Page last updated: 2024-10-25

cilostazol and Cerebral Microangiopathies

cilostazol has been researched along with Cerebral Microangiopathies in 6 studies

Research Excerpts

ExcerptRelevanceReference
"To test the feasibility, drug tolerability, safety, and effects of 1-year isosorbide mononitrate (ISMN) and cilostazol treatment on vascular, functional, and cognitive outcomes in patients with lacunar stroke."5.69Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial. ( Bamford, J; Bath, PM; Cvoro, V; Doubal, FN; England, T; Hassan, A; Heye, AK; Mhlanga, II; Montgomery, A; O'Brien, JT; Oatey, K; Roffe, C; Sprigg, N; Wardlaw, JM; Werring, DJ; Woodhouse, LJ, 2023)
"Cerebral small vessel disease is characterized by progressive cerebral white matter changes (WMCs)."3.11Cilostazol Versus Aspirin on White Matter Changes in Cerebral Small Vessel Disease: A Randomized Controlled Trial. ( Cho, SJ; Choi, SH; Choi, YH; Han, HJ; Jeong, JH; Kim, BC; Kim, EJ; Kim, JH; Kim, S; Lee, JH; Lee, JM; Na, DL; Oh, MS; Park, G; Park, HY; Park, KC; Park, KH; Park, KW; Park, SA; Shim, Y; Yoon, B; Yoon, SJ; Youn, YC, 2022)
"Cilostazol treatment improved BBB permeability and reduced gait disturbance, visual impairment and microglial activation in optic tract following BCCAO in vivo."1.43Cilostazol reduces blood brain barrier dysfunction, white matter lesion formation and motor deficits following chronic cerebral hypoperfusion. ( Cadonic, R; Edrissi, H; Hakim, AM; Schock, SC; Thompson, CS, 2016)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (33.33)24.3611
2020's4 (66.67)2.80

Authors

AuthorsStudies
Kim, BC1
Youn, YC1
Jeong, JH1
Han, HJ1
Kim, JH1
Lee, JH1
Park, KH1
Park, KW1
Kim, EJ1
Oh, MS1
Shim, Y1
Lee, JM1
Choi, YH1
Park, G1
Kim, S1
Park, HY1
Yoon, B1
Yoon, SJ1
Cho, SJ1
Park, KC1
Na, DL1
Park, SA1
Choi, SH1
Blair, GW2
Janssen, E1
Stringer, MS1
Thrippleton, MJ2
Chappell, F1
Shi, Y2
Hamilton, I2
Flaherty, K2
Appleton, JP2
Doubal, FN2
Bath, PM4
Wardlaw, JM4
Mhlanga, I1
Woodhouse, LJ2
Doubal, F2
Oatey, K2
Montgomery, AA1
Mhlanga, II1
Heye, AK1
Bamford, J1
Cvoro, V1
England, T1
Hassan, A1
Montgomery, A1
O'Brien, JT1
Roffe, C1
Sprigg, N2
Werring, DJ1
Law, ZK1
Dooley, R1
Shuler, K1
Richardson, C1
Stringer, M1
Boyd, J1
Edrissi, H1
Schock, SC1
Cadonic, R1
Hakim, AM1
Thompson, CS1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multicenter, Randomized, Double Blind Study to Compare the Efficacy Between Cilostazol and Aspirin on White Matter Changes by Cerebral Small Vessel Disease[NCT01932203]Phase 4255 participants (Actual)Interventional2013-07-17Active, not recruiting
Preventing Cognitive Decline and Dementia From Cerebral Small Vessel Disease[NCT02481323]Phase 257 participants (Actual)Interventional2016-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

5 trials available for cilostazol and Cerebral Microangiopathies

ArticleYear
Cilostazol Versus Aspirin on White Matter Changes in Cerebral Small Vessel Disease: A Randomized Controlled Trial.
    Stroke, 2022, Volume: 53, Issue:3

    Topics: Aged; Aged, 80 and over; Aspirin; Brain Ischemia; Cerebral Small Vessel Diseases; Cilostazol; Double

2022
Effects of Cilostazol and Isosorbide Mononitrate on Cerebral Hemodynamics in the LACI-1 Randomized Controlled Trial.
    Stroke, 2022, Volume: 53, Issue:1

    Topics: Aged; Cerebral Small Vessel Diseases; Cilostazol; Female; Hemodynamics; Humans; Isosorbide Dinitrate

2022
Cilostazol and isosorbide mononitrate for the prevention of progression of cerebral small vessel disease: baseline data and statistical analysis plan for the Lacunar Intervention Trial-2 (LACI-2) (ISRCTN14911850).
    Stroke and vascular neurology, 2023, Volume: 8, Issue:2

    Topics: Brain Ischemia; Cerebral Small Vessel Diseases; Cilostazol; Female; Humans; Middle Aged; Prospective

2023
Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial.
    JAMA neurology, 2023, 07-01, Volume: 80, Issue:7

    Topics: Aged; Cerebral Small Vessel Diseases; Cilostazol; Female; Humans; Male; Middle Aged; Quality of Life

2023
Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mon
    International journal of stroke : official journal of the International Stroke Society, 2018, Volume: 13, Issue:5

    Topics: Age Factors; Cerebral Small Vessel Diseases; Cilostazol; Cognition Disorders; Dementia; Double-Blind

2018

Other Studies

1 other study available for cilostazol and Cerebral Microangiopathies

ArticleYear
Cilostazol reduces blood brain barrier dysfunction, white matter lesion formation and motor deficits following chronic cerebral hypoperfusion.
    Brain research, 2016, 09-01, Volume: 1646

    Topics: Animals; Blood-Brain Barrier; Cell Survival; Cerebral Small Vessel Diseases; Cilostazol; Disease Mod

2016