chondroitin-sulfates and Lipidoses

Clinical, radiological, histochemical, ultrastructural, and biochemical studies were conducted on three cases of I-cell disease. I-cell disease can be readily distinguished from Hurler syndrome (mucopolysaccharidosis I) by the presence of hypertrophic gums, vacuolated lymphocytes in peripheral blood, and a normal level of urinary mucopolysaccharides. Accumulation of proteoglycans was more prominent in the inclusion bodies of I-cell chondrocytes in comparison to cultured fibroblasts, which contained a large amount of glycolipids and a small amount of proteoglycans. An autosomal recessive mode of inheritance was suggested in two of the cases.

Topics: Abnormalities, Multiple; Cartilage; Child, Preschool; Chondroitin Sulfates; Cytoplasmic Granules; Female; Fibroblasts; Growth Disorders; Humans; Infant; Lipidoses; Lymphocytes; Male; Psychomotor Disorders; Renal Aminoacidurias; Syndrome