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cilostazol and Acute Ischemic Stroke

cilostazol has been researched along with Acute Ischemic Stroke in 13 studies

Research Excerpts

ExcerptRelevanceReference
"We compared the risk of recurrent ischemic stroke, vascular events, and major bleeding between DAPT with cilostazol plus aspirin or clopidogrel and aspirin or clopidogrel alone in patients with ischemic stroke between 8 and 180 days before starting trial treatment and ECAS or without arterial stenosis."9.69Dual antiplatelet therapy with cilostazol in stroke patients with extracranial arterial stenosis or without arterial stenosis: A subgroup analysis of the CSPS.com trial. ( Hoshino, H; Kimura, K; Kitagawa, K; Minematsu, K; Okamura, S; Omae, K; Toyoda, K; Uchiyama, S; Yamaguchi, T, 2023)
"In the Cilostazol Stroke Prevention Study combination trial, patients with high-risk, non-cardioembolic ischemic stroke between 8 and 180 days after onset treated with aspirin or clopidogrel alone were recruited and randomly assigned to receive either monotherapy or dual antiplatelet therapy (DAPT) using cilostazol and followed up for 0."9.69Sex Difference in the Impact of Dual Antiplatelet Therapy using Cilostazol for Secondary Stroke Prevention: A Sub-Analysis of CSPS.com. ( Hoshino, H; Kimura, K; Minematsu, K; Omae, K; Origasa, H; Takahashi, K; Toyoda, K; Uchiyama, S; Yamaguchi, K; Yamaguchi, T, 2023)
" Patients with diagnosis codes for ischemic stroke without cardiac disease were included and divided into two groups, those receiving cilostazol and those receiving clopidogrel."8.31Long-term effectiveness and safety of cilostazol versus clopidogrel in secondary prevention of noncardioembolic ischemic stroke. ( Je, NK; Lee, YJ, 2023)
"Cilostazol is a PDE3 (phosphodiesterase III) inhibitor with a long track record of safety that is Food and Drug Administration and European Medicines Agency approved for the treatment of claudication in patients with peripheral arterial disease."6.72Cilostazol for Secondary Stroke Prevention: History, Evidence, Limitations, and Possibilities. ( de Havenon, A; Elm, JJ; Johnston, KC; Johnston, SC; Lansberg, MG; Madsen, TE; Sheth, KN; Shoamanesh, A; Toyoda, K; Turan, TN; Wardlaw, JM; Williams, OA, 2021)
"We compared the risk of recurrent ischemic stroke, vascular events, and major bleeding between DAPT with cilostazol plus aspirin or clopidogrel and aspirin or clopidogrel alone in patients with ischemic stroke between 8 and 180 days before starting trial treatment and ECAS or without arterial stenosis."5.69Dual antiplatelet therapy with cilostazol in stroke patients with extracranial arterial stenosis or without arterial stenosis: A subgroup analysis of the CSPS.com trial. ( Hoshino, H; Kimura, K; Kitagawa, K; Minematsu, K; Okamura, S; Omae, K; Toyoda, K; Uchiyama, S; Yamaguchi, T, 2023)
"In the Cilostazol Stroke Prevention Study combination trial, patients with high-risk, non-cardioembolic ischemic stroke between 8 and 180 days after onset treated with aspirin or clopidogrel alone were recruited and randomly assigned to receive either monotherapy or dual antiplatelet therapy (DAPT) using cilostazol and followed up for 0."5.69Sex Difference in the Impact of Dual Antiplatelet Therapy using Cilostazol for Secondary Stroke Prevention: A Sub-Analysis of CSPS.com. ( Hoshino, H; Kimura, K; Minematsu, K; Omae, K; Origasa, H; Takahashi, K; Toyoda, K; Uchiyama, S; Yamaguchi, K; Yamaguchi, T, 2023)
"Although dual antiplatelet therapy (DAPT) with aspirin and clopidogrel reduces the recurrence of ischemic stroke while significantly increasing the bleeding events compared with monotherapy, the CSPS."5.41Dual Antiplatelet Therapy Using Cilostazol With Aspirin or Clopidogrel: Subanalysis of the CSPS.com Trial. ( Hoshino, H; Houkin, K; Ishida, N; Isobe, M; Kimura, K; Matsumoto, M; Minematsu, K; Naritomi, H; Okada, Y; Omae, K; Origasa, H; Sakai, N; Tanaka, K; Terayama, Y; Tomimoto, H; Tominaga, T; Toyoda, K; Uchiyama, S; Yamaguchi, K; Yamaguchi, T; Yasuda, S, 2021)
" Search terms included ischemic stroke, aspirin, clopidogrel, dipyridamole, ticagrelor, cilostazol, prasugrel, glycoprotein IIb/IIIa inhibitors."5.22Antiplatelet Use in Ischemic Stroke. ( Ali, A; Baig, S; Bell, SM; Kamarova, M; Majid, A; Monks, K; Patel, H; Redgrave, J; Wasay, M, 2022)
" Cilostazol proved to be the most efficacious in reducing stroke recurrence and the risk of bleeding (RR = 0."5.22Antithrombotic therapy for secondary prevention in patients with stroke or transient ischemic attack: A multiple treatment network meta-analysis of randomized controlled trials. ( Bálint, A; El Abdallaoui, OEA; Komócsi, A; Kupó, P; Szapáry, L; Szapáry, LB; Tornyos, D, 2022)
" Randomized clinical trials that compared cilostazol to aspirin and reported the endpoints of ischemic stroke, intracranial hemorrhage and any bleeding were included."5.12Cilostazol Versus Aspirin for Secondary Stroke Prevention: Systematic Review and Meta-Analysis. ( Barrett, KM; Brott, TG; Ertekin-Taner, N; Gopal, N; Lin, MP; Meschia, JF; Ross, OA, 2021)
"Continuous treatment of cilostazol in patients with HD with PAD significantly decreases the risk of ED visits, hemorrhagic stroke, and cardiovascular events and improves ED visit-free and cardiovascular event-free rates during long-term follow-up."4.31Long-Term Effectiveness of Cilostazol in Patients with Hemodialysis with Peripheral Artery Disease. ( Chen, YY; Kao, ZK; Lin, CH; Wu, CK; Yang, YB; Yar, N, 2023)
"Patients who participated in the Acute Aspirin Plus Cilostazol Dual Therapy for Non-cardiogenic Stroke Patients Within 48 Hours of Symptom Onset (ADS) trial were included in this study."4.31Persistent High Pulse Pressure in Acute Non-Cardiogenic Ischemic Stroke as a Predictor of Neurological Deterioration and Recurrence of Ischemic Stroke: ADS Post-Hoc Analysis. ( Aoki, J; Fujimoto, S; Kimura, K; Matsuzono, K; Ozawa, T, 2023)
" Patients with diagnosis codes for ischemic stroke without cardiac disease were included and divided into two groups, those receiving cilostazol and those receiving clopidogrel."4.31Long-term effectiveness and safety of cilostazol versus clopidogrel in secondary prevention of noncardioembolic ischemic stroke. ( Je, NK; Lee, YJ, 2023)
"Cilostazol is a PDE3 (phosphodiesterase III) inhibitor with a long track record of safety that is Food and Drug Administration and European Medicines Agency approved for the treatment of claudication in patients with peripheral arterial disease."2.72Cilostazol for Secondary Stroke Prevention: History, Evidence, Limitations, and Possibilities. ( de Havenon, A; Elm, JJ; Johnston, KC; Johnston, SC; Lansberg, MG; Madsen, TE; Sheth, KN; Shoamanesh, A; Toyoda, K; Turan, TN; Wardlaw, JM; Williams, OA, 2021)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's13 (100.00)2.80

