six healthy euthyroid, five hypothyroid and five hyperthyroid patients." | 3.66 | Cimetidine induced prolactin (PRL) release in thyroid disease. ( Kyncl, M; Macaron, C; Singh, SP, 1979) |
| "Amlodipine, a dihydropyridine calcium antagonist, was synthesized in an attempt to develop a compound with a pharmacokinetic profile characteristic of this class, which would also have an increased oral bioavailability and extended clearance time." | 2.38 | The pharmacokinetic profile of amlodipine. ( Abernethy, DR, 1989) |
| "When cimetidine was pre-administered in SD rats of three age groups, all rats exhibited lower serum theophylline concentration and higher pharmacokinetics parameters (P < 0." | 1.28 | Effect of traditional Chinese herbal medicines on the pharmacokinetics of western drugs in Sprague-Dawley rats of different ages (II): Aminophylline-huan shao tan and aminophylline-pu chung yi chi tang. ( Chen, SM; Hou, SJ; Lin, SY; Perng, RI; Young, TK, 1992) |
| "Histamine was infused at 1." | 1.28 | Developmental changes in effects of histamine on segmental pulmonary vascular resistances. ( Chu, K; Clément de Cléty, S; Gordon, JB, 1991) |
| "We have studied the mechanisms of the increased dosage requirements of the H2-receptor antagonist cimetidine in paediatric burned patients in a pharmacokinetic and pharmacodynamic study." | 1.28 | Alteration by burn injury of the pharmacokinetics and pharmacodynamics of cimetidine in children. ( Greenblatt, DJ; Hagen, J; Hoaglin, DC; Martyn, JA, 1989) |
| "Cimetidine failed to increase PRL in rats of 1 and 4 days of age." | 1.27 | Serotoninergic involvement in the cimetidine-induced prolactin release. ( Becú, D; Libertun, C, 1983) |
| " This relationship might prove to be a useful method of individualizing cimetidine dosage in critically ill patients." | 1.27 | Pharmacokinetics of cimetidine in critically ill patients. ( Cameron, P; Ilett, KF; Nation, RL; Oh, TE; Thompson, W; Tjokrosetio, R, 1984) |
| " Consequently, a computer program was developed for cimetidine dosage regimen prediction which can be used for "normal" subjects, young and geriatric patients without and with renal impairment." | 1.27 | Prediction of cimetidine disposition in the aged. ( Ritschel, WA, 1983) |
| "82 ml/min/kg) and prolonged elimination half-life (29 vs." | 1.27 | Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol. ( Burstein, ES; Friedman, H; Greenblatt, DJ; Harmatz, JS; Locniskar, A; Ochs, HR; Shader, RI, 1987) |
| "Cimetidine treatment of DU patients did not change the PGE2 action, while the degree of stimulation by histamine was reduced." | 1.27 | Morphologically different biopsy specimens of the human gastric mucosa. II. Adenylate cyclase activity in response to prostaglandin E2 and histamine. ( Leyhe, T; Pfaff, G; Rettenmaier, G; Ruoff, HJ; Schmid, E, 1986) |
