ciglitazone has been researched along with Acute Liver Injury, Drug-Induced in 6 studies
ciglitazone: structure given in second source; PPAR agonist used for type II diabetes
ciglitazone : An aromatic ether that consists of 1,3-thiazolidine-2,4-dione with position 5 substituted by a 4-[(1-methylcyclohexyl)methoxy]benzyl group. A selective PPARgamma agonist.
Excerpt | Relevance | Reference |
---|---|---|
"Troglitazone was designed to combine tocopherol, anti-peroxidant, and thiazolidinedione." | 2.41 | [The development of thiazolidinedione drugs as anti-diabetic agents]. ( Kuzuya, T, 2000) |
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (16.67) | 29.6817 |
2010's | 5 (83.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Greene, N | 1 |
Fisk, L | 1 |
Naven, RT | 1 |
Note, RR | 1 |
Patel, ML | 1 |
Pelletier, DJ | 1 |
Morgan, RE | 2 |
Trauner, M | 1 |
van Staden, CJ | 2 |
Lee, PH | 1 |
Ramachandran, B | 1 |
Eschenberg, M | 1 |
Afshari, CA | 2 |
Qualls, CW | 1 |
Lightfoot-Dunn, R | 1 |
Hamadeh, HK | 2 |
Ekins, S | 1 |
Williams, AJ | 1 |
Xu, JJ | 1 |
Liu, Z | 1 |
Shi, Q | 1 |
Ding, D | 1 |
Kelly, R | 1 |
Fang, H | 1 |
Tong, W | 1 |
Chen, Y | 1 |
Kalyanaraman, N | 1 |
Kalanzi, J | 1 |
Dunn, RT | 1 |
Kuzuya, T | 1 |
1 review available for ciglitazone and Acute Liver Injury, Drug-Induced
Article | Year |
---|---|
[The development of thiazolidinedione drugs as anti-diabetic agents].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromans; Clinical Trials as Topic; Diabetes Mellit | 2000 |
5 other studies available for ciglitazone and Acute Liver Injury, Drug-Induced
Article | Year |
---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |