Page last updated: 2024-09-04

cilomilast and Pulmonary Disease, Chronic Obstructive

cilomilast has been researched along with Pulmonary Disease, Chronic Obstructive in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	28 (80.00)	29.6817
2010's	6 (17.14)	24.3611
2020's	1 (2.86)	2.80

Authors

Authors	Studies
Jabaris, SS; Kodimuthali, A; Pal, M	1
Huang, L; Jiang, HL; Lai, KF; Li, XS; Luo, ZH; Shan, WJ; Zhou, Q	1
Fortescue, R; Janjua, S; Poole, P	1
Chong, J; Leung, B; Poole, P	2
Fang, Q; Liu, X; Ma, Y; Michalski, J; Rennard, SI; Wang, J	1
Agusti, A	1
Barnhart, F; Canonica, WG; Knobil, K; Locantore, N; Morris, A; Rabe, KF; Rennard, S; Schachter, N; Zhu, Y	1
Tatlicioğlu, T	1
Black, PN; Chong, J; Leung, B; Poole, P	1
Dougall, IG; Ratcliffe, MJ	1
Giembycz, MA	3
Baan, R; Gauw, SA; Grootendorst, DC; Kelly, J; Murdoch, RD; Rabe, KF; Sterk, PJ	1
Amit, O; Barnes, NC; Brightling, CE; Compton, C; Edelson, J; Gamble, E; Grootendorst, DC; Hansel, TT; Jeffery, PK; Kroegel, C; Majumdar, S; Matin, D; Morell, F; Parker, D; Pavord, ID; Qiu, Y; Rabe, KF; Rennard, SI; Tat, T; Troy, S; Vignola, AM; Zhu, J	1
Bellia, V; Bousquet, J; Chiappara, G; Chimenti, L; Costanzo, G; Di Giorgi, R; Mirabella, F; Profita, M; Riccobono, L; Vignola, AM	1
Devillier, P	1
Kerstjens, HA; Timens, W	1
Dai, YR; Xia, XD; Xu, ZJ	1
Vignola, AM	1
Belleguic, C; Bertrand, C; Brinchault, G; Depincé, A; Lagente, V; Leportier-Comoy, C; Martin-Chouly, CA; Ouagued, M; Pruniaux, MP	1
Hanania, NA; Soto, FJ	1
Brown, WM	1
Cortijo, J; Morcillo, EJ; Sanz, MJ	1
Celli, B	1
Amit, O; Rennard, SI; Rickard, K; Schachter, N; Strek, M	1
Fan Chung, K	1
Daley-Yates, P; Down, G; Lim, S; Siederer, S	1
Artola, M; Berthelier, C; Bertrand, CP; Eichholtz, T; Lagente, V; Leclerc, O; Planquois, JM; Schmidlin, F	1
Bitter-Suermann, S; Kanniess, F; Magnussen, H; Watz, H	1
Schachter, EN	1
Ismail, MS; Martina, SD; Vesta, KS	1
Cui, X; Wang, D	1
Fitzgerald, M; Sturton, G	1

