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cilostazol and Carotid Stenosis

cilostazol has been researched along with Carotid Stenosis in 21 studies

Carotid Stenosis: Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)

Research Excerpts

ExcerptRelevanceReference
" We investigated the effects of cilostazol 200 mg, in addition to aspirin 100 mg and clopidogrel 75 mg, on carotid intima-media thickness (IMT) progression during a 2-year follow-up period in patients with acute coronary syndrome (ACS) requiring stent implantation."9.15Cilostazol reduces the progression of carotid intima-media thickness without increasing the risk of bleeding in patients with acute coronary syndrome during a 2-year follow-up. ( Ahn, CM; Hong, SJ; Kim, JS; Lim, DS; Park, JH, 2011)
" Diabetes mellitus and current smoker status were independent factors related to reactivity to clopidogrel."7.83Influence of Diabetes Mellitus and Cigarette Smoking on Variability of the Clopidogrel-Induced Antiplatelet Effect and Efficacy of Active Management of the Target P2Y12 Reaction Unit Range in Patients Undergoing Neurointerventional Procedures. ( Hironaka, Y; Kichikawa, K; Motoyama, Y; Nakagawa, I; Nakase, H; Park, HS; Takayama, K; Wada, T; Yokoyama, S, 2016)
" We investigated the effects of cilostazol 200 mg, in addition to aspirin 100 mg and clopidogrel 75 mg, on carotid intima-media thickness (IMT) progression during a 2-year follow-up period in patients with acute coronary syndrome (ACS) requiring stent implantation."5.15Cilostazol reduces the progression of carotid intima-media thickness without increasing the risk of bleeding in patients with acute coronary syndrome during a 2-year follow-up. ( Ahn, CM; Hong, SJ; Kim, JS; Lim, DS; Park, JH, 2011)
"Cilostazol seems to decrease total ISR rates in patients undergoing CAS without affecting MI/stroke/death events, both in the early and late settings."4.93Meta-Analysis of Studies Evaluating the Effect of Cilostazol on Major Outcomes After Carotid Stenting. ( Aggeli, K; Filis, K; Galyfos, G; Geropapas, G; Sianou, A; Sigala, F, 2016)
" Diabetes mellitus and current smoker status were independent factors related to reactivity to clopidogrel."3.83Influence of Diabetes Mellitus and Cigarette Smoking on Variability of the Clopidogrel-Induced Antiplatelet Effect and Efficacy of Active Management of the Target P2Y12 Reaction Unit Range in Patients Undergoing Neurointerventional Procedures. ( Hironaka, Y; Kichikawa, K; Motoyama, Y; Nakagawa, I; Nakase, H; Park, HS; Takayama, K; Wada, T; Yokoyama, S, 2016)
" We performed cognitive behavioral tests, including the water maze task, odor discrimination task, and novel object test; histological investigation of neuroinflammation, oligodendrocytes, myelin basic protein, and nodal or paranodal proteins at the nodes of Ranvier; and serial diffusion tensor imaging."3.83Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion. ( Back, DB; Choi, BR; Choi, DH; Han, JS; Han, SH; Kang, CH; Kim, BR; Kim, DH; Kim, HY; Kwon, KJ; Lee, J; Moon, WJ; Shin, CY, 2016)
"Bilateral common carotid artery stenosis (BCAS) mice were treated with oral administration of cilostazol or placebo starting from a week after the surgery."1.48Cilostazol alleviates white matter degeneration caused by chronic cerebral hypoperfusion in mice: Implication of its mechanism from gene expression analysis. ( Bannai, T; Iwata, A; Ohtomo, G; Ohtomo, R; Shindo, A; Tomimoto, H; Tsuji, S, 2018)
"A total of 949 patients with cervical carotid artery stenosis were enrolled at 43 institutions in Japan; 934 who had undergone CAS with antiplatelet drugs and followed for 1 year were analyzed."1.40Prospective registry of carotid artery stenting in Japan--investigation on device and antiplatelet for carotid artery stenting. ( Ezura, M; Hyodo, A; Matsubara, Y; Matsumaru, Y; Matsumoto, Y; Miyachi, S; Nakamura, M; Okada, Y; Sakai, C; Sakai, N; Terada, T; Yamagami, H; Yokoi, H, 2014)
"Cilostazol is a potent type III phosphodiesterase inhibitor, approved as an anti-platelet aggregation agent."1.35Activation of tyrosine hydroxylase prevents pneumonia in a rat chronic cerebral hypoperfusion model. ( Hattori, N; Miyamoto, N; Mochizuki, H; Tanaka, R; Urabe, T; Zhang, N, 2009)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (19.05)29.6817
2010's17 (80.95)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ohtomo, R1
Bannai, T1
Ohtomo, G1
Shindo, A1
Tomimoto, H1
Tsuji, S1
Iwata, A1
Park, SY1
Kim, HY2
Lee, YS1
Heo, HJ1
Shin, HK1
Lee, WS1
Hong, KW1
Kim, CD1
Tsutsumi, M1
Aikawa, H1
Nii, K1
Etou, H1
Sakamoto, K1
Kureshima, M1
Inoue, R1
Yoshida, H1
Matsumoto, Y3
Narita, S1
Kazekawa, K1
Tanaka, H1
Zaima, N1
Ito, H1
Hattori, K1
Yamamoto, N1
Konno, H1
Setou, M1
Unno, N1
Nakagawa, I3
Wada, T3
Park, HS3
Nishimura, F1
Yamada, S2
Nakagawa, H1
Kichikawa, K3
Nakase, H3
Fukuoka, T1
Hayashi, T1
Hirayama, M1
Maruyama, H1
Tanahashi, N1
Sakai, N2
Yamagami, H2
Matsubara, Y1
Ezura, M1
Hyodo, A2
Matsumaru, Y2
Miyachi, S2
Okada, Y1
Terada, T1
Yokoi, H1
Nakamura, M1
Sakai, C2
Miyazaki, Y1
Mori, T1
Iwata, T1
Aoyagi, Y1
Tanno, Y1
Kasakura, S1
Yoshioka, K1
Yokoyama, S2
Hironaka, Y1
Motoyama, Y2
Takayama, K1
Galyfos, G1
Geropapas, G1
Sigala, F1
Aggeli, K1
Sianou, A1
Filis, K1
Choi, BR1
Kim, DH1
Back, DB1
Kang, CH1
Moon, WJ1
Han, JS1
Choi, DH1
Kwon, KJ1
Shin, CY1
Kim, BR1
Lee, J1
Han, SH1
Zhang, N2
Miyamoto, N2
Tanaka, R2
Mochizuki, H2
Hattori, N2
Urabe, T2
Shimura, H1
Onodera, M1
Yoshimoto, T1
Fujimoto, S1
Muraki, M1
Kobayashi, R1
Yoshidumi, T1
Yamauchi, T1
Tokuda, K1
Kaneko, S1
Kai, Y1
Sugiu, K1
Fujinaka, T1
Yoshimura, S1
Hyogo, T1
Kuwayama, N1
Ahn, CM1
Hong, SJ1
Park, JH1
Kim, JS1
Lim, DS1
Yamaguchi, M1
Sasaki, M1
Ohba, H1
Mori, K1
Narumi, S1
Katsura, N1
Ohura, K1
Kudo, K1
Terayama, Y1
Kato, T1
Sakai, H1
Takagi, T1
Nishimura, Y1
Nighoghossian, N1
Derex, L1
Douek, P1
Akaji, K1
Tanizaki, Y1
Hiraga, K1
Akiyama, T1
Dembo, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Deep Learning Model Based on Routine Ultrasound Scanning Video to Help Doctors Improve the Diagnosis of Carotid Plaque[NCT05230576]2,000 participants (Actual)Observational2020-05-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for cilostazol and Carotid Stenosis

