Compounds > chromium
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chromium and Cell Transformation, Neoplastic

chromium has been researched along with Cell Transformation, Neoplastic in 62 studies

Research

Studies (62)

TimeframeStudies, this research(%)All Research%
pre-199011 (17.74)18.7374
1990's4 (6.45)18.2507
2000's10 (16.13)29.6817
2010's28 (45.16)24.3611
2020's9 (14.52)2.80

Authors

AuthorsStudies
Auerbach, SS; Mezencev, R1
Kondo, K; Tao, H; Uddin, MB; Wang, Z; Xie, J; Yang, C; Zeidler-Erdely, PC1
Chen, C; Ganapathy, S; Liu, J; Makriyannis, A; Xiong, R; Yu, T; Zhang, Q1
Bian, XK; Guo, JL; Han, YW; Lee, SC; Xu, SX; Zhao, JZ1
Edeni, D; Hossain, M; Islam, H; Li, C; Li, J; Liu, R; Phillips, JL; Platkin, S; Rahman, M; Xu, D1
Bian, XK; Han, YW; Lee, SC; Wang, JX; Xu, SX; Zhang, J; Zhao, JZ; Zhao, ML1
Kondo, K; Li, Y; Lin, HP; Maddy, D; Tao, H; Wang, Z; Xie, J; Yang, C; Yang, P1
Abreu, PL; Alpoim, MC; Cunha-Oliveira, T; Ferreira, LMR; Sobral, MC; Urbano, AM1
Costa, M; Li, P; Murphy, AJ; Sun, H; Zhang, X; Zhao, X1
Chen, C; Chen, Z; Huang, H; Huang, X; Liu, J; Liu, W; Liu, Y; Ren, X; Wu, D; Zhong, J1
Kim, D; Pratheeshkumar, P; Shi, X; Son, YO; Wang, Y; Zhang, Z1
Liu, Y; Lu, J; Tang, M; Wang, J; Wu, Z1
Humphries, B; Jiang, Y; Kondo, K; Shi, X; Wang, Z; Wu, J; Yang, C1
Chen, Y; Jiang, Y; Liu, Y; Lu, J; Shen, H; Tang, M; Wang, J; Wu, Z; Zhou, Z1
Aboueissa, AE; Martino, J; Wise, JP; Wise, SS1
Clementino, M; Kim, D; Zhang, Z1
Ge, X; He, J; Huang, YX; Jiang, BH; Liu, LZ; Liu, WJ; Qiu, JG; Wang, L; Zhou, FM1
Budhraja, A; Ding, SZ; Han, SY; Hitron, AJ; Li, XL; Lu, J; Michelli-Rivera, A; Pratheeshkumar, P; Wang, L; Wang, X; Yang, YX; Yin, YQ1
Bajpai, P; Budhwar, R; Kumar, S; Nigam, A; Priya, S1
Carpenter, R; He, J; Jiang, BH; Liu, LZ; Qi, Y; Qian, X; Wang, L; Wang, ZX; Xu, Q1
Campleman, SL; Proctor, DM; Suh, M; Thompson, CM1
Chappell, MA; Harris, MA; Haws, LC; Hays, SM; Kirman, CR; Mittal, L; Proctor, DM; Seiter, J; Suh, M; Tappero, RV; Thompson, CM; Vitale, R; Wolf, JC1
Cai, J; Hu, G; Huang, H; Li, X; Liu, J; Xia, B; Zhuang, Z1
Alarcão, A; Alpoim, MC; Carreira, I; Carvalho, L; Mendes, LA; Rodrigues, CF; Val, MM1
Asha, P; Dai, J; Divya, SP; Hitron, JA; Kim, D; Pratheeshkumar, P; Roy, RV; Shi, X; Son, YO; Wang, L; Wang, Y; Zhang, Z1
Darzynkiewicz, Z; Li, C; Park, S; Xu, D; Zhao, H1
Dai, J; Fai, LY; Kim, D; Kondo, K; Luo, J; Park, YH; Pratheeshkumar, P; Shi, X; Son, YO; Wang, L; Xu, M; Zhang, Z1
Chen, D; Costa, M; Fang, L; Jin, C; Kluz, T; Sun, H; Zhang, X1
Asha, P; Dai, J; Divya, SP; Hitron, JA; Kim, D; Pratheeshkumar, P; Roy, RV; Shi, X; Son, YO; Turcios, L; Wang, L; Zhang, Z1
Divya, SP; Hitron, JA; Pratheeshkumar, P; Roy, RV; Shi, X; Son, YO; Wang, L; Zhang, Z1
Chen, C; Ganapathy, S; Lafontant, J; Li, P; Xiong, R; Yu, T; Zhang, G1
Azad, N; Castranova, V; Iyer, AK; Lu, Y; Medan, D; Rojanasakul, Y; Wang, L1
Almeida, A; Alpoim, MC; Alves, M; Botelho, F; Carreira, I; Carvalho, L; Costa, AN; Matoso, E; Monteiro, C; Moreno, V; Rodrigues, CF; Santos, P; Urbano, AM1
Chen, C; Chiu, A; Chiu, N; Dalal, NS; Donehower, L; Hill, R; Katz, A; Lee, WK; Robertson, JD; Shi, XL; Wakeman, TP; Xu, B1
Budhraja, A; Chang, Q; Chen, F; Hitron, JA; Ke, Z; Luo, J; Shi, X; Son, YO; Sun, L; Wang, X; Zhang, Z1
Azad, N; Barnett, JB; Davis, ME; Guo, L; Jiang, BH; Luanpitpong, S; Medan, D; Rojanasakul, Y; Wang, L1
Clancy, HA; Costa, M; Kluz, T; Muñoz, A; Passantino, L; Sun, H; Zavadil, J1
Jiang, BH; Shi, D1
Antonucci, PG; Bryant, BH; Elmore, LW; Holt, SE; Little, JE; Wise, JP; Wise, SS1
Beaubier, J; Chiu, A; Chiu, N; Katz, AJ; Shi, X1
Feng, Z; Hu, W; Tang, MS1
Arakawa, H; Costa, M; Rom, W; Tang, MS; Wu, F1
Ceryak, S; Fornsaglio, JL; Ha, L; O'Brien, TJ; Patierno, SR; Pritchard, DE; Ramsey, KE; Stephan, DA1
Wise, JP; Wise, SS; Xie, H1
Kozachenko, VI; Pashin, IuV1
Sirover, MA1
Shiao, YH; Shibata, M; Shimada, H; Waalkes, MP1
Bajenova, OV; Hamilton, JW; Ihnat, MA; Kaltreider, RC; Lariviere, JP; McCaffrey, J; Nemeth, MJ; Oh, J; Pesce, CA; Rowell, EE; Turpie, BW1
Bridgewater, LC; Manning, FC; Patierno, SR1
Balansky, RM; Camoirano, A; D'Agostini, F; de Flora, S1
Alfonso-De Matte, MY; Kruk, PA; Moses-Soto, H1
Casto, BC; DiPaolo, JA1
Baruthio, F; Danière, MC; Elias, Z; Poirot, O1
Briggs, JA; Briggs, RC1
Stern, RM1
Sky-Peck, HH1
Sunderman, FW1
Hansen, K; Stern, RM1
Gomard, E; Leclerc, JC; Levy, JP1
Anghileri, LJ1
Ge, X; Ge, Z; Jiang, BH; Li, M; Liu, LZ; Qian, X; Shen, H; Shi, Z; Song, GX; Yin, J; Zhang, Z1

