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cimetidine and Aging

cimetidine has been researched along with Aging in 44 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"In a double-blind parallel-group study, 98 patients with symptomatic duodenal ulcer received omeprazole 20 mg o."9.06Symptom relief and duodenal ulcer healing with omeprazole or cimetidine. Opus (Omeprazole Peptic Ulcer Study) Research Group. ( Bate, CM; Crowe, JP; Peers, EM; Richardson, PD; Wilkinson, SP; Willoughby, CP, 1989)
"In this study, we compared the effects of cimetidine and omeprazole on the healing of acetic acid-induced gastric ulcers in 8-, 48-, and 96-week-old rats."7.71Influence of aging on gastric ulcer healing activities of cimetidine and omeprazole. ( Ishihara, M; Ito, M, 2002)
"These results suggest that, although the overall histamine-induced venodilation is conserved in aging, there is a loss of the signal transduction pathway activated by way of H2-receptors but no loss in function of H1-receptors."7.69H1- and H2-histamine receptor-mediated vasodilation varies with aging in humans. ( Bedarida, G; Blaschke, TF; Bushell, E; Hoffman, BB, 1995)
"Steady state piroxicam plasma samples from 85 patients suffering from osteoarthritis of the hip and/or the knee, and treated with piroxicam 20 mg daily for at least four weeks, were obtained."7.68Free plasma concentrations of piroxicam in patients with osteoarthritis: relation to age, sex and efficacy. ( Hundal, O; Rugstad, HE, 1993)
"The pharmacokinetics and metabolism of cimetidine were studied in five cystic fibrosis patients (mean age 12."7.67The bioavailability and pharmacokinetics of cimetidine and its metabolites in juvenile cystic fibrosis patients: age related differences as compared to adults. ( Assael, BM; Padoan, R; Schentag, JJ; Ziemniak, JA, 1984)
"Aging and cimetidine may each impair hepatic microsomal drug metabolism."7.67Effect of aging on hepatic elimination of cimetidine and subsequent interaction of aging and cimetidine on aminopyrine metabolism. ( Henderson, GI; Perez, A; Roberts, RK; Schenker, S; Speeg, KV, 1988)
"Cimetidine was a nonselective inhibitor of theophylline metabolic pathways in young men, but it exerted a greater inhibitory effect on N-demethylation pathways in the other groups."5.30Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers. ( Cusack, BJ; Loi, CM; Parker, BM; Vestal, RE, 1997)
") of stable isotope-labeled theophylline was administered with the oral dose of theophylline."5.27Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men. ( Cusack, BJ; Dawson, GW; Mercer, GD; Park, BK; Vestal, RE, 1987)
"In a double-blind parallel-group study, 98 patients with symptomatic duodenal ulcer received omeprazole 20 mg o."5.06Symptom relief and duodenal ulcer healing with omeprazole or cimetidine. Opus (Omeprazole Peptic Ulcer Study) Research Group. ( Bate, CM; Crowe, JP; Peers, EM; Richardson, PD; Wilkinson, SP; Willoughby, CP, 1989)
"In this study, we compared the effects of cimetidine and omeprazole on the healing of acetic acid-induced gastric ulcers in 8-, 48-, and 96-week-old rats."3.71Influence of aging on gastric ulcer healing activities of cimetidine and omeprazole. ( Ishihara, M; Ito, M, 2002)
"These results suggest that, although the overall histamine-induced venodilation is conserved in aging, there is a loss of the signal transduction pathway activated by way of H2-receptors but no loss in function of H1-receptors."3.69H1- and H2-histamine receptor-mediated vasodilation varies with aging in humans. ( Bedarida, G; Blaschke, TF; Bushell, E; Hoffman, BB, 1995)