ArticleYear
Meta-Analysis of Studies Evaluating the Effect of Cilostazol on Major Outcomes After Carotid Stenting.
    Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 2016, Volume: 23, Issue:1

    Topics: Angioplasty; Cardiovascular Agents; Carotid Stenosis; Chi-Square Distribution; Cilostazol; Humans; M

2016
The vulnerable carotid artery plaque: current imaging methods and new perspectives.
    Stroke, 2005, Volume: 36, Issue:12

    Topics: Anticoagulants; Biomarkers; C-Reactive Protein; Carotid Arteries; Carotid Stenosis; Cilostazol; Diag

2005

Trials

5 trials available for cilostazol and Carotid Stenosis

ArticleYear
Cilostazol reduces periprocedural hemodynamic depression in carotid artery stenting.
    Neurologia medico-chirurgica, 2013, Volume: 53, Issue:3

    Topics: Aged; Angioplasty; Bradycardia; Carotid Stenosis; Cilostazol; Clopidogrel; Female; Humans; Hypotensi

2013
Efficacy of cilostazol-based dual antiplatelet treatment in patients undergoing carotid artery stenting.
    Neurological research, 2017, Volume: 39, Issue:8

    Topics: Aged; Aged, 80 and over; Aspirin; Carotid Stenosis; Cilostazol; Clopidogrel; Drug Therapy, Combinati

2017
Cilostazol may suppress restenosis and new contralateral carotid artery stenosis after carotid endarterectomy.
    Neurologia medico-chirurgica, 2010, Volume: 50, Issue:7

    Topics: Aged; Carotid Stenosis; Cilostazol; Endarterectomy, Carotid; Female; Humans; Male; Platelet Aggregat

2010
Cilostazol reduces the progression of carotid intima-media thickness without increasing the risk of bleeding in patients with acute coronary syndrome during a 2-year follow-up.
    Heart and vessels, 2011, Volume: 26, Issue:5

    Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Analysis of Variance; Angioplasty, Balloon, Corona

2011
Cilostazol prevents progression of asymptomatic carotid artery stenosis in patients with contralateral carotid artery stenting.
    AJNR. American journal of neuroradiology, 2012, Volume: 33, Issue:7