| "7 Cimetidine was without effect on histamine sensitivity in young guinea-pigs after propranolol treatment but significantly reduced airway sensitivity to histamine in old guinea-pigs." | 1.26 | Changes in the response of guinea-pig airways in vivo and in vitro to cimetidine and propranolol during development. ( Brink, C; Douglas, JS; Duncan, PG, 1982) |
| " The age-related increase in bioavailability of oral cimetidine, as measured by AUC, was probably due to decreased total clearance of the drug, which resulted from the opposed changes (by themselves not significant) of distribution volume towards a decrease and of half-life towards an increase with age." | 1.26 | Blood level of cimetidine in relation to age. ( Borgogelli, E; Lodola, E; Redolfi, A, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (63.64) | 18.7374 |
| 1990's | 12 (27.27) | 18.2507 |
| 2000's | 3 (6.82) | 29.6817 |
| 2010's | 1 (2.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lambermont, VA | 1 |
| Schlepütz, M | 1 |
| Dassow, C | 1 |
| König, P | 1 |
| Zimmermann, LJ | 1 |
| Uhlig, S | 1 |
| Kramer, BW | 1 |
| Martin, C | 1 |
| Fu, HY | 1 |
| Murata, H | 1 |
| Kawano, S | 1 |
| Ochs, HR | 2 |
| Greenblatt, DJ | 3 |
| Verburg-Ochs, B | 1 |
| Harmatz, JS | 2 |
| Grehl, H | 1 |
| Becú, D | 1 |
| Libertun, C | 1 |
| Moffat, JA | 1 |
| Milne, B | 1 |
| Brink, C | 1 |
| Douglas, JS | 1 |
| Duncan, PG | 1 |
| Van Arsdalen, KN | 1 |
| Wein, AJ | 1 |
| Feely, J | 1 |
| Pereira, L | 1 |
| Guy, E | 1 |
| Hockings, N | 1 |
| Paradelis, AG | 1 |
| Triantaphyllidis, CJ | 1 |
| Fidani, V | 1 |
| Crassaris, LG | 1 |
| Papadopoulos, AG | 1 |
| Stavrakis, AO | 1 |
| Ziemniak, JA | 1 |
| Assael, BM | 1 |
| Padoan, R | 1 |
| Schentag, JJ | 1 |
| Nation, RL | 1 |
| Ilett, KF | 1 |
| Tjokrosetio, R | 1 |
| Oh, TE | 1 |
| Cameron, P | 1 |
| Thompson, W | 1 |
| Ritschel, WA | 1 |
| Drayer, DE | 1 |
| Romankiewicz, J | 1 |
| Lorenzo, B | 1 |
| Reidenberg, MM | 1 |
| Pries, JM | 1 |
| Harris, A | 1 |
| Cook, PJ | 1 |
| Jewell, DP | 1 |
| James, IM | 1 |
| Somogyi, A | 2 |
| Gugler, R | 2 |
| Bedarida, G | 1 |
| Bushell, E | 1 |
| Blaschke, TF | 1 |
| Hoffman, BB | 1 |
| Koutsoviti-Papadopoulou, M | 1 |
| Kounenis, G | 1 |
| Elezoglou, V | 1 |
| Kokolis, N | 1 |
| Seaton, MJ | 1 |
| Vesell, ES | 1 |
| Morra, L | 1 |
| Moccia, F | 1 |
| Mazzarello, GP | 1 |
| Bessone, G | 1 |
| Del Nero, E | 1 |
| Ponassi, GA | 1 |
| Hundal, O | 1 |
| Rugstad, HE | 1 |
| Kamei, C | 1 |
| Tasaka, K | 1 |
| Loi, CM | 1 |
| Parker, BM | 1 |
| Cusack, BJ | 2 |
| Vestal, RE | 2 |
| Ozaki, J | 1 |
| Tanimoto, N | 1 |
| Kuse, H | 1 |
| Hori, M | 1 |
| Ishihara, M | 1 |
| Ito, M | 1 |
| Redolfi, A | 1 |
| Borgogelli, E | 1 |
| Lodola, E | 1 |
| Macaron, C | 1 |
| Kyncl, M | 1 |
| Singh, SP | 1 |
| Bass, DM | 1 |
| Baylor, M | 1 |
| Broome, R | 1 |
| Greenberg, HB | 1 |
| Lin, SY | 1 |
| Hou, SJ | 1 |
| Perng, RI | 1 |
| Chen, SM | 1 |
| Young, TK | 1 |
| Gordon, JB | 1 |
| Clément de Cléty, S | 1 |
| Chu, K | 1 |
| Onodera, S | 1 |
| Yoshinaga, M | 1 |
| Takenaga, K | 1 |
| Toyoshima, A | 1 |
| Uchiyama, T | 1 |
| Keitoku, M | 1 |
| Maruyama, Y | 1 |
| Takishima, T | 1 |
| Crowe, JP | 1 |
| Wilkinson, SP | 1 |
| Bate, CM | 1 |
| Willoughby, CP | 1 |
| Peers, EM | 1 |
| Richardson, PD | 1 |
| Abernethy, DR | 1 |
| Hall, JA | 1 |
| Meisterling, EM | 1 |
| Lewis, PE | 1 |
| Dailey, RA | 1 |
| Martyn, JA | 1 |
| Hagen, J | 1 |
| Hoaglin, DC | 1 |
| Friedman, H | 1 |
| Burstein, ES | 1 |
| Locniskar, A | 1 |
| Shader, RI | 1 |
| Avril, P | 1 |
| Ducroc, R | 1 |
| Garzon, B | 1 |
| Moreau, E | 1 |
| Hervatin, F | 1 |
| Millet, P | 1 |
| Geloso, JP | 1 |
| Henderson, GI | 1 |
| Speeg, KV | 1 |
| Roberts, RK | 1 |
| Perez, A | 1 |
| Schenker, S | 1 |
| Ruoff, HJ | 1 |
| Leyhe, T | 1 |
| Pfaff, G | 1 |
| Rettenmaier, G | 1 |
| Schmid, E | 1 |
| Wilson, AD | 1 |
| Stokes, CR | 1 |
| Bourne, FJ | 1 |
| Mercer, GD | 1 |
| Dawson, GW | 1 |
| Park, BK | 1 |
| Frank, WO | 1 |
| Peace, KE | 1 |
| Watson, M | 1 |
| Seaman, JJ | 1 |
| Szego, PL | 1 |
| Braverman, A | 1 |
| Mico, B | 1 |
| Dickson, B | 1 |
4 reviews available for cimetidine and Aging
| Article | Year |
|---|---|
[QOL and the older people with peptic ulcer].
Topics: Abietanes; Aged; Aging; Anti-Ulcer Agents; Cimetidine; Diterpenes; Drug Therapy, Combination; Energy | 2002 |
Pharmacokinetics in anaesthesia.
Topics: Aging; Anesthetics; Cimetidine; Drug Interactions; Humans; Shock | 1983 |
Variables affecting nicotine metabolism.
Topics: Aging; Animals; Cimetidine; Dietary Proteins; Drug Interactions; Ethanol; Female; Genetic Variation; | 1993 |
The pharmacokinetic profile of amlodipine.
Topics: Administration, Oral; Aging; Amlodipine; Angina Pectoris; Animals; Biological Availability; Calcium | 1989 |
2 trials available for cimetidine and Aging
| Article | Year |
|---|---|
Symptom relief and duodenal ulcer healing with omeprazole or cimetidine. Opus (Omeprazole Peptic Ulcer Study) Research Group.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Cimetidine; Double-Blind Method; Duodenal Ulcer; | 1989 |
The effect of single intravenous doses of cimetidine or ranitidine on gastric secretion.
Topics: Adolescent; Adult; Aged; Aging; Cimetidine; Drug Evaluation; Gastric Acid; Gastric Mucosa; Humans; H | 1986 |
38 other studies available for cimetidine and Aging
| Article | Year |
|---|---|
Comparison of airway responses in sheep of different age in precision-cut lung slices (PCLS).
Topics: Aging; Allergens; Animals; Animals, Newborn; Biogenic Amines; Bronchoconstriction; Cimetidine; Hista | 2014 |
Disposition of clotiazepam: influence of age, sex, oral contraceptives, cimetidine, isoniazid and ethanol.
Topics: Adult; Aged; Aging; Azepines; Cimetidine; Contraceptives, Oral, Hormonal; Drug Interactions; Ethanol | 1984 |
Serotoninergic involvement in the cimetidine-induced prolactin release.
Topics: Aging; Animals; Cimetidine; Female; Fenclonine; Luteinizing Hormone; Male; Methysergide; Prolactin; | 1983 |
Changes in the response of guinea-pig airways in vivo and in vitro to cimetidine and propranolol during development.