"Steady state piroxicam plasma samples from 85 patients suffering from osteoarthritis of the hip and/or the knee, and treated with piroxicam 20 mg daily for at least four weeks, were obtained."3.68Free plasma concentrations of piroxicam in patients with osteoarthritis: relation to age, sex and efficacy. ( Hundal, O; Rugstad, HE, 1993)
"The pharmacokinetics and metabolism of cimetidine were studied in five cystic fibrosis patients (mean age 12."3.67The bioavailability and pharmacokinetics of cimetidine and its metabolites in juvenile cystic fibrosis patients: age related differences as compared to adults. ( Assael, BM; Padoan, R; Schentag, JJ; Ziemniak, JA, 1984)
"Roles of histamine and prostaglandins in the induction of ovarian cysts after unilateral ovarian manipulation (MAN) and in the process of ovulation were evaluated in prepubertal gilts treated with pregnant mare's serum gonadotropin (PMSG) and human chorionic gonadotropin (hCG)."3.67Formation of ovarian follicular cysts and corpora lutea after treatment with antihistamine or indomethacin in prepubertal gilts. ( Dailey, RA; Hall, JA; Lewis, PE; Meisterling, EM, 1989)
"Effects of acute intravenous administration of cimetidine on serum levels or PRL, TSH, LH and FSH were investigated in six healthy euthyroid, five hypothyroid and five hyperthyroid patients."3.66Cimetidine induced prolactin (PRL) release in thyroid disease. ( Kyncl, M; Macaron, C; Singh, SP, 1979)
"Amlodipine, a dihydropyridine calcium antagonist, was synthesized in an attempt to develop a compound with a pharmacokinetic profile characteristic of this class, which would also have an increased oral bioavailability and extended clearance time."2.38The pharmacokinetic profile of amlodipine. ( Abernethy, DR, 1989)
"When cimetidine was pre-administered in SD rats of three age groups, all rats exhibited lower serum theophylline concentration and higher pharmacokinetics parameters (P < 0."1.28Effect of traditional Chinese herbal medicines on the pharmacokinetics of western drugs in Sprague-Dawley rats of different ages (II): Aminophylline-huan shao tan and aminophylline-pu chung yi chi tang. ( Chen, SM; Hou, SJ; Lin, SY; Perng, RI; Young, TK, 1992)
"Histamine was infused at 1."1.28Developmental changes in effects of histamine on segmental pulmonary vascular resistances. ( Chu, K; Clément de Cléty, S; Gordon, JB, 1991)
"We have studied the mechanisms of the increased dosage requirements of the H2-receptor antagonist cimetidine in paediatric burned patients in a pharmacokinetic and pharmacodynamic study."1.28Alteration by burn injury of the pharmacokinetics and pharmacodynamics of cimetidine in children. ( Greenblatt, DJ; Hagen, J; Hoaglin, DC; Martyn, JA, 1989)
"Cimetidine failed to increase PRL in rats of 1 and 4 days of age."1.27Serotoninergic involvement in the cimetidine-induced prolactin release. ( Becú, D; Libertun, C, 1983)
" This relationship might prove to be a useful method of individualizing cimetidine dosage in critically ill patients."1.27Pharmacokinetics of cimetidine in critically ill patients. ( Cameron, P; Ilett, KF; Nation, RL; Oh, TE; Thompson, W; Tjokrosetio, R, 1984)
" Consequently, a computer program was developed for cimetidine dosage regimen prediction which can be used for "normal" subjects, young and geriatric patients without and with renal impairment."1.27Prediction of cimetidine disposition in the aged. ( Ritschel, WA, 1983)