Reviews

7 review(s) available for chromium and Cell Transformation, Neoplastic

ArticleYear
Impact of Carcinogenic Chromium on the Cellular Response to Proteotoxic Stress.
    International journal of molecular sciences, 2019, Oct-03, Volume: 20, Issue:19

    Topics: Carcinogens, Environmental; Cell Transformation, Neoplastic; Chromium; DNA Damage; Humans; Neoplasms; Oxidative Stress; Stress, Physiological

2019
Assessment of the mode of action for hexavalent chromium-induced lung cancer following inhalation exposures.
    Toxicology, 2014, Nov-05, Volume: 325

    Topics: Animals; Carcinogens, Environmental; Cell Transformation, Neoplastic; Chromium; DNA Damage; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Inhalation Exposure; Lung; Lung Neoplasms; Occupational Exposure; Risk Assessment; Risk Factors; Time Factors

2014
Review of chromium (VI) apoptosis, cell-cycle-arrest, and carcinogenesis.
    Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews, 2010, Volume: 28, Issue:3

    Topics: Apoptosis; Cell Cycle; Cell Transformation, Neoplastic; Chromium; Humans

2010
Genetic and cellular mechanisms in chromium and nickel carcinogenesis considering epidemiologic findings.
    Molecular and cellular biochemistry, 2004, Volume: 255, Issue:1-2

