ciglitazone has been researched along with Diabetes Mellitus, Adult-Onset in 14 studies
ciglitazone: structure given in second source; PPAR agonist used for type II diabetes
ciglitazone : An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ciglitazone was the first insulin sensitizer with a thiazolidinedione structure to reduce insulin resistance and hyperglycemia and many thiazolidinedione derivatives (TZDs) have since been reported as insulin sensitizers." | 4.80 | [Mechanisms of thiazolidinedione derivatives for hypoglycemic and insulin sensitizing effects]. ( Ikeda, H; Murase, K; Sugiyama, Y, 2000) |
| "Troglitazone was designed to combine tocopherol, anti-peroxidant, and thiazolidinedione." | 2.41 | [The development of thiazolidinedione drugs as anti-diabetic agents]. ( Kuzuya, T, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (50.00) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Hulin, B | 2 |
| Clark, DA | 2 |
| Goldstein, SW | 1 |
| McDermott, RE | 1 |
| Dambek, PJ | 1 |
| Kappeler, WH | 1 |
| Lamphere, CH | 1 |
| Lewis, DM | 2 |
| Rizzi, JP | 1 |
| Zask, A | 1 |
| Jirkovsky, I | 1 |
| Nowicki, JW | 1 |
| McCaleb, ML | 1 |
| Cantello, BC | 1 |
| Cawthorne, MA | 1 |
| Cottam, GP | 1 |
| Duff, PT | 1 |
| Haigh, D | 1 |
| Hindley, RM | 1 |
| Lister, CA | 1 |
| Smith, SA | 1 |
| Thurlby, PL | 1 |
| Malamas, MS | 2 |
| Sredy, J | 2 |
| Gunawan, I | 2 |
| Mihan, B | 2 |
| Sawicki, DR | 1 |
| Seestaller, L | 1 |
| Sullivan, D | 2 |
| Flam, BR | 1 |
| Sheu, ML | 1 |
| Pan, LY | 1 |
| Hu, HY | 1 |
| Su, HL | 1 |
| Sheehan, J | 1 |
| Tsou, HK | 1 |
| Pan, HC | 1 |
| Seto, SW | 1 |
| Lam, TY | 1 |
| Leung, GP | 1 |
| Au, AL | 1 |
| Ngai, SM | 1 |
| Chan, SW | 1 |
| Kwan, YW | 1 |
| Umeda, F | 1 |
| Newton, LS | 1 |
| Genereux, PE | 1 |
| Gibbs, EM | 1 |
| Petrie, J | 1 |
| Small, M | 1 |
| Connell, J | 1 |
| Arakawa, K | 1 |
| Inamasu, M | 1 |
| Matsumoto, M | 1 |
| Okumura, K | 1 |
| Yasuda, K | 1 |
| Akatsuka, H | 1 |
| Kawanami, S | 1 |
| Watanabe, A | 1 |
| Homma, K | 1 |
| Saiga, Y | 1 |
| Ozeki, M | 1 |
| Iijima, I | 1 |
| Kuzuya, T | 1 |
| Sugiyama, Y | 1 |
| Murase, K | 1 |
| Ikeda, H | 1 |
| McCaleb, M | 1 |
| Marra, F | 1 |
| Pastacaldi, S | 1 |
4 reviews available for ciglitazone and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Potential role of thiazolidinediones in older diabetic patients.
Topics: Aged; Aging; Animals; Benzopyrans; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Glucose | 1995 |
[The development of thiazolidinedione drugs as anti-diabetic agents].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromans; Clinical Trials as Topic; Diabetes Mellit | 2000 |
[Mechanisms of thiazolidinedione derivatives for hypoglycemic and insulin sensitizing effects].
Topics: Animals; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipid Metaboli | 2000 |
[Thiazolidinediones and PPARgamma system in repair of liver damage].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Antioxidants; Arteriosclerosis; Chro | 2002 |
10 other studies available for ciglitazone and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Novel thiazolidine-2,4-diones as potent euglycemic agents.
Topics: Alcohols; Animals; Benzopyrans; Blood Glucose; Diabetes Mellitus, Type 2; Hypoglycemic Agents; Keton | 1992 |
Synthesis and antihyperglycemic activity of novel 5-(naphthalenylsulfonyl)-2,4-thiazolidinediones.
Topics: Animals; Blood Glucose; Chemical Phenomena; Chemistry; Diabetes Mellitus, Type 2; Hypoglycemic Agent | 1990 |
[[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Hemoglobins; Hypoglycemic Agents; Mice; | 1994 |
New azolidinediones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.
Topics: 4-Nitrophenylphosphatase; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Huma | 2000 |
Potential Therapeutic Effects of Thiazolidinedione on Malignant Glioma.
Topics: Animals; Cell Cycle Proteins; Cell Line, Tumor; Diabetes Mellitus, Type 2; Glioblastoma; Glioma; Hyp | 2022 |
Comparison of vascular relaxation, lipolysis and glucose uptake by peroxisome proliferator-activated receptor-gamma activation in +db/+m and +db/+db mice.
Topics: Abdominal Fat; Adipocytes; Animals; Aorta, Thoracic; Carbohydrate Metabolism; Chromans; Diabetes Mel | 2007 |
Hypoglycemic activity of a series of alpha-alkylthio and alpha-alkoxy carboxylic acids related to ciglitazone.
Topics: 3T3 Cells; Adipocytes; Animals; Benzofurans; Carboxylic Acids; Diabetes Mellitus, Type 2; Hypoglycem | 1996 |
"Glitazones", a prospect for non-insulin-dependent diabetes.
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin Resistanc | 1997 |
Novel benzoxazole 2,4-thiazolidinediones as potent hypoglycemic agents. Synthesis and structure-activity relationships.
Topics: Animals; Benzopyrans; Benzoxazoles; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypoglyc | 1997 |
Antihyperglycemic activity of new 1,2,4-oxadiazolidine-3,5-diones.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Hypoglycemic Agen | 2001 |