chrysin has been researched along with Macular-Degeneration* in 1 studies
1 other study(ies) available for chrysin and Macular-Degeneration
| Article | Year |
|---|---|
Inhibition of Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor by Chrysin in a Rat Model of Choroidal Neovascularization.
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss among the elderly population. Vascular endothelial growth factor (VEGF) is essential for choroidal neovascularization (CNV) development in advanced, wet AMD. Chrysin (5,7-dihydroxyflavone) is a natural flavonoid with anti-inflammatory, anti-oxidative, and anti-angiogenic effects. We hypothesized that intravitreally injected chrysin may inhibit CNV due to its inhibitory effect on angiogenesis. To determine the effects of chrysin on an experimental CNV model, we induced CNV in Brown Norway rats with a diode laser. One week later, rats were injected intravitreally with chrysin in the right eye and vehicle in the left eye. The following week, we evaluated chrysin's effects via the CNV grade assessed with fluorescein angiography and histologic analyses. Hypoxia-inducible factor-1 alpha (HIF-1α) and VEGF expression in the retina/choroid complex were also measured in both eyes. The mean CNV grade was significantly lower in chrysin-treated vs. control eyes (2.34 ± 1.14 vs. 2.97 ± 1.05, Topics: Angiogenesis Inhibitors; Animals; Choroidal Neovascularization; Disease Models, Animal; Flavonoids; Fluorescein Angiography; Fluorescent Antibody Technique; Hypoxia-Inducible Factor 1, alpha Subunit; Intravitreal Injections; Lasers; Macular Degeneration; Male; Rats; Rats, Inbred BN; Vascular Endothelial Growth Factor A | 2020 |