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cimetidine and Acute Liver Injury, Drug-Induced

cimetidine has been researched along with Acute Liver Injury, Drug-Induced in 70 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Research Excerpts

ExcerptRelevanceReference
"Toxic hepatitis developed but in one out of 127 peptic ulcer patients treated with cimetidine."7.68[The effect of cimetidine and gastrozepin on liver function and the pharmacotherapy of "hepatogenous" gastroduodenal ulcers and erosions]. ( Bessonova, GA; Geller, LI; Griaznova, MV, 1991)
"The value of cimetidine in treatment of duodenal ulcer and the Zollinger-Ellison syndrome appears to be well established."4.76A consideration of the adverse effects of cimetidine. ( McGuigan, JE, 1981)
" Amatoxin, a peptide contained in several mushroom species, accounts for the majority of severe mushroom poisonings by binding to RNA polymerase II irreversibly, leading to severe hepatonecrosis."3.74Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model. ( Betten, DP; Clark, RF; Favata, M; Hernandez, M; Richardson, WH; Riffenburgh, RH; Tanen, DA; Tong, TC, 2007)
"A 51-year-old obese woman with a duodenal ulcer developed symptomatic, famotidine-induced hepatitis."3.69Hepatitis following treatments with famotidine and then cimetidine. ( Davis, RL; Egli, D; Hashimoto, F, 1994)
"A 41-year-old man with rheumatoid arthritis developed severe acute hepatitis 3 days after starting cimetidine for duodenal ulcer."3.68[Cimetidine hepatitis]. ( Cohen, N; Golik, A; Zaidenstein, R, 1992)
"Toxic hepatitis developed but in one out of 127 peptic ulcer patients treated with cimetidine."3.68[The effect of cimetidine and gastrozepin on liver function and the pharmacotherapy of "hepatogenous" gastroduodenal ulcers and erosions]. ( Bessonova, GA; Geller, LI; Griaznova, MV, 1991)
"A 62-year-old man developed asymptomatic anicteric hepatitis during cimetidine therapy for duodenal ulcer disease."3.67Cimetidine hepatitis. ( Graham, DY; Gyorkey, F; Schwartz, JT, 1986)
" We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts."1.37FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011)
"The aim of the present work was to clarify the involvement of free radicals, cytochrome P450 toxic metabolites, and deregulation of calcium homeostasis in the mechanism of diethyldithiocarbamate (DDC) hepatotoxicity."1.37The protective effects of ascorbic acid, cimetidine, and nifedipine on diethyldithiocarbamate-induced hepatic toxicity in albino rats. ( Badawy, MM; Gaafa, KM; Hamza, AA, 2011)
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."1.36Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010)
" Furthermore, the use of antidotes that reduced the toxic insult was also recorded using this technique."1.35Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum. ( Galanopoulou, P; Giannioti, K; Liapi, C; Mikros, E; Papalois, A; Theocharis, S; Zira, A, 2009)
"Cimetidine was the individual anti-ulcer drug with the highest risk of developing symptomatic acute liver disease."1.30The risk of acute liver injury associated with cimetidine and other acid-suppressing anti-ulcer drugs. ( García Rodríguez, LA; Stricker, BH; Wallander, MA, 1997)
"Dimethylacetamide (DMAc) is a skin-penetrating solvent able to induce hepatic damage after chronic exposure."1.29Toxicokinetics of dimethylacetamide (DMAc) in rat isolated perfused liver. ( Borm, PJ; Evelo, CT; Henderson, PT; Palmen, NG, 1993)
"Cimetidine pretreatment also significantly reduced the rate of hepatic glutathione depletion."1.27Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other histamine H2-receptor antagonists in vivo and in vitro in the rat and in man. ( Mitchell, MC; Schenker, S; Speeg, KV, 1984)

