cilostazol has been researched along with Arthritis, Rheumatoid in 6 studies
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, the effects of the phosphodiesterase (PDE) inhibitors vardenafil and cilostazol were examined against rheumatoid arthritis (RA)/diabetes mellitus (DM)-co-morbidity-induced endothelial dysfunction and vascular reactivity defects." | 7.91 | Vardenafil and cilostazol can improve vascular reactivity in rats with diabetes mellitus and rheumatoid arthritis co-morbidity. ( Abo-Saif, AA; El-Daly, ME; Messiha, BAS; Wahba, MGF, 2019) |
| "The present study assessed the effects of cilostazol on LPS-stimulated TLR4 signal pathways in synovial macrophages from patients with rheumatoid arthritis (RA)." | 7.79 | Suppression of PU.1-linked TLR4 expression by cilostazol with decrease of cytokine production in macrophages from patients with rheumatoid arthritis. ( Baek, SH; Hong, KW; Kim, CD; Lee, CW; Lee, SW; Lee, WS; Park, SY; Rhim, BY, 2013) |
| "This study aimed to assess the beneficial effects of the concurrent administration of cilostazol and methotrexate (MTX) on the synovial fibroblasts obtained from patients with rheumatoid arthritis (RA), and in a mouse model of collagen-induced arthritis (CIA)." | 7.78 | Efficacy of concurrent administration of cilostazol and methotrexate in rheumatoid arthritis: pharmacologic and clinical significance. ( Baek, SH; Hong, KW; Kim, CD; Kim, HY; Lee, CW; Lee, SW; Park, SY, 2012) |
| "To assess the effects of cilostazol in inhibiting proliferation and enhancing apoptosis in synovial cells from patients with rheumatoid arthritis (RA)." | 7.76 | Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2-linked heme oxygenase 1 induction. ( Chung, WT; Hong, KW; Kim, CD; Lee, SW; Lee, WS; Park, SY; Rhim, BY; Shin, HK, 2010) |
| " Here, the effects of the phosphodiesterase (PDE) inhibitors vardenafil and cilostazol were examined against rheumatoid arthritis (RA)/diabetes mellitus (DM)-co-morbidity-induced endothelial dysfunction and vascular reactivity defects." | 3.91 | Vardenafil and cilostazol can improve vascular reactivity in rats with diabetes mellitus and rheumatoid arthritis co-morbidity. ( Abo-Saif, AA; El-Daly, ME; Messiha, BAS; Wahba, MGF, 2019) |
| "The present study assessed the effects of cilostazol on LPS-stimulated TLR4 signal pathways in synovial macrophages from patients with rheumatoid arthritis (RA)." | 3.79 | Suppression of PU.1-linked TLR4 expression by cilostazol with decrease of cytokine production in macrophages from patients with rheumatoid arthritis. ( Baek, SH; Hong, KW; Kim, CD; Lee, CW; Lee, SW; Lee, WS; Park, SY; Rhim, BY, 2013) |
| "This study aimed to assess the beneficial effects of the concurrent administration of cilostazol and methotrexate (MTX) on the synovial fibroblasts obtained from patients with rheumatoid arthritis (RA), and in a mouse model of collagen-induced arthritis (CIA)." | 3.78 | Efficacy of concurrent administration of cilostazol and methotrexate in rheumatoid arthritis: pharmacologic and clinical significance. ( Baek, SH; Hong, KW; Kim, CD; Kim, HY; Lee, CW; Lee, SW; Park, SY, 2012) |
| "To assess the effects of cilostazol in inhibiting proliferation and enhancing apoptosis in synovial cells from patients with rheumatoid arthritis (RA)." | 3.76 | Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2-linked heme oxygenase 1 induction. ( Chung, WT; Hong, KW; Kim, CD; Lee, SW; Lee, WS; Park, SY; Rhim, BY; Shin, HK, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wahba, MGF | 1 |
| Messiha, BAS | 1 |
| El-Daly, ME | 1 |
| Abo-Saif, AA | 1 |
| Park, SY | 5 |
| Lee, SW | 5 |
| Lee, WS | 4 |
| Rhim, BY | 4 |
| Lee, SJ | 1 |
| Kwon, SM | 1 |
| Hong, KW | 5 |
| Kim, CD | 5 |
| Kim, HY | 2 |
| Lee, HR | 1 |
| Shin, HK | 1 |
| Chung, WT | 1 |
| Baek, SH | 2 |
| Lee, CW | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Phosphodiesterase 3 Inhibitor Cilostazol as Adjunct to Methotrexate in Patients With Rheumatoid Arthritis[NCT05594680] | Phase 3 | 70 participants (Anticipated) | Interventional | 2022-10-01 | Recruiting | ||
| Evaluation of the Effect of Cilostazol on the Clinical Outcomes of Rheumatoid Arthritis Patients[NCT05671497] | Phase 2/Phase 3 | 70 participants (Anticipated) | Interventional | 2022-11-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for cilostazol and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Vardenafil and cilostazol can improve vascular reactivity in rats with diabetes mellitus and rheumatoid arthritis co-morbidity.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cardiovascular Diseases; Cilostazol; Comorb | 2019 |
RhoA/ROCK-dependent pathway is required for TLR2-mediated IL-23 production in human synovial macrophages: suppression by cilostazol.
Topics: ADP Ribose Transferases; Amides; Animals; Arthritis, Rheumatoid; Botulinum Toxins; Case-Control Stud | 2013 |
Inhibition of HMGB1-induced angiogenesis by cilostazol via SIRT1 activation in synovial fibroblasts from rheumatoid arthritis.
Topics: Angiogenesis Inhibitors; Animals; Arthritis, Rheumatoid; Cells, Cultured; Cilostazol; Fibroblasts; H | 2014 |
Cilostazol enhances apoptosis of synovial cells from rheumatoid arthritis patients with inhibition of cytokine formation via Nrf2-linked heme oxygenase 1 induction.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Blotti | 2010 |
Efficacy of concurrent administration of cilostazol and methotrexate in rheumatoid arthritis: pharmacologic and clinical significance.
Topics: Animals; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Base Sequence; Cell Proliferation; | 2012 |
Efficacy of concurrent administration of cilostazol and methotrexate in rheumatoid arthritis: pharmacologic and clinical significance.
Topics: Animals; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Base Sequence; Cell Proliferation; | 2012 |
Efficacy of concurrent administration of cilostazol and methotrexate in rheumatoid arthritis: pharmacologic and clinical significance.
Topics: Animals; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Base Sequence; Cell Proliferation; | 2012 |
Efficacy of concurrent administration of cilostazol and methotrexate in rheumatoid arthritis: pharmacologic and clinical significance.
Topics: Animals; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Base Sequence; Cell Proliferation; | 2012 |
Suppression of PU.1-linked TLR4 expression by cilostazol with decrease of cytokine production in macrophages from patients with rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Cells, Cultured; Cilostazol; Cytokines; Diseas | 2013 |