ciglitazone has been researched along with Glioma in 6 studies
ciglitazone: structure given in second source; PPAR agonist used for type II diabetes
ciglitazone : An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study was undertaken to determine the precise mechanism of cell death induced by ciglitazone, a synthetic PPAR gamma agonist, in A172 human glioma cells." | 7.74 | Ciglitazone induces caspase-independent apoptosis through down-regulation of XIAP and survivin in human glioma cells. ( Choi, CH; Kang, DW; Kang, SK; Kim, YK; Park, JY, 2008) |
| "Treatment with GW9662 followed by CGZ resulted in a down-regulation of Akt activity and the loss of mitochondrial membrane potential (MMP), which was accompanied by a decrease in Bcl-2 expression and an increase in Bid cleavage." | 5.38 | Cell death is induced by ciglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) agonist, independently of PPARγ in human glioma cells. ( Jung, HL; Kim, DS; Kim, HJ; Kim, HR; Koo, HH; Lee, MW; Lee, SH; Noh, YH; Ryu, S; Son, MH; Sung, KW; Yang, JM; Yoo, KH, 2012) |
| " The present study was undertaken to determine the precise mechanism of cell death induced by ciglitazone, a synthetic PPAR gamma agonist, in A172 human glioma cells." | 3.74 | Ciglitazone induces caspase-independent apoptosis through down-regulation of XIAP and survivin in human glioma cells. ( Choi, CH; Kang, DW; Kang, SK; Kim, YK; Park, JY, 2008) |
| " Agonists of the peroxisome proliferator-activated receptor-gamma (PPARgamma), such as rosiglitazone, have been recently demonstrated to regulate inflammation by modulating the production of inflammatory mediators and adhesion molecules." | 3.73 | Rosiglitazone ameliorates cisplatin-induced renal injury in mice. ( Jang, KY; Jang, YB; Kang, KP; Kim, DH; Kim, W; Lee, JE; Lee, S; Moon, SO; Park, SK; Sung, MJ, 2006) |
| "Treatment with GW9662 followed by CGZ resulted in a down-regulation of Akt activity and the loss of mitochondrial membrane potential (MMP), which was accompanied by a decrease in Bcl-2 expression and an increase in Bid cleavage." | 1.38 | Cell death is induced by ciglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) agonist, independently of PPARγ in human glioma cells. ( Jung, HL; Kim, DS; Kim, HJ; Kim, HR; Koo, HH; Lee, MW; Lee, SH; Noh, YH; Ryu, S; Son, MH; Sung, KW; Yang, JM; Yoo, KH, 2012) |
| "Taken together, treatment of glioma cells with PPARgamma agonists may hold therapeutic potential for the treatment of gliomas." | 1.31 | Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma. ( Feinstein, D; Grommes, C; Heneka, MT; Klockgether, T; Koenigsknecht, J; Kraus, JA; Landreth, G; Schlegel, U; Zander, T, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Sheu, ML | 1 |
| Pan, LY | 1 |
| Hu, HY | 1 |
| Su, HL | 1 |
| Sheehan, J | 1 |
| Tsou, HK | 1 |
| Pan, HC | 1 |
| Lee, MW | 1 |
| Kim, DS | 1 |
| Kim, HR | 1 |
| Kim, HJ | 1 |
| Yang, JM | 1 |
| Ryu, S | 1 |
| Noh, YH | 1 |
| Lee, SH | 1 |
| Son, MH | 1 |
| Jung, HL | 1 |
| Yoo, KH | 1 |
| Koo, HH | 1 |
| Sung, KW | 1 |
| Lee, S | 1 |
| Kim, W | 1 |
| Moon, SO | 1 |
| Sung, MJ | 1 |
| Kim, DH | 1 |
| Kang, KP | 1 |
| Jang, YB | 1 |
| Lee, JE | 1 |
| Jang, KY | 1 |
| Park, SK | 1 |
| Lenman, A | 1 |
| Fowler, CJ | 1 |
| Kang, DW | 1 |
| Choi, CH | 1 |
| Park, JY | 1 |
| Kang, SK | 1 |
| Kim, YK | 1 |
| Zander, T | 1 |
| Kraus, JA | 1 |
| Grommes, C | 1 |
| Schlegel, U | 1 |
| Feinstein, D | 1 |
| Klockgether, T | 1 |
| Landreth, G | 1 |
| Koenigsknecht, J | 1 |
| Heneka, MT | 1 |
6 other studies available for ciglitazone and Glioma
| Article | Year |
|---|---|
Potential Therapeutic Effects of Thiazolidinedione on Malignant Glioma.
Topics: Animals; Cell Cycle Proteins; Cell Line, Tumor; Diabetes Mellitus, Type 2; Glioblastoma; Glioma; Hyp | 2022 |
Cell death is induced by ciglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) agonist, independently of PPARγ in human glioma cells.
Topics: Anilides; Apoptosis; Cell Line, Tumor; Glioma; Humans; PPAR gamma; Proto-Oncogene Proteins c-akt; Th | 2012 |
Rosiglitazone ameliorates cisplatin-induced renal injury in mice.
Topics: Anilides; Animals; Apoptosis; C-Peptide; Cell Line; Chromans; Cisplatin; Drug Evaluation, Preclinica | 2006 |
Interaction of ligands for the peroxisome proliferator-activated receptor gamma with the endocannabinoid system.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents; Brain; Brain Neoplasms; Cannabinoid Receptor Mod | 2007 |
Ciglitazone induces caspase-independent apoptosis through down-regulation of XIAP and survivin in human glioma cells.
Topics: Annexin A5; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Brain Neoplasms; Caspases; Cell | 2008 |
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Cadherins; Carrier Pro | 2002 |