Authors

AuthorsStudies
de Havenon, A1
Sheth, KN1
Madsen, TE1
Johnston, KC1
Turan, TN1
Toyoda, K4
Elm, JJ1
Wardlaw, JM1
Johnston, SC1
Williams, OA1
Shoamanesh, A1
Lansberg, MG1
Kamarova, M1
Baig, S1
Patel, H1
Monks, K1
Wasay, M1
Ali, A1
Redgrave, J1
Majid, A1
Bell, SM1
Shah, J1
Liu, S1
Yu, W1
Shirai, Y1
Toi, S1
Adachi, U1
Tsutsumi, Y1
Kitagawa, K2
Uchiyama, S3
Okamura, S1
Omae, K3
Hoshino, H3
Kimura, K4
Minematsu, K3
Yamaguchi, T3
Tornyos, D1
Komócsi, A1
Bálint, A1
Kupó, P1
El Abdallaoui, OEA1
Szapáry, L1
Szapáry, LB1
Takahashi, K1
Yamaguchi, K2
Origasa, H2
Wu, CK1
Lin, CH1
Yar, N1
Kao, ZK1
Yang, YB1
Chen, YY1
Liu, H1
Shao, T1
Yang, T1
Li, D1
Wang, H1
Cheng, Y1
Zhang, T1
Zhang, J1
Ozawa, T1
Fujimoto, S1
Aoki, J1
Matsuzono, K1
Lee, YJ1
Je, NK1
Lin, MP1
Meschia, JF1
Gopal, N1
Barrett, KM1
Ross, OA1
Ertekin-Taner, N1
Brott, TG1
Ishida, N1
Sakai, N1
Okada, Y1
Tanaka, K1
Naritomi, H1
Houkin, K1
Isobe, M1
Matsumoto, M1
Tominaga, T1
Tomimoto, H1
Terayama, Y1
Yasuda, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Cilostazol Stroke Prevention Study for Antiplatelet Combination[NCT01995370]Phase 41,884 participants (Actual)Interventional2013-12-13Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for cilostazol and Acute Ischemic Stroke