    Topics: Aged; Aged, 80 and over; Blood Vessel Prosthesis; Carotid Stenosis; Cilostazol; Female; Fibrinolytic

2012

Other Studies

14 other studies available for cilostazol and Carotid Stenosis

ArticleYear
Cilostazol alleviates white matter degeneration caused by chronic cerebral hypoperfusion in mice: Implication of its mechanism from gene expression analysis.
    Neuroscience letters, 2018, Jan-01, Volume: 662

    Topics: Animals; Brain; Carotid Stenosis; Cell Differentiation; Cilostazol; Corpus Callosum; Gene Expression

2018
Augmented improvement of cognition and memory by aripiprazole add-on for cilostazol treatment in the chronic cerebral hypoperfusion mouse model.
    Behavioural brain research, 2019, 06-03, Volume: 365

    Topics: Animals; Aripiprazole; Brain; Brain Ischemia; Carotid Stenosis; Cilostazol; Cognition; Cognitive Dys

2019
Cilostazol inhibits accumulation of triglycerides in a rat model of carotid artery ligation.
    Journal of vascular surgery, 2013, Volume: 58, Issue:5

    Topics: Animals; Cardiovascular Agents; Carotid Artery, Common; Carotid Stenosis; Cholesterol, HDL; Cilostaz

2013
Platelet inhibition by adjunctive cilostazol suppresses the frequency of cerebral ischemic lesions after carotid artery stenting in patients with carotid artery stenosis.
    Journal of vascular surgery, 2014, Volume: 59, Issue:3

    Topics: Aged; Angioplasty; Aspirin; Brain Ischemia; Carotid Stenosis; Cilostazol; Clopidogrel; Diffusion Mag

2014
Cilostazol inhibits leukocyte-endothelial cell interactions in murine microvessels after transient bilateral common carotid artery occlusion.
    Brain research, 2014, Jan-16, Volume: 1543

    Topics: Animals; Carotid Stenosis; Cilostazol; Disease Models, Animal; Dose-Response Relationship, Drug; End

2014
Prospective registry of carotid artery stenting in Japan--investigation on device and antiplatelet for carotid artery stenting.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2014, Volume: 23, Issue:6

    Topics: Aged; Aged, 80 and over; Aspirin; Carotid Arteries; Carotid Stenosis; Cilostazol; Clopidogrel; Drug

2014
Continuous daily use of cilostazol prevents in-stent restenosis following carotid artery stenting: serial angiographic investigation of 229 lesions.
    Journal of neurointerventional surgery, 2016, Volume: 8, Issue:5

    Topics: Aged; Aged, 80 and over; Angiography; Carotid Artery, Common; Carotid Stenosis; Cilostazol; Drug Adm

2016
Influence of Diabetes Mellitus and Cigarette Smoking on Variability of the Clopidogrel-Induced Antiplatelet Effect and Efficacy of Active Management of the Target P2Y12 Reaction Unit Range in Patients Undergoing Neurointerventional Procedures.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016, Volume: 25, Issue:1

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aspirin; Carotid Stenosis; Cilostazol; Clopidogrel; Dia

2016
Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion.
    Stroke, 2016, Volume: 47, Issue:2

    Topics: Animals; Behavior, Animal; Brain Ischemia; Carotid Stenosis; Chronic Disease; Cilostazol; Cognition;

2016
Activation of tyrosine hydroxylase prevents pneumonia in a rat chronic cerebral hypoperfusion model.
    Neuroscience, 2009, Jan-23, Volume: 158, Issue:2

    Topics: Animals; Bacteria; Carotid Stenosis; Chronic Disease; Cilostazol; Corpus Striatum; Cyclic AMP Respon

2009
Crucial role for Ser133-phosphorylated form of cyclic AMP-responsive element binding protein signaling in the differentiation and survival of neural progenitors under chronic cerebral hypoperfusion.
    Neuroscience, 2009, Aug-18, Volume: 162, Issue:2

    Topics: Animals; Apoptosis; Brain Ischemia; Carotid Stenosis; Cerebral Ventricles; Cerebrovascular Circulati

2009
Periprocedural cilostazol treatment and restenosis after carotid artery stenting: the Retrospective Study of In-Stent Restenosis after Carotid Artery Stenting (ReSISteR-CAS).
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2012, Volume: 21, Issue:3

    Topics: Aged; Carotid Stenosis; Cilostazol; Female; Graft Occlusion, Vascular; Humans; Male; Middle Aged; Pl

2012
Quantitative assessment of changes in carotid plaques during cilostazol administration using three-dimensional ultrasonography and non-gated magnetic resonance plaque imaging.
    Neuroradiology, 2012, Volume: 54, Issue:9

    Topics: Aged; Carotid Stenosis; Cilostazol; Female; Humans; Imaging, Three-Dimensional; Magnetic Resonance I

2012
[A case of carotid stenting via the transbrachial approach in the bovine arch].
    No shinkei geka. Neurological surgery, 2006, Volume: 34, Issue:3

    Topics: Aged; Aspirin; Brachial Artery; Carotid Artery, Common; Carotid Artery, Internal; Carotid Stenosis;

2006