    Topics: Animals; Carcinogens, Environmental; Cell Transformation, Neoplastic; Chromium; Drosophila; Electron Spin Resonance Spectroscopy; Environmental Exposure; Gene Expression Regulation, Neoplastic; Humans; Mutation; Neoplasms; Nickel; Occupational Diseases; Occupational Exposure; Occupational Health; Public Health; Recombination, Genetic

2004
[Mutagenic activity of chromium compounds].
    Gigiena i sanitariia, 1981, Issue:5

    Topics: Animals; Cell Transformation, Neoplastic; Chromates; Chromium; Chromosome Aberrations; Dose-Response Relationship, Drug; Environmental Pollutants; Genes; Humans; In Vitro Techniques; Mutagens; Neoplasms, Experimental; Salmonella typhimurium; Solubility

1981
Effects of metals in in vitro bioassays.
    Environmental health perspectives, 1981, Volume: 40

    Topics: Animals; Arsenic; Biological Assay; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chromium; Chromosome Aberrations; Cricetinae; Humans; Mesocricetus; Metals; Mutagenicity Tests; Neoplasms; Platinum; Selenium

1981
Trace metals and neoplasia.
    Clinical physiology and biochemistry, 1986, Volume: 4, Issue:1

    Topics: Animals; Arsenic; Beryllium; Cadmium; Carcinogens; Cell Transformation, Neoplastic; Chromium; Chromosome Aberrations; DNA; DNA Polymerase I; Environmental Exposure; Gastrointestinal Neoplasms; Humans; In Vitro Techniques; Neoplasms; Neoplasms, Experimental; Nickel; Occupational Diseases; Respiratory Tract Neoplasms; Selenium; Trace Elements

1986

Other Studies

55 other study(ies) available for chromium and Cell Transformation, Neoplastic

ArticleYear
Inferred inactivation of the Cftr gene in the duodena of mice exposed to hexavalent chromium (Cr(VI)) in drinking water supports its tumor-suppressor status and implies its potential role in Cr(VI)-induced carcinogenesis of the small intestines.
    Toxicology and applied pharmacology, 2021, 12-15, Volume: 433

    Topics: Administration, Oral; Animals; Cell Transformation, Neoplastic; Chromium; Cystic Fibrosis Transmembrane Conductance Regulator; Databases, Genetic; Drinking Water; Duodenal Neoplasms; Duodenum; Gene Expression Profiling; Gene Silencing; Mice; Risk Assessment; Systems Biology; Transcriptome; Tumor Suppressor Proteins; Water Pollutants, Chemical

2021
Chronic Hexavalent Chromium Exposure Upregulates the RNA Methyltransferase METTL3 Expression to Promote Cell Transformation, Cancer Stem Cell-Like Property, and Tumorigenesis.
    Toxicological sciences : an official journal of the Society of Toxicology, 2022, 04-26, Volume: 187, Issue:1

    Topics: Animals; Carcinogenesis; Cell Transformation, Neoplastic; Chromates; Chromium; Humans; Lung Neoplasms; Methyltransferases; Mice; Neoplastic Stem Cells; RNA

2022
PKC is an indispensable factor in promoting environmental toxin chromium-mediated transformation and drug resistance.
    Aging, 2022, 02-24, Volume: 14, Issue:4

    Topics: Carcinogenesis; Cell Transformation, Neoplastic; Chromium; Doxorubicin; Drug Resistance; Humans

2022
Hexavalent chromium induces centrosome amplification through ROS-ATF6-PLK4 pathway in colon cancer cells.
    Cell biology international, 2022, Volume: 46, Issue:7

    Topics: Activating Transcription Factor 6; Carcinogenesis; Cell Transformation, Neoplastic; Centrosome; Chromium; Colonic Neoplasms; Humans; Protein Serine-Threonine Kinases; Reactive Oxygen Species

2022
Effect of Gene 33/Mig6/ERRFI1 on hexavalent chromium-induced transformation of human bronchial epithelial cells depends on the length of exposure.
    Journal of environmental science and health. Part C, Toxicology and carcinogenesis, 2022, Volume: 40, Issue:3-4

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Transformation, Neoplastic; Chromium; Epithelial Cells; Humans; Mice; Mice, Nude

