cimetidine has been researched along with Acute Myelogenous Leukemia in 5 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 76-year-old woman with acute myelogenous leukemia with approximately 65% myeloblasts on bone marrow examination was treated daily with a combination of 4 megaU of leukocyte interferon IM and 1,000 mg cimetidine PO." | 7.67 | Complete remission in a patient with acute myelogenous leukemia treated with leukocyte alpha-interferon and cimetidine. ( Ankerst, J; Fäldt, R; Flodgren, P; Nilsson, PG; Sjögren, HO, 1984) |
| "A 76-year-old woman with acute myelogenous leukemia with approximately 65% myeloblasts on bone marrow examination was treated daily with a combination of 4 megaU of leukocyte interferon IM and 1,000 mg cimetidine PO." | 3.67 | Complete remission in a patient with acute myelogenous leukemia treated with leukocyte alpha-interferon and cimetidine. ( Ankerst, J; Fäldt, R; Flodgren, P; Nilsson, PG; Sjögren, HO, 1984) |
| " Successful treatment required aggressive surgical debridement, three times daily voriconazole dosing and cimetidine CYP2C19 inhibition." | 1.40 | Disseminated Scedosporium prolificans infection in an 'extensive metaboliser': navigating the minefield of drug interactions and pharmacogenomics. ( Paratz, E; Slavin, MA; Teh, BW; Thursky, KA; Todaro, M; Trubiano, JA; Wolf, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trubiano, JA | 1 |
| Paratz, E | 1 |
| Wolf, M | 1 |
| Teh, BW | 1 |
| Todaro, M | 1 |
| Thursky, KA | 1 |
| Slavin, MA | 1 |
| Sawutz, DG | 1 |
| Kalinyak, K | 1 |
| Whitsett, JA | 1 |
| Johnson, CL | 1 |
| Ankerst, J | 1 |
| Fäldt, R | 1 |
| Nilsson, PG | 1 |
| Flodgren, P | 1 |
| Sjögren, HO | 1 |
| Mehta, J | 1 |
| Powles, RL | 1 |
| Treleaven, J | 1 |
| Shields, M | 1 |
| Agrawal, S | 1 |
| Rege, K | 1 |
| Mitchell, P | 1 |
| Allard, S | 1 |
| Weiss, RB | 1 |
| Donehower, RC | 1 |
| Wiernik, PH | 1 |
| Ohnuma, T | 1 |
| Gralla, RJ | 1 |
| Trump, DL | 1 |
| Baker, JR | 1 |
| Van Echo, DA | 1 |
| Von Hoff, DD | 1 |
| Leyland-Jones, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Feasibility of a Randomized Controlled Clinical Trial Comparing the Use of Cetirizine to Replace Diphenhydramine in the Prevention of Reactions Related to Paclitaxel[NCT04237090] | Phase 3 | 27 participants (Actual) | Interventional | 2020-02-14 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for cimetidine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Disseminated Scedosporium prolificans infection in an 'extensive metaboliser': navigating the minefield of drug interactions and pharmacogenomics.
Topics: Aged; Antifungal Agents; Cimetidine; Cytochrome P-450 CYP2C19; Debridement; Drug Interactions; Human | 2014 |
Histamine H2 receptor desensitization in HL-60 human promyelocytic leukemia cells.
Topics: 1-Methyl-3-isobutylxanthine; Cell Differentiation; Cell Line; Cimetidine; Cyclic AMP; Dimaprit; Dino | 1984 |
Complete remission in a patient with acute myelogenous leukemia treated with leukocyte alpha-interferon and cimetidine.
Topics: Aged; Bone Marrow; Cimetidine; Evaluation Studies as Topic; Female; Humans; Interferon Type I; Leuke | 1984 |
Cimetidine-induced myelosuppression after bone marrow transplantation.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Cimetidine; Female; Hematopoiesis; Humans; Leukemia- | 1994 |
Hypersensitivity reactions from taxol.
Topics: Adult; Aged; Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Colonic Neoplasms; Dexamethas | 1990 |