ciglitazone has been researched along with Obesity in 11 studies
ciglitazone: structure given in second source; PPAR agonist used for type II diabetes
ciglitazone : An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Chronic administration of ADD-3878 for as long as 12 wk to young yellow KK mice, which were in the early stage of diabetes and obesity, depressed age-dependent rises in blood glucose, plasma triglyceride, and insulin without exerting any effect on obesity." | 5.27 | Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent. ( Fujita, T; Iwatsuka, H; Kawamatsu, Y; Sohda, T; Sugiyama, Y; Suzuoki, Z; Taketomi, S, 1983) |
| "Ciglitazone was also found to significantly attenuate the capacity of platelet-derived growth factor BB homodimer to induce sustained increases in intracellular free calcium." | 1.29 | Effects of ciglitazone on blood pressure and intracellular calcium metabolism. ( Benson, S; Feuerstein, BG; Hyun, WC; Kurtz, TW; Pershadsingh, HA; Szollosi, J, 1993) |
| " Chronic administration of ADD-3878 for as long as 12 wk to young yellow KK mice, which were in the early stage of diabetes and obesity, depressed age-dependent rises in blood glucose, plasma triglyceride, and insulin without exerting any effect on obesity." | 1.27 | Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent. ( Fujita, T; Iwatsuka, H; Kawamatsu, Y; Sohda, T; Sugiyama, Y; Suzuoki, Z; Taketomi, S, 1983) |
| "Ciglitazone treatment, which decreases insulin resistance in obese animals and leads to normalization of glucose metabolism in their pancreatic tissue, restored the enzyme-synthesis rates towards normal, showing that the abnormalities of enzyme synthesis were linked to the insulin resistance rather than to the obese genotype itself." | 1.27 | Changes in individual rates of pancreatic enzyme and isoenzyme biosynthesis in the obese Zucker rat. ( Kern, HF; Rausch, U; Trimble, ER, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, J | 1 |
| Oveisi, F | 1 |
| Gaetani, S | 1 |
| Lin, E | 1 |
| Piomelli, D | 1 |
| Seto, SW | 1 |
| Lam, TY | 1 |
| Leung, GP | 1 |
| Au, AL | 1 |
| Ngai, SM | 1 |
| Chan, SW | 1 |
| Kwan, YW | 1 |
| Kobayashi, M | 1 |
| Iwasaki, M | 1 |
| Ohgaku, S | 1 |
| Maegawa, H | 1 |
| Watanabe, N | 1 |
| Shigeta, Y | 1 |
| Fujita, T | 1 |
| Sugiyama, Y | 1 |
| Taketomi, S | 1 |
| Sohda, T | 1 |
| Kawamatsu, Y | 1 |
| Iwatsuka, H | 1 |
| Suzuoki, Z | 1 |
| Pershadsingh, HA | 1 |
| Szollosi, J | 1 |
| Benson, S | 1 |
| Hyun, WC | 1 |
| Feuerstein, BG | 1 |
| Kurtz, TW | 1 |
| Arakawa, K | 1 |
| Inamasu, M | 1 |
| Matsumoto, M | 1 |
| Okumura, K | 1 |
| Yasuda, K | 1 |
| Akatsuka, H | 1 |
| Kawanami, S | 1 |
| Watanabe, A | 1 |
| Homma, K | 1 |
| Saiga, Y | 1 |
| Ozeki, M | 1 |
| Iijima, I | 1 |
| Marra, F | 1 |
| Pastacaldi, S | 1 |
| Trimble, ER | 2 |
| Bruzzone, R | 1 |
| Belin, D | 1 |
| Chang, AY | 1 |
| Wyse, BM | 2 |
| Diani, AR | 1 |
| Sawada, GA | 1 |
| Rausch, U | 1 |
| Kern, HF | 1 |
1 review available for ciglitazone and Obesity
| Article | Year |
|---|---|
[Thiazolidinediones and PPARgamma system in repair of liver damage].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antioxidants; Arteriosclerosis; Chro | 2002 |
10 other studies available for ciglitazone and Obesity
| Article | Year |
|---|---|
Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats.
Topics: Animals; Body Weight; Butyrates; CD36 Antigens; Cholesterol; Coenzyme A Ligases; Eating; Endocannabi | 2005 |
Comparison of vascular relaxation, lipolysis and glucose uptake by peroxisome proliferator-activated receptor-gamma activation in +db/+m and +db/+db mice.
Topics: Abdominal Fat; Adipocytes; Animals; Aorta, Thoracic; Carbohydrate Metabolism; Chromans; Diabetes Mel | 2007 |
A new potentiator of insulin action. Post-receptor activation in vitro.
Topics: Adipose Tissue; Animals; Biological Transport, Active; Blood Glucose; Body Weight; Deoxyglucose; Dia | 1983 |
Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dogs; Fatty | 1983 |
Effects of ciglitazone on blood pressure and intracellular calcium metabolism.
Topics: Animals; Blood Pressure; Calcium; Female; Insulin; Intracellular Membranes; Obesity; Platelet-Derive | 1993 |
Novel benzoxazole 2,4-thiazolidinediones as potent hypoglycemic agents. Synthesis and structure-activity relationships.
Topics: Animals; Benzopyrans; Benzoxazoles; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypoglyc | 1997 |
Insulin resistance is accompanied by impairment of amylase-gene expression in the exocrine pancreas of the obese Zucker rat.
Topics: Amylases; Animals; Female; Gene Expression Regulation; Glucose; Insulin Resistance; Obesity; Pancrea | 1986 |
The hypoglycemic effect of ciglitazone in obese, hyperglycemic animal models.
Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Blood Glucose; Disease Models, Animal; Glycolysis; H | 1988 |
A review of the effects of ciglitazone on the pancreatic islets of obese, hyperglycemic mice.
Topics: Animals; Hyperglycemia; Hypoglycemic Agents; Insulin; Islets of Langerhans; Male; Mice; Mice, Obese; | 1988 |
Changes in individual rates of pancreatic enzyme and isoenzyme biosynthesis in the obese Zucker rat.
Topics: Amino Acids; Animals; Blood Glucose; Eating; Insulin; Isoelectric Focusing; Isoenzymes; Kinetics; Ob | 1987 |