cilostazol has been researched along with Depressive Disorder, Major in 6 studies
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cilostazol (CLS) has shown antidepressant effect in cardiovascular patients, post-stroke depression, and animal models through its neurotrophic and antiinflammatory activities." | 3.01 | Double-blind, randomized, placebo-controlled pilot study of the phosphodiesterase-3 inhibitor cilostazol as an adjunctive to antidepressants in patients with major depressive disorder. ( Abdallah, MS; Abo Mansour, HE; Elsawah, HK; Elsokary, MA; Mansour, NO; Mosalam, EM; Omara-Reda, H; Ramadan, AN; Zaki, SA, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Abdallah, MS | 1 |
| Ramadan, AN | 1 |
| Omara-Reda, H | 1 |
| Mansour, NO | 1 |
| Elsokary, MA | 1 |
| Elsawah, HK | 1 |
| Zaki, SA | 1 |
| Abo Mansour, HE | 1 |
| Mosalam, EM | 1 |
| Khadivi, A | 1 |
| Shobeiri, P | 1 |
| Momtazmaneh, S | 1 |
| Samsami, FS | 1 |
| Shalbafan, M | 1 |
| Shirazi, E | 1 |
| Akhondzadeh, S | 1 |
| Takahashi, K | 3 |
| Mikuni, M | 3 |
| Baba, H | 1 |
| Kubota, Y | 1 |
| Suzuki, T | 1 |
| Arai, H | 1 |
| Oshima, A | 2 |
| Inoue, K | 1 |
| Takeyoshi, H | 2 |
| Fukuda, M | 2 |
| Sakai, T | 1 |
| Kumano, T | 1 |
| Mashima, T | 1 |
| Ida, I | 1 |
| Ikeda, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-blind, Randomized, Placebo-Controlled Pilot Study of the Phosphodiesterase-3 Inhibitor Cilostazol as an Adjunctive to Antidepressants in Patients With Major Depressive Disorder[NCT04069819] | 80 participants (Actual) | Interventional | 2019-08-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for cilostazol and Depressive Disorder, Major
| Article | Year |
|---|---|
[Organic cause of emotional depression].
Topics: Animals; Brain; Cerebrovascular Circulation; Cilostazol; Depressive Disorder, Major; Glucose; Humans | 2007 |
2 trials available for cilostazol and Depressive Disorder, Major
| Article | Year |
|---|---|
Double-blind, randomized, placebo-controlled pilot study of the phosphodiesterase-3 inhibitor cilostazol as an adjunctive to antidepressants in patients with major depressive disorder.
Topics: Adult; Cilostazol; Depressive Disorder, Major; Double-Blind Method; Drug Therapy, Combination; Escit | 2021 |
Cilostazol as an adjunctive treatment in major depressive disorder: a pilot randomized, double-blind, and placebo-controlled clinical trial.
Topics: Cilostazol; Depressive Disorder, Major; Double-Blind Method; Humans; Iran; Pilot Projects; Sertralin | 2022 |
3 other studies available for cilostazol and Depressive Disorder, Major
| Article | Year |
|---|---|
[Augmentation therapy with cilostazol for the intractable geriatric major depressive disorder patients with deep white matter hyperintensities on T2-weighted brain MRI].
Topics: Aged; Brain; Cerebrovascular Disorders; Cilostazol; Depressive Disorder, Major; Female; Humans; Magn | 2012 |
Seven cases of late-life depression treated with cilostazol-augmented therapy.
Topics: Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Cilostazol; Depressive Disorder, | 2007 |
Novel augmentation therapy with cilostazol for the geriatric major depressive disorder patient with deep white matter hyperintensities on T2-weighted brain MRI: a case report.
Topics: Aged; Antidepressive Agents; Brain; Cilostazol; Depressive Disorder, Major; Drug Synergism; Female; | 2008 |