ci 994 has been researched along with Colonic Neoplasms in 4 studies
tacedinaline: oral cytostatic drug with impressive differential activity against leukemic cells & normal stem-cells
tacedinaline : A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Also used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Following treatment mice were evaluated for pharmacodynamic effects as well as the pharmacokinetic behavior of CI-994 and the de-acetylated derivative dinaline." | 1.30 | Preclinical pharmacokinetic, antitumor and toxicity studies with CI-994 (correction of CL-994) (N-acetyldinaline). ( Corbett, TH; Foster, BJ; Jones, L; LoRusso, PM; Wiegand, R, 1997) |
| "Treatment with salicylanilide, CI-940, mimosine, aphidicolin, quercetin or ciclopirolxalamine, which, like CI-994, block cells in the G1-S phase of the cell cycle, did not affect the production of this protein." | 1.29 | Role of a small molecular weight phosphoprotein in the mechanism of action of CI-994 (N-acetyldinaline). ( Hook, KE; Klohs, WD; Kraker, AJ; Rummel, SA; Steinkampf, RW, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kraker, AJ | 2 |
| Mizzen, CA | 1 |
| Hartl, BG | 1 |
| Miin, J | 1 |
| Allis, CD | 1 |
| Merriman, RL | 1 |
| Rummel, SA | 1 |
| Steinkampf, RW | 1 |
| Hook, KE | 1 |
| Klohs, WD | 1 |
| Seelig, MH | 1 |
| Berger, MR | 1 |
| Foster, BJ | 1 |
| Jones, L | 1 |
| Wiegand, R | 1 |
| LoRusso, PM | 1 |
| Corbett, TH | 1 |
4 other studies available for ci 994 and Colonic Neoplasms
| Article | Year |
|---|---|
Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma.
Topics: Acetylation; Antineoplastic Agents; Benzamides; Blotting, Western; Cell Line, Tumor; Cell Nucleus; C | 2003 |
Role of a small molecular weight phosphoprotein in the mechanism of action of CI-994 (N-acetyldinaline).
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Benzamides; Cell Cycle; Cell Nucleus; Colonic Neopla | 1995 |
Efficacy of dinaline and its methyl and acetyl derivatives against colorectal cancer in vivo and in vitro.
Topics: Animals; Antineoplastic Agents; Benzamides; Carcinogens; Colonic Neoplasms; Colorectal Neoplasms; Di | 1996 |
Preclinical pharmacokinetic, antitumor and toxicity studies with CI-994 (correction of CL-994) (N-acetyldinaline).
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Area Under Curve; Benzamides; Blood Cell Count; Bone | 1997 |