"82 ml/min/kg) and prolonged elimination half-life (29 vs."1.27Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol. ( Burstein, ES; Friedman, H; Greenblatt, DJ; Harmatz, JS; Locniskar, A; Ochs, HR; Shader, RI, 1987)
"Cimetidine treatment of DU patients did not change the PGE2 action, while the degree of stimulation by histamine was reduced."1.27Morphologically different biopsy specimens of the human gastric mucosa. II. Adenylate cyclase activity in response to prostaglandin E2 and histamine. ( Leyhe, T; Pfaff, G; Rettenmaier, G; Ruoff, HJ; Schmid, E, 1986)
"7 Cimetidine was without effect on histamine sensitivity in young guinea-pigs after propranolol treatment but significantly reduced airway sensitivity to histamine in old guinea-pigs."1.26Changes in the response of guinea-pig airways in vivo and in vitro to cimetidine and propranolol during development. ( Brink, C; Douglas, JS; Duncan, PG, 1982)
" The age-related increase in bioavailability of oral cimetidine, as measured by AUC, was probably due to decreased total clearance of the drug, which resulted from the opposed changes (by themselves not significant) of distribution volume towards a decrease and of half-life towards an increase with age."1.26Blood level of cimetidine in relation to age. ( Borgogelli, E; Lodola, E; Redolfi, A, 1979)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-199028 (63.64)18.7374
1990's12 (27.27)18.2507
2000's3 (6.82)29.6817
2010's1 (2.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lambermont, VA1
Schlepütz, M1
Dassow, C1
König, P1
Zimmermann, LJ1
Uhlig, S1
Kramer, BW1
Martin, C1
Fu, HY1
Murata, H1
Kawano, S1
Ochs, HR2
Greenblatt, DJ3
Verburg-Ochs, B1
Harmatz, JS2
Grehl, H1
Becú, D1
Libertun, C1
Moffat, JA1
Milne, B1
Brink, C1
Douglas, JS1
Duncan, PG1
Van Arsdalen, KN1
Wein, AJ1
Feely, J1
Pereira, L1
Guy, E1
Hockings, N1
Paradelis, AG1
Triantaphyllidis, CJ1
Fidani, V1
Crassaris, LG1
Papadopoulos, AG1
Stavrakis, AO1
Ziemniak, JA1
Assael, BM1
Padoan, R1
Schentag, JJ1
Nation, RL1
Ilett, KF1
Tjokrosetio, R1
Oh, TE1
Cameron, P1
Thompson, W1
Ritschel, WA1
Drayer, DE1
Romankiewicz, J1
Lorenzo, B1
Reidenberg, MM1
Pries, JM1
Harris, A1
Cook, PJ1
Jewell, DP1
James, IM1
Somogyi, A2
Gugler, R2
Bedarida, G1
Bushell, E1
Blaschke, TF1
Hoffman, BB1
Koutsoviti-Papadopoulou, M1
Kounenis, G1
Elezoglou, V1
Kokolis, N1
Seaton, MJ1
Vesell, ES1
Morra, L1
Moccia, F1
Mazzarello, GP1
Bessone, G1
Del Nero, E1
Ponassi, GA1
Hundal, O1
Rugstad, HE1
Kamei, C1
Tasaka, K1
Loi, CM1
Parker, BM1
Cusack, BJ2
Vestal, RE2
Ozaki, J1
Tanimoto, N1
Kuse, H1
Hori, M1
Ishihara, M1
Ito, M1
Redolfi, A1
Borgogelli, E1
Lodola, E1
Macaron, C1
Kyncl, M1
Singh, SP1
Bass, DM1
Baylor, M1
Broome, R1
Greenberg, HB1
Lin, SY1
Hou, SJ1
Perng, RI1
Chen, SM1
Young, TK1
Gordon, JB1
Clément de Cléty, S1
Chu, K1
Onodera, S1
Yoshinaga, M1
Takenaga, K1
Toyoshima, A1
Uchiyama, T1
Keitoku, M1
Maruyama, Y1
Takishima, T1
Crowe, JP1
Wilkinson, SP1
Bate, CM1
Willoughby, CP1
Peers, EM1
Richardson, PD1
Abernethy, DR1
Hall, JA1
Meisterling, EM1
Lewis, PE1
Dailey, RA1
Martyn, JA1
Hagen, J1
Hoaglin, DC1
Friedman, H1
Burstein, ES1
Locniskar, A1
Shader, RI1
Avril, P1
Ducroc, R1
Garzon, B1
Moreau, E1
Hervatin, F1
Millet, P1
Geloso, JP1
Henderson, GI1
Speeg, KV1
Roberts, RK1
Perez, A1
Schenker, S1
Ruoff, HJ1
Leyhe, T1
Pfaff, G1
Rettenmaier, G1
Schmid, E1
Wilson, AD1
Stokes, CR1
Bourne, FJ1
Mercer, GD1
Dawson, GW1
Park, BK1
Frank, WO1
Peace, KE1
Watson, M1
Seaman, JJ1
Szego, PL1
Braverman, A1
Mico, B1
Dickson, B1

