cimetidine has been researched along with Adenocarcinoma, Basal Cell in 51 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cimetidine was administered for 1 year and the histological features of the gastric mucosa were studied to determine if cimetidine induced greater than normal proliferative or metaplastic changes or atypia." | 5.27 | The effect of cimetidine on chronic gastric ulcers in rats. ( Deane, SA; Grierson, JM, 1988) |
| " We found that cimetidine treatment in a xenograft model using A549 lung adenocarcinoma cells resulted in decreased tumor volume compared to vehicle control; however, while the effect was in the same direction as the original study (Figure 4C; Sirota et al." | 3.85 | Replication Study: Discovery and preclinical validation of drug indications using compendia of public gene expression data. ( Aird, F; Kandela, I, 2017) |
| " We aimed to examine the effects of histamine, cimetidine, and ranitidine on in vitro proliferation and apoptosis in two human colorectal cancer cell lines, Caco-2 and LoVo." | 3.72 | The effect of H2 antagonists on proliferation and apoptosis in human colorectal cancer cell lines. ( Kumar, P; Mulcahy, H; Patchett, S; Rajendra, S, 2004) |
| "To evaluate the immunomodulatory effects of histamine in vivo, we analyzed an experimental syngenic tumor model using a colon adenocarcinoma cell line, CT-26, in Balb/c mice." | 3.71 | Effect of cimetidine on intratumoral cytokine expression in an experimental tumor. ( Ichikawa, A; Takahashi, K; Tanaka, S, 2001) |
| "The effects of combined administration of cimetidine and tetragastrin on gastric acid secretion, the labeling index of the gastric mucosa, and the incidence of gastric adenocarcinomas induced by N-methyl-N'-nitro-N-nitrosoguanidine were investigated in inbred Wistar rats." | 3.67 | Effect of cimetidine on inhibition by tetragastrin of carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. ( Baba, M; Iishi, H; Taniguchi, H; Tatsuta, M; Yamamoto, R; Yamamura, H, 1988) |
| "The possibility exists that Barrett's esophagus may be acquired in some instances and congenital in others." | 2.36 | Barrett's esophagus. ( Berardi, RS; Devaiah, KA, 1983) |
| "tumor growth, secondary lung metastasis and splenocyte cytotoxicity against YAC-1 lymphoma cells (51Cr release assay)." | 1.29 | Effects of histamine type-2 receptor antagonists on indomethacin and IL-2 immunotherapy of metastasis. ( Khoo, NK; Lala, PK; Saarloos, MN, 1993) |
| "Histamine has recently been shown to be a growth factor for some gastric and colorectal cancer cells." | 1.29 | Ranitidine and cimetidine differ in their in vitro and in vivo effects on human colonic cancer growth. ( Adams, WJ; Lawson, JA; Morris, DL, 1996) |
| "The O/E ratio of oesophageal cancer deaths also fell over the first six years of study, from 5." | 1.28 | Post-cimetidine surveillance for up to ten years: incidence of carcinoma of the stomach and oesophagus. ( Colin-Jones, DG; Langman, MJ; Lawson, DH; Logan, RF; Paterson, KR; Vessey, MP, 1991) |
| "Five of 99 cases of gastric cancer were exposed to cimetidine at least two years before diagnosis, whereas nine of 365 controls (selected from among users of the Group Health Cooperative pharmacy, matched on age, sex, and first year of pharmacy use) were similarly exposed." | 1.28 | Cimetidine use and gastric cancer. ( Feld, AD; Jick, H; Jick, SS; Schumacher, MC, 1990) |
