cifenline has been researched along with Heart Failure in 3 studies
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cibenzoline dosing is generally based on renal function, but serum concentrations might be greater than the expected therapeutic levels when standard oral dosing is used." | 1.33 | Heart failure elevates serum levels of cibenzoline in arrhythmic patients. ( Kamakura, S; Kitakaze, M; Komamura, K; Kotake, T; Miyatake, K; Morishita, H; Takada, M, 2006) |
| " Resulting plasma concentration-time profiles and urinary excretion rate data were used to determine pharmacokinetic parameters for cibenzoline." | 1.27 | Effect of congestive heart failure on the pharmacokinetics of cibenzoline. ( DeGrazia, F; Keefe, D; Massarella, JW; Miwa, B; Silvestri, T, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hamada, M | 1 |
| Ikeda, S | 1 |
| Shigematsu, Y | 1 |
| Kotake, T | 1 |
| Takada, M | 1 |
| Komamura, K | 1 |
| Kamakura, S | 1 |
| Miyatake, K | 1 |
| Kitakaze, M | 1 |
| Morishita, H | 1 |
| Massarella, JW | 1 |
| Silvestri, T | 1 |
| DeGrazia, F | 1 |
| Miwa, B | 1 |
| Keefe, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluating the Effect of Spironolactone on Hypertrophic Cardiomyopathy-- a Multicenter Randomized Control Trial[NCT02948998] | Phase 4 | 260 participants (Anticipated) | Interventional | 2018-05-14 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for cifenline and Heart Failure
| Article | Year |
|---|---|
Advances in medical treatment of hypertrophic cardiomyopathy.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Anti-Arrhythmia Agents; Calcium Channel Blocke | 2014 |
2 other studies available for cifenline and Heart Failure
| Article | Year |
|---|---|
Heart failure elevates serum levels of cibenzoline in arrhythmic patients.
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Body Weight; Drug Evaluation; Female; Heart | 2006 |
Effect of congestive heart failure on the pharmacokinetics of cibenzoline.
Topics: Aged; Biological Availability; Blood Pressure; Heart Failure; Heart Rate; Humans; Imidazoles; Male; | 1987 |