Reviews

4 reviews available for cimetidine and Aging

ArticleYear
[QOL and the older people with peptic ulcer].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60, Issue:8

    Topics: Abietanes; Aged; Aging; Anti-Ulcer Agents; Cimetidine; Diterpenes; Drug Therapy, Combination; Energy

2002
Pharmacokinetics in anaesthesia.
    Canadian Anaesthetists' Society journal, 1983, Volume: 30, Issue:3 Pt 1

    Topics: Aging; Anesthetics; Cimetidine; Drug Interactions; Humans; Shock

1983
Variables affecting nicotine metabolism.
    Pharmacology & therapeutics, 1993, Volume: 60, Issue:3

    Topics: Aging; Animals; Cimetidine; Dietary Proteins; Drug Interactions; Ethanol; Female; Genetic Variation;

1993
The pharmacokinetic profile of amlodipine.
    American heart journal, 1989, Volume: 118, Issue:5 Pt 2

    Topics: Administration, Oral; Aging; Amlodipine; Angina Pectoris; Animals; Biological Availability; Calcium

1989

Trials

2 trials available for cimetidine and Aging

ArticleYear
Symptom relief and duodenal ulcer healing with omeprazole or cimetidine. Opus (Omeprazole Peptic Ulcer Study) Research Group.
    Alimentary pharmacology & therapeutics, 1989, Volume: 3, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Cimetidine; Double-Blind Method; Duodenal Ulcer;

1989
The effect of single intravenous doses of cimetidine or ranitidine on gastric secretion.
    Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:6

    Topics: Adolescent; Adult; Aged; Aging; Cimetidine; Drug Evaluation; Gastric Acid; Gastric Mucosa; Humans; H

1986

Other Studies

38 other studies available for cimetidine and Aging

ArticleYear
Comparison of airway responses in sheep of different age in precision-cut lung slices (PCLS).
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Aging; Allergens; Animals; Animals, Newborn; Biogenic Amines; Bronchoconstriction; Cimetidine; Hista

2014
Disposition of clotiazepam: influence of age, sex, oral contraceptives, cimetidine, isoniazid and ethanol.
    European journal of clinical pharmacology, 1984, Volume: 26, Issue:1

    Topics: Adult; Aged; Aging; Azepines; Cimetidine; Contraceptives, Oral, Hormonal; Drug Interactions; Ethanol

1984
Serotoninergic involvement in the cimetidine-induced prolactin release.
    Endocrinology, 1983, Volume: 113, Issue:6

    Topics: Aging; Animals; Cimetidine; Female; Fenclonine; Luteinizing Hormone; Male; Methysergide; Prolactin;

1983
Changes in the response of guinea-pig airways in vivo and in vitro to cimetidine and propranolol during development.
    British journal of pharmacology, 1982, Volume: 75, Issue:3

    Topics: Aging; Airway Resistance; Animals; Bronchi; Cimetidine; Dimaprit; Female; Guanidines; Guinea Pigs; H

1982
Drug-induced sexual dysfunction in older men.
    Geriatrics, 1984, Volume: 39, Issue:10

    Topics: Aged; Aging; Antihypertensive Agents; Cimetidine; Clofibrate; Estrogens; Female; Humans; Male; Metoc

1984
Factors affecting the response to inhibition of drug metabolism by cimetidine--dose response and sensitivity of elderly and induced subjects.
    British journal of clinical pharmacology, 1984, Volume: 17, Issue:1

    Topics: Adult; Aged; Aging; Antipyrine; Cimetidine; Dose-Response Relationship, Drug; Female; Humans; Male;

1984
The influence of age on the distribution and activity of histamine receptors in the rat uterus.
    Methods and findings in experimental and clinical pharmacology, 1984, Volume: 6, Issue:2

    Topics: Aging; Animals; Carbachol; Cimetidine; Electric Stimulation; Female; Histamine; Pyrilamine; Rats; Ra

1984
The bioavailability and pharmacokinetics of cimetidine and its metabolites in juvenile cystic fibrosis patients: age related differences as compared to adults.
    European journal of clinical pharmacology, 1984, Volume: 26, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aging; Biological Availability; Biotransformation; Body Sur

1984
Pharmacokinetics of cimetidine in critically ill patients.
    European journal of clinical pharmacology, 1984, Volume: 26, Issue:3

    Topics: Adult; Aged; Aging; Cimetidine; Critical Care; Female; Humans; Infusions, Parenteral; Kinetics; Male

