ci 994 has been researched along with Disease Models, Animal in 8 studies
tacedinaline: oral cytostatic drug with impressive differential activity against leukemic cells & normal stem-cells
tacedinaline : A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Also used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Cooper, A | 1 |
| Butto, T | 1 |
| Hammer, N | 1 |
| Jagannath, S | 1 |
| Fend-Guella, DL | 1 |
| Akhtar, J | 1 |
| Radyushkin, K | 1 |
| Lesage, F | 1 |
| Winter, J | 1 |
| Strand, S | 1 |
| Roeper, J | 1 |
| Zechner, U | 1 |
| Schweiger, S | 1 |
| Zhang, S | 1 |
| Fujita, Y | 1 |
| Matsuzaki, R | 1 |
| Yamashita, T | 1 |
| Karnib, N | 1 |
| El-Ghandour, R | 1 |
| El Hayek, L | 1 |
| Nasrallah, P | 1 |
| Khalifeh, M | 1 |
| Barmo, N | 1 |
| Jabre, V | 1 |
| Ibrahim, P | 1 |
| Bilen, M | 1 |
| Stephan, JS | 1 |
| Holson, EB | 1 |
| Ratan, RR | 1 |
| Sleiman, SF | 1 |
| el-Beltagi, HM | 4 |
| Martens, AC | 4 |
| Dahab, GM | 1 |
| Hagenbeek, A | 4 |
| Lelieveld, P | 1 |
| Haroun, EA | 2 |
8 other studies available for ci 994 and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome.
Topics: Animals; Behavior, Animal; Benzamides; Brain; Craniofacial Abnormalities; Disease Models, Animal; Fe | 2020 |
Class I histone deacetylase (HDAC) inhibitor CI-994 promotes functional recovery following spinal cord injury.
Topics: Acetylation; Animals; Benzamides; Disease Models, Animal; Histone Deacetylase Inhibitors; Histones; | 2018 |
Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases.
Topics: Animals; Antidepressive Agents; Anxiety; Avoidance Learning; Behavior, Animal; Benzamides; Depressio | 2019 |
Efficacy of acetyldinaline for treatment of minimal residual disease (MRD): preclinical studies in the BNML rat model for human acute myelocytic leukemia.
Topics: Animals; Antineoplastic Agents; Benzamides; Bone Marrow Transplantation; Disease Models, Animal; Dru | 1993 |
Acetyldinaline: a new oral cytostatic drug with impressive differential activity against leukemic cells and normal stem cells--preclinical studies in a relevant rat model for human acute myelocytic leukemia.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Benzamides; Bone Marrow; Bone Marrow Cells; Ce | 1993 |
In vivo development of an acetyldinaline resistant subline of the BN rat acute myelocytic leukemia (BNML).
Topics: Animals; Antineoplastic Agents; Benzamides; Disease Models, Animal; Drug Resistance; Female; Leukemi | 1993 |
Leukemia cell lines resistant to cytosine arabinoside, cyclophosphamide or daunomycin are equally sensitive to the drug acetyldinaline as the parental cell line.
Topics: Animals; Antineoplastic Agents; Benzamides; Cyclophosphamide; Cytarabine; Daunorubicin; Disease Mode | 2000 |