cilostazol has been researched along with Migraine Disorders in 12 studies
Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cilostazol induced a mild to moderate headache in all but 3 participants (Range 0-7 on Numerical Rating Scale)." | 9.27 | Pre-treatment with sumatriptan for cilostazol induced headache in healthy volunteers. ( Falkenberg, K; Olesen, J, 2018) |
| "Whether migraine headache and migraine aura share common pathophysiological mechanisms remains to be understood." | 6.87 | Induction of migraine-like headache, but not aura, by cilostazol in patients with migraine with aura. ( Butt, JH; Hansen, AS; Kruuse, C; Lambertsen, KL; Rostrup, E, 2018) |
| "Cilostazol induced a mild to moderate headache in all but 3 participants (Range 0-7 on Numerical Rating Scale)." | 5.27 | Pre-treatment with sumatriptan for cilostazol induced headache in healthy volunteers. ( Falkenberg, K; Olesen, J, 2018) |
| "Our study revealed that migraine attacks can be provoked in patients by cAMP-mediated mechanisms using cilostazol, even when the CGRP receptor is blocked by erenumab." | 3.30 | Second messenger signalling bypasses CGRP receptor blockade to provoke migraine attacks in humans. ( Al-Karagholi, MA; Amirguliyev, S; Ashina, M; Deligianni, C; Do, TP; Guo, S; Lopez, CL; Snellman, J, 2023) |
| "Thirty patients with migraine without aura received 200 mg cilostazol on two different study days." | 2.94 | Subcutaneous sumatriptan reduces cilostazol induced headache in migraine patients. ( Bjerg, HR; Falkenberg, K; Olesen, J, 2020) |
| "The origin of migraine pain is unknown but possibly implicates the dura mater, which is pain sensitive in proximity to the meningeal arteries." | 2.90 | Meningeal contribution to migraine pain: a magnetic resonance angiography study. ( Amin, FM; Ashina, M; Christensen, CE; de Koning, PJH; Ghanizada, H; Khan, S; Larsson, HBW; Olinger, ACR; Younis, S, 2019) |
| "Initiating mechanisms of migraine headache remain poorly understood and a biomarker of migraine does not exist." | 2.90 | Investigating macrophage-mediated inflammation in migraine using ultrasmall superparamagnetic iron oxide-enhanced 3T magnetic resonance imaging. ( Amin, FM; Ashina, M; Birgens, H; Christensen, CE; Daldrup-Link, H; Fliedner, FP; Khan, S; Kjær, A; Larsson, HBW; Lindberg, U; Olinger, ACR; Tolnai, D; Younis, S, 2019) |
| "Only subjects who developed migraine-like attacks on study day 1 were included on study day 2." | 2.87 | Reproducibility of migraine-like attacks induced by phosphodiesterase-3-inhibitor cilostazol. ( Amin, FM; Ashina, M; Deen, M; Hougaard, A; Khan, S, 2018) |
| "Cilostazol is an inhibitor of phosphodiesterase 3 and thus causes accumulation of cAMP." | 2.87 | Cilostazol induced migraine does not respond to sumatriptan in a double blind trial. ( Ashina, M; Dunga, BÓÁ; Falkenberg, K; Guo, S; Olesen, J, 2018) |
| "Whether migraine headache and migraine aura share common pathophysiological mechanisms remains to be understood." | 2.87 | Induction of migraine-like headache, but not aura, by cilostazol in patients with migraine with aura. ( Butt, JH; Hansen, AS; Kruuse, C; Lambertsen, KL; Rostrup, E, 2018) |
| "A model for the testing of novel antimigraine drugs should ideally use healthy volunteers for ease of recruiting." | 2.82 | Toward a pragmatic migraine model for drug testing: I. Cilostazol in healthy volunteers. ( Ashina, M; Guo, S; Hansen, EK; Olesen, J, 2016) |
| "Various substances are known to trigger migraine attacks in patients and calcitonin gene-related peptide antagonising drugs are effective against migraine pain." | 1.62 | CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine. ( Chaker, J; Christensen, SL; Christensen, ST; David, A; Ernstsen, C; Haanes, KA; Kristensen, DM; La Cour, S; Olesen, J; Rasmussen, RH, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (75.00) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Do, TP | 1 |
| Deligianni, C | 1 |
| Amirguliyev, S | 1 |
| Snellman, J | 1 |
| Lopez, CL | 1 |
| Al-Karagholi, MA | 1 |
| Guo, S | 3 |
| Ashina, M | 6 |
| Falkenberg, K | 3 |
| Bjerg, HR | 1 |
| Olesen, J | 6 |
| Christensen, SL | 2 |
| Rasmussen, RH | 1 |
| Ernstsen, C | 1 |
| La Cour, S | 1 |
| David, A | 1 |