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-199038 (54.29)18.7374
1990's14 (20.00)18.2507
2000's6 (8.57)29.6817
2010's12 (17.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Greene, N1
Fisk, L1
Naven, RT1
Note, RR1
Patel, ML1
Pelletier, DJ1
Morgan, RE2
Trauner, M1
van Staden, CJ2
Lee, PH1
Ramachandran, B1
Eschenberg, M1
Afshari, CA2
Qualls, CW1
Lightfoot-Dunn, R1
Hamadeh, HK2
Ekins, S1
Williams, AJ1
Xu, JJ1
Chen, M2
Vijay, V1
Shi, Q2
Liu, Z2
Fang, H2
Tong, W3
Ding, D1
Kelly, R1
Sakatis, MZ1
Reese, MJ1
Harrell, AW1
Taylor, MA1
Baines, IA1
Chen, L1
Bloomer, JC1
Yang, EY1
Ellens, HM1
Ambroso, JL1
Lovatt, CA1
Ayrton, AD1
Clarke, SE1
Warner, DJ1
Chen, H1
Cantin, LD1
Kenna, JG2
Stahl, S1
Walker, CL1
Noeske, T1
Chen, Y1
Kalyanaraman, N1
Kalanzi, J1
Dunn, RT1
Suzuki, A1
Thakkar, S1
Yu, K1
Hu, C1
Salhanick, SD1
Wax, PM1
Schneider, SM1
Tan, HH1
Chang, CY1
Martin, P1
Zira, A1
Mikros, E1
Giannioti, K1
Galanopoulou, P1
Papalois, A1
Liapi, C1
Theocharis, S1
Ishihara, Y1
Ishii, S1
Sakai, Y1
Yamamura, N1
Onishi, Y1
Shimamoto, N1
Gaafa, KM1
Badawy, MM1
Hamza, AA1
Tong, TC1
Hernandez, M1
Richardson, WH1
Betten, DP1
Favata, M1
Riffenburgh, RH1
Clark, RF1
Tanen, DA1
Kosmidis, PA1
Kalofonos, HP1
Christodoulou, C1
Syrigos, K1
Makatsoris, T1
Skarlos, D1
Bakogiannis, C1
Nicolaides, C1
Bafaloukos, D1
Bamias, A1
Samantas, E1
Xiros, N1
Boukovinas, I1
Fountzilas, G1
Dimopoulos, MA1
Tayal, V1
Kalra, BS1
Agarwal, S1
Khurana, N1
Gupta, U1
Kolts, BE1
Langfitt, M1
Ivey, KJ1
Mitchell, MC2
Schenker, S2
Speeg, KV2
Leonard, TB1
Dent, JG1
Mariani, L1
Minora, T1
Souza Lima, MA2
Black, M1
Scott, WE1
Kanter, R1
Nagasue, N1
Yukaya, H1
Ogawa, Y1
Sasaki, Y1
Hirose, S1
Freston, JW1
Mogadam, M1
Peterson, FJ1
Knodell, RG1
Lindemann, NJ1
Steele, NM1
McGuigan, JE1
Soulé, JC1
Delchier, JC1
Morin, T1
Bader, JP1
Ruffalo, RL1
Thompson, JF1
Glade, G1
Saccar, CL1
Pereira, GR1
Lorenzini, I1
Jezequel, AM1
Orlandi, F1
Avant, GR1
Jackson, JE1
Ruiz Del Arbol, L1
Moreira, V1
Moreno, A1
Hernández Ranz, F1
Cano, A1
García Plaza, A1
Chmel, H1
Idali, B1
Miguil, M1
Moutawakkil, S1
Bouaggad, A1
Guartit, A1
Abassi, O1
Ben Aguida, M1
Palmen, NG1
Evelo, CT1
Borm, PJ1
Henderson, PT1
Hashimoto, F1
Davis, RL1
Egli, D1
Irita, K1
Sakai, H1
Yamakawa, M1
Nawata, H1
Yoshitake, J1
Takahashi, S1
García Rodríguez, LA1
Wallander, MA1
Stricker, BH1
Kaufenberg, AJ1
Shepherd, MF1
Villeneuve, JP1
Warner, HA1
Berthelot, P1
Zaidenstein, R1
Cohen, N1
Golik, A1
Polunina, TE2
Fomichev, VI1
Vasil'ev, AP1
Lewis, RK1
Paloucek, FP1
Geller, LI1
Bessonova, GA1
Griaznova, MV1
Marcus, DL1
Nadel, H1
Lew, G1
Freedman, ML1
Brown, BR1
Chevalier, X1
Awada, H1
Baetz, A1
Amor, B1
Boyd, PT1
Lepre, F1
Dickey, JD1
Landriault, H1
Sirois, G1
Chakrabarti, S1
Cote, MG1
Dixon, PA1
Udeagha, AU1
Zimmerman, HJ2
Jacob, L2
Bassan, H2
Gillespie, J2
Lukacs, L2
Abernathy, CO1
Lewis, JH1
Ivlev, AS1
Davis, M1
Satoh, H1
Gillette, JR1
Takemura, T1
Ferrans, VJ1
Jelenich, SE1
Neuberger, J1
Pohl, LR1
Vázquez Arnedo, M1
Pastor Fanco, A1
Bestue Fuster, JM1
Duddy, SK1
Hsia, MT1
Dobbs, JH1
Muir, JG1
Smith, RN1
Murase, T1
Hazama, H1
Okuno, H1
Shiozaki, Y1
Sameshima, Y1
Schwartz, JT1
Gyorkey, F1
Graham, DY1
Van Steenbergen, W1
Vanstapel, MJ1
Desmet, V1
Van Kerckvoorde, L1
De Keyzer, R1
Brijs, R1
Fevery, J1
De Groote, J1
Gugler, R1

