ciglitazone has been researched along with Glial Cell Tumors in 6 studies
ciglitazone: structure given in second source; PPAR agonist used for type II diabetes
ciglitazone : An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study was undertaken to determine the precise mechanism of cell death induced by ciglitazone, a synthetic PPAR gamma agonist, in A172 human glioma cells." | 7.74 | Ciglitazone induces caspase-independent apoptosis through down-regulation of XIAP and survivin in human glioma cells. ( Choi, CH; Kang, DW; Kang, SK; Kim, YK; Park, JY, 2008) |
| "Treatment with GW9662 followed by CGZ resulted in a down-regulation of Akt activity and the loss of mitochondrial membrane potential (MMP), which was accompanied by a decrease in Bcl-2 expression and an increase in Bid cleavage." | 5.38 | Cell death is induced by ciglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) agonist, independently of PPARγ in human glioma cells. ( Jung, HL; Kim, DS; Kim, HJ; Kim, HR; Koo, HH; Lee, MW; Lee, SH; Noh, YH; Ryu, S; Son, MH; Sung, KW; Yang, JM; Yoo, KH, 2012) |
| " The present study was undertaken to determine the precise mechanism of cell death induced by ciglitazone, a synthetic PPAR gamma agonist, in A172 human glioma cells." | 3.74 | Ciglitazone induces caspase-independent apoptosis through down-regulation of XIAP and survivin in human glioma cells. ( Choi, CH; Kang, DW; Kang, SK; Kim, YK; Park, JY, 2008) |
| " Agonists of the peroxisome proliferator-activated receptor-gamma (PPARgamma), such as rosiglitazone, have been recently demonstrated to regulate inflammation by modulating the production of inflammatory mediators and adhesion molecules." | 3.73 | Rosiglitazone ameliorates cisplatin-induced renal injury in mice. ( Jang, KY; Jang, YB; Kang, KP; Kim, DH; Kim, W; Lee, JE; Lee, S; Moon, SO; Park, SK; Sung, MJ, 2006) |
| "Treatment with GW9662 followed by CGZ resulted in a down-regulation of Akt activity and the loss of mitochondrial membrane potential (MMP), which was accompanied by a decrease in Bcl-2 expression and an increase in Bid cleavage." | 1.38 | Cell death is induced by ciglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) agonist, independently of PPARγ in human glioma cells. ( Jung, HL; Kim, DS; Kim, HJ; Kim, HR; Koo, HH; Lee, MW; Lee, SH; Noh, YH; Ryu, S; Son, MH; Sung, KW; Yang, JM; Yoo, KH, 2012) |
| "Taken together, treatment of glioma cells with PPARgamma agonists may hold therapeutic potential for the treatment of gliomas." | 1.31 | Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma. ( Feinstein, D; Grommes, C; Heneka, MT; Klockgether, T; Koenigsknecht, J; Kraus, JA; Landreth, G; Schlegel, U; Zander, T, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Sheu, ML | 1 |
| Pan, LY | 1 |
| Hu, HY | 1 |
| Su, HL | 1 |
| Sheehan, J | 1 |
| Tsou, HK | 1 |
| Pan, HC | 1 |
| Lee, MW | 1 |
| Kim, DS | 1 |
| Kim, HR | 1 |
| Kim, HJ | 1 |
| Yang, JM | 1 |
| Ryu, S | 1 |
| Noh, YH | 1 |
| Lee, SH | 1 |
| Son, MH | 1 |
| Jung, HL | 1 |
| Yoo, KH | 1 |
| Koo, HH | 1 |
| Sung, KW | 1 |
| Lee, S | 1 |
| Kim, W | 1 |
| Moon, SO | 1 |
| Sung, MJ | 1 |
| Kim, DH | 1 |
| Kang, KP | 1 |
| Jang, YB | 1 |
| Lee, JE | 1 |
| Jang, KY | 1 |
| Park, SK | 1 |
| Lenman, A | 1 |
| Fowler, CJ | 1 |
| Kang, DW | 1 |
| Choi, CH | 1 |
| Park, JY | 1 |
| Kang, SK | 1 |
| Kim, YK | 1 |
| Zander, T | 1 |
| Kraus, JA | 1 |
| Grommes, C | 1 |
| Schlegel, U | 1 |
| Feinstein, D | 1 |
| Klockgether, T | 1 |
| Landreth, G | 1 |
| Koenigsknecht, J | 1 |
| Heneka, MT | 1 |
6 other studies available for ciglitazone and Glial Cell Tumors
| Article | Year |
|---|---|
Potential Therapeutic Effects of Thiazolidinedione on Malignant Glioma.
Topics: Animals; Cell Cycle Proteins; Cell Line, Tumor; Diabetes Mellitus, Type 2; Glioblastoma; Glioma; Hyp | 2022 |
Cell death is induced by ciglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) agonist, independently of PPARγ in human glioma cells.
Topics: Anilides; Apoptosis; Cell Line, Tumor; Glioma; Humans; PPAR gamma; Proto-Oncogene Proteins c-akt; Th | 2012 |
Rosiglitazone ameliorates cisplatin-induced renal injury in mice.
Topics: Anilides; Animals; Apoptosis; C-Peptide; Cell Line; Chromans; Cisplatin; Drug Evaluation, Preclinica | 2006 |
Interaction of ligands for the peroxisome proliferator-activated receptor gamma with the endocannabinoid system.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents; Brain; Brain Neoplasms; Cannabinoid Receptor Mod | 2007 |
Ciglitazone induces caspase-independent apoptosis through down-regulation of XIAP and survivin in human glioma cells.
Topics: Annexin A5; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Brain Neoplasms; Caspases; Cell | 2008 |
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Cadherins; Carrier Pro | 2002 |