chrysin and Hemolysis

chrysin has been researched along with Hemolysis* in 2 studies

Other Studies

2 other study(ies) available for chrysin and Hemolysis

Article	Year
Preparation, characterization, and evaluation of amino acid modified magnetic nanoparticles: drug delivery and MRI contrast agent applications. Pharmaceutical development and technology, 2018, Volume: 23, Issue:10 This study is a report about the synthesis iron oxide magnetic nanoparticles (IONPs) which modified with positive and negative charged amino acids (AAs). l-Arginine (Arg) and l-aspartic acid (Asp) which have of guanidinium and carboxylic acid groups, respectively, were selected for this study. After loading chrysin in amino acids modified iron oxide magnetic nanoparticles (F@AAs@Chrysin NPs), it was characterized by XRD, TGA, FTIR, VSM, and TEM techniques. Finally, MTT assays on HFF-2 and HEK-293 cell lines were performed for determination of biocompatibility of AA coated IONPs. The results show that, the ζ-potential and average size of F@Arg@chrysin NPs and F@Asp@chrysin NPs were to -3.87, -2.12 mV, 18.75 ± 2.40 (mean ± SD ( Topics: Amino Acids; Cell Survival; Contrast Media; Drug Carriers; Drug Delivery Systems; Flavonoids; HEK293 Cells; Hemolysis; Humans; Magnetic Resonance Imaging; Magnetite Nanoparticles; Neoplasms	2018
Chrysin protects mice from Staphylococcus aureus pneumonia. Journal of applied microbiology, 2011, Volume: 111, Issue:6 To elucidate the effect of chrysin on α-haemolysin production by Staphylococcus aureus and protection against pneumonia in a murine model.. Haemolysis, Western blot and real-time RT-PCR assays were performed to evaluate the effect of chrysin on α-haemolysin secretion by Staph. aureus. The efficacy of chrysin against human alveolar epithelial cell injury by α-haemolysin was tested using live/dead staining or by measuring lactate dehydrogenase activity. Furthermore, we determined the protective effect of chrysin against Staph. aureus pneumonia through histopathology experiments in a mouse model. The production of α-haemolysin by Staph. aureus was inhibited when presented with an increasing subinhibitory concentration of chrysin in vitro. Consistent with this result, chrysin prevented α-haemolysin-mediated cell injury and protected mice from Staph. aureus pneumonia.. Chrysin is a potent inhibitor of α-haemolysin expression by Staph. aureus, and it conferred a significant degree of protection against Staph. aureus pneumonia.. The chrysin-mediated inhibition of α-haemolysin production and protection against Staph. aureus pneumonia may offer a new strategy in combating pathogen infections. Topics: Animals; Blotting, Western; Cell Line; Epithelial Cells; Female; Flavonoids; Hemolysin Proteins; Hemolysis; Humans; Lung; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Pneumonia, Staphylococcal; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; Staphylococcus aureus	2011

Article

Year

Preparation, characterization, and evaluation of amino acid modified magnetic nanoparticles: drug delivery and MRI contrast agent applications.

Pharmaceutical development and technology, 2018, Volume: 23, Issue:10

This study is a report about the synthesis iron oxide magnetic nanoparticles (IONPs) which modified with positive and negative charged amino acids (AAs). l-Arginine (Arg) and l-aspartic acid (Asp) which have of guanidinium and carboxylic acid groups, respectively, were selected for this study. After loading chrysin in amino acids modified iron oxide magnetic nanoparticles (F@AAs@Chrysin NPs), it was characterized by XRD, TGA, FTIR, VSM, and TEM techniques. Finally, MTT assays on HFF-2 and HEK-293 cell lines were performed for determination of biocompatibility of AA coated IONPs. The results show that, the ζ-potential and average size of F@Arg@chrysin NPs and F@Asp@chrysin NPs were to -3.87, -2.12 mV, 18.75 ± 2.40 (mean ± SD (

Topics: Amino Acids; Cell Survival; Contrast Media; Drug Carriers; Drug Delivery Systems; Flavonoids; HEK293 Cells; Hemolysis; Humans; Magnetic Resonance Imaging; Magnetite Nanoparticles; Neoplasms

2018

Chrysin protects mice from Staphylococcus aureus pneumonia.

Journal of applied microbiology, 2011, Volume: 111, Issue:6

To elucidate the effect of chrysin on α-haemolysin production by Staphylococcus aureus and protection against pneumonia in a murine model.. Haemolysis, Western blot and real-time RT-PCR assays were performed to evaluate the effect of chrysin on α-haemolysin secretion by Staph. aureus. The efficacy of chrysin against human alveolar epithelial cell injury by α-haemolysin was tested using live/dead staining or by measuring lactate dehydrogenase activity. Furthermore, we determined the protective effect of chrysin against Staph. aureus pneumonia through histopathology experiments in a mouse model. The production of α-haemolysin by Staph. aureus was inhibited when presented with an increasing subinhibitory concentration of chrysin in vitro. Consistent with this result, chrysin prevented α-haemolysin-mediated cell injury and protected mice from Staph. aureus pneumonia.. Chrysin is a potent inhibitor of α-haemolysin expression by Staph. aureus, and it conferred a significant degree of protection against Staph. aureus pneumonia.. The chrysin-mediated inhibition of α-haemolysin production and protection against Staph. aureus pneumonia may offer a new strategy in combating pathogen infections.

Topics: Animals; Blotting, Western; Cell Line; Epithelial Cells; Female; Flavonoids; Hemolysin Proteins; Hemolysis; Humans; Lung; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Pneumonia, Staphylococcal; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; Staphylococcus aureus

2011