Reviews

23 review(s) available for cilomilast and Pulmonary Disease, Chronic Obstructive

Article	Year
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. Journal of medicinal chemistry, 2008, Sep-25, Volume: 51, Issue:18 Topics: Asthma; Humans; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive	2008
Phosphodiesterase-4 inhibitors for chronic obstructive pulmonary disease. The Cochrane database of systematic reviews, 2020, 05-01, Volume: 5 Topics: Administration, Oral; Aminopyridines; Benzamides; Cyclohexanecarboxylic Acids; Cyclopropanes; Diarrhea; Disease Progression; Forced Expiratory Volume; Humans; Middle Aged; Nitriles; Peak Expiratory Flow Rate; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Quality of Life; Randomized Controlled Trials as Topic; Thiazoles; Vital Capacity	2020
Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease. The Cochrane database of systematic reviews, 2017, 09-19, Volume: 9 Topics: Administration, Oral; Aminopyridines; Benzamides; Cyclohexanecarboxylic Acids; Cyclopropanes; Disease Progression; Forced Expiratory Volume; Humans; Nitriles; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Quality of Life; Randomized Controlled Trials as Topic	2017
Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease. The Cochrane database of systematic reviews, 2013, Nov-04, Issue:11 Topics: Administration, Oral; Aminopyridines; Benzamides; Cyclohexanecarboxylic Acids; Cyclopropanes; Forced Expiratory Volume; Humans; Nitriles; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Quality of Life; Randomized Controlled Trials as Topic	2013
The efficacy and safety of cilomilast in COPD. Drugs, 2008, Volume: 68 Suppl 2 Topics: Bronchodilator Agents; Carboxylic Acids; Clinical Trials, Phase III as Topic; Cyclohexanecarboxylic Acids; Double-Blind Method; Humans; Multicenter Studies as Topic; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic	2008
[Selective phosphodiesterase-4 (PDE-4) inhibitors in COPD]. Tuberkuloz ve toraks, 2008, Volume: 56, Issue:4 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Benzamides; Carboxylic Acids; Cyclic AMP; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive	2008
Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease. The Cochrane database of systematic reviews, 2011, May-11, Issue:5 Topics: Administration, Oral; Aminopyridines; Benzamides; Cyclohexanecarboxylic Acids; Cyclopropanes; Forced Expiratory Volume; Humans; Nitriles; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Quality of Life; Randomized Controlled Trials as Topic	2011
Development status of second generation PDE4 inhibitors for asthma and COPD: the story so far. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, 2002, Volume: 57, Issue:1 Topics: Aminopyridines; Asthma; Benzamides; Bronchodilator Agents; Carboxylic Acids; Cyclohexanecarboxylic Acids; Cyclopropanes; Drug Interactions; Humans; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive	2002
[Physiopathology of COPD: choosing the right therapeutic targets]. Revue de pneumologie clinique, 2003, Volume: 59, Issue:2 Pt 2 Topics: Adrenal Cortex Hormones; Aged; Albuterol; Animals; Bacterial Infections; Bronchodilator Agents; Carboxylic Acids; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Therapy, Combination; Humans; Inflammation; Mucociliary Clearance; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Alveoli; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Randomized Controlled Trials as Topic; Rats; Rolipram; Salmeterol Xinafoate; Smoking; Theophylline; Time Factors	2003
Phosphodiesterase 4 inhibitors: antiinflammatory therapy for chronic obstructive pulmonary disease at last? American journal of respiratory and critical care medicine, 2003, Oct-15, Volume: 168, Issue:8 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Anti-Inflammatory Agents; Bronchodilator Agents; Carboxylic Acids; CD8-Positive T-Lymphocytes; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Humans; Inflammation; Leukocyte Count; Neutrophils; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive	2003
[Phosphosdiesterase 4 inhibitors in the treatment of pulmonary diseases]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2004, Volume: 27, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Asthma; Benzamides; Bronchodilator Agents; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Lung Diseases; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyridines	2004
PDE4 inhibitors in COPD--a more selective approach to treatment. Respiratory medicine, 2004, Volume: 98, Issue:6 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Benzamides; Bronchodilator Agents; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Nitriles; Phosphodiesterase Inhibitors; Pneumonia; Pulmonary Disease, Chronic Obstructive; Rolipram; Theophylline; Treatment Outcome	2004
Selective phosphodiesterase-4 inhibitors in chronic obstructive lung disease. Current opinion in pulmonary medicine, 2005, Volume: 11, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amides; Aminopyridines; Benzamides; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Indoles; Inflammation; Lung; Nitriles; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Disease, Chronic Obstructive	2005
Cilomilast GlaxoSmithKline. Current opinion in investigational drugs (London, England : 2000), 2005, Volume: 6, Issue:5 Topics: Animals; Carboxylic Acids; Cyclohexanecarboxylic Acids; Drug Industry; Humans; Meta-Analysis as Topic; Nitriles; Pulmonary Disease, Chronic Obstructive	2005
PDE4 inhibitors as new anti-inflammatory drugs: effects on cell trafficking and cell adhesion molecules expression. Pharmacology & therapeutics, 2005, Volume: 106, Issue:3 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Anti-Inflammatory Agents; Benzamides; Carboxylic Acids; Cell Adhesion Molecules; Cell Movement; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive	2005
Phosphodiesterase inhibitors in airways disease. European journal of pharmacology, 2006, Mar-08, Volume: 533, Issue:1-3 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Aminopyridines; Animals; Anti-Inflammatory Agents; Asthma; Benzamides; Carboxylic Acids; Clinical Trials as Topic; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Cyclic Nucleotide Phosphodiesterases, Type 7; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Isoenzymes; Nitriles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Disease, Chronic Obstructive	2006
Clinical pharmacology of Cilomilast. Clinical pharmacokinetics, 2006, Volume: 45, Issue:3 Topics: Animals; Carboxylic Acids; Cyclohexanecarboxylic Acids; Drug Interactions; Humans; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive	2006
[Pharmacological treatment of COPD and future of anti-inflammatory therapy]. Medizinische Klinik (Munich, Germany : 1983), 2006, Apr-15, Volume: 101, Issue:4 Topics: Acetylcysteine; Administration, Inhalation; Adrenal Cortex Hormones; Adrenergic beta-Agonists; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Bronchodilator Agents; Carboxylic Acids; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; Dyspnea; Expectorants; Forced Expiratory Volume; Forecasting; Humans; Inflammation; Infliximab; Lung; Macrolides; Nitriles; Phosphodiesterase Inhibitors; Pilot Projects; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Research; Respiratory Function Tests; Simvastatin; Smoking Cessation; Tetracycline; Theophylline; Tumor Necrosis Factor-alpha	2006
Cilomilast. Drugs of today (Barcelona, Spain : 1998), 2006, Volume: 42, Issue:4 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Bronchodilator Agents; Carboxylic Acids; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Drug Administration Schedule; Drug Interactions; Humans; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic	2006
An update and appraisal of the cilomilast Phase III clinical development programme for chronic obstructive pulmonary disease. British journal of clinical pharmacology, 2006, Volume: 62, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Aged, 80 and over; Carboxylic Acids; Clinical Trials, Phase III as Topic; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Female; Humans; Male; Middle Aged; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive; Research Design; Respiratory Function Tests; Treatment Outcome	2006
Cilomilast: orally active selective phosphodiesterase-4 inhibitor for treatment of chronic obstructive pulmonary disease. The Annals of pharmacotherapy, 2006, Volume: 40, Issue:10 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Humans; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive	2006
Evaluation of PDE4 inhibition for COPD. International journal of chronic obstructive pulmonary disease, 2006, Volume: 1, Issue:4 Topics: Aminopyridines; Benzamides; Calcium Channel Blockers; Carboxylic Acids; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Nitriles; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pulmonary Circulation; Pulmonary Disease, Chronic Obstructive; Severity of Illness Index	2006
Phosphodiesterase 4 inhibitors for the treatment of COPD. Chest, 2002, Volume: 121, Issue:5 Suppl Topics: Aminopyridines; Animals; Benzamides; Bronchodilator Agents; Carboxylic Acids; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cyclohexanecarboxylic Acids; Cyclopropanes; Humans; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive	2002

