chondroitin-sulfates and Skin-Ulcer

A case of pyoderma gangrenosum progressively developing after bilateral mastopexy at the surgical site is described. The described case was successfully treated with corticosteroids, the application of the dermal regeneration template Integra and autologous skin grafts. This approach was able to save the patient's life and to generate a high-quality aesthetical outcome. The article reported the case, reviewed the literature of pyoderma gangrenosum related to mastopexy or augmentation mammoplasty and discussed the use of a dermal regeneration template to optimise aesthetical results after reconstructive surgery.

Topics: Adult; Alginates; Chondroitin Sulfates; Collagen; Drainage; Female; Humans; Mammaplasty; Pyoderma Gangrenosum; Skin Ulcer; Skin, Artificial; Surgical Wound Infection; Tomography, X-Ray Computed; Wound Healing

We present the case of a 58-year-old lady who developed radionecrosis following irradiation of the chest wall following mastectomy. The ensuing radionecrosis of the soft tissue and bony rib cage on the left side of the chest wall progressed to advanced ischaemia with secondary infection and abscess formation. Initially the patient underwent left-sided chest wall reconstruction using a right-sided pedicled TRAM flap. The flap eventually became ischaemic and necrosed over a period of 3 weeks leaving the pleura and ribs exposed. The patient underwent VAC Therapy in order to promote the formation of granulation tissue. Several weeks later the greater Omentum was harvested as a pedicled flap and transposed into the defect which was then in turn covered with Integra and a split-skin graft. Complete wound closure was obtained with this Integra-omental flap reconstructive technique.

Topics: Breast Neoplasms; Chondroitin Sulfates; Collagen; Female; Humans; Mastectomy; Middle Aged; Necrosis; Omentum; Radiodermatitis; Skin Ulcer; Surgical Flaps; Thoracic Wall; Tissue and Organ Harvesting; Treatment Outcome; Wound Healing

This study aims at restoring the skin from traumatism by use of the collagen(from piglet skin) and konjac glucomannan-chondroitin sulfate blend film. The 2 cm x 4 cm skin traumatism model was established on both sides of the waist spinal column in 14 New Zealand rabbits each weighing 1.5-2.0 kg. One side was covered with blend film, the other side was used as a control. Then the changes of the skin traumatism were observed at different time-points after the operation, the wound tissue samples were taken for histological examination. The blend film could prevent skin traumatism from bleeding and infection. The skin traumatism treated by blend film showed signs of rectangle scab and the control showed signs of linear scab after healing. No obvious immune rejection was seen. The collagen-konjac glucomannan-chondroitin sulfate blend film can accelerate the restoration of skin from traumatism.

Topics: Animals; Chondroitin Sulfates; Collagen; Female; Male; Mannans; Membranes, Artificial; Rabbits; Skin; Skin Ulcer; Wound Healing