cilostazol has been researched along with Brain Edema in 2 studies
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the non-rtPA cohort, pretreatment by cilostazol significantly decreased the endothelial expression of adhesion molecules (P-selectin and intercellular adhesion molecule-1) and prevented platelet aggregation and leukocyte plugging in the microvessels after cerebral ischemia/reperfusion in the acute phase." | 7.78 | Cilostazol, a phosphodiesterase inhibitor, prevents no-reflow and hemorrhage in mice with focal cerebral ischemia. ( Fujita, Y; Hase, Y; Ihara, M; Ito, H; Kitamura, A; Maki, T; Nakabayashi, H; Okamoto, Y; Takahashi, R; Washida, K, 2012) |
| "Oral treatment with cilostazol 30 mg/kg two times at 5 min and 4 h significantly suppressed the hemispheric lesion area and volumes when detected by ADC, T2 images and histology, but 3 and 10 mg/kg cilostazol were without effect." | 5.32 | Cilostazol reduces brain lesion induced by focal cerebral ischemia in rats--an MRI study. ( Fukunaga, M; Hong, KW; Hosokawa, T; Ishikawa, M; Koga, K; Lee, JH; Lee, YK; Miyakoda, G; Mori, T, 2003) |
| "In the non-rtPA cohort, pretreatment by cilostazol significantly decreased the endothelial expression of adhesion molecules (P-selectin and intercellular adhesion molecule-1) and prevented platelet aggregation and leukocyte plugging in the microvessels after cerebral ischemia/reperfusion in the acute phase." | 3.78 | Cilostazol, a phosphodiesterase inhibitor, prevents no-reflow and hemorrhage in mice with focal cerebral ischemia. ( Fujita, Y; Hase, Y; Ihara, M; Ito, H; Kitamura, A; Maki, T; Nakabayashi, H; Okamoto, Y; Takahashi, R; Washida, K, 2012) |
| "Oral treatment with cilostazol 30 mg/kg two times at 5 min and 4 h significantly suppressed the hemispheric lesion area and volumes when detected by ADC, T2 images and histology, but 3 and 10 mg/kg cilostazol were without effect." | 1.32 | Cilostazol reduces brain lesion induced by focal cerebral ischemia in rats--an MRI study. ( Fukunaga, M; Hong, KW; Hosokawa, T; Ishikawa, M; Koga, K; Lee, JH; Lee, YK; Miyakoda, G; Mori, T, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hase, Y | 1 |
| Okamoto, Y | 1 |
| Fujita, Y | 1 |
| Kitamura, A | 1 |
| Nakabayashi, H | 1 |
| Ito, H | 1 |
| Maki, T | 1 |
| Washida, K | 1 |
| Takahashi, R | 1 |
| Ihara, M | 1 |
| Lee, JH | 1 |
| Lee, YK | 1 |
| Ishikawa, M | 1 |
| Koga, K | 1 |
| Fukunaga, M | 1 |
| Miyakoda, G | 1 |
| Mori, T | 1 |
| Hosokawa, T | 1 |
| Hong, KW | 1 |
2 other studies available for cilostazol and Brain Edema
| Article | Year |
|---|---|
Cilostazol, a phosphodiesterase inhibitor, prevents no-reflow and hemorrhage in mice with focal cerebral ischemia.
Topics: Administration, Oral; Animals; Antigens, CD; Brain; Brain Edema; Brain Ischemia; Calcium-Binding Pro | 2012 |
Cilostazol reduces brain lesion induced by focal cerebral ischemia in rats--an MRI study.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Cilostazol; Magnetic Resonance Imaging; Male; Rats; Rat | 2003 |