2022
Hexavalent chromium causes centrosome amplification by inhibiting the binding between TMOD2 and NPM2.
    Toxicology letters, 2023, May-01, Volume: 380

    Topics: Carcinogenesis; Cell Transformation, Neoplastic; Centrosome; Chromium; Humans

2023
Chronic Hexavalent Chromium Exposure Induces Cancer Stem Cell-Like Property and Tumorigenesis by Increasing c-Myc Expression.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 12-01, Volume: 172, Issue:2

    Topics: Animals; Bronchi; Carcinogenesis; Carcinogens, Environmental; Cell Line; Cell Transformation, Neoplastic; Chromium; Epithelial Cells; Gene Knockdown Techniques; Humans; Mice, Nude; MicroRNAs; Neoplastic Stem Cells; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; Up-Regulation; Xenograft Model Antitumor Assays

2019
Downregulation of hedgehog-interacting protein (HHIP) contributes to hexavalent chromium-induced malignant transformation of human bronchial epithelial cells.
    Carcinogenesis, 2021, 02-11, Volume: 42, Issue:1

    Topics: Bronchi; Carrier Proteins; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Chromium; DNA Methylation; Down-Regulation; Epithelial Cells; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Lung Neoplasms; Membrane Glycoproteins; Respiratory Mucosa; Signal Transduction

2021
Involvement of a novel regulatory cascade consisting of SET-H3K18ac/H3K27ac-53BP1 in Cr(VI)-induced malignant transformation of 16HBE cells.
    Toxicology letters, 2021, Mar-15, Volume: 339

    Topics: Bronchi; Cell Transformation, Neoplastic; Chromium; Epithelial Cells; Humans; Neoplasms; Tumor Cells, Cultured; Tumor Suppressor p53-Binding Protein 1

2021
Protection from Cr(VI)-induced malignant cell transformation and tumorigenesis of Cr(VI)-transformed cells by luteolin through Nrf2 signaling.
    Toxicology and applied pharmacology, 2017, 09-15, Volume: 331

    Topics: Carcinogenesis; Carcinogens, Environmental; Cell Line; Cell Transformation, Neoplastic; Chromium; Cytoprotection; Dose-Response Relationship, Drug; Humans; Luteolin; NF-E2-Related Factor 2; Signal Transduction

2017
Comparative Proteomics of Chromium-Transformed Beas-2B Cells by 2D-DIGE and MALDI-TOF/TOF MS.
    Biological trace element research, 2018, Volume: 185, Issue:1

    Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Chromium; Humans; Male; Mice; Mice, Nude; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proteomics; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Two-Dimensional Difference Gel Electrophoresis

2018
Upregulation of histone-lysine methyltransferases plays a causal role in hexavalent chromium-induced cancer stem cell-like property and cell transformation.
    Toxicology and applied pharmacology, 2018, 03-01, Volume: 342

    Topics: Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromium; Histone-Lysine N-Methyltransferase; Humans; Mice; Mice, Nude; Neoplastic Stem Cells; Up-Regulation; Xenograft Model Antitumor Assays

2018
Role of LKB1 in migration and invasion of Cr(VI)-transformed human bronchial epithelial Beas-2B cells.
    Anti-cancer drugs, 2018, Volume: 29, Issue:7

    Topics: AMP-Activated Protein Kinase Kinases; Animals; Cell Line; Cell Movement; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Chromium; Epithelial Cells; Humans; Lung Neoplasms; Mice, Nude; Neoplasm Invasiveness; Protein Serine-Threonine Kinases

2018
Hexavalent Chromium-Induced Chromosome Instability Drives Permanent and Heritable Numerical and Structural Changes and a DNA Repair-Deficient Phenotype.
    Cancer research, 2018, 08-01, Volume: 78, Issue:15

    Topics: Carcinogenesis; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Centrosome; Chromium; Chromosomal Instability; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; DNA Repair-Deficiency Disorders; Humans; Lung; Phenotype

2018
Constitutive Activation of NAD-Dependent Sirtuin 3 Plays an Important Role in Tumorigenesis of Chromium(VI)-Transformed Cells.
    Toxicological sciences : an official journal of the Society of Toxicology, 2019, 05-01, Volume: 169, Issue:1

    Topics: Bronchi; Cell Line, Transformed; Cell Proliferation; Cell Transformation, Neoplastic; Chromates; Chromium; Energy Metabolism; Enzyme Activation; Epithelial Cells; Humans; Kelch-Like ECH-Associated Protein 1; Mitochondria; Mitophagy; NF-E2-Related Factor 2; Sequestosome-1 Protein; Signal Transduction; Sirtuin 3