Reviews

8 reviews available for cimetidine and Acute Liver Injury, Drug-Induced

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr

2016
H2-receptor antagonists.
    International journal of dermatology, 1980, Volume: 19, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Cimetidine; Gastric Mucosa; G

1980
Cimetidine: II. Adverse reactions and patterns of use.
    Annals of internal medicine, 1982, Volume: 97, Issue:5

    Topics: Cardiovascular Diseases; Central Nervous System Diseases; Chemical and Drug Induced Liver Injury; Ci

1982
A consideration of the adverse effects of cimetidine.
    Gastroenterology, 1981, Volume: 80, Issue:1

    Topics: Agranulocytosis; Animals; Bone Marrow; Central Nervous System; Chemical and Drug Induced Liver Injur

1981
[Maintenance cimetidine treatment in duodenal ulcer disease. Second part: Side-effects and indications (author's transl)].
    Gastroenterologie clinique et biologique, 1980, Volume: 4, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; Chemical and Drug Induced Liver Injury; Cimetidine; Confusion; Dogs;

1980
Assessment and treatment of acetaminophen overdose.
    Clinical pharmacy, 1991, Volume: 10, Issue:10

    Topics: Acetaminophen; Acetylcysteine; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Ove

1991
Hepatic effects of drugs used in the treatment of peptic ulcer disease.
    The American journal of gastroenterology, 1987, Volume: 82, Issue:10

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Interactions; Female; Histamine H2 An

1987
Protective agents for acetaminophen overdose.
    Seminars in liver disease, 1986, Volume: 6, Issue:2

    Topics: Acetaminophen; Acetylcysteine; Animals; Cell Membrane; Chemical and Drug Induced Liver Injury; Cimet

1986

Trials

2 trials available for cimetidine and Acute Liver Injury, Drug-Induced

ArticleYear
Paclitaxel and gemcitabine versus carboplatin and gemcitabine in patients with advanced non-small-cell lung cancer. A phase III study of the Hellenic Cooperative Oncology Group.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcino

2008
Prophylaxis of upper gastrointestinal bleeding with cimetidine in patients undergoing partial hepatectomy.
    Annales chirurgiae et gynaecologiae, 1984, Volume: 73, Issue:1

    Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cimetidine; Female; Hepatectomy; Humans; Liver

1984

Other Studies

60 other studies available for cimetidine and Acute Liver Injury, Drug-Induced

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship;

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des

2011
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
    PLoS computational biology, 2011, Volume: 7, Issue:12

    Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da

2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily

2013
In response to Tong TC, et al. Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model.
    Annals of emergency medicine, 2008, Volume: 52, Issue:2

    Topics: Alpha-Amanitin; Amanitins; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Cimetidine; H

2008
Acetaminophen hepatotoxicity: current management.
    The Mount Sinai journal of medicine, New York, 2009, Volume: 76, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Antidotes; Charcoal; Chemical and Drug Induced Liver Injury; Cimetidi

2009
Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum.
    Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Acute Disease; Alanine Transaminase; Animals; Antidotes; Aspartate Am

2009
Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats.
    Journal of applied toxicology : JAT, 2011, Volume: 31, Issue:2

    Topics: alpha-Tocopherol; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cimetidine; Cytochr

2011
The protective effects of ascorbic acid, cimetidine, and nifedipine on diethyldithiocarbamate-induced hepatic toxicity in albino rats.
    Drug and chemical toxicology, 2011, Volume: 34, Issue:4

    Topics: Animals; Ascorbic Acid; Biomarkers; Calcium; Chemical and Drug Induced Liver Injury; Cimetidine; Cyt

2011
Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model.
    Annals of emergency medicine, 2007, Volume: 50, Issue:3

    Topics: Acetylcysteine; Alanine Transaminase; Amanitins; Animals; Antidotes; Aspartate Aminotransferases; Ch

2007
Hepatoprotective effect of tocopherol against isoniazid and rifampicin induced hepatotoxicity in albino rabbits.
    Indian journal of experimental biology, 2007, Volume: 45, Issue:12

    Topics: Animals; Antioxidants; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cimetidine; Do

2007
Drugs and the liver.
    Comprehensive therapy, 1984, Volume: 10, Issue:12

    Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv

1984
Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other histamine H2-receptor antagonists in vivo and in vitro in the rat and in man.
    The Journal of clinical investigation, 1984, Volume: 73, Issue:2

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Glucuronates; Glutathion

1984
Effects of H2 receptor antagonists on the hepatotoxicity of various chemicals.
    Research communications in chemical pathology and pharmacology, 1984, Volume: 44, Issue:3

    Topics: 1-Propanol; Acetaminophen; Animals; Bromobenzenes; Carbon Tetrachloride Poisoning; Chemical and Drug

1984
[Drug surveillance. Monitoring the collateral effects of drugs in the post-marketing phase: cimetidine. I].
    La Clinica terapeutica, 1984, Apr-15, Volume: 109, Issue:1

    Topics: Chemical and Drug Induced Liver Injury; Cimetidine; Endocrine System Diseases; Evaluation Studies as

1984
Hepatitis associated with ranitidine.
    Annals of internal medicine, 1984, Volume: 101, Issue:2

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cimetidine; Female; Humans; Leukocyte Count; Liver Fun

1984
Possible ranitidine hepatotoxicity.
    Annals of internal medicine, 1984, Volume: 101, Issue:2

    Topics: Adult; Chemical and Drug Induced Liver Injury; Cholangitis; Cimetidine; Diagnosis, Differential; Fem

1984
The GI drug column. The ACG committee on FDA related matters.
    The American journal of gastroenterology, 1983, Volume: 78, Issue:3

    Topics: Alginates; Aluminum Hydroxide; Antacids; Bicarbonates; Chemical and Drug Induced Liver Injury; Cheno

1983
Prevention of acetaminophen and cocaine hepatotoxicity in mice by cimetidine treatment.
    Gastroenterology, 1983, Volume: 85, Issue:1

    Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Co

1983
Cimetidine and acetylcysteine as antidote for acetaminophen overdose.
    Southern medical journal, 1982, Volume: 75, Issue:8

    Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Cimetidine; Cytoch

1982
Cimetidine in pregnancy: apparent transient liver impairment in the newborn.
    American journal of diseases of children (1960), 1980, Volume: 134, Issue:1

    Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cimetidine; Fema

1980
Cimetidine-induced hepatitis. Electron microscopic observations and clinical pattern of liver injury.
    Digestive diseases and sciences, 1981, Volume: 26, Issue:3

    Topics: Adult; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Hypersensitivity; Guanidines; Humans