| "Cimetidine was administered for 1 year and the histological features of the gastric mucosa were studied to determine if cimetidine induced greater than normal proliferative or metaplastic changes or atypia." | 1.27 | The effect of cimetidine on chronic gastric ulcers in rats. ( Deane, SA; Grierson, JM, 1988) |
| "A case of gastric cancer occurring seven years after a highly selective vagotomy is described." | 1.27 | Gastric cancer following highly selective vagotomy. ( Houghton, PW; Leaper, DJ, 1987) |
| "I have reviewed Barrett's esophagus in the light of recent advances." | 1.26 | Barrett's esophagus: an old entity rediscovered. ( Mangla, JC, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (62.75) | 18.7374 |
| 1990's | 13 (25.49) | 18.2507 |
| 2000's | 4 (7.84) | 29.6817 |
| 2010's | 2 (3.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kandela, I | 2 |
| Zervantonakis, I | 1 |
| Aird, F | 1 |
| Fujiwara, S | 1 |
| Noguchi, T | 2 |
| Suehiro, S | 1 |
| Kikuchi, R | 1 |
| Uchida, Y | 1 |
| Rajendra, S | 1 |
| Mulcahy, H | 1 |
| Patchett, S | 1 |
| Kumar, P | 1 |
| Doldi, K | 1 |
| Manger, B | 1 |
| Koch, B | 1 |
| Riemann, J | 1 |
| Hermanek, P | 1 |
| Kalden, JR | 1 |
| Berardi, RS | 1 |
| Devaiah, KA | 1 |
| Dreghorn, CR | 1 |
| Moffat, LE | 1 |
| Rodrigo Rodríguez, M | 1 |
| González San Martín, P | 1 |
| Alonso Antón, P | 1 |
| de Portugal Alvarez, J | 1 |
| Sorkin, EM | 1 |
| Ogawa, GS | 1 |
| Rodríguez, S | 1 |
| Moreno Otero, R | 1 |
| Mearin Manrique, F | 1 |
| Pajares García, JM | 1 |
| Lewis, JH | 1 |
| Woods, M | 1 |
| Taylor, TV | 3 |
| Lee, D | 2 |
| Howatson, AG | 2 |
| Anderson, J | 2 |
| Macleod, IB | 2 |
| Mangla, JC | 1 |
| Knigge, U | 2 |
| Dejgård, A | 1 |
| Christiansen, PM | 1 |
| Svendsen, LB | 1 |
| Ross, C | 1 |
| Frederiksen, HJ | 1 |
| Graversen, P | 1 |
| Kjaergård, J | 1 |
| Luke, M | 1 |
| Stimpel, H | 1 |
| Sparsø, BH | 1 |
| Saarloos, MN | 1 |
| Khoo, NK | 1 |
| Lala, PK | 1 |
| Kondratenko, TY | 1 |
| Zacharova, IV | 1 |
| Kuzina, NV | 1 |
| Severin, ES | 1 |
| Kornilova, ZCh | 1 |
| Perelman, MI | 1 |
| Hassall, E | 1 |
| Lawson, JA | 1 |
| Adams, WJ | 1 |
| Morris, DL | 1 |
| Overgaard, H | 1 |
| Timshel, S | 1 |
| Teicher, BA | 1 |
| Holden, SA | 1 |
| Goff, DA | 1 |
| Wright, JE | 1 |
| Tretyakov, O | 1 |
| Ayash, LJ | 1 |
| Mirvish, SS | 1 |
| Sasson, AR | 1 |
| Gamagami, R | 1 |
| An, Z | 1 |
| Wang, X | 1 |
| Moossa, AR | 1 |
| Hoffman, RM | 1 |
| Suleiman, UL | 1 |
| Harrison, M | 1 |
| Britton, A | 1 |
| McPherson, K | 1 |
| Bates, T | 1 |
| Takahashi, K | 1 |
| Tanaka, S | 1 |
| Ichikawa, A | 1 |
| Elder, JB | 1 |
| Ganguli, PC | 1 |
| Gillespie, IE | 1 |
| Buck, JP | 1 |
| Murgatroyd, RE | 1 |
| Boylston, AW | 1 |
| Baron, JH | 1 |
| Tutton, PJ | 2 |
| Barkla, DH | 2 |
| Colin-Jones, DG | 1 |
| Langman, MJ | 1 |
| Lawson, DH | 1 |
| Logan, RF | 1 |
| Paterson, KR | 1 |
| Vessey, MP | 1 |
| Arima, N | 1 |
| Yamashita, Y | 1 |
| Morishita, T | 1 |
| Fujita, T | 1 |
| Nakamura, A | 1 |
| Nakata, H | 1 |
| Chiba, T | 1 |
| Nakajima, I | 1 |
| Chu, TM | 1 |
| Schumacher, MC | 1 |
| Jick, SS | 1 |
| Jick, H | 1 |
| Feld, AD | 1 |
| Klimczak, J | 1 |
| Lahat, N | 1 |
| Alexander, B | 1 |
| Levin, DR | 1 |
| Moskovitz, B | 1 |
| Hennessy, TP | 1 |
| Spechler, SJ | 1 |
| Goyal, RK | 1 |
| Wiernik, PH | 1 |
| Schwartz, EL | 1 |
| Strauman, JJ | 1 |
| Dutcher, JP | 1 |
| Lipton, RB | 1 |
| Paietta, E | 1 |
| Amland, PF | 1 |
| Svane, S | 1 |
| Tatsuta, M | 2 |