2019
Suppression of miR-143 contributes to overexpression of IL-6, HIF-1α and NF-κB p65 in Cr(VI)-induced human exposure and tumor growth.
    Toxicology and applied pharmacology, 2019, 09-01, Volume: 378

    Topics: Animals; Bronchi; Carcinogenesis; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Chromium; Epithelial Cells; Female; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-6; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; NF-kappa B; Reactive Oxygen Species; Signal Transduction; Transcription Factor RelA

2019
Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells.
    Toxicology and applied pharmacology, 2013, May-15, Volume: 269, Issue:1

    Topics: Antigens, CD; Cadherins; Carcinogens, Environmental; Catalase; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Shape; Cell Transformation, Neoplastic; Chromium; Dose-Response Relationship, Drug; Epithelial Cells; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Reactive Oxygen Species; Respiratory Mucosa; RNA, Messenger; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Vimentin

2013
Lipoic acid prevents Cr(6+) induced cell transformation and the associated genomic dysregulation.
    Environmental toxicology and pharmacology, 2013, Volume: 36, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Cell Transformation, Neoplastic; Chromium; Gene Expression Profiling; Gene Expression Regulation; Macrophages, Peritoneal; Male; Mice; Microarray Analysis; Thioctic Acid

2013
Repression of miR-143 mediates Cr (VI)-induced tumor angiogenesis via IGF-IR/IRS1/ERK/IL-8 pathway.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 134, Issue:1

    Topics: Animals; Carcinogens, Environmental; Cell Line; Cell Transformation, Neoplastic; Chromium; Down-Regulation; Epithelial Cells; Humans; Insulin Receptor Substrate Proteins; Interleukin-8; Lung Neoplasms; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neovascularization, Pathologic; Receptor, IGF Type 1; Up-Regulation

2013
Synchrotron-based imaging of chromium and γ-H2AX immunostaining in the duodenum following repeated exposure to Cr(VI) in drinking water.
    Toxicological sciences : an official journal of the Society of Toxicology, 2015, Volume: 143, Issue:1

    Topics: Animals; Cell Transformation, Neoplastic; Chromates; Chromium; DNA Damage; Duodenal Neoplasms; Duodenum; Female; Histones; Hyperplasia; Immunohistochemistry; Intestinal Absorption; Intestinal Mucosa; Mice; Microspectrophotometry; Microvilli; Rats, Inbred F344; Risk Assessment; Spectrometry, X-Ray Emission; Synchrotrons; Time Factors; Water Pollutants, Chemical

2015
[Investigation of the action mechanisms of poly-ADP-ribosylation in hexavalent chromium induced cell damage].
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2014, Volume: 48, Issue:8

    Topics: Bronchi; Cell Transformation, Neoplastic; Chromium; Cofilin 1; DNA Repair; Epithelial Cells; Glycoside Hydrolases; Humans; Tandem Mass Spectrometry

2014
Senescent bronchial fibroblasts induced to senescence by Cr(VI) promote epithelial-mesenchymal transition when co-cultured with bronchial epithelial cells in the presence of Cr(VI).
    Mutagenesis, 2015, Volume: 30, Issue:2

    Topics: Bronchi; Cell Transformation, Neoplastic; Cellular Senescence; Chromium; Coculture Techniques; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibroblasts; Humans

2015
Luteolin inhibits Cr(VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways.
    Toxicology and applied pharmacology, 2014, Dec-01, Volume: 281, Issue:2

    Topics: Angiogenic Proteins; Animals; Anticarcinogenic Agents; Apoptosis Regulatory Proteins; Bronchi; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Chromium; Cytoprotection; Dose-Response Relationship, Drug; Epithelial Cells; Free Radical Scavengers; Humans; Inflammation Mediators; Lung Neoplasms; Luteolin; Mice, Nude; Oxidative Stress; Potassium Dichromate; Reactive Oxygen Species; Signal Transduction; Transfection; Xenograft Model Antitumor Assays

2014
Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells.
    Oncotarget, 2016, Feb-23, Volume: 7, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Apoptosis; Blotting, Western; Carcinogens, Environmental; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chromium; DNA Damage; Epithelial Cells; Humans; Immunoprecipitation; Lung; Lung Neoplasms; Micronucleus Tests; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Suppressor Proteins

