chondroitin-sulfates and Facial-Neoplasms

In 2010 excellent aesthetic results after basal cell carcinoma excision and one-stage coverage with Integra without split thickness skin graft (STSG) were published in a series of 10 Asian patients. Our aim in this study was to verify these results in a series of Caucasian patients and evaluate this procedure as a possible new standard.. 6 patients with facial basal cell carcinoma were treated by regular excision with 3 mm safety margins and one-stage coverage with Integra without STSG, followed by a clinical evaluation and fotodocumentation.. In 3 patients local infection occurred with a complete loss of the Integra. 2 out of these 3 patients showed an unaesthetic scar and are considering another surgical approach for correction. The other 3 patients had an uneventful course, unfortunately 2 out of these patients (67%) developed an unaesthetic scar as well and are also considering surgical correction.. Because of aesthetically unsatisfactory results and high infection rates we abandoned this procedure after 6 patients only. Our standard remains excision with 3 mm safety margins, histological analysis and one-stage repair with local facial flaps.

Topics: Adult; Aged; Carcinoma, Basal Cell; Chondroitin Sulfates; Cicatrix; Collagen; Facial Neoplasms; Female; Follow-Up Studies; Humans; Male; Microsurgery; Middle Aged; Plastic Surgery Procedures; Postoperative Complications; Skin Neoplasms; Skin Transplantation; Surgical Wound Infection

In an effort to minimize the radial forearm flap donor-site morbidity, the flap was elevated using the suprafascial dissection technique, in six patients with various facial defects. The donor site was covered primarily with Integra artificial skin and secondarily with an ultrathin split-thickness skin graft. The mean time to wound healing of the forearm donor site was 24 days. There were no flap failures, and all flaps healed uneventfully. At the end of the follow-up, all patients showed normal range of motion of the wrist and the fingers, normal power grip, and power pinch. All patients evaluated the esthetic appearance of the forearm donor site as very good. In conclusion, suprafascial dissection of the forearm flap creates a superior graft recipient site, and the use of Integra artificial dermis is a valuable advancement to further minimize the donor-site morbidity, resulting in excellent functional and aesthetic outcomes.

Topics: Aged; Chondroitin Sulfates; Collagen; Facial Neoplasms; Female; Follow-Up Studies; Forearm; Humans; Male; Middle Aged; Plastic Surgery Procedures; Skin Neoplasms; Skin Transplantation; Skin, Artificial; Surgical Flaps; Tissue and Organ Harvesting; Treatment Outcome

Topics: Carcinoma, Basal Cell; Chondroitin Sulfates; Collagen; Facial Neoplasms; Female; Forehead; Humans; Middle Aged; Mohs Surgery; Plastic Surgery Procedures; Skin Neoplasms; Skin, Artificial