Compounds > cilomilast
Page last updated: 2024-09-04

cilomilast and Emesis

cilomilast has been researched along with Emesis in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's6 (60.00)29.6817
2010's2 (20.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Barnette, MS; Bartus, JO; Bender, PE; Bochnowicz, S; Burman, M; Christensen, SB; Cieslinski, LB; DeWolf, WE; Eggleston, DS; Forster, CJ; Gleason, JG; Griswold, DE; Grous, M; Guider, A; Haltiwanger, RC; Hillegas, LM; Karpinski, JM; Manning, CD; Osborn, RR; Ryan, MD; Torphy, TJ; Underwood, DC1
Auclair, E; Avenel, N; Bertin, B; Bigot, C; Burnouf, C; Calvet, A; Chan, K; Doherty, AM; Durand, C; Fasquelle, V; Féru, F; Gilbertsen, R; Jacobelli, H; Kebsi, A; Lallier, E; Maignel, J; Martin, B; Milano, S; Ouagued, M; Pascal, Y; Pruniaux, MP; Puaud, J; Rocher, MN; Terrasse, C; Wrigglesworth, R1
Ishida, A; Kishikawa, K; Kusumi, K; Nakai, H; Obata, T; Ochiai, H; Ohtani, T; Toda, M1
Bachert, EL; Cheng, JB; Cohan, VL; Duplantier, AJ; Jenkinson, TH; Kraus, KG; McKechney, MW; Pillar, JD; Watson, JW1
Kawanishi, M; Kawasaki, K; Kodama, T; Kubota, T; Maekawara, N; Naganuma, K; Nagumo, H; Nakamura, J; Ohkawa, N; Ohtsuka, Y; Omura, A; Saitoh, M; Takemura, M; Tsujita, R; Yokoi, H1
He, J; Ke, H; Peng, T; Qi, B; Shi, J1
Balachandran, S; Chaudhary, S; Dastidar, SG; Gupta, N; Nanda, K; Palle, V; Rajagopal, D; Ray, A; Seth, MK; Sharma, P; Shirumalla, R1
Ball, D; Barnette, MS; Capper-Spudich, EA; Davis, TG; Ferrari, L; Knowles, RG; Kou, JP; Lucas, FS; Nials, AT; Peterson, JJ; Podolin, PL; Solanke, YE; Williamson, RA; Wiseman, J; Wren, P1
Asaka, N; Kakuo, H; Kiniwa, M; Ohmori, K; Oka, T; Sasaki, E; Togawa, M; Yamada, S1
Iwata, M; Kobayashi, M; Kubo, S; Ohtsu, Y; Shimizu, Y; Takahashi, K1

Reviews

1 review(s) available for cilomilast and Emesis

ArticleYear
Advances in the Development of Phosphodiesterase-4 Inhibitors.
    Journal of medicinal chemistry, 2020, 10-08, Volume: 63, Issue:19

    Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Development; Drug Discovery; Humans; Molecular Structure; Phosphodiesterase 4 Inhibitors; Protein Conformation; Quinolones; Vomiting

2020

Other Studies

9 other study(ies) available for cilomilast and Emesis

ArticleYear
1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma.
    Journal of medicinal chemistry, 1998, Mar-12, Volume: 41, Issue:6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Body Temperature; Brain; Bronchoconstriction; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Dogs; Gastric Acid; Guinea Pigs; Humans; Mice; Monocytes; Nitriles; Phosphodiesterase Inhibitors; Pyrrolidinones; Rabbits; Recombinant Proteins; Rolipram; Stereoisomerism; Structure-Activity Relationship; Tumor Necrosis Factor-alpha; Vomiting

1998
Synthesis, structure-activity relationships, and pharmacological profile of 9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro[1,4]diazepino[6, 7,1-hi]indoles: discovery of potent, selective phosphodiesterase type 4 inhibitors.
    Journal of medicinal chemistry, 2000, Dec-14, Volume: 43, Issue:25