1981
Cimetidine protects against acetaminophen hepatotoxicity in rats.
    Gastroenterology, 1981, Volume: 81, Issue:6

    Topics: Acetaminophen; Alanine Transaminase; Aminopyrine; Animals; Aspartate Aminotransferases; Chemical and

1981
Cimetidine protects against acetaminophen hepatoxicity.
    Veterinary and human toxicology, 1981, Volume: 23, Issue:Suppl 1

    Topics: Acetaminophen; Adolescent; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Female; Guan

1981
Bridging hepatic necrosis associated with cimetidine.
    The American journal of gastroenterology, 1980, Volume: 74, Issue:3

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cimetidine; Esophagitis, Peptic; Guanidines; Humans; L

1980
Fatal acute hepatic necrosis due to fluconazole.
    The American journal of medicine, 1995, Volume: 99, Issue:2

    Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Cimetidine; Fatal Outcome; Fluconazole; Human

1995
[Acute phostoxin poisoning].
    Presse medicale (Paris, France : 1983), 1995, Apr-01, Volume: 24, Issue:13

    Topics: Acute Disease; Adult; Aluminum Compounds; Cardiotonic Agents; Chemical and Drug Induced Liver Injury

1995
Toxicokinetics of dimethylacetamide (DMAc) in rat isolated perfused liver.
    Human & experimental toxicology, 1993, Volume: 12, Issue:2

    Topics: Acetamides; Animals; Bile; Chemical and Drug Induced Liver Injury; Cimetidine; Cryoprotective Agents

1993
Hepatitis following treatments with famotidine and then cimetidine.
    The Annals of pharmacotherapy, 1994, Volume: 28, Issue:1

    Topics: Chemical and Drug Induced Liver Injury; Cimetidine; Duodenal Ulcer; Famotidine; Fatty Liver; Female;

1994
Effects of OP 2507, a stable analogue of prostaglandin I2, on carbon tetrachloride-induced liver damage in starved rats.
    The Tohoku journal of experimental medicine, 1996, Volume: 178, Issue:3

    Topics: Alanine Transaminase; Animals; Antioxidants; Carbon Tetrachloride Poisoning; Chemical and Drug Induc

1996
The risk of acute liver injury associated with cimetidine and other acid-suppressing anti-ulcer drugs.
    British journal of clinical pharmacology, 1997, Volume: 43, Issue:2

    Topics: Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Anti-Ulcer Agents; Case-Control Studies; Ch

1997
Role of cimetidine in the treatment of acetaminophen poisoning.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1998, Jul-15, Volume: 55, Issue:14

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Overdose; Humans; L

1998
Cimetidine hepatitis.
    Gastroenterology, 1979, Volume: 77, Issue:1

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Hypersensitivity; Esophagitis, Peptic

1979
Cimetidine hepatitis.
    Gastroenterology, 1979, Volume: 77, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Cimetidine; Guanidines; Humans

1979
[Cimetidine hepatitis].
    Harefuah, 1992, Dec-15, Volume: 123, Issue:12

    Topics: Acute Disease; Adult; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Cimetidine; Duo

1992
[Acute drug-induced hepatitis in a patient with peptic ulcer].
    Klinicheskaia meditsina, 1992, Volume: 70, Issue:2

    Topics: Aged; Cephalothin; Chemical and Drug Induced Liver Injury; Cimetidine; Duodenal Ulcer; Humans; Male;

1992
[The effect of cimetidine and gastrozepin on liver function and the pharmacotherapy of "hepatogenous" gastroduodenal ulcers and erosions].
    Terapevticheskii arkhiv, 1991, Volume: 63, Issue:8

    Topics: Adult; Anti-Ulcer Agents; Chemical and Drug Induced Liver Injury; Cimetidine; Drug Evaluation; Drug

1991
Cimetidine suppresses chemically induced experimental hepatic porphyria.
    The American journal of the medical sciences, 1990, Volume: 300, Issue:4

    Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chemical and Drug Induced Liver Inju