| Iishi, H | 2 |
| Baba, M | 2 |
| Mikuni, T | 1 |
| Taniguchi, H | 2 |
| Boom, SJ | 1 |
| Blower, AL | 1 |
| McMahon, RF | 1 |
| Lawler, W | 1 |
| Yamamura, H | 1 |
| Yamamoto, R | 1 |
| Deane, SA | 1 |
| Grierson, JM | 1 |
| Xue, LF | 1 |
| Cheng, J | 1 |
| Wang, JW | 1 |
| Song, Y | 1 |
| Gu, SX | 1 |
| Stockley, I | 1 |
| Kiff, ES | 1 |
| Houghton, PW | 1 |
| Leaper, DJ | 1 |
| Cheret, AM | 1 |
| Laboisse, CL | 1 |
| Roumagnac, I | 1 |
| Augeron, C | 1 |
| Lewin, MJ | 1 |
| Jewell, LD | 1 |
| Fields, AL | 1 |
| Murray, CJ | 1 |
| Thomson, AB | 1 |
| Maguire, LC | 1 |
| Roszman, TL | 1 |
| Lackey, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534] | 29 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for cimetidine and Adenocarcinoma, Basal Cell
| Article | Year |
|---|---|
Barrett's esophagus.
Topics: Adenocarcinoma; Adolescent; Adult; Age Factors; Aged; Animals; Barrett Esophagus; Carcinoma, Squamou | 1983 |
Barrett's esophagus: new definitions and approaches in children.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Barrett Esophagus; Child; Child, Preschool; Cimetidine; End | 1993 |
Studies on experimental animals involving surgical procedures and/or nitrosamine treatment related to the etiology of esophageal adenocarcinoma.
Topics: Adenocarcinoma; Animals; Bile Acids and Salts; Bile Reflux; Cimetidine; Duodenogastric Reflux; Esoph | 1997 |
Barrett's oesophagus.
Topics: Adenocarcinoma; Adolescent; Adult; Barrett Esophagus; Cimetidine; Epithelium; Esophageal Diseases; E | 1985 |
Barrett's esophagus.
Topics: Adenocarcinoma; Antacids; Barrett Esophagus; Bethanechol; Bethanechol Compounds; Cimetidine; Epithel | 1986 |
1 trial available for cimetidine and Adenocarcinoma, Basal Cell
| Article | Year |
|---|---|
Cimetidine as an adjuvant treatment in colorectal cancer. A double-blind, randomized pilot study.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Cimetidine; Colonic Neoplasm | 1995 |
45 other studies available for cimetidine and Adenocarcinoma, Basal Cell
| Article | Year |
|---|---|
Registered report: Discovery and preclinical validation of drug indications using compendia of public gene expression data.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antibiotics, Antineoplastic; Carcinoma, Renal Cell; | 2015 |
Replication Study: Discovery and preclinical validation of drug indications using compendia of public gene expression data.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Carcinoma, Renal Cell; Cimetidine; Data | 2017 |
[A case of multiple lung metastases of colon cancer with long-term survival following 5'-DFUR and cimetidine therapy].
Topics: Adenocarcinoma; Adjuvants, Immunologic; Aged; Antimetabolites, Antineoplastic; Cimetidine; Colonic N | 2003 |
The effect of H2 antagonists on proliferation and apoptosis in human colorectal cancer cell lines.
Topics: Adenocarcinoma; Apoptosis; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Cimetidine; Colorecta | 2004 |
Cimetidine, nitrosation, and cancer.
Topics: Adenocarcinoma; Cimetidine; Duodenal Ulcer; Guanidines; Humans; Male; Middle Aged; Nitroso Compounds | 1981 |
Spontaneous suppressor cell activity in the peripheral blood of patients with malignant and chronic inflammatory bowel diseases.
Topics: Adenocarcinoma; Adult; Antigens, Surface; Cells, Cultured; Cimetidine; Colonic Neoplasms; Crohn Dise | 1984 |
Changing patterns of gastric surgery in a district general hospital.
