chondroitin-sulfates and Retinal-Detachment

This study examines the impact of corneal surface lubricants used during pars plana vitrectomy on corneal edema.. This prospective, observational, clinical study occurred at an academic institution. Participants were individuals aged 18 years and older who had already consented to undergo pars plana vitrectomy, without pre-existing corneal pathology. A corneal lubricant was chosen by the surgeon. Corneal thickness was measured preoperatively and postoperatively using pachymetry and anterior segment optical coherence tomography (AS-OCT). Main outcome measure was change in corneal thickness as measured by pachymetry.. Forty-one patients completed the study protocol. The 23 subjects in the SHCS group had a significantly smaller increase in corneal thickness as measured by pachymetry compared with the 18 subjects in the HPMC group (29.9 μm vs. 58.1 μm, P value 0.02). When measured by anterior segment optical coherence tomography, the SHCS group had a smaller increase in corneal thickness compared with the HPMC group (0.04 mm vs. 0.06 mm, P value 0.09) but did not reach significance.. SHCS is associated with reduced postoperative increase in corneal pachymetry as compared to HPMC.

Topics: Aged; Chondroitin Sulfates; Cornea; Corneal Pachymetry; Drug Combinations; Female; Humans; Hyaluronic Acid; Hypromellose Derivatives; Lubricants; Male; Middle Aged; Prospective Studies; Retinal Detachment; Retinal Perforations; Tomography, Optical Coherence; Vitrectomy; Vitreous Hemorrhage

To determine whether ophthalmic viscoelastic devices (OVDs) can be used during vitrectomy to prevent perflorocarbon liquid (PFCL) from leaking into the subretinal space through retinal tears in eyes with proliferative vitreoretinopathy (PVR). The OVDs are adhesive materials that can temporally close retinal breaks. We introduce a "soft shell technique", which allows the unfolding of the retina by PFCL.. We studied five eyes of five patients with proliferative vitreoretinopathy that underwent vitrectomy using the soft shell technique. After removing the core vitreous, the OVDs were carefully injected over the area where confluent retinal folds were formed with possible retinal breaks. This created a soft shell shield on the retina that can prevent the intravitreal PFCL from leaking into the subretinal space.. The soft shell technique still allowed the PFCL to unfold the retina even if iatrogenic breaks are present. The high viscosity of OVDs sealed the iatrogenic retinal breaks and thus prevented the PFCL from leaking into the subretinal space during the vitrectomy. All patients had an improvement of the visual acuity, and four eyes had a reattachment of the retina.. Although only five eyes were examined, the success of the soft shell technique indicates that it can be used with PFCL, which facilitates the unfolding of the contracted retina.

Topics: Adult; Aged; Chondroitin Sulfates; Drainage; Drug Combinations; Fluorocarbons; Humans; Hyaluronic Acid; Laser Coagulation; Male; Middle Aged; Retinal Detachment; Silicone Oils; Viscosupplements; Vitrectomy; Vitreoretinopathy, Proliferative

Topics: Chondroitin Sulfates; Glucosamine; History, 19th Century; History, 20th Century; Retinal Detachment; Surgical Procedures, Operative