Trials

4 trial(s) available for cilomilast and Pulmonary Disease, Chronic Obstructive

Article	Year
Does a single dose of the phosphodiesterase 4 inhibitor, cilomilast (15 mg), induce bronchodilation in patients with chronic obstructive pulmonary disease? Pulmonary pharmacology & therapeutics, 2003, Volume: 16, Issue:2 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Albuterol; Analysis of Variance; Area Under Curve; Bronchodilator Agents; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Ipratropium; Male; Maximal Expiratory Flow Rate; Middle Aged; Nitriles; Pulmonary Disease, Chronic Obstructive	2003
Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine, 2003, Oct-15, Volume: 168, Issue:8 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biopsy; Bronchodilator Agents; Carboxylic Acids; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Interleukin-8; Leukocyte Count; Leukocyte Elastase; Male; Middle Aged; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive; Sputum; Treatment Outcome	2003
The novel phosphodiesterase 4 inhibitor, CI-1044, inhibits LPS-induced TNF-alpha production in whole blood from COPD patients. Pulmonary pharmacology & therapeutics, 2005, Volume: 18, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Azepines; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dexamethasone; Dose-Response Relationship, Drug; Female; France; Humans; Male; Middle Aged; Niacinamide; Nitriles; Phosphodiesterase Inhibitors; Polysaccharides, Bacterial; Pulmonary Disease, Chronic Obstructive; Rolipram; Tumor Necrosis Factor-alpha	2005
Cilomilast for COPD: results of a 6-month, placebo-controlled study of a potent, selective inhibitor of phosphodiesterase 4. Chest, 2006, Volume: 129, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Aged; Aged, 80 and over; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Forced Expiratory Volume; Humans; Male; Middle Aged; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive; Retrospective Studies; Treatment Outcome	2006