Topics: Aging; Airway Resistance; Animals; Bronchi; Cimetidine; Dimaprit; Female; Guanidines; Guinea Pigs; H | 1982 |
Drug-induced sexual dysfunction in older men.
Topics: Aged; Aging; Antihypertensive Agents; Cimetidine; Clofibrate; Estrogens; Female; Humans; Male; Metoc | 1984 |
Factors affecting the response to inhibition of drug metabolism by cimetidine--dose response and sensitivity of elderly and induced subjects.
Topics: Adult; Aged; Aging; Antipyrine; Cimetidine; Dose-Response Relationship, Drug; Female; Humans; Male; | 1984 |
The influence of age on the distribution and activity of histamine receptors in the rat uterus.
Topics: Aging; Animals; Carbachol; Cimetidine; Electric Stimulation; Female; Histamine; Pyrilamine; Rats; Ra | 1984 |
The bioavailability and pharmacokinetics of cimetidine and its metabolites in juvenile cystic fibrosis patients: age related differences as compared to adults.
Topics: Administration, Oral; Adolescent; Adult; Aging; Biological Availability; Biotransformation; Body Sur | 1984 |
Pharmacokinetics of cimetidine in critically ill patients.
Topics: Adult; Aged; Aging; Cimetidine; Critical Care; Female; Humans; Infusions, Parenteral; Kinetics; Male | 1984 |
Prediction of cimetidine disposition in the aged.
Topics: Administration, Oral; Adult; Aged; Aging; Cimetidine; Female; Guanidines; Half-Life; Humans; Infusio | 1983 |
Age and renal clearance of cimetidine.
Topics: Adult; Aged; Aging; Cimetidine; Creatinine; Dementia; Female; Guanidines; Humans; Kidney; Male; Midd | 1982 |
Coping with reflux esophagitis in the aged.
Topics: Aged; Aging; Antacids; Cimetidine; Esophagitis, Peptic; Esophagogastric Junction; Esophagoscopy; Gas | 1982 |
Cimetidine and cerebral blood flow in elderly patients.
Topics: Adult; Aged; Aging; Cerebrovascular Circulation; Cimetidine; Depression, Chemical; Guanidines; Human | 1981 |
Clinical pharmacokinetics of cimetidine with observations on the plasma concentration-response curve.
Topics: Adult; Aging; Cimetidine; Gastric Acid; Guanidines; Half-Life; Humans; Kinetics; Middle Aged | 1981 |
H1- and H2-histamine receptor-mediated vasodilation varies with aging in humans.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cimetidine; Dose-Response Relationship, Drug; Female; Hand; H | 1995 |
Effect of cimetidine on the histamine and dimaprit induced responses on the guinea pig ileum during development.
Topics: Aging; Animals; Animals, Newborn; Cimetidine; Dimaprit; Female; Guinea Pigs; Histamine; Histamine Ag | 1993 |
Defective burst-promoting activity of T lymphocytes from anemic and nonanemic elderly people.
Topics: Aged; Aged, 80 and over; Aging; Anemia; Cimetidine; Colony-Forming Units Assay; Erythroid Precursor | 1994 |
Free plasma concentrations of piroxicam in patients with osteoarthritis: relation to age, sex and efficacy.
Topics: Aged; Aged, 80 and over; Aging; Cimetidine; Drug Therapy, Combination; Female; Humans; Male; Middle | 1993 |
Effect of histamine on memory retrieval in old rats.
Topics: Acetylcholine; Aging; Animals; Anticonvulsants; Avoidance Learning; Cerebrovascular Circulation; Cim | 1993 |
Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers.
Topics: Adult; Age Factors; Aged; Aging; Analysis of Variance; Biotransformation; Cimetidine; Ciprofloxacin; | 1997 |
Comparison of arterial blood gases and acid-base balance in young and aged beagle dogs, with regard to postprandial alkaline tide.
Topics: Acid-Base Equilibrium; Aging; Animals; Anti-Ulcer Agents; Blood Gas Analysis; Cimetidine; Dogs; Gase | 2000 |
Influence of aging on gastric ulcer healing activities of cimetidine and omeprazole.