2016
Activation of Epidermal Growth Factor Receptor/p38/Hypoxia-inducible Factor-1α Is Pivotal for Angiogenesis and Tumorigenesis of Malignantly Transformed Cells Induced by Hexavalent Chromium.
    The Journal of biological chemistry, 2016, 07-29, Volume: 291, Issue:31

    Topics: Animals; Cell Transformation, Neoplastic; Chromium; ErbB Receptors; Female; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Occupational Exposure; p38 Mitogen-Activated Protein Kinases

2016
Hexavalent Chromium (Cr(VI)) Down-Regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Acetylation; Basic Helix-Loop-Helix Transcription Factors; Carcinogens, Environmental; Cell Line; Cell Transformation, Neoplastic; Chromium; Epigenesis, Genetic; Histones; Humans; Lung; Lung Neoplasms; Lysine; Neoplasm Proteins; Up-Regulation

2016
Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling.
    Oncotarget, 2016, Aug-09, Volume: 7, Issue:32

    Topics: A549 Cells; Animals; Apoptosis Regulatory Proteins; Bronchi; Cell Transformation, Neoplastic; Cells, Cultured; Chromium; Epithelial Cells; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Reactive Oxygen Species; Respiratory Mucosa; RNA-Binding Proteins; Signal Transduction

2016
Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells.
    Toxicology and applied pharmacology, 2016, 09-15, Volume: 307

    Topics: Cell Line; Cell Transformation, Neoplastic; Chromium; Cyclooxygenase 2; Humans; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Tumor Necrosis Factor-alpha

2016
Chromium IV exposure, via Src/Ras signaling, promotes cell transformation.
    Molecular carcinogenesis, 2017, Volume: 56, Issue:7

    Topics: Carcinogens, Environmental; Cell Transformation, Neoplastic; Cells, Cultured; Chromium; Humans; Keratinocytes; Lung; Lung Neoplasms; Oxidation-Reduction; ras Proteins; Reactive Oxygen Species; Signal Transduction; Skin Neoplasms; src-Family Kinases

2017
Nitric oxide-mediated bcl-2 stabilization potentiates malignant transformation of human lung epithelial cells.
    American journal of respiratory cell and molecular biology, 2010, Volume: 42, Issue:5

    Topics: Apoptosis; Caspase 9; Cell Line; Cell Transformation, Neoplastic; Chromium; Cysteine; Epithelial Cells; Humans; Lung; Mutant Proteins; Mutation; Nitric Oxide; Nitroso Compounds; Protein Stability; Proto-Oncogene Proteins c-bcl-2; Superoxides

2010
Human bronchial epithelial cells malignantly transformed by hexavalent chromium exhibit an aneuploid phenotype but no microsatellite instability.
    Mutation research, 2009, Nov-02, Volume: 670, Issue:1-2

    Topics: Aneuploidy; Biomarkers, Tumor; Bronchi; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chromium; Chromosome Aberrations; DNA Repair; Epithelial Cells; Gene Expression Profiling; Humans; Microsatellite Instability; Respiratory Mucosa

2009
NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 123, Issue:2

    Topics: Animals; Bronchi; Carcinogens; Cell Line; Cell Membrane; Cell Survival; Cell Transformation, Neoplastic; Chromates; Chromium; Enzyme Activation; Epithelial Cells; Gene Silencing; Humans; Mice; Mice, Nude; NADPH Oxidases; Neoplasm Transplantation; Neoplasms; Oxidative Stress; Oxidoreductases; Phosphorylation; Reactive Oxygen Species; RNA, Small Interfering; Transfection; Xenograft Model Antitumor Assays

2011
Multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of Cr(VI)-transformed lung cells.
    PloS one, 2012, Volume: 7, Issue:5

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Chromium; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Humans; Lung; Lung Neoplasms; Male; Mice; Neoplasm Invasiveness; Neovascularization, Pathologic; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53

2012
Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer.
    Metallomics : integrated biometal science, 2012, Volume: 4, Issue:8

    Topics: Arsenic; Bronchi; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Chromium; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Nickel; Vanadium

2012
Antioxidant properties of apple juice and its protection against Cr(VI)-induced cellular injury.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 2002, Volume: 21, Issue:3