Other Studies

8 other study(ies) available for cilomilast and Pulmonary Disease, Chronic Obstructive

Article	Year
Dual β2-adrenoceptor agonists-PDE4 inhibitors for the treatment of asthma and COPD. Bioorganic & medicinal chemistry letters, 2012, Feb-15, Volume: 22, Issue:4 Topics: Adrenergic beta-2 Receptor Agonists; Animals; Asthma; Drug Design; Guinea Pigs; Inhibitory Concentration 50; Molecular Structure; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Trachea	2012
PGE 2 desensitizes β -agonist effect on human lung fibroblast-mediated collagen gel contraction through upregulating PDE4. Mediators of inflammation, 2013, Volume: 2013 Topics: Adrenergic beta-2 Receptor Agonists; Albuterol; Anti-Inflammatory Agents, Non-Steroidal; Collagen; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dinoprostone; Fibroblasts; Gels; Gene Expression Regulation; Humans; Indomethacin; Lung; Nitriles; Phosphodiesterase 4 Inhibitors; Pulmonary Disease, Chronic Obstructive; Salmeterol Xinafoate; Up-Regulation	2013
The efficacy and safety of cilomilast in COPD. Forward. Drugs, 2008, Volume: 68 Suppl 2 Topics: Bronchodilator Agents; Carboxylic Acids; Cyclohexanecarboxylic Acids; Humans; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive	2008
Comparison of the anti-inflammatory effects of Cilomilast, Budesonide and a p38 Mitogen activated protein kinase inhibitor in COPD lung tissue macrophages. BMC pharmacology & toxicology, 2012, Nov-13, Volume: 13 Topics: Anti-Inflammatory Agents; Budesonide; Cells, Cultured; Cyclohexanecarboxylic Acids; Female; Humans; Interleukin-6; Lipopolysaccharides; Macrophages, Alveolar; Male; Middle Aged; Naphthalenes; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase 4 Inhibitors; Protein Kinase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Tumor Necrosis Factor-alpha	2012
Effect of cilomilast (Ariflo) on TNF-alpha, IL-8, and GM-CSF release by airway cells of patients with COPD. Thorax, 2003, Volume: 58, Issue:7 Topics: Adult; Aged; Bronchodilator Agents; Carboxylic Acids; Cell Count; Cells, Cultured; Chemotaxis, Leukocyte; Cyclohexanecarboxylic Acids; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-8; Male; Middle Aged; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive; Respiratory Mucosa; Sputum; Tumor Necrosis Factor-alpha	2003
COPD, inflammation and its modulation by phosphodiesterase 4 inhibitors: time to look beyond the FEV1. Chest, 2006, Volume: 129, Issue:1 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Carboxylic Acids; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Forced Expiratory Volume; Humans; Inflammation; Nitriles; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive; Treatment Outcome	2006
Involvement of MMP-12 and phosphodiesterase type 4 in cigarette smoke-induced inflammation in mice. The European respiratory journal, 2006, Volume: 27, Issue:6 Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Bronchoalveolar Lavage Fluid; Carboxylic Acids; Chromosome Deletion; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Matrix Metalloproteinase 12; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Neutrophils; Nitriles; Pneumonia; Pulmonary Disease, Chronic Obstructive; Smoking	2006
Cilomilast: a breath of relief? Trends in molecular medicine, 2001, Volume: 7, Issue:10 Topics: Bronchodilator Agents; Carboxylic Acids; Clinical Trials, Phase III as Topic; Cyclohexanecarboxylic Acids; Humans; Lung; Multicenter Studies as Topic; Nitriles; Pulmonary Disease, Chronic Obstructive	2001