chromomycins and Carcinoma--Hepatocellular

Change in beta-glucuronidase activity of six Yoshida ascites hepatomas was examined after treatment of host rats with one of 12 anticancer agents. The hepatomas, AH-66F, AH-130, AH-109A, AH-60C, and AH-44, in decreasing order showed more or less distinct increase in beta-glucuronidase activity after treatment of the rats with Nitromin, Endoxan, 864-T, Carbazilquinone, Mitomycin-C, Toyomycin, Daunomycin, Neocarzinostatin, vincristine sulfate, 5-fluorouracil, or cytosine arabinoside only when the cytological effect was positive. Moreover, degree of the increase was generally correlated with that of cytological effect. Bleomycin was ineffective either enzymically or cytologically. AH-66 was insensitive to any of the agents tested in increasing beta-glucuronidase activity and showed only a very slight cytological response to some of the agents. Acid deoxyribonuclease behaved like beta-glucuronidase but to a lesser extent. The above order of drug sensitivity of the hepatomas was not in parallel with that of normal beta-glucuronidase level, which also did not correlate with the life span of host rats.

Topics: Animals; Antineoplastic Agents; Bleomycin; Carbazilquinone; Carcinoma, Hepatocellular; Chromomycins; Cyclophosphamide; Cytarabine; Daunorubicin; Deoxyribonucleases; Fluorouracil; Glucuronidase; Liver Neoplasms; Male; Mesylates; Mitomycins; Neoplasms, Experimental; Nitro Compounds; Rats; Sarcoma, Yoshida; Tosyl Compounds; Vincristine; Zinostatin

Topics: Adult; Aged; Alpha-Globulins; Antigens, Neoplasm; Antineoplastic Agents; Carcinoma, Hepatocellular; Chromomycins; Cyclophosphamide; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Fetal Proteins; Fluorouracil; Humans; Immunodiffusion; Liver Neoplasms; Male; Middle Aged; Mitomycins