| Chaker, J | 1 |
| Haanes, KA | 1 |
| Christensen, ST | 1 |
| Kristensen, DM | 1 |
| Khan, S | 3 |
| Deen, M | 1 |
| Hougaard, A | 1 |
| Amin, FM | 3 |
| Petersen, S | 1 |
| Sørensen, DB | 1 |
| Jansen-Olesen, I | 1 |
| Holland, PR | 1 |
| Strother, L | 1 |
| Dunga, BÓÁ | 1 |
| Butt, JH | 1 |
| Rostrup, E | 1 |
| Hansen, AS | 1 |
| Lambertsen, KL | 1 |
| Kruuse, C | 1 |
| Christensen, CE | 2 |
| Ghanizada, H | 1 |
| Younis, S | 2 |
| Olinger, ACR | 2 |
| de Koning, PJH | 1 |
| Larsson, HBW | 2 |
| Fliedner, FP | 1 |
| Tolnai, D | 1 |
| Birgens, H | 1 |
| Daldrup-Link, H | 1 |
| Kjær, A | 1 |
| Lindberg, U | 1 |
| Hansen, EK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Sumatriptan and Placebo Injection on Cilostazol Induced Headache[NCT03422796] | 30 participants (Actual) | Interventional | 2017-11-01 | Completed | |||
| The Effect of Sumatriptan and Placebo on Cilostazol Induced Headache. Development of a Pragmatic Migraine Model[NCT02486276] | 30 participants (Actual) | Interventional | 2015-06-30 | Completed | |||
| Pretreatment With Sumatriptan on Cilostazol Induced Headache in Healthy Volunteers. Development of a Pragmatic Migraine Model[NCT03156920] | 30 participants (Actual) | Interventional | 2017-05-23 | Completed | |||
| Investigation of Vascular Inflammation in Migraine Without Aura Using Molecular Nano-imaging and Black Blood Imaging MRI[NCT02549898] | 34 participants (Actual) | Interventional | 2015-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 trials available for cilostazol and Migraine Disorders
| Article | Year |
|---|---|
Second messenger signalling bypasses CGRP receptor blockade to provoke migraine attacks in humans.
Topics: Calcitonin Gene-Related Peptide; Cilostazol; Cyclic AMP; Humans; Migraine Disorders; Receptors, Calc | 2023 |
Subcutaneous sumatriptan reduces cilostazol induced headache in migraine patients.
Topics: Adult; Cilostazol; Cross-Over Studies; Double-Blind Method; Female; Humans; Injections, Subcutaneous | 2020 |
Reproducibility of migraine-like attacks induced by phosphodiesterase-3-inhibitor cilostazol.
Topics: Adult; Cilostazol; Female; Humans; Male; Middle Aged; Migraine Disorders; Phosphodiesterase 3 Inhibi | 2018 |
Cilostazol induced migraine does not respond to sumatriptan in a double blind trial.
Topics: Adult; Cilostazol; Cross-Over Studies; Cyclic AMP; Double-Blind Method; Female; Humans; Male; Middle | 2018 |
Pre-treatment with sumatriptan for cilostazol induced headache in healthy volunteers.
Topics: Adult; Cilostazol; Cross-Over Studies; Double-Blind Method; Female; Headache; Healthy Volunteers; Hu | 2018 |
Induction of migraine-like headache, but not aura, by cilostazol in patients with migraine with aura.
Topics: Adult; Cilostazol; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Migra | 2018 |
Meningeal contribution to migraine pain: a magnetic resonance angiography study.
Topics: Adolescent; Adult; Carotid Arteries; Cilostazol; Female; Headache; Humans; Magnetic Resonance Angiog | 2019 |
Investigating macrophage-mediated inflammation in migraine using ultrasmall superparamagnetic iron oxide-enhanced 3T magnetic resonance imaging.
Topics: Adult; Animals; Brain; Cilostazol; Dextrans; Female; Humans; Inflammation; Macrophages; Magnetic Res | 2019 |
Toward a pragmatic migraine model for drug testing: I. Cilostazol in healthy volunteers.
Topics: Adolescent; Adult; Cilostazol; Cross-Over Studies; Double-Blind Method; Female; Healthy Volunteers; | 2016 |
3 other studies available for cilostazol and Migraine Disorders
| Article | Year |
|---|---|
CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine.
Topics: Animals; Calcitonin Gene-Related Peptide; Cilostazol; Cromakalim; Humans; Mice; Mice, Knockout; Migr | 2021 |
Cilostazol induces C-fos expression in the trigeminal nucleus caudalis and behavioural changes suggestive of headache with the migraine-like feature photophobia in female rats.
Topics: Animals; Behavior, Animal; Cilostazol; Disease Models, Animal; Female; Migraine Disorders; Proto-Onc | 2018 |
Cilostazol as a chemically induced preclinical model of migraine.
Topics: Animals; Cilostazol; Female; Headache; Migraine Disorders; Photophobia; Rats; Trigeminal Nuclei | 2018 |