cimetidine has been researched along with Adverse Drug Event in 20 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These results were consistent with the cell-level pharmacodynamic (PD) modeling analysis which leveraged the time-course effects of drugs as single agents and drug combinations." | 1.72 | Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin. ( Ait-Oudhia, S; Lesko, LJ; Mody, H; Vaidya, TR, 2022) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (55.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pedersen, JM | 1 |
| Matsson, P | 1 |
| Bergström, CA | 1 |
| Norinder, U | 1 |
| Hoogstraate, J | 1 |
| Artursson, P | 1 |
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Mody, H | 1 |
| Vaidya, TR | 1 |
| Lesko, LJ | 1 |
| Ait-Oudhia, S | 1 |
| Tayal, V | 1 |
| Kalra, BS | 1 |
| Agarwal, S | 1 |
| Khurana, N | 1 |
| Gupta, U | 1 |
| Coleman, MD | 1 |
| Clark, BG | 1 |
| Vestal, RE | 1 |
| Havey, RJ | 1 |
| Bilynskiĭ, BT | 1 |
| Shparik, IaV | 1 |
| Maher, JF | 1 |
| Crooks, J | 1 |
| Platt, D | 1 |
| McQueen, EG | 1 |
| Melmon, KL | 1 |
| Nierenberg, DW | 1 |
| Andreev, E | 1 |
| Koopman, M | 1 |
| Arisz, L | 1 |
| Reus, VI | 1 |
| Temple, RJ | 1 |
| Jones, JK | 1 |
| Crout, JR | 1 |
| Gugler, R | 1 |
4 reviews available for cimetidine and Adverse Drug Event
| Article | Year |
|---|---|
Over-the-counter and iatrogenically induced psychoses: a review of the literature.
Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Appetite Depressants; Aspirin; Cimetidine; Disulfir | 1984 |
[Carcinogenicity of various drugs].
Topics: Adult; Animals; Anti-Bacterial Agents; Arsenicals; Barbiturates; Brain Neoplasms; Carcinogens; Child | 1984 |
Clinicopathologic spectrum of drug nephrotoxicity.
Topics: Aminoglycosides; Analgesics; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antineoplastic Agents; | 1984 |
A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible?
Topics: Adrenal Cortex Hormones; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvuls | 1999 |
16 other studies available for cimetidine and Adverse Drug Event
| Article | Year |
|---|---|
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi | 2008 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin.
Topics: Carcinoma, Hepatocellular; Cimetidine; Cisplatin; Drug-Related Side Effects and Adverse Reactions; H | 2022 |
Hepatoprotective effect of tocopherol against isoniazid and rifampicin induced hepatotoxicity in albino rabbits.
Topics: Animals; Antioxidants; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cimetidine; Do | 2007 |
Improvement of patient tolerance to dapsone: current and future developments.
Topics: Antioxidants; Cimetidine; Dapsone; Dermatologic Agents; Drug-Related Side Effects and Adverse Reacti | 2007 |
Adverse drug reactions in the elderly: case studies.
Topics: Acetazolamide; Aged; Anemia, Hemolytic; Bromocriptine; Captopril; Chlorpropamide; Cimetidine; Clonid | 1984 |
Drug epidemiology and clinical pharmacology: their contribution to patient care.
Topics: Anticoagulants; Cimetidine; Drug Information Services; Drug Prescriptions; Drug Utilization; Drug-Re | 1983 |
[Drug incompatibility in the aged].
Topics: Aged; Anticoagulants; Antidepressive Agents; Biotransformation; Cardiac Glycosides; Cimetidine; Drug | 1983 |
New Zealand committee on adverse drug reactions: fifteenth annual report 1980.
Topics: Adult; Aged; Cimetidine; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Infant; Ma | 1981 |
Drug interactions and the prepared observer.
Topics: Cimetidine; Computers; Drug Information Services; Drug Interactions; Drug-Related Side Effects and A | 1981 |
Behavioral side effects of medical drugs.
Topics: Adrenal Cortex Hormones; Aged; Antihypertensive Agents; Antitubercular Agents; Aspirin; Behavior; Ca | 1979 |
Adverse effects of newly marketed drugs.
Topics: Cimetidine; Drug-Related Side Effects and Adverse Reactions; Humans; Male; Research | 1979 |
[Hepatic drug interactions].
Topics: Chemical and Drug Induced Liver Injury; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Drug Interac | 1985 |