cilastatin--imipenem-drug-combination and Ureteral-Calculi

Although septic shock has a high mortality rate of 43%, recently the endotoxin adsorption column was established and its efficacy is interesting. We report a very effective case of endotoxin adsorption the rapy for septic shock due to acute pyelonephritis. A 59-year-old man with chief complaints of pyrexia and right backache was referred to our hospital with a small right ureteral stone (4 mm) associated with a low degree of right hydronephrosis. Since it was diagnosed as right acute pyelonephritis, antibiotics were administered; and then septic shock occurred on the day of hospitalization. Endotoxin adsorption therapy was performed for two days and hemodynamic stability was achieved. The concentration of blood endotoxin was reduced remarkably and the efficacy of endotoxin adsorption therapy was suggested.

Topics: Acute Disease; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinations; Endotoxins; Escherichia coli; Escherichia coli Infections; Hemofiltration; Humans; Imipenem; Male; Middle Aged; Pyelonephritis; Shock, Septic; Sorption Detoxification; Treatment Outcome; Ureteral Calculi