cilostazol has been researched along with Aging in 10 studies
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, we tested whether cilostazol, a selective PDE3 inhibitor, prevents the cognitive deterioration that occurs during the course of normal aging in mice." | 3.88 | Long-term cilostazol administration prevents age-related decline of hippocampus-dependent memory in mice. ( Endo, S; Ito, H; Yanai, S, 2018) |
| "To investigate whether cilostazol (CAS 73963-72-1), a selective phosphodiesterase 3 inhibitor, reduces the progression of atherogenic diet-induced atherosclerosis, cilostazol was orally administered twice a day for 4 weeks to male apolipoprotein-E knockout (ApoE KO) mice." | 3.74 | Anti-atherosclerotic effect of cilostazol in apolipoprotein-E knockout mice. ( Hashimoto, A; Hirose, Y; Imaizumi, T; Ito, H; Miyakoda, G; Mori, T; Okutsu, R; Takase, H, 2007) |
| " This protective effect of cilostazol could be attributed to reduced oxidative stress, increased NO bioavailability and EDHF-type relaxation." | 1.48 | Phosphodiesterase-3 inhibitor cilostazol reverses endothelial dysfunction with ageing in rat mesenteric resistance arteries. ( Duarte, GP; Gomes-Pereira, L; Lima-Leal, GA; Moreira, HS; Santos-Rocha, J; Xavier, FE, 2018) |
| " Long-term administration of cilostazol restored the impaired context-dependent conditioned fear memory of SAMP8 to match that in normal aging control substrain SAMR1." | 1.46 | Long-term cilostazol administration ameliorates memory decline in senescence-accelerated mouse prone 8 (SAMP8) through a dual effect on cAMP and blood-brain barrier. ( Endo, S; Ishiwata, K; Ito, H; Toyohara, J; Yanai, S, 2017) |
| "Sildenafil failed to prevent CCH-induced retrograde amnesia, but it reduced hippocampal cell death." | 1.42 | Cilostazol but not sildenafil prevents memory impairment after chronic cerebral hypoperfusion in middle-aged rats. ( Bacarin, CC; de Oliveira, JN; de Oliveira, RM; Ferreira, ED; Godinho, J; Milani, H; Zaghi, GG, 2015) |
| "Intermittent claudication is a form of exercise intolerance characterized by muscle pain during walking in patients with peripheral artery disease (PAD)." | 1.40 | Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice. ( Alcantara, R; Baltgalvis, KA; Claypool, MD; Friera, AM; Godinez, G; Goff, D; Gururaja, T; Hansen, D; Hitoshi, Y; Jenkins, Y; Kinsella, TM; Lang, W; Lau, D; Li, W; Li, Y; Markovtsov, V; McCaughey, K; McLaughlin, J; Nguyen, H; Pan, A; Park, G; Payan, DG; Shaw, SJ; Singh, BK; Singh, R; Smith, IJ; Sun, TQ; Uy, G; White, K, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nurullahoğlu-Atalık, KE | 1 |
| Kutlu, S | 1 |
| Solak, H | 1 |
| Koca, RÖ | 1 |
| Yanai, S | 2 |
| Ito, H | 3 |
| Endo, S | 2 |
| Moreira, HS | 1 |
| Lima-Leal, GA | 1 |
| Santos-Rocha, J | 1 |
| Gomes-Pereira, L | 1 |
| Duarte, GP | 1 |
| Xavier, FE | 1 |
| Baltgalvis, KA | 1 |
| White, K | 1 |
| Li, W | 1 |
| Claypool, MD | 1 |
| Lang, W | 1 |
| Alcantara, R | 1 |
| Singh, BK | 1 |
| Friera, AM | 1 |
| McLaughlin, J | 1 |
| Hansen, D | 1 |
| McCaughey, K | 1 |
| Nguyen, H | 1 |