Topics: Adenocarcinoma; Cimetidine; Female; Hospitals, District; Humans; Male; Peptic Ulcer; Peptic Ulcer Pe | 1984 |
[Cimetidine and gastric cancer].
Topics: Adenocarcinoma; Cimetidine; False Negative Reactions; Humans; Lymphoma; Stomach Neoplasms | 1983 |
Cimetidine potentiation of narcotic action.
Topics: Adenocarcinoma; Aged; Cimetidine; Drug Synergism; Guanidines; Humans; Lung Neoplasms; Male; Methadon | 1983 |
[Cimetidine and stomach cancer: deceptive response and diagnostic delay].
Topics: Adenocarcinoma; Aged; Cimetidine; False Negative Reactions; Female; Guanidines; Humans; Male; Middle | 1983 |
Gastric carcinoma in patients with unoperated duodenal ulcer disease.
Topics: Adenocarcinoma; Cimetidine; Duodenal Ulcer; Female; Humans; Intestinal Polyps; Male; Middle Aged; Pr | 1982 |
Gastric cancer and cimetidine.
Topics: Adenocarcinoma; Adult; Aged; Cimetidine; Female; Guanidines; Humans; Male; Middle Aged; Peptic Ulcer | 1981 |
Barrett's esophagus: an old entity rediscovered.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Barrett Esophagus; Bethanechol Compounds; Biopsy; Child; Ch | 1981 |
[Cancer of the stomach - and cimetidine].
Topics: Adenocarcinoma; Aged; Biopsy; Cimetidine; Diagnosis, Differential; Female; Guanidines; Humans; Male; | 1980 |
Effects of histamine type-2 receptor antagonists on indomethacin and IL-2 immunotherapy of metastasis.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Cimetidine; Famotidine; Female; Histamine H2 Antago | 1993 |
The study of histamine H1- and H2-receptors in human lung cancer.
Topics: Adenocarcinoma; Adult; Airway Obstruction; Chronic Disease; Cimetidine; Humans; Lung Neoplasms; Midd | 1993 |
Ranitidine and cimetidine differ in their in vitro and in vivo effects on human colonic cancer growth.
Topics: Adenocarcinoma; Animals; Cell Division; Cimetidine; Colonic Neoplasms; Cyclic AMP; Drug Interactions | 1996 |
[Late recurrence of stomach cancer in a patient treated with a H2 receptor antagonist].
Topics: Adenocarcinoma; Antineoplastic Agents; Cimetidine; Histamine H2 Antagonists; Humans; Male; Middle Ag | 1996 |
Antitumor efficacy and pharmacokinetic analysis of 4-hydroperoxycyclophosphamide in comparison with cyclophosphamide +/- hepatic enzyme effectors.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Pro | 1996 |
Cimetidine: an inhibitor or promoter of tumor growth?
Topics: Adenocarcinoma; Adjuvants, Immunologic; Animals; Cell Division; Cimetidine; Colonic Neoplasms; Femal | 1999 |
H2-receptor antagonists may increase the risk of cardio-oesophageal adenocarcinoma: a case-control study.
Topics: Adenocarcinoma; Adult; Age Distribution; Aged; Anti-Inflammatory Agents, Non-Steroidal; Case-Control | 2000 |
Effect of cimetidine on intratumoral cytokine expression in an experimental tumor.
Topics: Adenocarcinoma; Animals; Cell Division; Cimetidine; Colonic Neoplasms; Cytokines; Histamine; Histami | 2001 |
Cimetidine and gastric cancer.
Topics: Adenocarcinoma; Adult; Aged; Cimetidine; Female; Guanidines; Humans; Male; Middle Aged; Nitroso Comp | 1979 |
Gastric cancer in patients who have taken cimetidine.
Topics: Achlorhydria; Adenocarcinoma; Adult; Aged; Cimetidine; Female; Guanidines; Humans; Male; Stomach Neo | 1979 |
Perforation of gastric carcinoma (at site of previous benign ulcer) after withdrawal of cimetidine.
Topics: Adenocarcinoma; Cimetidine; Guanidines; Humans; Male; Middle Aged; Peptic Ulcer Perforation; Stomach | 1979 |
Cell proliferation in dimethylhydrazine-induced colonic adenocarcinomata following cytotoxic drug treatment.
Topics: 5,7-Dihydroxytryptamine; Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Cimetidine; | 1978 |
Stimulation of cell proliferation by histamine H2 receptors in dimethylhdrazine-induced adenocarcinomata.
