chrysin and Uveitis

Uveitis is a common cause of blindness worldwide. Experimental autoimmune uveitis (EAU) is an animal model of noninfectious uveitis. Chrysin (5,7-dihydroxyflavone) is a member of the flavonoid family and has anti-inflammatory effects. We immunized C57BL/6J mice with human interphotoreceptor retinoid-binding protein peptide 1-20 to induce EAU. Chrysin was administered intragastrically at 25 mg/kg daily to the chrysin-treated mice from 3 days before immunization to 21 days after immunization. Vehicle was administered to the mice in the control group according to the same protocol. Lower clinical and histopathological scores, increased integrity of the blood-retinal barrier (BRB) and higher expression of tight junction proteins were observed in the chrysin-treated mice. Chrysin significantly decreased the proportions of Th1, Th17 and CD4

Topics: Adenosylhomocysteinase; Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Blood-Retinal Barrier; Cytokines; Female; Flavonoids; Humans; Immunologic Memory; Inflammation Mediators; Macrophages; Mice; Mice, Inbred C57BL; Models, Animal; Nitric Oxide Synthase Type II; Peptides; Th1 Cells; Th17 Cells; Tight Junction Proteins; Transcription Factor RelA; Uveitis