Topics: Aging; Animals; Cimetidine; Gastrins; Male; Omeprazole; Rats; Rats, Wistar; Stomach Ulcer | 2002 |
Blood level of cimetidine in relation to age.
Topics: Adult; Aged; Aging; Blood Urea Nitrogen; Body Weight; Cimetidine; Creatinine; Female; Guanidines; Ha | 1979 |
Cimetidine induced prolactin (PRL) release in thyroid disease.
Topics: Adult; Aged; Aging; Cimetidine; Female; Follicle Stimulating Hormone; Guanidines; Humans; Hyperthyro | 1979 |
Increased bioavailability of cimetidine with age?
Topics: Adult; Aging; Biological Availability; Cimetidine; Guanidines; Humans; Middle Aged | 1979 |
Molecular basis of age-dependent gastric inactivation of rhesus rotavirus in the mouse.
Topics: Aging; Animals; Capsid; Capsid Proteins; Cimetidine; Electrophoresis, Polyacrylamide Gel; Intestines | 1992 |
Effect of traditional Chinese herbal medicines on the pharmacokinetics of western drugs in Sprague-Dawley rats of different ages (II): Aminophylline-huan shao tan and aminophylline-pu chung yi chi tang.
Topics: Aging; Aminophylline; Animals; Biological Availability; Cimetidine; Cytochrome P-450 Enzyme System; | 1992 |
Developmental changes in effects of histamine on segmental pulmonary vascular resistances.
Topics: Aging; Animals; Animals, Newborn; Chlorpheniramine; Cimetidine; Histamine; Histamine H1 Antagonists; | 1991 |
[Effects of cernitin pollen extract (CN-009) on the isolated bladder smooth muscles and the intravesical pressure].
Topics: Aging; Animals; Atropine; Cats; Cimetidine; Diphenhydramine; Dose-Response Relationship, Drug; Drug | 1991 |
Different histamine actions in proximal and distal human coronary arteries in vitro.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Cimetidine; Coronary Vessels; Culture Tech | 1990 |
Formation of ovarian follicular cysts and corpora lutea after treatment with antihistamine or indomethacin in prepubertal gilts.
Topics: Aging; Animals; Cimetidine; Female; Follicular Phase; Histamine; Histamine H1 Antagonists; Indometha | 1989 |
Alteration by burn injury of the pharmacokinetics and pharmacodynamics of cimetidine in children.
Topics: Adolescent; Adult; Aging; Burns; Child; Child, Preschool; Cimetidine; Creatinine; Female; Gastric Ac | 1989 |
Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol.
Topics: Administration, Oral; Adult; Aged; Aging; Anti-Anxiety Agents; Bromazepam; Cimetidine; Contraceptive | 1987 |
[Development of gastric sensitivity to histamine in the rat].
Topics: Aging; Animals; Bucladesine; Cimetidine; Fetus; Gastric Acid; Gastric Mucosa; Histamine; Kinetics; R | 1986 |
Effect of aging on hepatic elimination of cimetidine and subsequent interaction of aging and cimetidine on aminopyrine metabolism.
Topics: Aging; Aminopyrine; Aminopyrine N-Demethylase; Animals; Cimetidine; Kidney; Liver; Male; Metabolic C | 1988 |
Morphologically different biopsy specimens of the human gastric mucosa. II. Adenylate cyclase activity in response to prostaglandin E2 and histamine.
Topics: Adenylyl Cyclases; Adult; Aged; Aging; Biopsy; Cimetidine; Dinoprostone; Dose-Response Relationship, | 1986 |
Responses of intraepithelial lymphocytes to T-cell mitogens: a comparison between murine and porcine responses.
Topics: Aging; Animals; Cimetidine; Concanavalin A; Indomethacin; Interleukin-2; Lymphocyte Activation; Lymp | 1986 |
Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cimetidine; Drug Interactions; Half-Life; Humans; Hydrocortis | 1987 |