cilastatin--imipenem-drug-combination and Liver-Failure

Carbapenems are broad-spectrum antibacterial molecules. Imipenem-cilastatin and meropenem are the two main molecules used in French healthcare services.. We aimed to evaluate the relative strengths and weaknesses of these two molecules by considering their pharmacokinetic, pharmacodynamic, microbiological, and clinical properties. We demonstrated that imipenem-cilastatin and meropenem are not alike.. Review of the literature by querying the MEDLINE network.. Imipenem-cilastatin is the first marketed molecule of the carbapenem class. It is more effective against Gram-positive cocci. Its stability does not allow for long infusions and its main adverse effect on the central nervous system limits its use. Meropenem is more effective against Gram-negative bacilli. Its stability and its milder adverse effects distinguish it from imipenem-cilastatin.. Meropenem is preferred for daily use in healthcare services when carbapenems are to be used.

Topics: Anti-Bacterial Agents; Bacterial Infections; Biotransformation; Child; Child, Preschool; Cilastatin, Imipenem Drug Combination; Contraindications, Drug; Drug Resistance, Microbial; Drug Resistance, Multiple, Bacterial; Drug Stability; Female; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Infant; Liver Failure; Meropenem; Molecular Structure; Organ Specificity; Pregnancy; Pregnancy Complications, Infectious; Protein Binding