1984
Prediction of cimetidine disposition in the aged.
    Methods and findings in experimental and clinical pharmacology, 1983, Volume: 5, Issue:4

    Topics: Administration, Oral; Adult; Aged; Aging; Cimetidine; Female; Guanidines; Half-Life; Humans; Infusio

1983
Age and renal clearance of cimetidine.
    Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:1

    Topics: Adult; Aged; Aging; Cimetidine; Creatinine; Dementia; Female; Guanidines; Humans; Kidney; Male; Midd

1982
Coping with reflux esophagitis in the aged.
    Geriatrics, 1982, Volume: 37, Issue:9

    Topics: Aged; Aging; Antacids; Cimetidine; Esophagitis, Peptic; Esophagogastric Junction; Esophagoscopy; Gas

1982
Cimetidine and cerebral blood flow in elderly patients.
    British journal of clinical pharmacology, 1981, Volume: 11, Issue:1

    Topics: Adult; Aged; Aging; Cerebrovascular Circulation; Cimetidine; Depression, Chemical; Guanidines; Human

1981
Clinical pharmacokinetics of cimetidine with observations on the plasma concentration-response curve.
    Methods and findings in experimental and clinical pharmacology, 1981, Volume: 3 Suppl 1

    Topics: Adult; Aging; Cimetidine; Gastric Acid; Guanidines; Half-Life; Humans; Kinetics; Middle Aged

1981
H1- and H2-histamine receptor-mediated vasodilation varies with aging in humans.
    Clinical pharmacology and therapeutics, 1995, Volume: 58, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Cimetidine; Dose-Response Relationship, Drug; Female; Hand; H

1995
Effect of cimetidine on the histamine and dimaprit induced responses on the guinea pig ileum during development.
    General pharmacology, 1993, Volume: 24, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Cimetidine; Dimaprit; Female; Guinea Pigs; Histamine; Histamine Ag

1993
Defective burst-promoting activity of T lymphocytes from anemic and nonanemic elderly people.
    Annals of hematology, 1994, Volume: 68, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Anemia; Cimetidine; Colony-Forming Units Assay; Erythroid Precursor

1994
Free plasma concentrations of piroxicam in patients with osteoarthritis: relation to age, sex and efficacy.
    Clinical rheumatology, 1993, Volume: 12, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Cimetidine; Drug Therapy, Combination; Female; Humans; Male; Middle

1993
Effect of histamine on memory retrieval in old rats.
    Biological & pharmaceutical bulletin, 1993, Volume: 16, Issue:2

    Topics: Acetylcholine; Aging; Animals; Anticonvulsants; Avoidance Learning; Cerebrovascular Circulation; Cim

1993
Aging and drug interactions. III. Individual and combined effects of cimetidine and cimetidine and ciprofloxacin on theophylline metabolism in healthy male and female nonsmokers.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2

    Topics: Adult; Age Factors; Aged; Aging; Analysis of Variance; Biotransformation; Cimetidine; Ciprofloxacin;

1997
Comparison of arterial blood gases and acid-base balance in young and aged beagle dogs, with regard to postprandial alkaline tide.
    The Journal of toxicological sciences, 2000, Volume: 25, Issue:3

    Topics: Acid-Base Equilibrium; Aging; Animals; Anti-Ulcer Agents; Blood Gas Analysis; Cimetidine; Dogs; Gase

2000
Influence of aging on gastric ulcer healing activities of cimetidine and omeprazole.
    European journal of pharmacology, 2002, May-31, Volume: 444, Issue:3

    Topics: Aging; Animals; Cimetidine; Gastrins; Male; Omeprazole; Rats; Rats, Wistar; Stomach Ulcer

2002
Blood level of cimetidine in relation to age.
    European journal of clinical pharmacology, 1979, May-21, Volume: 15, Issue:4

    Topics: Adult; Aged; Aging; Blood Urea Nitrogen; Body Weight; Cimetidine; Creatinine; Female; Guanidines; Ha

1979
Cimetidine induced prolactin (PRL) release in thyroid disease.
    Clinical endocrinology, 1979, Volume: 11, Issue:4

    Topics: Adult; Aged; Aging; Cimetidine; Female; Follicle Stimulating Hormone; Guanidines; Humans; Hyperthyro

