chondroitin-sulfates and Neuralgia

chondroitin-sulfates has been researched along with Neuralgia* in 1 studies

Other Studies

1 other study(ies) available for chondroitin-sulfates and Neuralgia

Article	Year
Effect of repeated oral administration of chondroitin sulfate on neuropathic pain induced by partial sciatic nerve ligation in mice. Journal of pharmacological sciences, 2018, Volume: 137, Issue:4 We examined whether chondroitin sulfate (CS), a compound used to treat osteoarthritis and joint pain, is effective against partial sciatic nerve ligation (PSNL)-induced neuropathic pain. Repeated oral administration of CS (300 mg/kg, b.i.d. for 20 days) resulted in inhibition of tactile allodynia observed 21 days after PSNL. On day 21, phosphorylation of spinal p38 mitogen-activated protein kinase (MAPK) was attenuated by CS. CS also inhibited c-Fos upregulation in ipsilateral deep dorsal horn (laminae III-IV) neurons, which receive Aβ-fiber afferent inputs. These findings suggest that CS attenuates PSNL-induced tactile allodynia by inhibiting spinal p38 MAPK phosphorylation and Aβ-fiber activation. Topics: Administration, Oral; Amyloid beta-Peptides; Animals; Chondroitin Sulfates; Hyperalgesia; Ligation; Male; Mice, Inbred Strains; Neuralgia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-fos; Sciatic Nerve; Spinal Cord; Spinal Cord Dorsal Horn	2018

Article

Year

Effect of repeated oral administration of chondroitin sulfate on neuropathic pain induced by partial sciatic nerve ligation in mice.

Journal of pharmacological sciences, 2018, Volume: 137, Issue:4

We examined whether chondroitin sulfate (CS), a compound used to treat osteoarthritis and joint pain, is effective against partial sciatic nerve ligation (PSNL)-induced neuropathic pain. Repeated oral administration of CS (300 mg/kg, b.i.d. for 20 days) resulted in inhibition of tactile allodynia observed 21 days after PSNL. On day 21, phosphorylation of spinal p38 mitogen-activated protein kinase (MAPK) was attenuated by CS. CS also inhibited c-Fos upregulation in ipsilateral deep dorsal horn (laminae III-IV) neurons, which receive Aβ-fiber afferent inputs. These findings suggest that CS attenuates PSNL-induced tactile allodynia by inhibiting spinal p38 MAPK phosphorylation and Aβ-fiber activation.

Topics: Administration, Oral; Amyloid beta-Peptides; Animals; Chondroitin Sulfates; Hyperalgesia; Ligation; Male; Mice, Inbred Strains; Neuralgia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-fos; Sciatic Nerve; Spinal Cord; Spinal Cord Dorsal Horn

2018