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Azepines; Binding, Competitive; Brain; Bronchoalveolar Lavage; Cell Line; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Dogs; Eosinophils; Ferrets; Guinea Pigs; Humans; In Vitro Techniques; Indoles; Isoenzymes; Male; Monocytes; Niacinamide; Ovalbumin; Phosphodiesterase I; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Radioligand Assay; Rats; Rats, Wistar; Structure-Activity Relationship; Trachea; Tumor Necrosis Factor-alpha; Vomiting

2000
New orally active PDE4 inhibitors with therapeutic potential.
    Bioorganic & medicinal chemistry letters, 2004, Jan-05, Volume: 14, Issue:1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Oral; Animals; Bronchoconstriction; Bronchoconstrictor Agents; Cyclic Nucleotide Phosphodiesterases, Type 4; Ferrets; Gastric Emptying; Guinea Pigs; Humans; Phosphodiesterase Inhibitors; Pyrazoles; Pyridines; Rats; Tumor Necrosis Factor-alpha; Vomiting

2004
SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase.
    Journal of medicinal chemistry, 2007, Jan-25, Volume: 50, Issue:2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Biological Availability; Cyclic Nucleotide Phosphodiesterases, Type 4; Dogs; Eosinophils; Female; Ferrets; Heterocyclic Compounds, 3-Ring; Humans; In Vitro Techniques; Isoenzymes; Male; Phosphodiesterase Inhibitors; Pyrazoles; Pyridines; Rats; Recombinant Proteins; Structure-Activity Relationship; Triazoles; Vomiting

2007
Discovery of selective PDE4B inhibitors.
    Bioorganic & medicinal chemistry letters, 2009, Jun-15, Volume: 19, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Area Under Curve; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Discovery; Humans; Inhibitory Concentration 50; Mice; Phenylacetates; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pyrimidines; Structure-Activity Relationship; Thiophenes; Tumor Necrosis Factor-alpha; Vomiting

2009
Pharmacology of a novel, orally active PDE4 inhibitor.
    Pharmacology, 2009, Volume: 83, Issue:5

    Topics: Animals; Carboxylic Acids; Cell Line, Transformed; Cyclic AMP; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dogs; Female; Guinea Pigs; Humans; Inflammation; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Nitriles; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Rolipram; Tumor Necrosis Factor-alpha; Vomiting

2009
The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 330, Issue:3

    Topics: Aminopyridines; Animals; Benzamides; Carboxylic Acids; Cyclohexanecarboxylic Acids; Cyclopropanes; Ferrets; Humans; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Neutrophils; Nitriles; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pica; Piperazines; Pyridines; Rats; Rats, Inbred Lew; Receptors, Adrenergic, alpha-2; Rolipram; Tumor Necrosis Factor-alpha; Vomiting

2009
Effects of the new benzimidazole derivative TAS-203, an orally active phosphodiesterase 4 inhibitor, on airway inflammation in rats and emetic responses in ferrets.
    Arzneimittel-Forschung, 2010, Volume: 60, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Benzimidazoles; Chemotaxis, Leukocyte; Cloning, Molecular; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Ferrets; Guinea Pigs; Humans; Inflammation; Lipopolysaccharides; Male; Nitriles; Phosphodiesterase 4 Inhibitors; Platelet Activating Factor; Rats; Rats, Inbred BN; Rats, Inbred Lew; Respiratory Tract Diseases; Tissue Distribution; Triazoles; Tumor Necrosis Factor-alpha; Vomiting

2010
ASP3258, an orally active potent phosphodiesterase 4 inhibitor with low emetic activity.
    International immunopharmacology, 2011, Volume: 11, Issue:6

    Topics: Adrenergic alpha-2 Receptor Antagonists; Aminopyridines; Animals; Benzamides; Blood Cells; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Cyclopropanes; Enzyme Inhibitors; Ferrets; Interleukin-4; Lipopolysaccharides; Macrophages, Alveolar; Naphthyridines; Nitriles; Pneumonia; Rats; Tumor Necrosis Factor-alpha; Vomiting

2011