ArticleYear
Cilostazol for Secondary Stroke Prevention: History, Evidence, Limitations, and Possibilities.
    Stroke, 2021, Volume: 52, Issue:10

    Topics: Cilostazol; Evidence-Based Medicine; Humans; Ischemic Stroke; Phosphodiesterase 3 Inhibitors; Second

2021
Antiplatelet Use in Ischemic Stroke.
    The Annals of pharmacotherapy, 2022, Volume: 56, Issue:10

    Topics: Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Humans; Ischemic Stroke; Platelet Aggre

2022
Contemporary antiplatelet therapy for secondary stroke prevention: a narrative review of current literature and guidelines.
    Stroke and vascular neurology, 2022, Volume: 7, Issue:5

    Topics: Aspirin; Brain Ischemia; Cilostazol; Clopidogrel; Dipyridamole; Humans; Ischemic Attack, Transient;

2022
Antithrombotic therapy for secondary prevention in patients with stroke or transient ischemic attack: A multiple treatment network meta-analysis of randomized controlled trials.
    PloS one, 2022, Volume: 17, Issue:8

    Topics: Aspirin; Cilostazol; Fibrinolytic Agents; Hemorrhage; Humans; Ischemic Attack, Transient; Ischemic S

2022
Cilostazol Versus Aspirin for Secondary Stroke Prevention: Systematic Review and Meta-Analysis.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2021, Volume: 30, Issue:3

    Topics: Aged; Anti-Inflammatory Agents; Aspirin; Cilostazol; Female; Humans; Intracranial Hemorrhages; Ische

2021

Trials

4 trials available for cilostazol and Acute Ischemic Stroke

ArticleYear
Cilostazol improves endothelial function in patients with ischemic stroke: A randomized controlled single-center study with flow-mediated dilation technique.
    Journal of the neurological sciences, 2022, 08-15, Volume: 439

    Topics: Brain Ischemia; Cilostazol; Dilatation; Humans; Ischemic Stroke; Platelet Aggregation Inhibitors; St

2022
Dual antiplatelet therapy with cilostazol in stroke patients with extracranial arterial stenosis or without arterial stenosis: A subgroup analysis of the CSPS.com trial.
    International journal of stroke : official journal of the International Stroke Society, 2023, Volume: 18, Issue:4

    Topics: Aspirin; Cerebral Infarction; Cilostazol; Clopidogrel; Constriction, Pathologic; Drug Therapy, Combi

2023
Sex Difference in the Impact of Dual Antiplatelet Therapy using Cilostazol for Secondary Stroke Prevention: A Sub-Analysis of CSPS.com.
    Journal of atherosclerosis and thrombosis, 2023, Jun-01, Volume: 30, Issue:6

    Topics: Cilostazol; Drug Therapy, Combination; Female; Humans; Ischemic Stroke; Male; Platelet Aggregation I

2023
Dual Antiplatelet Therapy Using Cilostazol With Aspirin or Clopidogrel: Subanalysis of the CSPS.com Trial.
    Stroke, 2021, Volume: 52, Issue:11

    Topics: Aged; Aspirin; Cerebral Hemorrhage; Cilostazol; Clopidogrel; Drug Therapy, Combination; Dual Anti-Pl

2021

Other Studies

4 other studies available for cilostazol and Acute Ischemic Stroke

ArticleYear
Long-Term Effectiveness of Cilostazol in Patients with Hemodialysis with Peripheral Artery Disease.
    Journal of atherosclerosis and thrombosis, 2023, Aug-01, Volume: 30, Issue:8

    Topics: Adult; Cilostazol; Hemorrhagic Stroke; Humans; Ischemic Stroke; Peripheral Arterial Disease; Platele

2023
Comparison of Cilostazol versus Clopidogrel in Addition to Aspirin in Patients with Ischemic Stroke who Underwent Intracranial or Extracranial Artery Stent Implantation.
    Journal of atherosclerosis and thrombosis, 2023, Aug-01, Volume: 30, Issue:8

    Topics: Arteries; Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Hemorrhage; Humans; Ischemic

2023
Persistent High Pulse Pressure in Acute Non-Cardiogenic Ischemic Stroke as a Predictor of Neurological Deterioration and Recurrence of Ischemic Stroke: ADS Post-Hoc Analysis.
    Journal of atherosclerosis and thrombosis, 2023, Nov-01, Volume: 30, Issue:11

    Topics: Blood Pressure; Cilostazol; Humans; Ischemic Attack, Transient; Ischemic Stroke; Recurrence; Stroke

2023
Long-term effectiveness and safety of cilostazol versus clopidogrel in secondary prevention of noncardioembolic ischemic stroke.
    European journal of clinical pharmacology, 2023, Volume: 79, Issue:8

    Topics: Aspirin; Cilostazol; Clopidogrel; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Hemorrhagi

2023