    Topics: Antioxidants; Apoptosis; Beverages; Biological Assay; Carcinogens, Environmental; Cell Transformation, Neoplastic; Chemoprevention; Chromium; Comet Assay; DNA Damage; Epithelial Cells; Flow Cytometry; Humans; Lipid Peroxidation; Lung; Male; Malus; NF-kappa B; Prostatic Neoplasms; Reactive Oxygen Species; Tumor Cells, Cultured

2002
Telomerase-mediated lifespan extension of human bronchial cells does not affect hexavalent chromium-induced cytotoxicity or genotoxicity.
    Molecular and cellular biochemistry, 2004, Volume: 255, Issue:1-2

    Topics: Carcinogens, Environmental; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Chromates; Chromium; DNA-Binding Proteins; Humans; Karyotyping; Recombinant Proteins; Telomerase

2004
Chromium(VI) enhances (+/-)-anti-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-induced cytotoxicity and mutagenicity in mammalian cells through its inhibitory effect on nucleotide excision repair.
    Biochemistry, 2004, Nov-09, Volume: 43, Issue:44

    Topics: Adenine Phosphoribosyltransferase; Animals; Benzopyrans; Carcinogens, Environmental; Cell Death; Cell Transformation, Neoplastic; CHO Cells; Chromium; Cricetinae; DNA Adducts; DNA Repair; Drug Synergism; Epoxy Compounds; Genes, Reporter; Humans; Mutagenesis

2004
Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites.
    Carcinogenesis, 2006, Volume: 27, Issue:3

    Topics: Base Sequence; Carcinogens, Environmental; Cell Transformation, Neoplastic; Chromium; DNA Adducts; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Humans; Lung Neoplasms; Molecular Sequence Data; Point Mutation; Tumor Suppressor Protein p53

2006
Resistance to apoptosis, increased growth potential, and altered gene expression in cells that survived genotoxic hexavalent chromium [Cr(VI)] exposure.
    Molecular and cellular biochemistry, 2005, Volume: 279, Issue:1-2

    Topics: Apoptosis; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Chromates; Chromium; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation; Humans; Mutagens; Sodium Compounds; Telomerase; Time Factors; Transfection

2005
Deficient repair of particulate hexavalent chromium-induced DNA double strand breaks leads to neoplastic transformation.
    Mutation research, 2008, Jan-08, Volume: 649, Issue:1-2

    Topics: Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Bronchi; Cell Cycle Proteins; Cell Transformation, Neoplastic; Cells, Cultured; Chromium; Comet Assay; DNA Breaks, Double-Stranded; DNA Repair; DNA-Binding Proteins; Fluorescent Antibody Technique; Humans; MRE11 Homologue Protein; Protein Serine-Threonine Kinases; RNA, Small Interfering; Transfection; Tumor Suppressor Proteins

2008
In Vitro models and methods for bioassay and studies of cellular mechanisms.
    Environmental health perspectives, 1981, Volume: 40

    Topics: Animals; Bacteria; Biological Assay; Carcinogens; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cell-Free System; Chromium; Chromosome Aberrations; Metals; Mutagenicity Tests; Neoplasms

1981
Cadmium suppresses apoptosis induced by chromium.
    Journal of toxicology and environmental health. Part A, 1998, May-22, Volume: 54, Issue:2

    Topics: Animals; Apoptosis; Cadmium; Carcinogens; Cell Transformation, Neoplastic; CHO Cells; Chromium; Cricetinae; Cricetulus; Drug Interactions; In Vitro Techniques; Metallothionein

1998
Molecular basis for effects of carcinogenic heavy metals on inducible gene expression.
    Environmental health perspectives, 1998, Volume: 106 Suppl 4

    Topics: Animals; Arsenic; Cell Transformation, Neoplastic; Chick Embryo; Chromium; Environmental Exposure; Gene Expression; Genetic Markers; Humans; Neoplasms; Promoter Regions, Genetic; Rats; Toxicity Tests; Transcription Factors

1998
Arrest of replication by mammalian DNA polymerases alpha and beta caused by chromium-DNA lesions.
    Molecular carcinogenesis, 1998, Volume: 23, Issue:4

    Topics: Ascorbic Acid; Cell Cycle; Cell Transformation, Neoplastic; Chromium; DNA Adducts; DNA Damage; DNA Polymerase beta; DNA Polymerase I; DNA Replication; DNA-Directed DNA Polymerase; DNA, Bacterial; Humans; Plasmids

