ciglitazone has been researched along with Leiomyoma in 3 studies
ciglitazone: structure given in second source; PPAR agonist used for type II diabetes
ciglitazone : An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.
Leiomyoma: A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response studies on proliferation found that uterine leiomyoma was more sensitive to inhibition by ciglitizone treatments than normal myometrium." | 1.34 | Growth inhibition and apoptosis induced in human leiomyoma cells by treatment with the PPAR gamma ligand ciglitizone. ( Bae, I; Cha, SD; Cho, CH; Jeon, DS; Kwon, KY; Kwon, SH; Nam, DH; Ramachandran, S; Shin, SJ; Song, DK, 2007) |
| "Human leiomyomas were also found to express all three PPAR isoforms, and primary cultures of these cells were sensitive to the inhibitory effects of PPARgamma ligands." | 1.32 | Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. ( Broaddus, RR; Copland, JA; Fischer, SM; Gottardis, MM; Houston, KD; Walker, CL, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Houston, KD | 1 |
| Copland, JA | 1 |
| Broaddus, RR | 1 |
| Gottardis, MM | 1 |
| Fischer, SM | 1 |
| Walker, CL | 1 |
| Kim, BY | 1 |
| Cho, CH | 2 |
| Song, DK | 2 |
| Mun, KC | 1 |
| Suh, SI | 1 |
| Kim, SP | 1 |
| Shin, DH | 1 |
| Jang, BC | 1 |
| Kwon, TK | 1 |
| Cha, SD | 2 |
| Bae, I | 2 |
| Bae, JH | 1 |
| Nam, DH | 1 |
| Ramachandran, S | 1 |
| Kwon, KY | 1 |
| Jeon, DS | 1 |
| Shin, SJ | 1 |
| Kwon, SH | 1 |
3 other studies available for ciglitazone and Leiomyoma
| Article | Year |
|---|---|
Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma.
Topics: Animals; Cell Division; Chromans; Docosahexaenoic Acids; Estradiol; Female; Humans; Leiomyoma; Ligan | 2003 |
Ciglitizone inhibits cell proliferation in human uterine leiomyoma via activation of store-operated Ca2+ channels.
Topics: Calcium; Calcium Channels; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Fe | 2005 |
Growth inhibition and apoptosis induced in human leiomyoma cells by treatment with the PPAR gamma ligand ciglitizone.
Topics: Apoptosis; Blotting, Western; Caspase 8; Cell Cycle; Cell Proliferation; Dose-Response Relationship, | 2007 |