Topics: Adenocarcinoma; Animals; Cell Division; Cimetidine; Colon; Colonic Neoplasms; Dimethylhydrazines; Hi | 1978 |
Post-cimetidine surveillance for up to ten years: incidence of carcinoma of the stomach and oesophagus.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cimetidine; Cohort Studies; Esoph | 1991 |
[Evidence for the presence of histamine H2 receptor on poorly differentiated human gastric cancer cell line, MKN45].
Topics: Adenocarcinoma; Cell Line; Cimetidine; Cyclic AMP; Humans; Pyrilamine; Receptors, Histamine H2; Stom | 1991 |
Synergistic antitumor activity of interleukin-2 and cimetidine against syngeneic murine tumor.
Topics: Adenocarcinoma; Animals; Antigens, Surface; Antineoplastic Combined Chemotherapy Protocols; Cimetidi | 1991 |
Cimetidine use and gastric cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antacids; Case-Control Studies; Cimetidine; Esophagitis, Pe | 1990 |
[Use of cimetidine with histamine in 4 patients with inoperable neoplasms of the upper part of the digestive tract].
Topics: Adenocarcinoma; Aged; Carcinoma; Cimetidine; Drug Therapy, Combination; Esophageal Neoplasms; Histam | 1985 |
The relationship between clinical stage, natural killer activity and related immunological parameters in adenocarcinoma of the prostate.
Topics: Adenocarcinoma; Aged; Cimetidine; Cytotoxicity, Immunologic; Humans; Indomethacin; Interleukin-2; Ki | 1989 |
Phase I clinical and pharmacokinetic study of taxol.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Alkaloids; Alopecia; Cimetidine; Dexamethasone; Diph | 1987 |
[H2 receptor antagonist treatment and stomach cancer].
Topics: Adenocarcinoma; Adult; Aged; Cimetidine; Female; Histamine H2 Antagonists; Humans; Male; Stomach Neo | 1987 |
Effects of propranolol and cimetidine on cysteamine inhibition of gastric carcinogenesis induced in Wistar rats by N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Adenocarcinoma; Animals; Cimetidine; Cysteamine; Gastric Acid; Gastric Mucosa; Gastrins; Male; Methy | 1989 |
Healing of a malignant gastric ulcer with cimetidine.
Topics: Adenocarcinoma; Aged; Cimetidine; Humans; Male; Stomach Neoplasms; Stomach Ulcer; Wound Healing | 1988 |
Effect of cimetidine on inhibition by tetragastrin of carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
Topics: Adenocarcinoma; Animals; Cimetidine; DNA; Gastric Acid; Gastric Mucosa; Gastrins; Hyperplasia; Male; | 1988 |
The effect of cimetidine on chronic gastric ulcers in rats.
Topics: Adenocarcinoma; Animals; Cimetidine; Female; Male; Rats; Rats, Inbred Strains; Stomach Neoplasms; St | 1988 |
[Histamine and lung cancer. II. Human lung cancer cell line and histamine].
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Cell Division; Cell Line; Cimetidine; Histamine; Humans; L | 1988 |
Gastric carcinoma arising during five years treatment with cimetidine for duodenal ulceration.
Topics: Adenocarcinoma; Cimetidine; Duodenal Ulcer; Humans; Male; Middle Aged; Stomach Neoplasms | 1987 |
Gastric cancer following highly selective vagotomy.
Topics: Adenocarcinoma; Cimetidine; Humans; Male; Middle Aged; Stomach Neoplasms; Stomach Ulcer; Vagotomy, P | 1987 |
Highly histamine-responsive clones from the human gastric adenocarcinoma cell line HGT-1.
Topics: Adenocarcinoma; Adenylyl Cyclases; Cell Line; Cimetidine; Clone Cells; Diphenhydramine; Guanylyl Imi | 1986 |
Erosive gastroduodenitis with marked epithelial atypia after hepatic arterial infusion chemotherapy.
Topics: Adenocarcinoma; Aluminum; Cimetidine; Colonic Neoplasms; Fluorouracil; Gastric Mucosa; Humans; Infus | 1985 |
Failure of cimetidine as an immunomodulator in cancer patients and normal subjects.
Topics: Adenocarcinoma; Adjuvants, Immunologic; Cimetidine; Humans; Immunoglobulins; Leukocyte Count; Lympho | 1985 |