| Smith, IJ | 1 |
| Godinez, G | 1 |
| Shaw, SJ | 1 |
| Goff, D | 1 |
| Singh, R | 1 |
| Markovtsov, V | 1 |
| Sun, TQ | 1 |
| Jenkins, Y | 1 |
| Uy, G | 1 |
| Li, Y | 1 |
| Pan, A | 1 |
| Gururaja, T | 1 |
| Lau, D | 1 |
| Park, G | 1 |
| Hitoshi, Y | 1 |
| Payan, DG | 1 |
| Kinsella, TM | 1 |
| Godinho, J | 1 |
| de Oliveira, JN | 1 |
| Ferreira, ED | 1 |
| Zaghi, GG | 1 |
| Bacarin, CC | 1 |
| de Oliveira, RM | 1 |
| Milani, H | 1 |
| Toyohara, J | 1 |
| Ishiwata, K | 1 |
| Potente, M | 1 |
| Dimmeler, S | 1 |
| Ota, H | 1 |
| Eto, M | 1 |
| Ogawa, S | 1 |
| Iijima, K | 1 |
| Akishita, M | 1 |
| Ouchi, Y | 1 |
| Yashiro, Y | 1 |
| Ohhashi, T | 1 |
| Takase, H | 1 |
| Hashimoto, A | 1 |
| Okutsu, R | 1 |
| Hirose, Y | 1 |
| Imaizumi, T | 1 |
| Miyakoda, G | 1 |
| Mori, T | 1 |
1 review available for cilostazol and Aging
| Article | Year |
|---|---|
SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis.
Topics: Aging; Animals; Atherosclerosis; Cilostazol; Homeostasis; Humans; Nitric Oxide Synthase Type III; Ox | 2010 |
9 other studies available for cilostazol and Aging
| Article | Year |
|---|---|
Cilostazol enhances atorvastatin-induced vasodilation of female rat aorta during aging.
Topics: Aging; Animals; Aorta; Atorvastatin; Cilostazol; Dose-Response Relationship, Drug; Drug Combinations | 2017 |
Long-term cilostazol administration prevents age-related decline of hippocampus-dependent memory in mice.
Topics: Age Factors; Aging; Animals; Cilostazol; Conditioning, Classical; Exploratory Behavior; Hippocampus; | 2018 |
Phosphodiesterase-3 inhibitor cilostazol reverses endothelial dysfunction with ageing in rat mesenteric resistance arteries.
Topics: Aging; Animals; Arterial Pressure; Cilostazol; Cyclic Nucleotide Phosphodiesterases, Type 3; Endothe | 2018 |
Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Apolipoproteins E; Arginine; Cilostazol; Diet, High-F | 2014 |
Cilostazol but not sildenafil prevents memory impairment after chronic cerebral hypoperfusion in middle-aged rats.
Topics: Aging; Amnesia, Retrograde; Animals; Brain Ischemia; Carotid Artery Diseases; Carotid Artery, Intern | 2015 |
Long-term cilostazol administration ameliorates memory decline in senescence-accelerated mouse prone 8 (SAMP8) through a dual effect on cAMP and blood-brain barrier.
Topics: Aging; Amygdala; Animals; Blood-Brain Barrier; Capillary Permeability; Cilostazol; Conditioning, Cla | 2017 |
NO targets SIRT1: a novel signaling network in endothelial senescence.
Topics: Aging; Animals; Cardiovascular Agents; Cellular Senescence; Cilostazol; Drug Design; Endothelium, Va | 2008 |
Age-dependent changes in the regulatory roles of nitric oxide and vasodilator prostanoids on the mechanical activities of isolated rabbit spinal arterioles.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acetylcholine; Age Factors; Aging; Animals; Arginine; Arteriole | 2003 |
Anti-atherosclerotic effect of cilostazol in apolipoprotein-E knockout mice.
Topics: Aging; Animals; Apolipoproteins E; Atherosclerosis; Cholesterol; Cholesterol, HDL; Cilostazol; Lipid | 2007 |