1990
Cimetidine pretreatment and halothane hepatotoxicity.
    British journal of anaesthesia, 1990, Volume: 64, Issue:5

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Halothane; Humans; Premedication

1990
Danazol induced pancreatitis and hepatitis.
    Clinical rheumatology, 1990, Volume: 9, Issue:2

    Topics: Acetaminophen; Adult; Chemical and Drug Induced Liver Injury; Cimetidine; Danazol; Female; Humans; L

1990
Chronic active hepatitis associated with cimetidine.
    BMJ (Clinical research ed.), 1989, Feb-04, Volume: 298, Issue:6669

    Topics: Adult; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cime

1989
Effect of cimetidine on hepatic biochemical changes, liver toxicity and major urinary metabolite excretion of trichloroethylene in rats.
    Journal of applied toxicology : JAT, 1989, Volume: 9, Issue:2

    Topics: Alanine Transaminase; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cimetidine

1989
The effect of some hepatotoxins on the sulphoxidation of cimetidine in rat.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1986, Volume: 83, Issue:2

    Topics: 1-Propanol; Animals; Bromobenzenes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver

1986
Effects of H2-blocking agents on hepatocytes in vitro: correlation with potential for causing hepatic disease in patients.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1986, Volume: 182, Issue:4

    Topics: Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cimetidine; Histamine

1986
[Severe acute drug-induced hepatitis in a patient with benign hyperbilirubinemia of the Gilbert type].
    Klinicheskaia meditsina, 1988, Volume: 66, Issue:2

    Topics: Adult; Chemical and Drug Induced Liver Injury; Cimetidine; Gastroenteritis; Gilbert Disease; Humans;

1988
Investigation of the immunological basis of halothane-induced hepatotoxicity.
    Advances in experimental medicine and biology, 1986, Volume: 197

    Topics: Animals; Antigen-Antibody Complex; Cell Membrane; Chemical and Drug Induced Liver Injury; Cimetidine

1986
[Cimetidine and toxic hepatitis].
    Revista espanola de las enfermedades del aparato digestivo, 1987, Volume: 71, Issue:1

    Topics: Adult; Chemical and Drug Induced Liver Injury; Cimetidine; Duodenal Ulcer; Humans; Male

1987
Cytoprotective effects of modulators of oxidative xenobiotic metabolism in precocene II-induced hepatotoxicity.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1987, Volume: 9, Issue:2

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzopyrans; Cell Survival; Chemical and

1987
Ranitidine and hepatic injury.
    Annals of internal medicine, 1986, Volume: 105, Issue:1

    Topics: Chemical and Drug Induced Liver Injury; Cimetidine; Humans; Ranitidine; Retrospective Studies

1986
H2-antagonists and hepatitis.
    Annals of internal medicine, 1986, Volume: 105, Issue:5

    Topics: Chemical and Drug Induced Liver Injury; Cimetidine; Humans; Ranitidine

1986
Effect of H2-receptor antagonists on acetaminophen-induced hepatic injury.
    Japanese journal of pharmacology, 1986, Volume: 41, Issue:4

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cimetidine; Famotidine; Glutathione;

1986
Effects of three H2 antagonists on the isolated perfused rat liver. Correlation of bile flow changes with potential for causing hepatic disease in patients.
    Biochemical pharmacology, 1986, Dec-15, Volume: 35, Issue:24

    Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Cimetidine; Imidazoles; In Vitro Techniques;

1986
Cimetidine hepatitis.
    Journal of clinical gastroenterology, 1986, Volume: 8, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Cimetidine; Duodenal Ulcer; Humans; Male; Microscopy, Electr

1986
Cimetidine-induced liver injury. Report of three cases.
    Journal of hepatology, 1985, Volume: 1, Issue:4

    Topics: Aged; Chemical and Drug Induced Liver Injury; Cimetidine; Gastritis; Gastritis, Hypertrophic; Humans

1985
[Hepatic drug interactions].
    Fortschritte der Medizin, 1985, Nov-07, Volume: 103, Issue:41

    Topics: Chemical and Drug Induced Liver Injury; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Drug Interac

1985