chondroitin-sulfates and Hand-Deformities--Acquired

chondroitin-sulfates has been researched along with Hand-Deformities--Acquired* in 2 studies

Trials

1 trial(s) available for chondroitin-sulfates and Hand-Deformities--Acquired

Article	Year
A two-year study of chondroitin sulfate in erosive osteoarthritis of the hands: behavior of erosions, osteophytes, pain and hand dysfunction. Drugs under experimental and clinical research, 2004, Volume: 30, Issue:1 The aim of this study was to evaluate the effect of 800 mg/die of chondroitin sulfate (CHS) per os plus naproxen versus naproxen over 2 years in patients with erosive osteoarthritis (EOA) of the hands. Joint count for erosions, Heberden and Bouchard nodes, Dreiser's algofunctional index and physicians' and patients' global assessment of disease activity were studied. A total of 24 consecutive patients (22 women and 2 men, mean age 53.0 +/- 6) suffering from symptomatic OA with radiographic characteristics of EOA were evaluated. The patients were divided into two groups of 12 patients each. The first group took naproxen 500 mg only. The second group was treated with CHS 800 mg orally plus naproxen 500 mg. Joint counts, radiological hand examinations and assessment of disease activity were performed at baseline, at 12 months and at 24 months. In the second year the treated group showed significant worsening in erosion, Heberden, Bouchard and Dreiser scores was recorded. Physician and patient global assessments of disease activity showed no significant difference from baseline scores. The untreated group showed significant worsening in erosion, Heberden and Bouchard nodes, Dreiser index and physician and patient global assessment scores. This study confirms the partial efficacy of oral CHS in improving some aspects of EOA. Topics: Anti-Inflammatory Agents, Non-Steroidal; Chondroitin Sulfates; Disease Progression; Drug Therapy, Combination; Female; Finger Joint; Hand Deformities, Acquired; Humans; Male; Middle Aged; Naproxen; Osteoarthritis; Pain; Prospective Studies; Radiography; Severity of Illness Index; Treatment Outcome	2004

Article

Year

A two-year study of chondroitin sulfate in erosive osteoarthritis of the hands: behavior of erosions, osteophytes, pain and hand dysfunction.

Drugs under experimental and clinical research, 2004, Volume: 30, Issue:1

The aim of this study was to evaluate the effect of 800 mg/die of chondroitin sulfate (CHS) per os plus naproxen versus naproxen over 2 years in patients with erosive osteoarthritis (EOA) of the hands. Joint count for erosions, Heberden and Bouchard nodes, Dreiser's algofunctional index and physicians' and patients' global assessment of disease activity were studied. A total of 24 consecutive patients (22 women and 2 men, mean age 53.0 +/- 6) suffering from symptomatic OA with radiographic characteristics of EOA were evaluated. The patients were divided into two groups of 12 patients each. The first group took naproxen 500 mg only. The second group was treated with CHS 800 mg orally plus naproxen 500 mg. Joint counts, radiological hand examinations and assessment of disease activity were performed at baseline, at 12 months and at 24 months. In the second year the treated group showed significant worsening in erosion, Heberden, Bouchard and Dreiser scores was recorded. Physician and patient global assessments of disease activity showed no significant difference from baseline scores. The untreated group showed significant worsening in erosion, Heberden and Bouchard nodes, Dreiser index and physician and patient global assessment scores. This study confirms the partial efficacy of oral CHS in improving some aspects of EOA.

Topics: Anti-Inflammatory Agents, Non-Steroidal; Chondroitin Sulfates; Disease Progression; Drug Therapy, Combination; Female; Finger Joint; Hand Deformities, Acquired; Humans; Male; Middle Aged; Naproxen; Osteoarthritis; Pain; Prospective Studies; Radiography; Severity of Illness Index; Treatment Outcome

2004

Other Studies

1 other study(ies) available for chondroitin-sulfates and Hand-Deformities--Acquired

Article	Year
[Dupuytren contracture in childhood]. Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V..., 1985, Volume: 17, Issue:3 A two-year old boy suffered a contracture of the second and third digit beginning at the age of seven months. The clinical examination suggested a diagnosis of early Dupuytren's disease. A partial fasciectomy was performed. Histological examination showed a fibrosis palmaris similar to Dupuytren's disease. The biochemical examination (Glycans, hyaluronic acid, chrondroitinsulfat, dermatansulfat and heparansulfat) showed also changes in the extracellular proteoglycanmatrix similar to those found in adult Dupuytren's disease. Topics: Child, Preschool; Chondroitin Sulfates; Dermatan Sulfate; Dupuytren Contracture; Fascia; Glycosaminoglycans; Hand; Hand Deformities, Acquired; Heparitin Sulfate; Humans; Hyaluronic Acid; Male; Tendons	1985

Article

Year

[Dupuytren contracture in childhood].

Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse : Organ der V..., 1985, Volume: 17, Issue:3

A two-year old boy suffered a contracture of the second and third digit beginning at the age of seven months. The clinical examination suggested a diagnosis of early Dupuytren's disease. A partial fasciectomy was performed. Histological examination showed a fibrosis palmaris similar to Dupuytren's disease. The biochemical examination (Glycans, hyaluronic acid, chrondroitinsulfat, dermatansulfat and heparansulfat) showed also changes in the extracellular proteoglycanmatrix similar to those found in adult Dupuytren's disease.

Topics: Child, Preschool; Chondroitin Sulfates; Dermatan Sulfate; Dupuytren Contracture; Fascia; Glycosaminoglycans; Hand; Hand Deformities, Acquired; Heparitin Sulfate; Humans; Hyaluronic Acid; Male; Tendons

1985