1998
Interactions between N-acetylcysteine and ascorbic acid in modulating mutagenesis and carcinogenesis.
    International journal of cancer, 2000, Dec-01, Volume: 88, Issue:5

    Topics: Acetylcysteine; Animals; Ascorbic Acid; Carcinogenicity Tests; Cell Transformation, Neoplastic; Chromium; Drug Stability; Female; Lung Neoplasms; Mice; Mutagenesis; Urethane

2000
Calcium-mediated telomerase activity in ovarian epithelial cells.
    Archives of biochemistry and biophysics, 2002, Mar-15, Volume: 399, Issue:2

    Topics: Cadmium; Calcium; Cell Transformation, Neoplastic; Cells, Cultured; Chromium; Epithelial Cells; Female; Humans; Ovarian Neoplasms; Telomerase; Tumor Cells, Cultured; Verapamil

2002
Quantitative studies of in vitro morphological transformation of Syrian hamster cells by inorganic metal salts.
    Cancer research, 1979, Volume: 39, Issue:3

    Topics: Animals; Arsenic; Beryllium; Cadmium; Cell Transformation, Neoplastic; Cells, Cultured; Chromium; Cricetinae; Dose-Response Relationship, Drug; Embryo, Mammalian; Female; Maternal-Fetal Exchange; Mesocricetus; Metals; Nickel; Pregnancy

1979
Role of solubilized chromium in the induction of morphological transformation of Syrian hamster embryo (SHE) cells by particulate chromium(VI) compounds.
    Carcinogenesis, 1991, Volume: 12, Issue:10

    Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chromates; Chromium; Cricetinae; Embryo, Mammalian; Intracellular Fluid; Lead; Mesocricetus; Solubility; Zinc; Zinc Compounds

1991
Characterization of chromium effects on a rat liver epithelial cell line and their relevance to in vitro transformation.
    Cancer research, 1988, Nov-15, Volume: 48, Issue:22

    Topics: Animals; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Chromium; DNA; Epithelium; Glutathione; Liver; Neoplasm Transplantation; Proteins; Rats; Rats, Inbred F344

1988
Indicators of matrix dependent variation in effective dose for chromium and nickel aerosol exposures.
    The Science of the total environment, 1988, Jun-01, Volume: 71, Issue:3

    Topics: Aerosols; Air Pollutants, Occupational; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Chromium; Mutagenicity Tests; Nickel

1988
Carcinogenicity and mutagenicity of some metals and their compounds.
    IARC scientific publications, 1986, Issue:71

    Topics: Animals; Arsenic; Cadmium; Carcinogens; Cell Transformation, Neoplastic; Chromium; Chromosome Aberrations; DNA; DNA Damage; DNA-Directed DNA Polymerase; Humans; Metals; Microsomes, Liver; Mutagens; Nickel; Nucleoproteins; Platinum; Tin; Transcription, Genetic

1986
Welding fumes and chromium compounds in cell transformation assays.
    Journal of applied toxicology : JAT, 1985, Volume: 5, Issue:5

    Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chromium; Cricetinae; Gases; Humans; Mesocricetus; Potassium Dichromate; Welding

1985
Spontaneous antilymphoma reaction of preleukaemic AKR mice is a non-T-cell killing.
    Nature, 1974, Aug-23, Volume: 250, Issue:5468

    Topics: Age Factors; AKR murine leukemia virus; Animals; Antigen-Antibody Reactions; Antigens, Neoplasm; Antilymphocyte Serum; Cell Transformation, Neoplastic; Chromium; Complement System Proteins; Cytotoxicity Tests, Immunologic; Female; Immunity, Cellular; Leukemia, Experimental; Lymphocytes; Lymphoma; Male; Mice; Mice, Inbred AKR; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Rats; Spleen

1974
Interaction of ethylenediaminetetraacetic acid with plasma proteins. II. Its effects on the binding of indium and chromium.
    Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1969, Volume: 2, Issue:3

    Topics: Blood Proteins; Cell Transformation, Neoplastic; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Chromium; Chromium Isotopes; Edetic Acid; Humans; Indium; Protein Binding; Serum Albumin

1969
Chromium (VI)-induced ALDH1A1/EGF axis promotes lung cancer progression.
    Clinical and translational medicine, 2022, Volume: 12, Issue:12

    Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Epidermal Growth Factor; Humans; Lung; Lung Neoplasms; Neoplastic Processes; Retinal Dehydrogenase; Tics

2022