chondroitin-sulfates and Urination-Disorders

We studied the feasibility and efficacy of intravesical instillations with 40 ml chondroitin sulfate 0.2% solution to prevent or reduce acute radiation cystitis in women undergoing pelvic radiotherapy.. In a comparative pilot study in 20 patients, half of the patients received instillations. Instillations' bother was measured with visual analog scores (VAS, 0-10); bladder pain, with VAS; micturition-related quality of life, with the urogenital distress inventory (UDI).. One of the instilled patients discontinued the instillations. The first median "acceptability"-VAS was 0 (range, 0-3); the last median was 1 (range, 0-3). "Bladder pain"-VAS peaked halfway in the treatment among controls (median, 1; range, 0-5) and after treatment in the instilled patients (median, 1; range, 1-3). UDI scores showed over time median follow-up scores at or above median baseline scores in controls and at or below median baseline scores in instilled patients.. Intravesical instillations with chondroitin sulfate 0.2% solution may decrease the bother related to bladder symptoms and are well tolerated.

Topics: Acute Disease; Administration, Intravesical; Adult; Aged; Aged, 80 and over; Chondroitin Sulfates; Cystitis; Female; Humans; Middle Aged; Pain Measurement; Patient Acceptance of Health Care; Pilot Projects; Quality of Life; Radiation Injuries; Radiotherapy; Surveys and Questionnaires; Urination; Urination Disorders; Uterine Cervical Neoplasms; Uterine Neoplasms