cibinetide and Pre-Eclampsia

Preeclampsia is a severe disease of late pregnancy. Etiological factors and a pathogenetic pattern of events still require significant clarification, but it is now recognized that a large role is played by placentation disorders and emerging endothelial dysfunction. The administration of short-chain peptides mimicking the spatial structure of the B erythropoietin chain may become one of the directions of searching for new drugs for preeclampsia prevention and therapy. Simulation of ADMA-like preeclampsia in Wistar rats was performed by the administration of a non-selective NOS blocker L-NAME from the 14th to 20th day of pregnancy. The administration of the pHBSP at the doses of 10 µg/kg and 250 µg/kg corrected the established morphofunctional disorders. The greatest effect was observed at a dose of 250 µg/kg. There was a decrease in systolic and diastolic blood pressure by 31.2 and 32.8%, respectively (

Topics: Animals; bcl-2-Associated X Protein; Blood Pressure; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Erythropoietin; Female; Microcirculation; NG-Nitroarginine Methyl Ester; Oligopeptides; Placenta; Pre-Eclampsia; Pregnancy; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar