Page last updated: 2024-10-25

cimetidine and Acute Myelogenous Leukemia

cimetidine has been researched along with Acute Myelogenous Leukemia in 5 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Research Excerpts

ExcerptRelevanceReference
"A 76-year-old woman with acute myelogenous leukemia with approximately 65% myeloblasts on bone marrow examination was treated daily with a combination of 4 megaU of leukocyte interferon IM and 1,000 mg cimetidine PO."7.67Complete remission in a patient with acute myelogenous leukemia treated with leukocyte alpha-interferon and cimetidine. ( Ankerst, J; Fäldt, R; Flodgren, P; Nilsson, PG; Sjögren, HO, 1984)
"A 76-year-old woman with acute myelogenous leukemia with approximately 65% myeloblasts on bone marrow examination was treated daily with a combination of 4 megaU of leukocyte interferon IM and 1,000 mg cimetidine PO."3.67Complete remission in a patient with acute myelogenous leukemia treated with leukocyte alpha-interferon and cimetidine. ( Ankerst, J; Fäldt, R; Flodgren, P; Nilsson, PG; Sjögren, HO, 1984)
" Successful treatment required aggressive surgical debridement, three times daily voriconazole dosing and cimetidine CYP2C19 inhibition."1.40Disseminated Scedosporium prolificans infection in an 'extensive metaboliser': navigating the minefield of drug interactions and pharmacogenomics. ( Paratz, E; Slavin, MA; Teh, BW; Thursky, KA; Todaro, M; Trubiano, JA; Wolf, M, 2014)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Trubiano, JA1
Paratz, E1
Wolf, M1
Teh, BW1
Todaro, M1
Thursky, KA1
Slavin, MA1
Sawutz, DG1
Kalinyak, K1
Whitsett, JA1
Johnson, CL1
Ankerst, J1
Fäldt, R1
Nilsson, PG1
Flodgren, P1
Sjögren, HO1
Mehta, J1
Powles, RL1
Treleaven, J1
Shields, M1
Agrawal, S1
Rege, K1
Mitchell, P1
Allard, S1
Weiss, RB1
Donehower, RC1
Wiernik, PH1
Ohnuma, T1
Gralla, RJ1
Trump, DL1
Baker, JR1
Van Echo, DA1
Von Hoff, DD1
Leyland-Jones, B1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Feasibility of a Randomized Controlled Clinical Trial Comparing the Use of Cetirizine to Replace Diphenhydramine in the Prevention of Reactions Related to Paclitaxel[NCT04237090]Phase 327 participants (Actual)Interventional2020-02-14Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

5 other studies available for cimetidine and Acute Myelogenous Leukemia

ArticleYear
Disseminated Scedosporium prolificans infection in an 'extensive metaboliser': navigating the minefield of drug interactions and pharmacogenomics.
    Mycoses, 2014, Volume: 57, Issue:9

    Topics: Aged; Antifungal Agents; Cimetidine; Cytochrome P-450 CYP2C19; Debridement; Drug Interactions; Human

2014
Histamine H2 receptor desensitization in HL-60 human promyelocytic leukemia cells.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 231, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Cell Differentiation; Cell Line; Cimetidine; Cyclic AMP; Dimaprit; Dino

1984
Complete remission in a patient with acute myelogenous leukemia treated with leukocyte alpha-interferon and cimetidine.
    Cancer immunology, immunotherapy : CII, 1984, Volume: 17, Issue:1

    Topics: Aged; Bone Marrow; Cimetidine; Evaluation Studies as Topic; Female; Humans; Interferon Type I; Leuke

1984
Cimetidine-induced myelosuppression after bone marrow transplantation.
    Leukemia & lymphoma, 1994, Volume: 13, Issue:1-2

    Topics: Adolescent; Adult; Bone Marrow Transplantation; Cimetidine; Female; Hematopoiesis; Humans; Leukemia-

1994
Hypersensitivity reactions from taxol.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1990, Volume: 8, Issue:7

    Topics: Adult; Aged; Alkaloids; Antineoplastic Agents, Phytogenic; Cimetidine; Colonic Neoplasms; Dexamethas

1990