ci 994 and Cancer of Prostate studies

ci 994 and Cancer of Prostate

ci 994 has been researched along with Cancer of Prostate in 2 studies

tacedinaline: oral cytostatic drug with impressive differential activity against leukemic cells & normal stem-cells
tacedinaline : A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Also used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.

Research Excerpts

Excerpt	Relevance	Reference
" These results demonstrate that compound 2 and its combination with SAHA are potentially useful agents that warrant further preclinical development for treatment of prostate cancer."	1.35	Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts. ( Belosay, A; Gediya, LK; Khandelwal, A; Njar, VC; Purushottamachar, P, 2008)

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

2 (100.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Gediya, LK	2
Belosay, A	2
Khandelwal, A	2
Purushottamachar, P	2
Njar, VC	2
Patel, J	1
Sabnis, G	1
Mehta, J	1

Studies

Gediya, LK

Belosay, A

Khandelwal, A

Purushottamachar, P

Njar, VC

Patel, J

Sabnis, G

Mehta, J

Other Studies

2 other studies available for ci 994 and Cancer of Prostate

Article	Year
Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts. Bioorganic & medicinal chemistry, 2008, Mar-15, Volume: 16, Issue:6 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Cycle; Cell Differentiatio	2008
Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro. Journal of medicinal chemistry, 2008, Jul-10, Volume: 51, Issue:13 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carbamates; Cell Line, Tumor; Cell Proliferation;	2008

Article

Year

Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts.

Bioorganic & medicinal chemistry, 2008, Mar-15, Volume: 16, Issue:6

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Cycle; Cell Differentiatio

2008

Design, synthesis, and evaluation of novel mutual prodrugs (hybrid drugs) of all-trans-retinoic acid and histone deacetylase inhibitors with enhanced anticancer activities in breast and prostate cancer cells in vitro.

Journal of medicinal chemistry, 2008, Jul-10, Volume: 51, Issue:13

Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carbamates; Cell Line, Tumor; Cell Proliferation;

2008