1979
Increased bioavailability of cimetidine with age?
    European journal of clinical pharmacology, 1979, Volume: 16, Issue:6

    Topics: Adult; Aging; Biological Availability; Cimetidine; Guanidines; Humans; Middle Aged

1979
Molecular basis of age-dependent gastric inactivation of rhesus rotavirus in the mouse.
    The Journal of clinical investigation, 1992, Volume: 89, Issue:6

    Topics: Aging; Animals; Capsid; Capsid Proteins; Cimetidine; Electrophoresis, Polyacrylamide Gel; Intestines

1992
Effect of traditional Chinese herbal medicines on the pharmacokinetics of western drugs in Sprague-Dawley rats of different ages (II): Aminophylline-huan shao tan and aminophylline-pu chung yi chi tang.
    Mechanisms of ageing and development, 1992, Volume: 66, Issue:1

    Topics: Aging; Aminophylline; Animals; Biological Availability; Cimetidine; Cytochrome P-450 Enzyme System;

1992
Developmental changes in effects of histamine on segmental pulmonary vascular resistances.
    Journal of applied physiology (Bethesda, Md. : 1985), 1991, Volume: 71, Issue:1

    Topics: Aging; Animals; Animals, Newborn; Chlorpheniramine; Cimetidine; Histamine; Histamine H1 Antagonists;

1991
[Effects of cernitin pollen extract (CN-009) on the isolated bladder smooth muscles and the intravesical pressure].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1991, Volume: 97, Issue:5

    Topics: Aging; Animals; Atropine; Cats; Cimetidine; Diphenhydramine; Dose-Response Relationship, Drug; Drug

1991
Different histamine actions in proximal and distal human coronary arteries in vitro.
    Cardiovascular research, 1990, Volume: 24, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; Cimetidine; Coronary Vessels; Culture Tech

1990
Formation of ovarian follicular cysts and corpora lutea after treatment with antihistamine or indomethacin in prepubertal gilts.
    Biology of reproduction, 1989, Volume: 40, Issue:3

    Topics: Aging; Animals; Cimetidine; Female; Follicular Phase; Histamine; Histamine H1 Antagonists; Indometha

1989
Alteration by burn injury of the pharmacokinetics and pharmacodynamics of cimetidine in children.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Aging; Burns; Child; Child, Preschool; Cimetidine; Creatinine; Female; Gastric Ac

1989
Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol.
    Clinical pharmacology and therapeutics, 1987, Volume: 41, Issue:5

    Topics: Administration, Oral; Adult; Aged; Aging; Anti-Anxiety Agents; Bromazepam; Cimetidine; Contraceptive

1987
[Development of gastric sensitivity to histamine in the rat].
    Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1986, Volume: 303, Issue:18

    Topics: Aging; Animals; Bucladesine; Cimetidine; Fetus; Gastric Acid; Gastric Mucosa; Histamine; Kinetics; R

1986
Effect of aging on hepatic elimination of cimetidine and subsequent interaction of aging and cimetidine on aminopyrine metabolism.
    Biochemical pharmacology, 1988, Jul-01, Volume: 37, Issue:13

    Topics: Aging; Aminopyrine; Aminopyrine N-Demethylase; Animals; Cimetidine; Kidney; Liver; Male; Metabolic C

1988
Morphologically different biopsy specimens of the human gastric mucosa. II. Adenylate cyclase activity in response to prostaglandin E2 and histamine.
    Pharmacology, 1986, Volume: 33, Issue:3

    Topics: Adenylyl Cyclases; Adult; Aged; Aging; Biopsy; Cimetidine; Dinoprostone; Dose-Response Relationship,

1986
Responses of intraepithelial lymphocytes to T-cell mitogens: a comparison between murine and porcine responses.
    Immunology, 1986, Volume: 58, Issue:4

    Topics: Aging; Animals; Cimetidine; Concanavalin A; Indomethacin; Interleukin-2; Lymphocyte Activation; Lymp

1986
Aging and drug interactions. I. Effect of cimetidine and smoking on the oxidation of theophylline and cortisol in healthy men.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Cimetidine; Drug Interactions; Half-Life; Humans; Hydrocortis

1987