ci 994 has been researched along with Leukemia, Myeloid, Acute in 4 studies
tacedinaline: oral cytostatic drug with impressive differential activity against leukemic cells & normal stem-cells
tacedinaline : A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Also used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.
Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In vitro, CI-994 in combination with cytarabine (ara-C), daunorubicin and mitoxantrone, resulted in moderate synergism." | 1.35 | CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo. ( Comijn, EM; Hubeek, I; Kaspers, GJ; Merriman, RL; Padron, JM; Peters, GJ; Van der Wilt, CL, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hubeek, I | 1 |
| Comijn, EM | 1 |
| Van der Wilt, CL | 1 |
| Merriman, RL | 1 |
| Padron, JM | 1 |
| Kaspers, GJ | 1 |
| Peters, GJ | 1 |
| el-Beltagi, HM | 3 |
| Martens, AC | 3 |
| Dahab, GM | 1 |
| Hagenbeek, A | 3 |
| Lelieveld, P | 1 |
| Haroun, EA | 2 |
4 other studies available for ci 994 and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
CI-994 (N-acetyl-dinaline) in combination with conventional anti-cancer agents is effective against acute myeloid leukemia in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Blood Cell Count; Cell Prolifer | 2008 |
Efficacy of acetyldinaline for treatment of minimal residual disease (MRD): preclinical studies in the BNML rat model for human acute myelocytic leukemia.
Topics: Animals; Antineoplastic Agents; Benzamides; Bone Marrow Transplantation; Disease Models, Animal; Dru | 1993 |
Acetyldinaline: a new oral cytostatic drug with impressive differential activity against leukemic cells and normal stem cells--preclinical studies in a relevant rat model for human acute myelocytic leukemia.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzamides; Bone Marrow; Bone Marrow Cells; Ce | 1993 |
In vivo development of an acetyldinaline resistant subline of the BN rat acute myelocytic leukemia (BNML).
Topics: Animals; Antineoplastic Agents; Benzamides; Disease Models, Animal; Drug Resistance; Female; Leukemi | 1993 |